ANTHRANILIC ACID DERIVATIVES

Abstract
Compounds of formula (I) are provided, wherein X is CH═CH, CH2O wherein the oxygen atom is bound to ring B, or OCH2 wherein the oxygen atom is bound to ring A; Y is hydrogen, straight or branched C1-C6 alkyl or a pharmaceutically acceptable inorganic cation; R1 is ethyl or cyclopropyl; and R2 and R3 are the same or different and are selected from F, Cl, Br, CF3 and OCF3. The compounds are useful for the treatment of autoimmune diseases, inflammatory diseases, organ transplant rejection, and malignant neoplasia. Pharmaceutical compositions comprising the compounds, methods of using the compounds, and methods for preparing the compounds are also provided.
Description
FIELD OF THE INVENTION

The present invention relates to novel anthranilic acid derivatives, which are stable towards oxidation by human cytochrome P450 and are potent inhibitors of dihydroorotate dehydrogenase (DHODH), to be used for clinical treatment of autoimmune diseases, inflammatory diseases, organ transplant rejection and malignant neoplasia. These compounds and pharmaceutical compositions of this invention are particularly useful for preventing and treating acute and chronic inflammation, rheumatoid arthritis, multiple sclerosis, type-1 diabetes, inflammatory bowel disease, psoriasis, transplant rejection and malignant neoplastic disease. More particularly, the present invention relates to novel derivatives suitable for the treatment of rheumatoid arthritis and transplant rejection.


BACKGROUND OF THE INVENTION

Rheumatoid Arthritis (RA) is a chronic inflammatory disease of unknown cause that leads to pain, stiffness, swelling and limitation in the motion and function of multiple joints. If left untreated, RA can produce serious destruction of joints that frequently leads to permanent disability. RA currently has a worldwide distribution with an estimated prevalence of 0.5 to 1%.


The main symptom of RA is the persistent inflammation of the joints, usually in a symmetric distribution. This inflammation leads to the destruction of cartilage, bone erosion and structural changes in the joint, which may range from minimal joint damage to debilitating disease. Some patients also experience the effects of RA in places other than the joints.


RA is a chronic disorder for which no cure currently exists. The major goals of treatment are to reduce pain and discomfort, prevent deformities, and minimize loss of joint function to maintain a productive and active life. For treatment to be considered successful, inflammation must be suppressed. Many pathways involved in the generation of the disease have been recognized and some of these have been unequivocally identified as important by therapeutic proof of principle studies. Major pharmacological treatments for RA include, but are not limited to, analgesics, non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and disease modifying anti-rheumatic drugs (DMARDs), including biologicals.


NSAIDs are typically given at the onset of symptoms and serve to reduce inflammation and pain thereby improving function. NSAIDs relieve symptoms but do not slow disease progression, so patients will eventually need additional or replacement therapies. Thus, DMARDs are typically added to the treatment regimen soon after diagnosis. The goal of DMARD use is to slow down the progression of disease. Methotrexate (MTX) (Merck Index 12th Ed., #6065) is currently the most commonly prescribed first-line DMARD. However, the administration of MTX has been associated with serious side effects such as skin reactions, pulmonary pneumonitis, gastrointestinal disturbances, hepatotoxicity and renal toxicity. The second leading oral DMARD is leflunomide (ARAVA®). However, as with MTX, leflunomide has been shown to have serious side effects including hepato- and haematological toxicity as well as pulmonary pneumonitis.


A number of biologicals have recently been approved for clinical treatment of RA. These drugs (proteins, e.g., monoclonal antibodies) prevent in general pro-inflammatory cytokines, in particular TNF-α and IL-1, from interacting with their receptors. Biologicals are often added to the treatment regimen once DMARD therapy is no longer adequate, or side effects have become unmanageable. The most commonly prescribed biologicals, e.g., infliximab (REMICADE®), block tissue necrosis factor-alpha (TNF-α), which is a pro-inflammatory cytokine produced by macrophages and lymphocytes. The pro-inflammatory effects of TNF-α suggest that inhibition of TNF-α would be clinically useful in RA. Indeed, clinical trial data has confirmed the efficacy of these TNF inhibitors in relieving the signs and symptoms of RA. However, these biologicals have potentially severe side effects including severe infections, sepsis, tuberculosis and fatal liver toxicity.


Dihydroorotate dehydrogenase (DHODH) catalyzes the conversion of dihydroorotate to orotate concurrent with the reduction of ubiquinone. DHODH controls the rate limiting step in the de novo pyrimidine biosynthesis. DHODH inhibition results in decreased cellular levels of ribonucleotide uridine monophosphate (rUMP), thus arresting proliferating cells in the G1 phase of the cell cycle. The inhibition of de novo pyrimidine nucleotide synthesis is of great interest in view of the observations that lymphocytes seem not to be able to undergo clonal expansion when this pathway is blocked.


Two major compound classes of mammalian DHODH inhibitors have been described in the literature. These are represented by brequinar (Merck Index 12th Ed., #1394), of formula







and the active metabolite A771726 of leflunomide, of formula







Proof of concept for DHODH inhibition has been established for brequinar. Indeed, biochemical and x-ray crystallographic studies have demonstrated that brequinar is a competitive inhibitor versus the co-factor ubiquinone.


WO 2005/075410 discloses anthranilic acid derivatives of general formula (A)







This PCT application concerns compounds which inhibit DHODH, useful for preventing and treating acute and chronic inflammation, rheumatoid arthritis, multiple sclerosis, type-1 diabetes, inflammatory bowel disease, psoriasis, transplant rejection and malignant neoplastic disease. The type and position of the R2/R3 substitution are stated to be crucial for a strong DHODH inhibition. Compounds wherein R2/R3 are lipophilic substituents with high 1-values in the range of 0.5 to 2 (Kubinyi, 1993) are said to display maximal inhibition. Moreover, monosubstitution, i.e., R3 is hydrogen, is indicated to be superior to di-substitution, the position of the monosubstitution being important for the effect. Thus, in monosubstituted compounds, the ortho-substitution is stated to be superior to meta-substitution, and far superior to substitution in the para-position. In a preferred embodiment of WO 2005/075410, X is CH2, O, S, CH═CH, OCH2, CH2O or CH2S, and R2 and R3 are the same or different and represent hydrogen or substituents in the 2-, 3- or 5-positions. In a more preferred embodiment of WO 2005/075410, X is OCH2, Y is hydrogen, R2 is a substituent in the ortho-position and is trifluoromethyl, and R3 is hydrogen. In a further preferred embodiment of said application, X is O, Y is hydrogen, and R2 and R3 are substituents in the meta- and meta'-positions, and are trifluoromethyl.


EP0497740 discloses benzyloxyphenyl derivatives of general formula (B)







This patent concerns compounds possessing antihyperproliferative/anti-inflammatory and anticancer activity. In a preferred group of compounds, R1 and R3 are methoxy, and the benzyloxy moiety is in meta-position in respect to R6. R6 is carboxy or an ester group, R5 is hydroxy or acetylamino, especially hydroxy.


EP0815087 discloses trisubstituted phenyl derivatives of general formula (C)







This patent concerns compounds for the treatment of inflammatory and proliferative skin diseases and cancer. The compounds are to be administered topically or in divided doses up to four times a day. In the most preferred compounds, R1 and R2 are methoxy, W is CH2CH2, and R3 and R4 together with the phenyl ring form a condensed ring system.


Research Disclosure, 1998, 409(May), P561-P562 (No. 40953) discloses synthetic analogues of the natural product lavendustin A, of general formula (D)







Compounds are disclosed wherein R1 and R2 are the same or different and represent alkoxy, alkyl or alkenyloxy, R3 is i.a. alkoxy and R4 is i.a. acylamino.


Gennari et al., (1994) reported an anaerobic degradation in soil of 2-nitrophenoxy acids used as herbicides, e.g., acifluorfen, (Merck Index 12th Ed., #111) that gives compound E







There is no teaching in the literature disclosing the use of compound E as a pharmaceutical agent.


SUMMARY OF THE INVENTION

A primary objective of the present invention is to provide structurally novel anthranilic acid derivatives, which by virtue of their pharmacological profile, with high potency in experimental models and low level of side effects, are considered to be of value in the treatment of autoimmune diseases, inflammatory diseases, organ transplant rejection and malignant neoplasia. In particular, according to one aspect, the invention aims to provide compounds that show a substantial stability towards oxidation by human cytochrome P450 and that inhibit DHODH.


Furthermore, the invention aims to provide a pharmaceutical composition containing a therapeutically effective amount of a compound according to the invention, as well as the use of a compound of the invention for the treatment and prevention of diseases, in particular diseases where there is an advantage in inhibiting DHODH.


According to an important aspect of the invention, compounds are provided that may be used for preventing and treating, but not restricted to, acute and chronic inflammation, rheumatoid arthritis, multiple sclerosis, type-1 diabetes, inflammatory bowel disease, psoriasis, transplant rejection and malignant neoplastic disease. In one embodiment, the present invention provides compounds suitable for the treatment of rheumatoid arthritis and transplant rejection.


Thus, according to one aspect the present invention provides compounds of formula (I)







wherein


X is CH═CH, CH2O wherein the oxygen is bound to ring B, or OCH2 wherein the oxygen is bound to ring A;


Y is hydrogen, straight or branched C1-C6 alkyl or a pharmaceutically acceptable inorganic cation;


R1 is ethyl or cyclopropyl; and


R2 and R3 are the same or different and are selected from F, Cl, Br, CF3 and OCF3.


In one particular embodiment of the invention, X is CH2O wherein the oxygen is bound to ring B. In another particular embodiment of the invention, X is OCH2 wherein the oxygen is bound to ring A. In still a further embodiment of the invention, X is CH═CH.


In one embodiment of the invention, R2 is CF3 or OCF3. In one embodiment of the invention, Y is a pharmaceutically acceptable cation selected from e.g., Li+, Na+, K+, Mg2+, Ca2+ and Zn2+. In one embodiment of the invention, in which Y is a divalent cation, the salt contains two anthranilic acid derivative moieties for each cation Y. In another embodiment, in which Y is a divalent cation, the salt comprises one negative monovalent counterion, e.g., a halogen or a bicarbonate (HCO3) anion, e.g., Cl or Br, and one anthranilic acid derivative moiety for each cation Y.


In one embodiment of the invention, Y is a straight or branched C1-C6 alkyl group, e.g., a straight or branched C1-C4 alkyl group, or a straight or branched C1-C3 alkyl group.


In one preferred embodiment of the invention, X is CH2O wherein the oxygen is bound to ring B; Y is hydrogen, straight or branched C1-C6 alkyl or a pharmaceutically acceptable inorganic cation; R1 is ethyl or cyclopropyl; and R2 and R3 are the same or different and are selected from F, Cl, Br, CF3 and OCF3.


In one preferred embodiment of the invention, X is CH2O wherein the oxygen is bound to ring B; Y is hydrogen or a pharmaceutically acceptable inorganic cation; R1 is ethyl or cyclopropyl; and R2 and R3 are the same or different and are selected from F, Cl, Br, CF3 and OCF3.


In another preferred embodiment of the invention, X is CH2O wherein the oxygen is bound to ring B; Y is hydrogen, straight or branched CT-C6 alkyl or a pharmaceutically acceptable inorganic cation; R1 is ethyl or cyclopropyl; R2 is CF3 or OCF3; and R3 is F, Cl, Br, CF3 or OCF3.


In still another preferred embodiment of the invention, X is CH2O wherein the oxygen is bound to ring B; Y is hydrogen or a pharmaceutically acceptable inorganic cation; R1 is ethyl or cyclopropyl; R2 is CF3 or OCF3; and R3 is F, Cl, Br, CF3 or OCF3.


Some of the most preferred compounds of formula (I) are:

  • 5-(2-Chloro-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid;
  • 5-(2-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid;
  • 5-(2-Bromo-4-chloro-phenoxymethyl)-2-propionylamino-benzoic acid;
  • 5-[(E)-2-(2,4-Bis-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid;
  • 5-[(E)-2-(2-Chloro-4-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid;
  • 5-[(E)-2-(2,4-Dichloro-phenyl)-vinyl]-2-propionylamino-benzoic acid; and
  • 5-[(E)-2-(4-Chloro-2-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid.


Further aspects and embodiments of the invention will present themselves to the skilled person in light of the following detailed description and are as defined in the claims.







DETAILED DESCRIPTION OF THE INVENTION

The compounds of formula (I) unexpectedly displayed extraordinary resistance towards oxidation by the human cytochrome P450 enzymes in conjunction with potent inhibition of the DHODH enzyme. In contrast to this, compounds of formula (A) according to the above-mentioned WO 2005/075410, wherein R3 is hydrogen and R2 is ortho or meta, have been found to be extensively metabolized by human cytochrome P450 enzymes, primarily the CYP2C9 isoform. There is no rat or mouse orthologue of the human CYP2C9 enzyme. These in vivo findings are reflected in in vitro liver microsome preparations where T½ is >200 minutes for rat, 150 minutes for mouse and 3 minutes for human. The P450 enzymes exhibit broad substrate specificity and the same oxidation are in general catalyzed to by alternative enzymes in preclinical species. However, for the compounds of this invention, a pronounced across species variation in oxidation activity is seen in vitro in microsomes from various species including human and consequently preclinical in vivo models fail to predict the metabolic and pharmacokinetic behavior of these compounds in human. Therefore, human liver microsomes comprising the important cytochrome P450 enzymes have been used for predicting pharmacokinetic properties of these compounds in human.


Table 1 illustrates the impact of substitution pattern on the metabolic stability and the DHODH inhibitory potency.


















TABLE 1













Jurkat











IC50
t1/2


Compound
Type
X
ortho
meta
para
meta′
R1
(μM)
(min)
























PA 1
prior art
OCH2
CF3



C-propyl
0.62
3


PA 2
prior art
CH2O
CF3



Et
0.49
4


PA 3
prior art
CH═CH
CF3



Et
0.12
13


PA 4
prior art
CH2O

CF3


Et
0.43
22


PA 5
prior art
OCH2

CF3

CF3
Et
5.4
n.d.


PA 6
prior art
CH2O

CF3

CF3
Et
1.13
n.d.


INV 1
Invention
CH2O
CF3

CF3

Et
0.6
stable


INV 2
Invention
CH2O
CF3

F

Et
0.58
236


INV 3
Invention
CH2O
CF3

Br

Et
0.47
234


INV 4
Invention
CH2O
Cl

CF3

Et
0.42
stable


INV 5
Invention
CH2O
Cl

F

Et
0.19
323


INV 6
Invention
CH2O
Cl

Cl

Et
0.35
199


INV 7
Invention
CH2O
Br

CF3

Et
0.49
408


INV 8
Invention
CH2O
Br

F

Et
0.36
320


INV 9
Invention
CH2O
Br

Cl

Et
0.24
168


INV 10
Invention
CH2O
Cl

OCF3

Et
0.24
stable


INV 11
Invention
CH═CH
CF3

CF3

Et
0.09
489


INV 12
Invention
CH═CH
CF3

F

Et
0.16
159


INV 13
Invention
CH═CH
CF3

Cl

Et
0.05
105


INV 14
Invention
CH═CH
F

F

Et
0.24
213


INV 15
Invention
CH═CH
Cl

F

Et
0.035
137


INV 16
Invention
CH═CH
Cl

Cl

Et
0.02
110


INV 17
Invention
CH2O

CF3
F

Et
0.53
104


INV 18
Invention
CH2O

CF3
Cl

Et
0.84
464


INV 19
Invention
CH2O

Cl
F

Et
0.42
71


INV 20
Invention
CH2O

CI
Br

Et
0.73
72


INV 21
Invention
CH2O

CI
OCF3

Et
0.89
168


INV 22
Invention
CH2O

Br
OCF3

Et
0.71
198


INV 23
Invention
CH═CH

CF3
F

Et
0.75
147


INV 24
Invention
CH═CH

CF3
Cl

Et
0.57
345


INV 25
Invention
CH═CH

F
CF3

Et
0.74
stable


INV 26
Invention
CH═CH

Cl
F

Et
0.75
73


INV 27
Invention
CH═CH

Cl
Cl

Et
0.48
115


INV 28
Invention
CH═CH

Cl
OCF3

Et
0.6
n.d.


INV 29
Invention
OCH2
CF3

Cl

Et
0.57
110


INV 30
Invention
OCH2
Br

CF3

Et
0.59
191


INV 31
Invention
OCH2
CF3

Br

C-propyl
0.42
232


REF 1
Reference
CH2O
Cl

CH3

Et
0.07
1


REF 2
Reference
CH2O
Cl

OCH3

Et
0.18
4


REF 3
Reference
CH2O
CH3

Cl

Et
0.39
16


REF 4
Reference
CH2O
OCH3

Cl

Et
0.99
34


REF 5
Reference
CH2O
CH3

CH3

Et
0.51
3


REF 6
Reference
CH2O

CH3
Cl

Et
0.31
16


REF 7
Reference
OCH2
OCH3


OCH3
Et
3.24
4











REF 8
Reference
2-acetylamino-5-(2,5-dimethoxy-benzyloxy)-
6.2





benzoic acid


REF 9
Reference
2-acetylamino-5-[2-(2,5-dimethoxy-phenyl)-ethyl]-
12




benzoic acid


REF 10
Reference
2-Propionylamino-5-(2-trifluoromethyl-benzyloxy)-
12.3




benzoic acid methyl ester





Notes:


t1/2 equal to “stable” indicates that that no degradation could be confirmed in the assay


n.d. = not determined


Et = ethyl


C-propyl = cyclopropyl






In those of the compounds shown in Table 1 that are according to the invention (INV 1-31), “ortho” and “meta” correspond to R3, while “para” corresponds to R2.


As pointed out herein above, one important object of the invention is to provide compounds that show a substantial stability towards oxidation by human cytochrome P450 and that inhibit DHODH.


In order to obtain continuous plasma drug exposure after once-daily administration to human, compounds demonstrating a substantial in vitro metabolic stability towards oxidation by cytochrome P450, e.g., a half-life (t1/2) longer than 70 min in the human in vitro system used are preferred. A metabolic stability half-life of longer than 70 minutes corresponds to a predicted hepatic extraction ratio of less than 0.3, which is considered as low according to Rowland et al. (Rowland M and Tozer T. N., (1995), in Clinical Pharmacokinetics Concepts and Applications, third edition, Williams & Wilkins, USA, p. 163).


Thus, by a compound having a “substantial stability towards oxidation by human cytochrome P450” is meant that the compound has a stability towards oxidation by human cytochrome P450 that preferably allows treatment of a mammal subject, such as a human subject, by administration of a therapeutically effective dose only once or twice a day, more preferably by a once-daily administration.


In one embodiment of the invention, compounds according to formula (I) as herein defined are provided having a substantial in vitro metabolic stability towards oxidation by cytochrome P450, e.g., a half-life (t1/2) longer than about 70 minutes, or longer than about 100 minutes, longer than about 200 minutes or even longer than about 300 minutes, e.g., a half-life within the range of from 70 to 500 minutes, or 100 to 400 minutes, or even longer, when tested in the human in vitro system as described in the present application.


In another embodiment of the invention, a pharmaceutical composition is provided comprising a therapeutically effective amount of a compound according to formula (I) as herein defined, which compound has a substantial in vitro metabolic stability towards oxidation by cytochrome P450, e.g., a half-life (t1/2) longer than about 70 minutes, or longer than about 100 minutes, longer than about 200 minutes or even longer than about 300 minutes, e.g., a half-life within the range of from 70 to 500 minutes, e.g. 100 to 400 minutes, or even longer, when tested in the human in vitro system as described in the present application.


For the purpose of the present invention, “a therapeutically effective amount” should be construed in the conventional sense, i.e., as an amount sufficient to provide a health benefit to the subject being treated. Such a health benefit may be e.g., a curing of the disorder, a slowing down of its progression, or a relief of any symptom of the disorder.


According to one aspect of the invention, there is provided the use of the compounds of the invention for preparing a medicament suitable for the treatment of disorders that are beneficially influenced by inhibiting DHODH.


In one embodiment, the medicament is for the treatment of disorders selected from autoimmune diseases, inflammatory diseases, organ transplant rejection and malignant neoplasia.


In another embodiment, the disorders are selected from acute and chronic inflammation, rheumatoid arthritis, multiple sclerosis, type-1 diabetes, inflammatory bowel disease, psoriasis, transplant rejection and malignant neoplastic disease, in particular rheumatoid arthritis and transplant rejection.


In one embodiment, the invention provides the use of the compounds of the invention for preparing a medicament suitable for the treatment of disorders as mentioned herein above, by daily or bi-daily administration of a therapeutically effective amount of the compounds to a mammal in need of such treatment, more preferably by daily administration.


Synthetic Methods

The compounds of general formula (I) may be prepared e.g., by the following methods:







In method A, the compounds of formula I wherein X is OCH2 wherein the oxygen is bound to ring A are prepared by reacting a compound of formula II, with a benzylic reagent wherein A is a leaving group, e.g., bromide, chloride, mesyloxy or tosyloxy.


The reaction may be carried out in a suitable solvent such as a polar aprotic solvent, e.g., acetone, acetonitrile or DMF, in the presence of an alkali metal carbonate, e.g., potassium carbonate. If Y is a C1-C6 alkyl group, the acid function may be obtained by simple alkaline hydrolysis of the ester functionality. The acid function may be converted into the corresponding salt by reaction with a suitable base.







In method B, the compounds of formula I wherein X is CH2O wherein the oxygen is bound to ring B are prepared by reacting a compound of formula IV with a phenol V in a suitable solvent such as a polar aprotic solvent, e.g., acetone, acetonitrile or DMF, in the presence of an alkali metal carbonate, e.g., potassium carbonate. If Y is a C1-C6 alkyl group, the acid function may be obtained by simple alkaline hydrolysis of the ester functionality. The acid function may be converted into the corresponding salt by reaction with a suitable base.







In method C, compounds of formula I wherein X is CH═CH are prepared by reacting a compound of formula VI with a styrene VII (Heck-reaction) with palladium catalysis in a suitable solvent such as a polar aprotic solvent, e.g., DMF, in the presence of an alkali metal carbonate, e.g., potassium carbonate. If Y is a C1-C6 alkyl group, the acid function may be obtained by simple alkaline hydrolysis of the ester functionality. The acid function may be converted into the corresponding salt by reaction with a suitable base.







In method D, compounds of formula VIII are transformed to the corresponding 5-benzyl bromide IV by reaction with 1,3-dibromo-5,5-dimethyl hydantoin (CAS No.: 77-48-5) (Patil, S D, Jones C, Nair M G, Galivan J, Maley F, Kisliuk R L, Gaumont Y, Duch D, Ferone R, J. Med. Chem., 1989, 32, 1284-89).







In method E, compounds of the general formula IX (e.g., II (W═OH), VI (W═Br) and VIII (W═CH3)) are prepared from commercially available 5-substituted anthranilic acids. Reaction of such an acid with an anhydrous alcohol in the presence of thionyl chloride (SOCl2, CAS No.: 7719-09-7) provides the anthranilic ester. Suitable acylating reagents to transform the anthranilic ester to the amide (IX) are, for example, acid anhydrides and acyl chlorides (A is a leaving group).







In method F, phenols of the general formula V, e.g., non-commercially available phenols, are prepared from commercially available anilines by diazotation followed by boiling in 33% sulfuric acid.


Synthetic Procedures

In general, nuclear magnetic resonances were recorded at 400 MHz using Bruker ARX 400 spectrometer. The spectra were obtained in CDCl3, CDCl3+TFA or D6-DMSO and the shift scale was referenced to the shift of TMS, defined as 0.00 ppm. Abbreviations used in the description of NMR spectra are: s=singlet, d=doublet, t=triplet, q=quartet, dd=double doublet, dt=double triplet, m=multiplet and b=broad signal. In the Examples below AutoNom Standard was used to generate the compound names.


Example 1
2,4-(Bis-trifluoromethyl)-phenol
Method F

To an ice-cold solution of 2,4-bis(trifluoromethyl)-aniline (1.26 g, 5.50 mmol) in sulphuric acid (33%, 40 ml) was added a solution of sodium nitrite (0.46 g, 6.67 mmol) in water (2 ml). After 3 h at 0° C. urea (0.10 g, 1.67 mmol) was added and the reaction mixture was stirred at 0° C. for an additional ten minutes. The reaction mixture was then added to boiling sulphuric acid (33%, 100 ml) and refluxed for 1 h. The reaction mixture was allowed to reach room temperature and was then extracted with ethyl acetate. The organic phase was washed first with water and then with brine, dried over sodium sulphate, filtered and evaporated to dryness. The crude product was chromatographed on silica gel using heptane/ethyl acetate (4/1) as eluent to give 0.29 g (23%) of the title compound. 1H NMR (CDCl3) δ 7.08 (d, 1H), 7.17 (bs, 1H), 7.67 (dd, 1H), 7.80 (d, 1H).


Example 2
5-(2,4-Dichloro-benzyloxy)-2-propionylamino-benzoic acid
Method A

A mixture of 5-hydroxy-2-propionyl-carbonyl-amino-benzoic acid methyl ester (200 mg, 0.90 mmol), 2,4-dichloro-benzyl bromide (235 mg, 0.99 mmol) and potassium carbonate (411 mg, 2.97 mmol) in acetone (5 ml) was heated to reflux. After 4 hours, the reaction mixture was allowed to reach room temperature, was acidified with 1 M HCl and the resulting precipitate collected by filtration, washed with water and dried under vacuum to give pure 5-(2,4-dichloro-benzyloxy)-2-propionylamino-benzoic acid methyl ester (254 mg, 66%). This was hydrolyzed in ethanol (3 mL) and 1.0 M NaOH (3 mL) overnight and then acidified with 1.0 M HCl. The resulting precipitate was collected by filtration, washed with water and dried under vacuum (223 mg, 91%). 1H-NMR (DMSO-d6) δ 1.12 (t, 3H), 2.38 (q, 2H), 5.17 (s, 2H), 7.31 (dd, 1H), 7.49 (dd, 1H), 7.54 (d, 1H), 7.64 (d, 2H), 7.70 (d, 1H), 8.38 (d, 1H), 10.80 (s, 1H), 13.66 (bs, 1H).


In essentially the same manner the following compounds were obtained from the corresponding starting materials:

  • 5-(4-Bromo-2-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid


1H-NMR (DMSO-d6) δ 0.81 (d, 4H), 1.66 (m, 1H), 5.22 (s, 2H), 7.26 (dd, 1H), 7.49 (d, 1H), 7.71 (d, 1H), 7.95 (d, 1H), 8.29 (d, 1H), 10.96 (s, 1H), 13.64 (bs, 1H)

  • 5-(4-Fluoro-2-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid


1H-NMR (CDCl3+TFA) δ: 1.35 (t, 3H), 2.62 (q, 2H), 5.27 (s, 2H), 7.31 (dd, 1H), 7.46 (dd, 1H), 7.70-7.74 (m, 2H), 8.58 (d, 1H), 10.77 (s, 1H)

  • 5-(2,4-Bis-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.12 (t, 3H), 2.38 (q, 2H), 5.37 (s, 2H), 7.32 (dd, 1H), 7.54 (d, 1H), 8.04 (d, 1H), 8.11 (s, 1H), 8.15 (d, 1H), 8.39 (d, 1H), 10.80 (s, 1H), 13.60 (bs, 1H)

  • 5-(4-Chloro-2-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.12 (t, 3H), 2.38 (q, 2H), 5.24 (s, 2H), 7.29 (dd, 1H), 7.51 (d, 1H), 7.78-7.84 (m, 2H), 7.87 (s, 1H), 8.39 (d, 1H), 10.80 (s, 1H), 13.60 (bs, 1H)

  • 5-(2-Chloro-4-fluoro-benzyloxy)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.12 (t, 3H), 2.38 (q, 2H), 5.14 (s, 2H), 7.26-7.32 (m, 2H), 7.52-7.55 (m, 2H), 7.67 (dd, 1H), 8.39 (d, 1H), 10.80 (s, 1H), 13.60 (bs, 1H)

  • 2-(Cyclopropanecarbonyl-amino)-5-(4-fluoro-2-trifluoromethyl-benzyloxy)-benzoic acid


1H-NMR (DMSO-d6) δ 0.84 (d, 4H), 1.70 (m, 1H), 5.22 (s, 2H), 7.27 (dd, 1H), 7.51 (d, 1H), 7.61 (dt, 1H), 7.71 (dd, 1H), 7.84 (dd, 1H), 8.31 (d, 1H), 11.00 (s, 1H), 13.72 (bs, 1H)

  • 5-(2-Bromo-4-fluoro-benzyloxy)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.12 (t, 3H), 2.38 (q, 2H), 5.13 (s, 2H), 7.29-7.35 (m, 2H), 7.54 (d, 1H), 7.64-7.70 (m, 2H), 8.38 (d, 1H), 10.80 (s, 1H), 13.68 (bs, 1H)

  • 5-(2-Fluoro-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.12 (t, 3H), 2.38 (q, 2H), 5.28 (s, 2H), 7.33 (dd, 1H), 7.56 (d, 1H), 7.66 (d, 1H), 7.76 (d, 1H), 7.81 (t, 1H), 8.39 (d, 1H), 10.80 (s, 1H), 13.69 (bs, 1H)

  • 5-(2-Bromo-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.12 (t, 3H), 2.38 (q, 2H), 5.24 (s, 2H), 7.33 (dd, 1H), 7.56 (d, 1H), 7.80-7.86 (m, 2H), 8.09 (s, 1H), 8.39 (d, 1H), 10.81 (s, 1H), 13.70 (bs, 1H)

  • 5-(4-Chloro-3-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.12 (t, 3H), 2.38 (q, 2H), 5.22 (s, 2H), 7.31 (dd, 1H), 7.55 (d, 1H), 7.75-7.79 (m, 2H), 7.96 (s, 1H), 8.39 (d, 1H), 10.80 (s, 1H), 13.69 (bs, 1H)

  • 5-(3,4-Dibromo-benzyloxy)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.12 (t, 3H), 2.37 (q, 2H), 5.12 (s, 2H), 7.28 (dd, 1H), 7.41 (dd, 1H), 7.53 (d, 1H), 7.79 (d, 1H), 7.86 (d, 1H), 8.39 (d, 1H), 10.85 (s, 1H), 13.68 (bs, 1H)

  • 5-(4-Bromo-3-chloro-benzyloxy)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.12 (t, 3H), 2.37 (q, 2H), 5.13 (s, 2H), 7.29 (dd, 1H), 7.37 (dd, 1H), 7.53 (d, 1H), 7.73 (d, 1H), 7.80 (d, 1H), 8.39 (d, 1H), 10.84 (s, 1H), 13.69 (bs, 1H)

  • 5-(4-Bromo-2-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.11 (t, 3H), 2.37 (q, 2H), 5.22 (s, 2H), 7.27 (dd, 1H), 7.50 (d, 1H), 7.72 (d, 1H), 7.95 (d, 1H), 7.97 (s, 1H), 8.37 (d, 1H), 10.82 (s, 1H), 13.69 (bs, 1H)

  • 5-(2,4-Difluoro-benzyloxy)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.11 (t, 3H), 2.37 (q, 2H), 5.12 (s, 2H), 7.13 (dt, 1H), 7.27-7.34 (m, 2H), 7.53 (d, 1H), 7.62 (q, 1H), 8.37 (d, 1H), 10.83 (s, 1H), 13.68 (bs, 1H)

  • 5-(4-Chloro-2-fluoro-benzyloxy)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.11 (t, 3H), 2.37 (q, 2H), 5.14 (s, 2H), 7.29 (dd, 1H), 7.34 (dd, 1H), 7.50 (dd, 1H), 7.53 (d, 1H), 7.59 (t, 1H), 8.37 (d, 1H), 10.82 (s, 1H), 13.68 (bs, 1H)

  • 5-(4-Bromo-2-fluoro-benzyloxy)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.11 (t, 3H), 2.37 (q, 2H), 5.13 (s, 2H), 7.29 (dd, 1H), 7.46 (dd, 1H), 7.50-7.54 (m, 2H), 7.62 (dd, 1H), 8.37 (d, 1H), 10.81 (s, 1H), 13.66 (bs, 1H)

  • 5-(2-Chloro-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid
  • 5-(4-Bromo-2-chloro-benzyloxy)-2-propionylamino-benzoic acid
  • 5-(2-Bromo-4-chloro-benzyloxy)-2-propionylamino-benzoic acid
  • 5-(2,4-Dibromo-benzyloxy)-2-propionylamino-benzoic acid
  • 5-(3,4-Bis-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid
  • 5-(4-Fluoro-3-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.12 (t, 3H), 2.38 (q, 2H), 5.20 (s, 2H), 7.30 (dd, 1H), 7.54 (d, 1H), 7.57 (d, 1H), 7.84-7.87 (m, 1H), 7.89 (d, 1H), 8.39 (d, 1H), 10.81 (s, 1H), 13.66 (bs, 1H)

  • 5-(4-Bromo-3-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid
  • 5-(3-Fluoro-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.12 (t, 3H), 2.38 (q, 2H), 5.24 (s, 2H), 7.31 (dd, 1H), 7.56 (dd, 1H), 7.64-7.68 (m, 2H), 7.71 (s, 1H), 8.40 (d, 1H), 10.81 (s, 1H), 13.67 (bs, 1H)

  • 5-(3,4-Difluoro-benzyloxy)-2-propionylamino-benzoic acid
  • 5-(4-Chloro-3-fluoro-benzyloxy)-2-propionylamino-benzoic acid
  • 5-(4-Bromo-3-fluoro-benzyloxy)-2-propionylamino-benzoic acid
  • 5-(3-Chloro-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid
  • 5-(3-Chloro-4-fluoro-benzyloxy)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.12 (t, 3H), 2.37 (q, 2H), 5.11 (s, 2H), 7.28 (dd, 1H), 7.44 (t, 1H), 7.46-7.49 (m, 1H), 7.53 (d, 1H), 7.69 (dd, 1H), 8.38 (d, 1H), 10.80 (s, 1H), 13.66 (bs, 1H)

  • 5-(3,4-Dichloro-benzyloxy)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.12 (t, 3H), 2.37 (q, 2H), 5.15 (s, 2H), 7.29 (dd, 1H), 7.46 (dd, 1H), 7.53 (d, 1H), 7.67 (d, 1H), 7.74 (dd, 1H), 8.38 (d, 1H), 10.79 (s, 1H), 13.65 (bs, 1H)

  • 5-(3-Bromo-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid
  • 5-(3-Bromo-4-fluoro-benzyloxy)-2-propionylamino-benzoic acid
  • 5-(3-Bromo-4-chloro-benzyloxy)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.12 (t, 3H), 2.38 (q, 2H), 5.14 (s, 2H), 7.29 (dd, 1H), 7.50 (dd, 1H), 7.53 (d, 1H), 7.66 (d, 1H), 7.87 (d, 1H), 8.38 (d, 1H), 10.79 (s, 1H), 13.68 (bs, 1H)

  • 5-(3-Chloro-4-trifluoromethoxy-benzyloxy)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.12 (t, 3H), 2.38 (q, 2H), 5.18 (s, 2H), 7.31 (dd, 1H), 7.55 (d, 1H), 7.58 (dd, 1H), 7.62 (dd, 1H), 7.80 (d, 1H), 8.38 (d, 1H), 10.80 (s, 1H), 13.68 (bs, 1H)

  • 5-(2,4-Bis-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid


1H-NMR (DMSO-d6) δ 0.82 (d, 4H), 1.70 (m, 1H), 5.36 (s, 2H), 7.28 (dd, 1H), 7.52 (d, 1H), 8.03 (d, 1H), 8.10 (s, 1H), 8.14 (d, 1H), 8.31 (d, 1H), 11.04 (s, 1H), 13.70 (bs, 1H)

  • 5-(4-Chloro-2-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid


1H-NMR (DMSO-d6) δ 0.83 (d, 4H), 1.70 (m, 1H), 5.23 (s, 2H), 7.26 (dd, 1H), 7.50 (d, 1H), 7.78-7.83 (m, 2H), 7.87 (d, 1H), 8.30 (d, 1H), 11.02 (s, 1H), 13.66 (bs, 1H)

  • 2-(Cyclopropanecarbonyl-amino)-5-(2-fluoro-4-trifluoromethyl-benzyloxy)-benzoic acid


1H-NMR (DMSO-d6) δ 0.83 (d, 4H), 1.70 (m, 1H), 5.26 (s, 2H), 7.30 (dd, 1H), 7.55 (d, 1H), 7.64 (d, 1H), 7.74 (d, 1H), 7.80 (t, 1H), 8.31 (d, 1H), 11.02 (s, 1H), 13.69 (bs, 1H)

  • 2-(Cyclopropanecarbonyl-amino)-5-(2,4-difluoro-benzyloxy)-benzoic acid


1H-NMR (DMSO-d6) δ 0.83 (d, 4H), 1.70 (m, 1H), 5.12 (s, 2H), 7.13 (dt, 1H), 7.27 (dd, 1H), 7.31 (dt, 1H), 7.53 (d, 1H), 7.62 (q, 1H), 8.30 (d, 1H), 11.02 (s, 1H), 13.66 (bs, 1H)

  • 5-(4-Chloro-2-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid


1H-NMR (DMSO-d6) δ 0.82 (d, 4H), 1.70 (m, 1H), 5.14 (s, 2H), 7.27 (dd, 1H), 7.33 (dd, 1H), 7.50 (dd, 1H), 7.52 (d, 1H), 7.59 (t, 1H), 8.30 (d, 1H), 11.02 (s, 1H), 13.67 (bs, 1H)

  • 5-(4-Bromo-2-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid


1H-NMR (DMSO-d6) δ 0.84 (d, 4H), 1H), 1.70 (m, 1H), 5.13 (s, 2H), 7.27 (dd, 1H), 7.46 (dd, 7.50-7.54 (m, 2H), 7.61 (dd, 1H), 8.30 (d, 1H), 11.02 (s, 1H), 13.68 (bs, 1H)

  • 5-(2-Chloro-4-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 5-(2-Chloro-4-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid


1H-NMR (DMSO-d6) δ 0.84 (d, 4H), 1.69 (m, 1H), 5.13 (s, 2H), 7.25-7.30 (m, 2H), 7.51-7.54 (m, 2H), 7.66 (dd, 1H), 8.30 (d, 1H), 11.02 (s, 1H), 13.68 (bs, 1H)

  • 2-(Cyclopropanecarbonyl-amino)-5-(2,4-dichloro-benzyloxy)-benzoic acid


1H-NMR (DMSO-d6) δ 0.84 (d, 4H), 1.70 (m, 1H), 5.15 (s, 2H), 7.28 (dd, 1H), 7.48 (dd, 1H), 7.52 (d, 1H), 7.62 (d, 1H), 7.69 (d, 1H), 8.31 (d, 1H), 11.03 (s, 1H), 13.69 (bs, 1H)

  • 5-(4-Bromo-2-chloro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 5-(2-Bromo-4-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid


1H-NMR (DMSO-d6) δ 0.84 (d, 4H), 1.70 (m, 1H), 5.22 (s, 2H), 7.30 (dd, 1H), 7.54 (d, 1H), 7.79-7.84 (m, 2H), 8.07 (s, 1H), 8.32 (d, 1H), 11.03 (s, 1H), 13.70 (bs, 1H)

  • 5-(2-Bromo-4-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid


1H-NMR (DMSO-d6) δ 0.84 (d, 4H), 1.70 (m, 1H), 5.11 (s, 2H), 7.27 (dd, 1H), 7.32 (dt, 1H), 7.52 (d, 1H), 7.63-7.68 (m, 2H), 8.30 (d, 1H), 11.06 (s, 1H), 13.70 (bs, 1H)

  • 5-(2-Bromo-4-chloro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 2-(Cyclopropanecarbonyl-amino)-5-(2,4-dibromo-benzyloxy)-benzoic acid
  • 5-(3,4-Bis-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 2-(Cyclopropanecarbonyl-amino)-5-(4-fluoro-3-trifluoromethyl-benzyloxy)-benzoic acid
  • 5-(4-Chloro-3-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 5-(4-Bromo-3-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 2-(Cyclopropanecarbonyl-amino)-5-(3-fluoro-4-trifluoromethyl-benzyloxy)-benzoic acid
  • 2-(Cyclopropanecarbonyl-amino)-5-(3,4-difluoro-benzyloxy)-benzoic acid
  • 5-(4-Chloro-3-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 5-(4-Bromo-3-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 5-(3-Chloro-4-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 5-(3-Chloro-4-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 2-(Cyclopropanecarbonyl-amino)-5-(3,4-dichloro-benzyloxy)-benzoic acid
  • 5-(4-Bromo-3-chloro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 5-(3-Bromo-4-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 5-(3-Bromo-4-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 5-(3-Bromo-4-chloro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 2-(Cyclopropanecarbonyl-amino)-5-(3,4-dibromo-benzyloxy)-benzoic acid


Example 3
5-(2,4-Dichloro-phenoxymethyl)-2-propionylamino-benzoic acid
Method B

A mixture of 5-bromomethyl-2-propionylamino-benzoic acid methyl ester (200 mg, 0.67 mmol), 2,4-dichloro-phenol (119 mg, 0.73 mmol) and potassium carbonate (278 mg, 2.01 mmol) in acetone (5 ml) was heated to reflux. After 4 hours, the reaction mixture was allowed to reach room temperature, was acidified with 1 M HCl and the resulting precipitate collected by filtration, washed with water and dried under vacuum to give pure 5-(2,4-dichloro-phenoxymethyl)-2-propionylamino-benzoic acid methyl ester (184 mg, 72%). This was hydrolyzed in ethanol (3 mL) and 1.0 M NaOH (3 mL) overnight and then acidified with 1.0 M HCl. The resulting precipitate was collected by filtration, washed with water and dried under vacuum (165 mg, 93%). 1H-NMR (DMSO-d6) δ 1.12 (t, 3H), 2.42 (q, 2H), 5.21 (s, 2H), 7.27 (d, 1H), 7.39 (dd, 1H), 7.60 (d, 1H), 7.66 (dd, 1H), 8.09 (d, 1H), 8.53 (d, 1H), 11.18 (s, 1H), 13.71 (bs, 1H).


In essentially the same manner the following compounds were obtained from the corresponding starting materials:

  • 5-(2-Chloro-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.12 (t, 3H), 2.41 (q, 2H), 5.17 (s, 2H), 7.19 (dt, 1H), 7.25 (dd, 1H), 7.45 (dd, 1H), 7.66 (dd, 1H), 8.08 (d, 1H), 8.52 (d, 1H), 11.15 (s, 1H), 13.72 (bs, 1H)

  • 5-(2-Chloro-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.12 (t, 3H), 2.42 (q, 2H), 5.30 (s, 2H), 7.43 (d, 1H), 7.70 (m, 2H), 7.86 (d, 1H), 8.11 (d, 1H), 8.54 (d, 1H), 11.16 (s, 1H), 13.75 (bs, 1H)

  • 5-(2-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.12 (t, 3H), 2.42 (q, 2H), 5.22 (s, 2H), 7.32-7.39 (m, 2H), 7.59 (d, 1H), 7.67 (dd, 1H), 8.09 (d, 1H), 8.53 (d, 1H), 11.15 (s, 1H), 13.73 (bs, 1H)

  • 5-(2-Bromo-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.13 (t, 3H), 2.43 (q, 2H), 5.18 (s, 2H), 7.24 (d, 1H), 7.58 (d, 1H), 7.68 (dd, 1H), 8.09 (d, 1H), 8.53 (d, 1H), 11.14 (s, 1H), 13.74 (bs, 1H)

  • 5-(2-Bromo-4-chloro-phenoxymethyl)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.13 (t, 3H), 2.43 (q, 2H), 5.21 (s, 2H), 7.23 (d, 1H), 7.44 (d, 1H), 7.68 (dd, 1H), 7.73 (s, 1H), 8.10 (d, 1H), 8.53 (d, 1H), 11.13 (s, 1H), 13.74 (bs, 1H)

  • 5-(2-Bromo-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.13 (t, 3H), 2.43 (q, 2H), 5.31 (s, 2H), 7.40 (d, 1H), 7.70 (dd, 1H), 7.76 (d, 1H), 7.99 (s, 1H), 8.12 (d, 1H), 8.54 (d, 1H), 11.15 (s, 1H), 13.77 (bs, 1H)

  • 5-(4-Bromo-2-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.13 (t, 3H), 2.42 (q, 2H), 5.28 (s, 2H), 7.34 (d, 1H), 7.63 (dd, 1H), 7.79 (s, 1H), 7.84 (d, 1H), 8.09 (d, 1H), 8.52 (d, 1H), 11.12 (s, 1H), 13.70 (bs, 1H)

  • 5-(2,4-Bis-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.13 (t, 3H), 2.42 (q, 2H), 5.39 (s, 2H), 7.57 (d, 1H), 7.65 (dd, 1H), 7.93 (d, 1H), 8.06 (dd, 1H), 8.12 (d, 1H), 8.54 (d, 1H), 11.13 (s, 1H), 13.78 (bs, 1H)

  • 5-(4-Fluoro-2-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.13 (t, 3H), 2.42 (q, 2H), 5.26 (s, 2H), 7.39 (dd, 1H), 7.51-7.57 (m, 2H), 7.63 (dd, 1H), 8.10 (d, 1H), 8.53 (d, 1H), 11.16 (s, 1H), 13.70 (bs, 1H)

  • 2-(Cyclopropanecarbonyl-amino)-5-(4-fluoro-2-trifluoromethyl-phenoxymethyl)-benzoic acid


1H-NMR (DMSO-d6) δ 0.87 (d, 4H), 1.73 (m, 1H), 5.25 (s, 2H), 7.39 (dd, 1H), 7.40-7.57 (m, 2H), 7.61 (dd, 1H), 8.09 (d, 1H), 8.46 (d, 1H), 11.44 (s, 1H), 13.71 (bs, 1H)

  • 5-(2-Chloro-4-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid


1H-NMR (DMSO-d6) δ 0.87 (d, 4H), 1.73 (m, 1H), 5.18 (s, 2H), 7.20 (dt, 1H), 7.27 (t, 1H), 7.46 dd, 1H), 7.64 (dd, 1H), 8.09 (d, 1H), 8.46 (d, 1H), 11.41 (s, 1H), 13.74 (bs, 1H)

  • 5-(2-Chloro-4-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid


1H-NMR (DMSO-d6) δ 0.87 (d, 4H), 1.73 (m, 1H), 5.31 (s, 2H), 7.44 (d, 1H), 7.67 (dd, 1H), 7.72 (dd, 1H), 7.87 (d, 1H), 8.12 (d, 1H), 8.47 (d, 1H), 11.43 (s, 1H), 13.75 (bs, 1H)

  • 5-(2-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid


1H-NMR (DMSO-d6) δ 0.88 (d, 4H), 1.74 (m, 1H), 5.23 (s, 2H), 7.33-7.40 (m, 2H), 7.61 (d, 1H), 7.66 (dd, 1H), 8.10 (d, 1H), 8.47 (d, 1H), 11.41 (s, 1H), 13.76 (bs, 1H)

  • 2-(Cyclopropanecarbonyl-amino)-5-(2,4-dichloro-phenoxymethyl)-benzoic acid


1H-NMR (DMSO-d6) δ 0.87 (d, 4H), 1.73 (m, 1H), 5.21 (s, 2H), 7.27 (d, 1H), 7.39 (dd, 1H), 7.60 (d, 1H), 7.65 (dd, 1H), 8.09 (d, 1H), 8.47 (d, 1H), 11.37 (s, 1H), 13.74 (bs, 1H)

  • 5-(4-Fluoro-3-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.14 (t, 3H), 2.42 (q, 2H), 5.16 (s, 2H), 7.35-7.39 (m, 2H), 7.45 (t, 1H), 7.67 (dd, 1H), 8.07 (d, 1H), 8.53 (d, 1H), 11.18 (s, 1H), 13.73 (bs, 1H)

  • 5-(4-Chloro-3-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.12 (t, 3H), 2.41 (q, 2H), 5.19 (s, 2H), 7.34 (dd, 1H), 7.44 (d, 1H), 7.65 (d, 1H), 7.67 (dd, 1H), 8.07 (d, 1H), 8.53 (d, 1H), 11.17 (s, 1H), 13.76 (bs, 1H)

  • 5-(3-Chloro-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.12 (t, 3H), 2.42 (q, 2H), 5.09 (s, 2H), 7.01 (dt, 1H), 7.26 (dd, 1H), 7.34 (t, 1H), 7.65 (dd, 1H), 8.04 (d, 1H), 8.53 (d, 1H), 11.14 (s, 1H), 13.73 (bs, 1H)

  • 5-(3-Bromo-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.13 (t, 3H), 2.42 (q, 2H), 5.15 (s, 2H), 7.14 (d, 1H), 7.46-7.49 (m, 2H), 7.67 (dd, 1H), 8.07 (d, 1H), 8.54 (d, 1H), 11.16 (s, 1H), 13.74 (bs, 1H)

  • 5-(4-Bromo-3-chloro-phenoxymethyl)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.13 (t, 3H), 2.42 (q, 2H), 5.13 (s, 2H), 6.98 (d, 1H), 7.35 (s, 1H), 7.66 (d, 2H), 8.05 (d, 1H), 8.53 (d, 1H), 11.17 (s, 1H), 13.76 (bs, 1H)

  • 5-(3-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.13 (t, 3H), 2.42 (q, 2H), 5.16 (s, 2H), 7.11 (d, 1H), 7.38 (s, 1H), 7.51 (d, 1H), 7.68 (dd, 1H), 8.07 (d, 1H), 8.54 (d, 1H), 11.14 (s, 1H), 13.75 (bs, 1H)

  • 5-(3-Chloro-4-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid


1H-NMR (DMSO-d6) δ 0.87 (d, 4H), 1.73 (m, 1H), 5.10 (s, 2H), 7.03 (dt, 1H), 7.28 (dd, 1H), 7.35 (t, 1H), 7.64 (dd, 1H), 8.05 (d, 1H), 8.48 (d, 1H), 11.38 (s, 1H), 13.74 (bs, 1H)

  • 2-(Cyclopropanecarbonyl-amino)-5-(4-fluoro-3-trifluoromethyl-phenoxymethyl)-benzoic acid


1H-NMR (DMSO-d6) δ 0.87 (d, 4H), 1.73 (m, 1H), 5.17 (s, 2H), 7.37-7.40 (m, 2H), 7.46 (t, 1H), 8.08 (d, 1H), 8.47 (d, 1H), 11.41 (s, 1H), 13.75 (bs, 1H)

  • 5-(4-Chloro-2-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid
  • 5-(2-Fluoro-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid
  • 5-(2,4-Difluoro-phenoxymethyl)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.13 (t, 3H), 2.42 (q, 2H), 5.15 (s, 2H), 7.03 (tt, 1H), 7.25-7.33 (m, 2H), 7.65 (dd, 1H), 8.06 (d, 1H), 8.53 (d, 1H), 11.27 (s, 1H), 13.72 (bs, 1H)

  • 5-(4-Chloro-2-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.13 (t, 3H), 2.42 (q, 2H), 5.18 (s, 2H), 7.23 (ddd, 1H), 7.29 (t, 1H), 7.46 (dd, 1H), 7.65 (dd, 1H), 8.07 (d, 1H), 8.53 (d, 1H), 11.24 (s, 1H), 13.77 (bs, 1H)

  • 5-(4-Bromo-2-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.13 (t, 3H), 2.42 (q, 2H), 5.17 (s, 2H), 7.24 (t, 1H), 7.35 (ddd, 1H), 7.56 (dd, 1H), 7.65 (dd, 1H), 8.07 (d, 1H), 8.53 (d, 1H), 11.23 (s, 1H), 13.74 (bs, 1H)

  • 5-(4-Bromo-2-chloro-phenoxymethyl)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.13 (t, 3H), 2.42 (q, 2H), 5.21 (s, 2H), 7.21 (d, 1H), 7.50 (dd, 1H), 7.66 (dd, 1H), 7.69 (d, 1H), 8.09 (d, 1H), 8.53 (d, 1H), 11.16 (s, 1H), 13.77 (bs, 1H)

  • 5-(2,4-Dibromo-phenoxymethyl)-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.13 (t, 3H), 2.42 (q, 2H), 5.21 (s, 2H), 7.18 (d, 1H), 7.54 (dd, 1H), 7.67 (dd, 1H), 7.82 (d, 1H), 8.09 (d, 1H), 8.53 (d, 1H), 11.18 (s, 1H), 13.73 (bs, 1H)

  • 5-(3,4-Bis-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid
  • 5-(4-Bromo-3-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid
  • 5-(3-Fluoro-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid
  • 5-(3,4-Difluoro-phenoxymethyl)-2-propionylamino-benzoic acid
  • 5-(4-Chloro-3-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid
  • 5-(4-Bromo-3-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid
  • 5-(3-Chloro-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid
  • 5-(3,4-Dichloro-phenoxymethyl)-2-propionylamino-benzoic acid
  • 5-(3-Bromo-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid
  • 5-(3-Bromo-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid
  • 5-(3-Bromo-4-chloro-phenoxymethyl)-2-propionylamino-benzoic acid
  • 5-(3,4-Dibromo-phenoxymethyl)-2-propionylamino-benzoic acid
  • 5-(2,4-Bis-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid


1H-NMR (DMSO-d6) δ 0.87 (d, 4H), 1.73 (m, 1H), 5.39 (s, 2H), 7.57 (d, 1H), 7.63 (dd, 1H), 7.94 (d, 1H), 8.06 (dd, 1H), 8.12 (d, 1H), 8.48 (d, 1H), 11.41 (s, 1H), 13.72 (bs, 1H)

  • 5-(4-Chloro-2-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 5-(4-Bromo-2-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid


1H-NMR (DMSO-d6) δ 0.87 (d, 4H), 1.73 (m, 1H), 5.28 (s, 2H), 7.34 (d, 1H), 7.61 (dd, 1H), 7.78 (d, 1H), 7.84 (dd, 1H), 8.09 (d, 1H), 8.46 (d, 1H), 11.40 (s, 1H), 13.70 (bs, 1H)

  • 2-(Cyclopropanecarbonyl-amino)-5-(2-fluoro-4-trifluoromethyl-phenoxymethyl)-benzoic acid
  • 2-(Cyclopropanecarbonyl-amino)-5-(2,4-difluoro-phenoxymethyl)-benzoic acid


1H-NMR (DMSO-d6) δ 0.87 (d, 4H), 1.73 (m, 1H), 5.15 (s, 2H), 7.02 (tt, 1H), 7.25-7.33 (m, 2H), 7.64 (dd, 1H), 8.06 (dd, 1H), 8.47 (d, 1H), 11.39 (s, 1H), 13.76 (bs, 1H)

  • 5-(4-Chloro-2-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid


1H-NMR (DMSO-d6) δ 0.87 (d, 4H), 1.73 (m, 1H), 5.18 (s, 2H), 7.23 (d, 1H), 7.29 (t, 1H), 7.46 (dd, 1H), 7.64 (dd, 1H), 8.07 (d, 1H), 8.47 (d, 1H), 11.43 (s, 1H), 13.73 (bs, 1H)

  • 5-(4-Bromo-2-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid


1H-NMR (DMSO-d6) δ 0.87 (d, 4H), 1.73 (m, 1H), 5.17 (s, 2H), 7.24 (t, 1H), 7.35 (dt, 1H), 7.56 (dd, 1H), 7.64 (dd, 1H), 8.07 (d, 1H), 8.47 (d, 1H), 11.44 (s, 1H), 13.75 (bs, 1H)

  • 5-(4-Bromo-2-chloro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid


1H-NMR (DMSO-d6) δ 0.87 (d, 4H), 1.73 (m, 1H), 5.21 (s, 2H), 7.22 (d, 1H), 7.50 (dd, 1H), 7.65 (dd, 1H), 7.69 (d, 1H), 8.09 (d, 1H), 8.47 (d, 1H), 11.39 (s, 1H), 13.74 (bs, 1H)

  • 5-(2-Bromo-4-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid


1H-NMR (DMSO-d6) δ 0.87 (d, 4H), 1.73 (m, 1H), 5.31 (s, 2H), 7.39 (d, 1H), 7.67 (dd, 1H), 7.75 (dd, 1H), 7.98 (d, 1H), 8.12 (d, 1H), 8.48 (d, 1H), 11.42 (s, 1H), 13.73 (bs, 1H)

  • 5-(2-Bromo-4-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid


1H-NMR (DMSO-d6) δ 0.87 (d, 4H), 1.73 (m, 1H), 5.18 (s, 2H), 7.23-7.27 (m, 2H), 7.58 (dd, 1H), 7.66 (dd, 1H), 8.10 (d, 1H), 8.47 (d, 1H), 11.39 (s, 1H), 13.73 (bs, 1H)

  • 5-(2-Bromo-4-chloro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid


1H-NMR (DMSO-d6) δ 0.87 (d, 4H), 1.73 (m, 1H), 5.21 (s, 2H), 7.24 (d, 1H), 7.43 (dd, 1H), 7.65 (dd, 1H), 7.72 (d, 1H), 8.10 (d, 1H), 8.47 (d, 1H), 11.38 (s, 1H), 13.75 (bs, 1H)

  • 2-(Cyclopropanecarbonyl-amino)-5-(2,4-dibromo-phenoxymethyl)-benzoic acid


1H-NMR (DMSO-d6) δ 0.87 (d, 4H), 1.73 (m, 1H), 5.20 (s, 2H), 7.18 (d, 1H), 7.54 (dd, 1H), 7.65 (dd, 1H), 7.81 (d, 1H), 8.09 (d, 1H), 8.47 (d, 1H), 11.37 (s, 1H), 13.74 (bs, 1H)

  • 5-(2-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 5-(3,4-Bis-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 5-(4-Chloro-3-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 5-(4-Bromo-3-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 2-(Cyclopropanecarbonyl-amino)-5-(3-fluoro-4-trifluoromethyl-phenoxymethyl)-benzoic acid
  • 2-(Cyclopropanecarbonyl-amino)-5-(3,4-difluoro-phenoxymethyl)-benzoic acid
  • 5-(4-Chloro-3-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 5-(4-Bromo-3-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 5-(3-Chloro-4-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 2-(Cyclopropanecarbonyl-amino)-5-(3,4-dichloro-phenoxymethyl)-benzoic acid
  • 5-(4-Bromo-3-chloro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 5-(3-Bromo-4-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 5-(3-Bromo-4-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 5-(3-Bromo-4-chloro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 2-(Cyclopropanecarbonyl-amino)-5-(3,4-dibromo-phenoxymethyl)-benzoic acid


Example 4
5-[(E)-2-(2,4-Dichloro-phenyl)-vinyl]-2-propionylamino-benzoic acid
Method C

A mixture of 5-bromomethyl-2-propionylamino-benzoic acid methyl ester (172 mg, 0.60 mmol), 2,4-dichloro-1-vinyl-benzene (125 mg, 0.72 mmol), potassium carbonate (100 mg, 0.66 mmol), tri-butyl amine (160 μl, 0.66 mmol) and bis(tri-phenyl-phosphino)palladium (II) di-chloride in DMF (3 ml) was heated to 130° C. After 30 minutes, the reaction mixture was allowed to reach room temperature, acidified with 2 M HCl and the resulting precipitate collected by filtration, washed with water and dried under vacuum to give crude 5-[(E)-2-(2,4-dichloro-phenyl)-vinyl]-2-propionylamino-benzoic acid methyl ester. This was hydrolyzed in ethanol (3 mL) and 1.0 M NaOH (3 mL) overnight and then acidified with 1.0 M HCl. The resulting precipitate was collected by filtration, washed with water and dried under vacuum (136 mg, 62% total yield). 1H-NMR (DMSO-d6) δ 1.14 (t, 3H), 2.43 (q, 2H), 7.32 (d, 1H), 7.37 (d, 1H), 7.44 (dd, 1H), 7.63 (d, 1H), 7.87-7.91 (m, 1H), 8.17 (d, 1H), 8.57 (d, 1H), 11.19 (s, 1H), 13.80 (bs, 1H)


In essentially the same manner the following compounds were obtained from the corresponding starting materials:

  • 5-[(E)-2-(4-Fluoro-2-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.14 (t, 3H), 2.44 (q, 2H), 7.25 (dd, 1H), 7.36 (d, 1H), 7.62 (dt, 1H), 7.65 (dd, 1H), 7.85 (dd, 1H), 8.06 (dd, 1H), 8.16 (d, 1H), 8.57 (d, 1H), 11.20 (s, 1H), 13.79 (bs, 1H)

  • 5-[(E)-2-(2,4-Bis-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.14 (t, 3H), 2.45 (q, 2H), 7.33 (dd, 1H), 7.59 (d, 1H), 7.93 (dd, 1H), 8.03 (s, 1H), 8.09 (d, 1H), 8.21 (d, 1H), 8.26 (d, 1H), 8.60 (d, 1H), 11.22 (s, 1H), 13.83 (bs, 1H)

  • 5-[(E)-2-(2-Chloro-4-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.14 (t, 3H), 2.44 (q, 2H), 7.26-7.34 (m, 3H), 7.49 (dd, 1H), 7.90 (dd, 1H), 7.94 (dd, 1H), 8.16 (d, 1H), 8.57 (d, 1H), 11.17 (s, 1H), 13.75 (bs, 1H)

  • 5-[(E)-2-(2,4-Difluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.14 (t, 3H), 2.44 (q, 2H), 7.14 (dt, 1H), 7.20 (d, 1H), 7.27-7.34 (m, 2H), 7.86 (q, 1H), 7.90 (dd, 1H), 8.15 (d, 1H), 8.56 (d, 1H), 11.16 (s, 1H), 13.79 (bs, 1H)

  • 5-[(E)-2-(4-Chloro-2-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.14 (t, 3H), 2.44 (q, 2H), 7.24 (dd, 1H), 7.43 (d, 1H), 7.77-7.80 (m, 2H), 7.86 (dd, 1H), 8.04 (d, 1H), 8.16 (d, 1H), 8.58 (d, 1H), 11.19 (s, 1H), 13.81 (bs, 1H)

  • 5-[(E)-2-(2-Fluoro-4-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.14 (t, 3H), 2.44 (q, 2H), 7.30 (d, 1H), 7.53 (d, 1H), 7.61 (d, 1H), 7.71 (d, 1H), 7.97 (dd, 1H), 8.04 (t, 1H), 8.21 (d, 1H), 8.58 (d, 1H), 11.20 (s, 1H), 13.81 (bs, 1H)

  • 2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(4-fluoro-2-trifluoromethyl-phenyl)-vinyl]-benzoic acid


1H-NMR (DMSO-d6) δ 0.89 (d, 4H), 1.75 (m, 1H), 7.27 (dd, 1H), 7.37 (d, 1H), 7.61 (dt, 1H), 7.65 (dd, 1H), 7.85 (d, 1H), 8.07 (dd, 1H), 8.16 (d, 1H), 8.51 (d, 1H), 11.40 (s, 1H), 13.82 (bs, 1H)

  • 5-[(E)-2-(4-Chloro-2-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid


1H-NMR (DMSO-d6) δ 0.89 (d, 4H), 1.75 (m, 1H), 7.24 (dd, 1H), 7.44 (d, 1H), 7.78-7.81 (m, 2H), 7.85 (dd, 1H), 8.04 (d, 1H), 8.17 (d, 1H), 8.51 (d, 1H), 11.41 (s, 1H), 13.86 (bs, 1H)

  • 5-[(E)-2-(4-Chloro-3-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.14 (t, 3H), 2.44 (q, 2H), 7.35 (d, 1H), 7.51 (d, 1H), 7.73 (d, 1H), 7.89 (dd, 1H), 7.94 (dd, 1H), 8.09 (d, 1H), 8.23 (d, 1H), 8.57 (d, 1H), 11.18 (s, 1H), 13.78 (bs, 1H)

  • 5-[(E)-2-(4-Fluoro-3-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.14 (t, 3H), 2.44 (q, 2H), 7.33 (d, 1H), 7.43 (d, 1H), 7.53 (dd, 1H), 7.86 (dd, 1H), 7.98 (m, 1H), 8.02 (d, 1H), 8.21 (d, 1H), 8.56 (d, 1H), 11.17 (s, 1H), 13.76 (bs, 1H)

  • 5-[(E)-2-(3-Chloro-4-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.14 (t, 3H), 2.44 (q, 2H), 7.22 (d, 1H), 7.34 (d, 1H), 7.43 (t, 1H), 7.62 (m, 1H), 7.84 (dd, 1H), 7.88 (dd, 1H), 8.17 (d, 1H), 8.55 (d, 1H), 11.16 (s, 1H), 13.78 (bs, 1H)

  • 5-[(E)-2-(3-Fluoro-4-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.14 (t, 3H), 2.44 (q, 2H), 7.32 (d, 1H), 7.55 (d, 1H), 7.62 (d, 1H), 7.74-7.80 (m, 2H), 7.90 (dd, 1H), 8.22 (d, 1H), 8.58 (d, 1H), 11.20 (s, 1H), 13.81 (bs, 1H)

  • 5-[(E)-2-(3-Chloro-4-trifluoromethoxy-phenyl)-vinyl]-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.14 (t, 3H), 2.44 (q, 2H), 7.24 (d, 1H), 7.42 (d, 1H), 7.56 (d, 1H), 7.68 (dd, 1H), 7.86 (dd, 1H), 7.96 (d, 1H), 8.19 (d, 1H), 8.56 (d, 1H), 11.18 (s, 1H), 13.77 (bs, 1H)

  • 5-[(E)-2-(3,4-Dichloro-phenyl)-vinyl]-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.14 (t, 3H), 2.44 (q, 2H), 7.22 (d, 1H), 7.42 (d, 1H), 7.59-7.64 (m, 2H), 7.86 (dd, 1H), 7.91 (d, 1H), 8.19 (d, 1H), 8.56 (d, 1H), 11.18 (s, 1H), 13.77 (bs, 1H)

  • 5-[(E)-2-(4-Chloro-2-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid


1H-NMR (DMSO-d6) δ 1.14 (t, 3H), 2.43 (q, 2H), 7.21 (d, 1H), 7.33 (dd, 1H), 7.39 (d, 1H), 7.48 (dd, 1H), 7.84 (t, 1H), 7.91 (dd, 1H), 8.17 (d, 1H), 8.56 (d, 1H), 11.28 (s, 1H), 13.77 (bs, 1H)

  • 5-[(E)-2-(2-Chloro-4-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid
  • 5-[(E)-2-(3,4-Bis-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid
  • 5-[(E)-2-(3,4-Difluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid
  • 5-[(L)-2-(4-Chloro-3-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid
  • 5-[(E)-2-(2,4-Bis-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid


1H-NMR (DMSO-d6) δ 0.89 (d, 4H), 1.75 (m, 1H), 7.32 (dd, 1H), 7.58 (d, 1H), 7.90 (dd, 1H), 8.02 (s, 1H), 8.09 (d, 1H), 8.21 (d, 1H), 8.26 (d, 1H), 8.54 (d, 1H), 11.52 (s, 1H), 13.79 (bs, 1H)

  • 2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(2-fluoro-4-trifluoromethyl-phenyl)-vinyl]-benzoic acid


1H-NMR (DMSO-d6) δ 0.89 (d, 4H), 1.75 (m, 1H), 7.30 (dd, 1H), 7.54 (d, 1H), 7.61 (d, 1H), 7.71 (d, 1H), 7.95 (dd, 1H), 8.04 (t, 1H), 8.21 (d, 1H), 8.52 (d, 1H), 11.48 (s, 1H), 13.77 (bs, 1H)

  • 2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(2,4-difluoro-phenyl)-vinyl]-benzoic acid


1H-NMR (DMSO-d6) δ 0.88 (d, 4H), 1.74 (m, 1H), 7.15 (dt, 1H), 7.20 (d, 1H), 7.27-7.35 (m, 2H), 7.83-7.90 (m, 2H), 8.15 (d, 1H), 8.49 (d, 1H), 11.43 (s, 1H), 13.80 (bs, 1H)

  • 5-[(E)-2-(4-Chloro-2-fluoro-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid


1H-NMR (DMSO-d6) δ 0.88 (d, 4H), 1.74 (m, 1H), 7.21 (d, 1H), 7.33 (dd, 1H), 7.39 (d, 1H), 7.48 (dd, 1H), 7.85 (t, 1H), 7.90 (dd, 1H), 8.16 (d, 1H), 8.50 (d, 1H), 11.46 (s, 1H), 13.82 (bs, 1H)

  • 5-[(E)-2-(2-Chloro-4-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 5-[(E)-2-(2-Chloro-4-fluoro-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(2,4-dichloro-phenyl)-vinyl]-benzoic acid


1H-NMR (DMSO-d6) δ 0.89 (d, 4H), 1.75 (m, 1H), 7.34 (d, 1H), 7.40 (d, 1H), 7.47 (dd, 1H), 7.66 (d, 1H), 7.89 (dd, 1H), 7.92 (d, 1H), 8.18 (d, 1H), 8.51 (d, 1H), 11.48 (s, 1H), 13.82 (bs, 1H)

  • 5-[(E)-2-(3,4-Bis-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(4-fluoro-3-trifluoromethyl-phenyl)-vinyl]-benzoic acid
  • 5-[(E)-2-(4-Chloro-3-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(3-fluoro-4-trifluoromethyl-phenyl)-vinyl]-benzoic acid
  • 2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(3,4-difluoro-phenyl)-vinyl]-benzoic acid
  • 5-[(E)-2-(4-Chloro-3-fluoro-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 5-[(E)-2-(3-Chloro-4-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 5-[(E)-2-(3-Chloro-4-fluoro-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid
  • 2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(3,4-dichloro-phenyl)-vinyl]-benzoic acid


Pharmacological and Pharmacokinetic Methods
Inhibition of T-Cell Proliferation

Inhibition of T cell proliferation was studied in a functional assay. A human T lymphoblast cell line (Jurkat) was cultured in the presence and absence, respectively, of DHODH inhibiting compounds. Jurkat cells were seeded in microtiterplates at a concentration of 5×105/mL in RPMI 1640 growth media supplemented with ultraglutamin, 10% fetal calf serum, 1 mM sodium pyruvat, 10 mM HEPES and 0.1 mg/mL gentamycin. A dilution series of ten different concentrations of inhibitor was added to the wells and the plates were kept in a cell incubator for 3 days. At the beginning of the last 4 hours period, the cultures were pulsed with 10 μl/well 0.1 Ci/mmol 3H-TdR and then harvested on filter papers and counted with a β-counter. The IC50 values for each compound were calculated from the obtained dose response curves. Adding uridine to a concentration of about 50 μM in the wells monitored the specificity for the mechanism i.e., the inhibition of cell proliferation is due to DHODH inhibition and not to a general cell toxicity of the compounds. This addition of uridine reverses the anti-proliferative effect by bypassing the DHODH enzyme using an external source of pyrimidine. Results in respect of a number of compounds of the invention are reported as Jurkat IC50 (in μM) in Table 1.


Metabolic Stability in Human Liver Microsomes

The metabolic stability of the test compounds was determined using human liver microsomes. Incubations were performed with a compound concentration of 0.5 μM and a protein concentration of 1 mg/mL in 50 mM sodium phosphate buffer at physiological pH (7.4) and temperature (37° C.). The incubation mixture was preincubated at 37° C. prior to addition of NADPH (1 mM, final concentration). At several time points during 60 minutes, aliquots were removed and added to a 96 well plate placed on dry ice and deep-frozen. Samples were analyzed with LC-MS for concentration of parent compound. From the slope of the log [parent compound] vs. incubation time regression line, the in vitro half-life (t½) was determined. The intrinsic clearance (CLint) can be calculated using a modified Michaelis-Menten relationship, i.e., CLint=ln 2/t½. The CLint can then be converted to CL by using the well-stirred model of hepatic extraction. A value of 1.24 L/h/kg of the hepatic blood flow in man can be used. Results with respect to a number of compounds of the invention are reported as t½ (in minutes) in Table 1.


WO 2005/075410 discloses anthranilic acid derivatives that are stated to inhibit DHODH. However, when tested in in vitro systems based on human cells, compounds of WO 2005/075410 were found to have very short oxidation half-life and/or low T-cell anti-proliferative effect (cf. Table 1). On the other hand, the present inventors now have found a number of ortho, para- or meta, para-disubstituted anthranilic acid derivatives having a substantially enhanced stability towards oxidation by human P450 cytochrome in combination with a high T-cell anti-proliferative effect. This finding is very surprising and could not have been foreseen by the skilled person on the basis of teachings of WO 2005/075410 which, as pointed out herein above, while teaching the importance of the substitution pattern, stresses that di-substitution should imperatively be in the ortho,meta-, ortho,meta′-, or meta,meta′-positions.


EP0497740 discloses compounds that are stated to be useful as antihyperproliferative/anti-inflammatory and anticancer agents. The compound disclosed as most preferred is 5-(2,5-dimethoxy-benzyloxy)-2-hydroxy-benzoic acid methyl ester. The present inventors found 5-(2,5-dimethoxy-benzyloxy)-2-hydroxy-benzoic acid to be inactive as DHODH inhibitor. EP0497740 also discloses the compound 2-acetylamino-5-(2,5-dimethoxy-benzyloxy)-benzoic acid methyl ester, which inhibits cell proliferation. This anti-proliferative effect, however, is unrelated to DHODH inhibition. The compound 2-acetylamino-5-(2,5-dimethoxy-benzyloxy)-benzoic acid (termed compound REF-8) has been tested and found to display only a weak inhibitory effect on T-cell proliferation, and a short half-life in human beings, cf. Table 1.


EP0815087 discloses compounds structurally related to compounds of formula (I) that are stated to be useful for the treatment of proliferative and/or inflammatory disorders and cancer, e.g., 2-acetylamino-5-[2-(2,5-dimethoxy-phenyl)-ethyl]-benzoic acid methyl ester. 2-Acetylamino-5-[2-(2,5-dimethoxy-phenyl)-ethyl]-benzoic acid (termed compound REF-9) has been tested and found to display a very weak inhibitory effect on T-cell proliferation, cf. Table 1.


The inhibition of T cell proliferation was studied in a human T lymphoblast cell line (Jurkat). The IC50 value for each compound was calculated from the dose response curve. The IC50 values of representative compounds are shown in Table 1. Adding uridine was used to monitor the specificity of the DHODH mechanism. The metabolic stability was studied in human liver microsomes. The metabolic stability expressed as t½ (minutes) is shown in Table 1. Table 1 exemplifies the invention, without limiting the scope thereof.


Pharmaceutically acceptable salts of the compounds of formula (I) can be prepared by reacting the free acid with a base in water or in an organic solvent. Lists of suitable salts found in Remington: The Science and Practice of Pharmacy. 21st Edition. Philadelphia, Pa. Lippincott Williams & Wilkins. 2005. Effective quantities of the compounds of this invention are preferably administered to a patient in need of such treatment according to usual routes of administration and formulated in usual pharmaceutical compositions comprising an effective amount of the active ingredient and a suitable pharmaceutically acceptable carrier. Such compositions may take a variety of forms, e.g., solutions, suspensions, emulsions, tablets, capsules, and powders prepared for oral administration, sterile solutions for parental administration, and suppositories for rectal administration or suitable topical formulations. Conventional procedures for the selection and preparation of suitable pharmaceutical formulations are described, for example, in Pharmaceutics, The Science of Dosage Form Design (2001) Edited by Aulton, Michael E. (ISBN: 0443055173).


A suitable daily dose for use in the treatment of a disease selected from autoimmune diseases, inflammatory diseases, organ transplant rejection and malignant neoplasia is contemplated to vary between 0.005 mg/kg to about 10 mg/kg body weight, in particular between 0.025 mg/kg to 2 mg/kg body weight, depending upon the specific condition to be treated, the age and weight of the specific patient, and the specific patient's response to the medication. The exact individual dosage, as well as the daily dosage, will be determined according to standard medical principles under the direction of a physician.

Claims
  • 1. A compound of formula (I)
  • 2. The compound according to claim 1, wherein X is CH2O wherein the oxygen is bound to ring B.
  • 3. The compound according to claim 2, wherein Y is hydrogen or a pharmaceutically acceptable inorganic cation.
  • 4. The compound according to claim 2, wherein R2 is CF3 or OCF3.
  • 5. The compound according to claim 2, wherein R2 is CF3 or OCF3 and Y is hydrogen or a pharmaceutically acceptable inorganic cation.
  • 6. The compound according to claim 5, wherein Y is selected from the group consisting of Li+, Na+, K+, Mg2+, Ca2+ and Zn2+.
  • 7. The compound according to claim 1, wherein R2 is CF3 or OCF3.
  • 8. The compound according to claim 1, wherein X is OCH2 wherein the oxygen is bound to ring A.
  • 9. The compound according to claim 1, wherein X is CH═CH.
  • 10. The compound according to claim 1, wherein Y is a pharmaceutically acceptable inorganic cation.
  • 11. The compound according to claim 10, wherein Y is a divalent cation.
  • 12. The compound according to claim 11, further comprising a negative monovalent counterion.
  • 13. The compound according to claim 12, wherein the negative monovalent counterion is a halogen ion or a bicarbonate ion.
  • 14. The compound according to claim 10, wherein Y is selected from the group consisting of Li+, Na+, K+, Mg2+, Ca2+ and Zn2+.
  • 15. The compound according to claim 10, wherein R2 is CF3 or OCF3.
  • 16. The compound according to claim 1, wherein the compound exhibits an in vitro metabolic stability towards oxidation by cytochrome P450 characterized by a half-life (t1/2) of longer than about 70 minutes.
  • 17. The compound according to claim 16, wherein the compound is characterized by a half-life (t1/2) of longer than about 100 minutes.
  • 18. The compound according to claim 17, wherein the compound is characterized by a half-life (t1/2) of longer than about 200 minutes.
  • 19. The compound according to claim 1, selected from the group consisting of 5-(2,4-Dichloro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-2-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Fluoro-2-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2,4-Bis-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Chloro-2-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2-Chloro-4-fluoro-benzyloxy)-2-propionylamino-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(4-fluoro-2-trifluoromethyl-benzyloxy)-benzoic acid,5-(2-Bromo-4-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(2-Fluoro-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2-Bromo-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Chloro-3-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(3,4-Dibromo-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-3-chloro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-2-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2,4-Difluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Chloro-2-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-2-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(2-Chloro-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-2-chloro-benzyloxy)-2-propionylamino-benzoic acid,5-(2-Bromo-4-chloro-benzyloxy)-2-propionylamino-benzoic acid,5-(2,4-Dibromo-benzyloxy)-2-propionylamino-benzoic acid,5-(3,4-Bis-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Fluoro-3-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-3-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Fluoro-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(3,4-Difluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Chloro-3-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-3-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Chloro-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Chloro-4-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(3,4-Dichloro-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Bromo-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Bromo-4-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Bromo-4-chloro-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Chloro-4-trifluoromethoxy-benzyloxy)-2-propionylamino-benzoic acid,5-(2,4-Bis-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Chloro-2-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2-fluoro-4-trifluoromethyl-benzyloxy)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-difluoro-benzyloxy)-benzoic acid,5-(4-Chloro-2-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-2-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Chloro-4-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Chloro-4-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-dichloro-benzyloxy)-benzoic acid,5-(4-Bromo-2-chloro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-chloro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-dibromo-benzyloxy)-benzoic acid,5-(3,4-Bis-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(4-fluoro-3-trifluoromethyl-benzyloxy)-benzoic acid,5-(4-Chloro-3-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-3-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(3-fluoro-4-trifluoromethyl-benzyloxy)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(3,4-difluoro-benzyloxy)-benzoic acid,5-(4-Chloro-3-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-3-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3-Chloro-4-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3-Chloro-4-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(3,4-dichloro-benzyloxy)-benzoic acid,5-(4-Bromo-3-chloro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3-Bromo-4-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3-Bromo-4-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3-Bromo-4-chloro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(3,4-dibromo-benzyloxy)-benzoic acid,5-(2,4-Dichloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-2-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2,4-Bis-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Fluoro-2-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(4-fluoro-2-trifluoromethyl-phenoxymethyl)-benzoic acid,5-(2-Chloro-4-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Chloro-4-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-dichloro-phenoxymethyl)-benzoic acid,5-(4-Fluoro-3-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Chloro-3-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Chloro-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Bromo-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-3-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Chloro-4-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(4-fluoro-3-trifluoromethyl-phenoxymethyl)-benzoic acid,5-(4-Chloro-2-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Fluoro-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2,4-Difluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Chloro-2-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-2-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-2-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2,4-Dibromo-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3,4-Bis-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-3-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Fluoro-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3,4-Difluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Chloro-3-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-3-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Chloro-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3,4-Dichloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Bromo-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Bromo-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Bromo-4-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3,4-Dibromo-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2,4-Bis-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Chloro-2-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-2-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2-fluoro-4-trifluoromethyl-phenoxymethyl)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-difluoro-phenoxymethyl)-benzoic acid,5-(4-Chloro-2-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-2-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-2-chloro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-chloro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-dibromo-phenoxymethyl)-benzoic acid,5-(2-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3,4-Bis-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Chloro-3-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-3-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(3-fluoro-4-trifluoromethyl-phenoxymethyl)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(3,4-difluoro-phenoxymethyl)-benzoic acid,5-(4-Chloro-3-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-3-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3-Chloro-4-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(3,4-dichloro-phenoxymethyl)-benzoic acid,5-(4-Bromo-3-chloro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3-Bromo-4-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3-Bromo-4-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3-Bromo-4-chloro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(3,4-dibromo-phenoxymethyl)-benzoic acid,5-[(E)-2-(2,4-Dichloro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Fluoro-2-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Bis-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2-Chloro-4-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Difluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Chloro-2-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2-Fluoro-4-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(4-fluoro-2-trifluoromethyl-phenyl)-vinyl]-benzoic acid,5-[(E)-2-(4-Chloro-2-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-[(E)-2-(4-Chloro-3-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Fluoro-3-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3-Chloro-4-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3-Fluoro-4-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3-Chloro-4-trifluoromethoxy-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3,4-Dichloro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Chloro-2-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2-Chloro-4-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3,4-Bis-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3,4-Difluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Chloro-3-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Bis-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(2-fluoro-4-trifluoromethyl-phenyl)-vinyl]-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(2,4-difluoro-phenyl)-vinyl]-benzoic acid,5-[(E)-2-(4-Chloro-2-fluoro-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-[(E)-2-(2-Chloro-4-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-[(E)-2-(2-Chloro-4-fluoro-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(2,4-dichloro-phenyl)-vinyl]-benzoic acid,5-[(E)-2-(3,4-Bis-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(4-fluoro-3-trifluoromethyl-phenyl)-vinyl]-benzoic acid,5-[(E)-2-(4-Chloro-3-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(3-fluoro-4-trifluoromethyl-phenyl)-vinyl]-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(3,4-difluoro-phenyl)-vinyl]-benzoic acid,5-[(E)-2-(4-Chloro-3-fluoro-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-[(E)-2-(3-Chloro-4-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-[(E)-2-(3-Chloro-4-fluoro-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(3,4-dichloro-phenyl)-vinyl]-benzoic acid,
  • 20. The compound according to claim 1, selected from the group consisting of 5-(2,4-Dichloro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-2-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Fluoro-2-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2,4-Bis-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Chloro-2-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2-Chloro-4-fluoro-benzyloxy)-2-propionylamino-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(4-fluoro-2-trifluoromethyl-benzyloxy)-benzoic acid,5-(2-Bromo-4-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(2-Fluoro-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2-Bromo-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Chloro-3-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(3,4-Dibromo-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-3-chloro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-2-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2,4-Difluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Chloro-2-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-2-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Fluoro-3-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Fluoro-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Chloro-4-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(3,4-Dichloro-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Bromo-4-chloro-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Chloro-4-trifluoromethoxy-benzyloxy)-2-propionylamino-benzoic acid,5-(2,4-Bis-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Chloro-2-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2-fluoro-4-trifluoromethyl-benzyloxy)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-difluoro-benzyloxy)-benzoic acid,5-(4-Chloro-2-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-2-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Chloro-4-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-dichloro-benzyloxy)-benzoic acid,5-(2-Bromo-4-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2,4-Dichloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-2-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2,4-Bis-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Fluoro-2-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(4-fluoro-2-trifluoromethyl-phenoxymethyl)-benzoic acid,5-(2-Chloro-4-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Chloro-4-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-dichloro-phenoxymethyl)-benzoic acid,5-(4-Fluoro-3-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Chloro-3-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Chloro-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Bromo-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-3-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Chloro-4-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(4-fluoro-3-trifluoromethyl-phenoxymethyl)-benzoic acid,5-(2,4-Difluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Chloro-2-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-2-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-2-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2,4-Dibromo-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2,4-Bis-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-2-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-difluoro-phenoxymethyl)-benzoic acid,5-(4-Chloro-2-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-2-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-2-chloro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-chloro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-dibromo-phenoxymethyl)-benzoic acid,5-[(E)-2-(2,4-Dichloro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Fluoro-2-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Bis-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2-Chloro-4-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Difluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Chloro-2-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2-Fluoro-4-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(4-fluoro-2-trifluoromethyl-phenyl)-vinyl]-benzoic acid,5-[(E)-2-(4-Chloro-2-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-[(E)-2-(4-Chloro-3-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Fluoro-3-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3-Chloro-4-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3-Fluoro-4-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3-Chloro-4-trifluoromethoxy-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3,4-Dichloro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Chloro-2-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Bis-trifluoromethyl-phenye-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(2-fluoro-4-trifluoromethyl-phenyl)-vinyl]-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(2,4-difluoro-phenyl)-vinyl]-benzoic acid,5-[(E)-2-(4-Chloro-2-fluoro-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-[(E)-2-(2-Chloro-4-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-[(E)-2-(2-Chloro-4-fluoro-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(2,4-dichloro-phenyl)-vinyl]-benzoic acid, and pharmaceutically acceptable salts thereof.
  • 21. The compound according to claim 1, selected from the group consisting of 5-(4-Bromo-2-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Chloro-2-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2-Bromo-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2,4-Dichloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-2-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2,4-Bis-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Fluoro-2-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Fluoro-3-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Chloro-3-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Chloro-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Bromo-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-3-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Dichloro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Fluoro-2-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Bis-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2-Chloro-4-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Difluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Chloro-2-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Chloro-3-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Fluoro-3-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3-Chloro-4-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3-Fluoro-4-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3-Chloro-4-trifluoromethoxy-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3,4-Dichloro-phenyl)-vinyl]-2-propionylamino-benzoic acid, and pharmaceutically acceptable salts thereof.
  • 22. The compound according to claim 1, selected from the group consisting of 5-(2-Chloro-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Bis-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2-Chloro-4-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Dichloro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Chloro-2-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid, and
  • 23. A pharmaceutical composition comprising a compound according to claim 1 as an active ingredient and a pharmaceutically acceptable excipient.
  • 24. The pharmaceutical composition according to claim 23, wherein X is CH2O wherein the oxygen is bound to ring B.
  • 25. The pharmaceutical composition according to claim 24, wherein Y is hydrogen or a pharmaceutically acceptable inorganic cation.
  • 26. The pharmaceutical composition according to claim 24, wherein R2 is CF3 or OCF3.
  • 27. The pharmaceutical composition according to claim 24, wherein R2 is CF3 or OCF3 and Y is hydrogen or a pharmaceutically acceptable inorganic cation.
  • 28. The pharmaceutical composition according to claim 27, wherein Y is selected from the group consisting of Li+, Na+, K+, Mg2+, C2+ and Zn2+.
  • 29. The pharmaceutical composition according to claim 23, wherein R2 is CF3 or OCF3.
  • 30. The pharmaceutical composition according to claim 23, wherein X is OCH2 wherein the oxygen is bound to ring A.
  • 31. The pharmaceutical composition according to claim 23, wherein X is CH═CH.
  • 32. The pharmaceutical composition according to claim 23, wherein Y is a pharmaceutically acceptable inorganic cation.
  • 33. The pharmaceutical composition according to claim 32, wherein Y is a divalent cation.
  • 34. The pharmaceutical composition according to claim 33, further comprising a negative monovalent counterion.
  • 35. The pharmaceutical composition according to claim 34, wherein the negative monovalent counterion is a halogen ion or a bicarbonate ion.
  • 36. The pharmaceutical composition according to claim 32, wherein Y is selected from the group consisting of Li+, Na+, K+, Mg2+, Ca2+ and Zn2+.
  • 37. The pharmaceutical composition according to claim 32, wherein R2 is CF3 or OCF3.
  • 38. The pharmaceutical composition according to claim 23, wherein the compound exhibits an in vitro metabolic stability towards oxidation by cytochrome P450 characterized by a half-life (t1/2) of longer than about 70 minutes.
  • 39. The pharmaceutical composition according to claim 38, wherein the compound is characterized by a half-life (t1/2) of longer than about 100 minutes.
  • 40. The pharmaceutical composition according to claim 39, wherein the compound is characterized by a half-life (t1/2) of longer than about 200 minutes.
  • 41. The pharmaceutical composition according to claim 23, wherein the compound is selected from the group consisting of 5-(2,4-Dichloro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-2-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Fluoro-2-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2,4-Bis-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Chloro-2-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2-Chloro-4-fluoro-benzyloxy)-2-propionylamino-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(4-fluoro-2-trifluoromethyl-benzyloxy)-benzoic acid,5-(2-Bromo-4-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(2-Fluoro-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2-Bromo-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Chloro-3-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(3,4-Dibromo-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-3-chloro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-2-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2,4-Difluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Chloro-2-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-2-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(2-Chloro-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-2-chloro-benzyloxy)-2-propionylamino-benzoic acid,5-(2-Bromo-4-chloro-benzyloxy)-2-propionylamino-benzoic acid,5-(2,4-Dibromo-benzyloxy)-2-propionylamino-benzoic acid,5-(3,4-Bis-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Fluoro-3-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-3-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Fluoro-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(3,4-Difluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Chloro-3-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-3-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Chloro-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Chloro-4-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(3,4-Dichloro-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Bromo-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Bromo-4-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Bromo-4-chloro-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Chloro-4-trifluoromethoxy-benzyloxy)-2-propionylamino-benzoic acid,5-(2,4-Bis-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Chloro-2-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2-fluoro-4-trifluoromethyl-benzyloxy)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-difluoro-benzyloxy)-benzoic acid,5-(4-Chloro-2-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-2-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Chloro-4-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Chloro-4-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-dichloro-benzyloxy)-benzoic acid,5-(4-Bromo-2-chloro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-chloro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-dibromo-benzyloxy)-benzoic acid,5-(3,4-Bis-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(4-fluoro-3-trifluoromethyl-benzyloxy)-benzoic acid,5-(4-Chloro-3-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-3-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(3-fluoro-4-trifluoromethyl-benzyloxy)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(3,4-difluoro-benzyloxy)-benzoic acid,5-(4-Chloro-3-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-3-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3-Chloro-4-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3-Chloro-4-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(3,4-dichloro-benzyloxy)-benzoic acid,5-(4-Bromo-3-chloro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3-Bromo-4-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3-Bromo-4-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3-Bromo-4-chloro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(3,4-dibromo-benzyloxy)-benzoic acid,5-(2,4-Dichloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-2-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2,4-Bis-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Fluoro-2-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(4-fluoro-2-trifluoromethyl-phenoxymethyl)-benzoic acid,5-(2-Chloro-4-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Chloro-4-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-dichloro-phenoxymethyl)-benzoic acid,5-(4-Fluoro-3-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Chloro-3-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Chloro-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Bromo-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-3-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Chloro-4-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(4-fluoro-3-trifluoromethyl-phenoxymethyl)-benzoic acid,5-(4-Chloro-2-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Fluoro-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2,4-Difluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Chloro-2-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-2-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-2-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2,4-Dibromo-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3,4-Bis-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-3-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Fluoro-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3,4-Difluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Chloro-3-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-3-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Chloro-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3,4-Dichloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Bromo-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Bromo-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Bromo-4-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3,4-Dibromo-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2,4-Bis-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Chloro-2-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-2-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2-fluoro-4-trifluoromethyl-phenoxymethyl)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-difluoro-phenoxymethyl)-benzoic acid,5-(4-Chloro-2-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-2-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-2-chloro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-chloro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-dibromo-phenoxymethyl)-benzoic acid,5-(2-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3,4-Bis-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Chloro-3-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-3-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(3-fluoro-4-trifluoromethyl-phenoxymethyl)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(3,4-difluoro-phenoxymethyl)-benzoic acid,5-(4-Chloro-3-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-3-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3-Chloro-4-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(3,4-dichloro-phenoxymethyl)-benzoic acid,5-(4-Bromo-3-chloro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3-Bromo-4-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3-Bromo-4-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3-Bromo-4-chloro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(3,4-dibromo-phenoxymethyl)-benzoic acid,5-[(E)-2-(2,4-Dichloro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Fluoro-2-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Bis-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2-Chloro-4-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Difluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Chloro-2-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2-Fluoro-4-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(4-fluoro-2-trifluoromethyl-phenyl)-vinyl]-benzoic acid,5-[(E)-2-(4-Chloro-2-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-[(E)-2-(4-Chloro-3-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Fluoro-3-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3-Chloro-4-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3-Fluoro-4-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3-Chloro-4-trifluoromethoxy-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3,4-Dichloro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Chloro-2-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2-Chloro-4-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3,4-Bis-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3,4-Difluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Chloro-3-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Bis-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(2-fluoro-4-trifluoromethyl-phenyl)-vinyl]-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(2,4-difluoro-phenyl)-vinyl]-benzoic acid,5-[(E)-2-(4-Chloro-2-fluoro-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-[(E)-2-(2-Chloro-4-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-[(E)-2-(2-Chloro-4-fluoro-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(2,4-dichloro-phenyl)-vinyl]-benzoic acid,5-[(E)-2-(3,4-Bis-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(4-fluoro-3-trifluoromethyl-phenyl)-vinyl]-benzoic acid,5-[(E)-2-(4-Chloro-3-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(3-fluoro-4-trifluoromethyl-phenyl)-vinyl]-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(3,4-difluoro-phenyl)-vinyl]-benzoic acid,5-[(E)-2-(4-Chloro-3-fluoro-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-[(E)-2-(3-Chloro-4-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-[(E)-2-(3-Chloro-4-fluoro-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(3,4-dichloro-phenyl)-vinyl]-benzoic acid,
  • 42. The pharmaceutical composition according to claim 23, wherein the compound is selected from the group consisting of 5-(2,4-Dichloro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-2-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Fluoro-2-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2,4-Bis-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Chloro-2-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2-Chloro-4-fluoro-benzyloxy)-2-propionylamino-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(4-fluoro-2-trifluoromethyl-benzyloxy)-benzoic acid,5-(2-Bromo-4-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(2-Fluoro-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2-Bromo-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Chloro-3-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(3,4-Dibromo-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-3-chloro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-2-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2,4-Difluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Chloro-2-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-2-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Fluoro-3-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Fluoro-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Chloro-4-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(3,4-Dichloro-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Bromo-4-chloro-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Chloro-4-trifluoromethoxy-benzyloxy)-2-propionylamino-benzoic acid,5-(2,4-Bis-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Chloro-2-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2-fluoro-4-trifluoromethyl-benzyloxy)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-difluoro-benzyloxy)-benzoic acid,5-(4-Chloro-2-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-2-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Chloro-4-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-dichloro-benzyloxy)-benzoic acid,5-(2-Bromo-4-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2,4-Dichloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-2-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2,4-Bis-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Fluoro-2-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(4-fluoro-2-trifluoromethyl-phenoxymethyl)-benzoic acid,5-(2-Chloro-4-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Chloro-4-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-dichloro-phenoxymethyl)-benzoic acid,5-(4-Fluoro-3-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Chloro-3-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Chloro-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Bromo-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-3-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Chloro-4-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(4-fluoro-3-trifluoromethyl-phenoxymethyl)-benzoic acid,5-(2,4-Difluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Chloro-2-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-2-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-2-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2,4-Dibromo-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2,4-Bis-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-2-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-difluoro-phenoxymethyl)-benzoic acid,5-(4-Chloro-2-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-2-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-2-chloro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-chloro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-dibromo-phenoxymethyl)-benzoic acid,5-[(E)-2-(2,4-Dichloro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Fluoro-2-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Bis-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2-Chloro-4-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Difluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Chloro-2-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2-Fluoro-4-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(4-fluoro-2-trifluoromethyl-phenyl)-vinyl]-benzoic acid,5-[(E)-2-(4-Chloro-2-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-[(E)-2-(4-Chloro-3-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Fluoro-3-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3-Chloro-4-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3-Fluoro-4-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3-Chloro-4-trifluoromethoxy-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3,4-Dichloro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Chloro-2-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Bis-trifluoromethyl-phenye-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(2-fluoro-4-trifluoromethyl-phenyl)-vinyl]-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(2,4-difluoro-phenyl)-vinyl]-benzoic acid,5-[(E)-2-(4-Chloro-2-fluoro-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-[(E)-2-(2-Chloro-4-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-[(E)-2-(2-Chloro-4-fluoro-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(2,4-dichloro-phenyl)-vinyl]-benzoic acid, and pharmaceutically acceptable salts thereof.
  • 43. The pharmaceutical composition according to claim 23, wherein the compound is selected from the group consisting of 5-(4-Bromo-2-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Chloro-2-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2-Bromo-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2,4-Dichloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-2-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2,4-Bis-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Fluoro-2-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Fluoro-3-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Chloro-3-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Chloro-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Bromo-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-3-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Dichloro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Fluoro-2-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Bis-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2-Chloro-4-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Difluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Chloro-2-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Chloro-3-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Fluoro-3-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3-Chloro-4-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3-Fluoro-4-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3-Chloro-4-trifluoromethoxy-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3,4-Dichloro-phenyl)-vinyl]-2-propionylamino-benzoic acid, and pharmaceutically acceptable salts thereof.
  • 44. The pharmaceutical composition according to claim 23, wherein the compound is selected from the group consisting of 5-(2-Chloro-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Bis-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2-Chloro-4-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Dichloro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Chloro-2-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid, and
  • 45. The pharmaceutical composition according to claim 23, wherein the active ingredient is present in an amount providing a daily dosage of from about 0.005 mg/kg to about 10 mg/kg body weight.
  • 46. The pharmaceutical composition according to claim 45, wherein the active ingredient is present in an amount providing a daily dosage of from about 0.025 mg/kg to about 2 mg/kg body weight.
  • 47. The pharmaceutical composition according to claim 23, having a form selected from the group consisting of a solution, suspension, emulsion, tablet, capsule, or powder for oral administration, a sterile solution for parental administration, a suppository for rectal administration, and a topical formulation.
  • 48. A method of treating a disorder or condition responsive to inhibition of dihydroorotate dehydrogenase (DHODH) in a patient, the method comprising administering, to a patient in need thereof, a therapeutically effective amount of a compound according to claim 1.
  • 49. The method according to claim 48, wherein X is CH2O wherein the oxygen is bound to ring B.
  • 50. The method according to claim 49, wherein Y is hydrogen or a pharmaceutically acceptable inorganic cation.
  • 51. The method according to claim 49, wherein R2 is CF3 or OCF3.
  • 52. The method according to claim 49, wherein R2 is CF3 or OCF3 and Y is hydrogen or a pharmaceutically acceptable inorganic cation.
  • 53. The method according to claim 52, wherein Y is selected from the group consisting of Li+, Na+, K+, Mg2+, Ca2+ and Zn2+.
  • 54. The method according to claim 48, wherein R2 is CF3 or OCF3.
  • 55. The method according to claim 48, wherein X is OCH2 wherein the oxygen is bound to ring A.
  • 56. The method according to claim 48, wherein X is CH═CH.
  • 57. The method according to claim 48, wherein Y is a pharmaceutically acceptable inorganic cation.
  • 58. The method according to claim 57, wherein Y is a divalent cation.
  • 59. The method according to claim 58, further comprising a negative monovalent counterion.
  • 60. The method according to claim 59, wherein the negative monovalent counterion is a halogen ion or a bicarbonate ion.
  • 61. The method according to claim 57, wherein Y is selected from the group consisting of Li+, Na+, K+, Mg2+, Ca2+ and Zn2+.
  • 62. The method according to claim 57, wherein R2 is CF3 or OCF3.
  • 63. The method according to claim 48, wherein the compound is selected from the group consisting of 5-(2,4-Dichloro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-2-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Fluoro-2-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2,4-Bis-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Chloro-2-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2-Chloro-4-fluoro-benzyloxy)-2-propionylamino-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(4-fluoro-2-trifluoromethyl-benzyloxy)-benzoic acid,5-(2-Bromo-4-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(2-Fluoro-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2-Bromo-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Chloro-3-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(3,4-Dibromo-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-3-chloro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-2-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2,4-Difluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Chloro-2-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-2-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(2-Chloro-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-2-chloro-benzyloxy)-2-propionylamino-benzoic acid,5-(2-Bromo-4-chloro-benzyloxy)-2-propionylamino-benzoic acid,5-(2,4-Dibromo-benzyloxy)-2-propionylamino-benzoic acid,5-(3,4-Bis-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Fluoro-3-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-3-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Fluoro-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(3,4-Difluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Chloro-3-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-3-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Chloro-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Chloro-4-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(3,4-Dichloro-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Bromo-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Bromo-4-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Bromo-4-chloro-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Chloro-4-trifluoromethoxy-benzyloxy)-2-propionylamino-benzoic acid,5-(2,4-Bis-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Chloro-2-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2-fluoro-4-trifluoromethyl-benzyloxy)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-difluoro-benzyloxy)-benzoic acid,5-(4-Chloro-2-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-2-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Chloro-4-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Chloro-4-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-dichloro-benzyloxy)-benzoic acid,5-(4-Bromo-2-chloro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-chloro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-dibromo-benzyloxy)-benzoic acid,5-(3,4-Bis-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(4-fluoro-3-trifluoromethyl-benzyloxy)-benzoic acid,5-(4-Chloro-3-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-3-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(3-fluoro-4-trifluoromethyl-benzyloxy)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(3,4-difluoro-benzyloxy)-benzoic acid,5-(4-Chloro-3-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-3-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3-Chloro-4-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3-Chloro-4-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(3,4-dichloro-benzyloxy)-benzoic acid,5-(4-Bromo-3-chloro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3-Bromo-4-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3-Bromo-4-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3-Bromo-4-chloro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(3,4-dibromo-benzyloxy)-benzoic acid,5-(2,4-Dichloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-2-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2,4-Bis-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Fluoro-2-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(4-fluoro-2-trifluoromethyl-phenoxymethyl)-benzoic acid,5-(2-Chloro-4-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Chloro-4-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-dichloro-phenoxymethyl)-benzoic acid,5-(4-Fluoro-3-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Chloro-3-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Chloro-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Bromo-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-3-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Chloro-4-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(4-fluoro-3-trifluoromethyl-phenoxymethyl)-benzoic acid,5-(4-Chloro-2-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Fluoro-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2,4-Difluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Chloro-2-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-2-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-2-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2,4-Dibromo-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3,4-Bis-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-3-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Fluoro-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3,4-Difluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Chloro-3-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-3-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Chloro-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3,4-Dichloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Bromo-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Bromo-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Bromo-4-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3,4-Dibromo-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2,4-Bis-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Chloro-2-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-2-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2-fluoro-4-trifluoromethyl-phenoxymethyl)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-difluoro-phenoxymethyl)-benzoic acid,5-(4-Chloro-2-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-2-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-2-chloro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-chloro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-dibromo-phenoxymethyl)-benzoic acid,5-(2-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3,4-Bis-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Chloro-3-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-3-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(3-fluoro-4-trifluoromethyl-phenoxymethyl)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(3,4-difluoro-phenoxymethyl)-benzoic acid,5-(4-Chloro-3-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-3-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3-Chloro-4-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(3,4-dichloro-phenoxymethyl)-benzoic acid,5-(4-Bromo-3-chloro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3-Bromo-4-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3-Bromo-4-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(3-Bromo-4-chloro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(3,4-dibromo-phenoxymethyl)-benzoic acid,5-[(E)-2-(2,4-Dichloro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Fluoro-2-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Bis-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2-Chloro-4-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Difluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Chloro-2-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2-Fluoro-4-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(4-fluoro-2-trifluoromethyl-phenyl)-vinyl]-benzoic acid,5-[(E)-2-(4-Chloro-2-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-[(E)-2-(4-Chloro-3-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Fluoro-3-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3-Chloro-4-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3-Fluoro-4-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3-Chloro-4-trifluoromethoxy-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3,4-Dichloro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Chloro-2-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2-Chloro-4-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3,4-Bis-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3,4-Difluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Chloro-3-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Bis-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(2-fluoro-4-trifluoromethyl-phenyl)-vinyl]-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(2,4-difluoro-phenyl)-vinyl]-benzoic acid,5-[(E)-2-(4-Chloro-2-fluoro-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-[(E)-2-(2-Chloro-4-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-[(E)-2-(2-Chloro-4-fluoro-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(2,4-dichloro-phenyl)-vinyl]-benzoic acid,5-[(E)-2-(3,4-Bis-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(4-fluoro-3-trifluoromethyl-phenyl)-vinyl]-benzoic acid,5-[(E)-2-(4-Chloro-3-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(3-fluoro-4-trifluoromethyl-phenyl)-vinyl]-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(3,4-difluoro-phenyl)-vinyl]-benzoic acid,5-[(E)-2-(4-Chloro-3-fluoro-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-[(E)-2-(3-Chloro-4-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-[(E)-2-(3-Chloro-4-fluoro-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(3,4-dichloro-phenyl)-vinyl]-benzoic acid, and pharmaceutically acceptable salts thereof.
  • 64. The method according to claim 48, wherein the compound is selected from the group consisting of 5-(2,4-Dichloro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-2-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Fluoro-2-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2,4-Bis-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Chloro-2-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2-Chloro-4-fluoro-benzyloxy)-2-propionylamino-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(4-fluoro-2-trifluoromethyl-benzyloxy)-benzoic acid,5-(2-Bromo-4-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(2-Fluoro-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2-Bromo-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Chloro-3-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(3,4-Dibromo-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-3-chloro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-2-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2,4-Difluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Chloro-2-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Bromo-2-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(4-Fluoro-3-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Fluoro-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Chloro-4-fluoro-benzyloxy)-2-propionylamino-benzoic acid,5-(3,4-Dichloro-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Bromo-4-chloro-benzyloxy)-2-propionylamino-benzoic acid,5-(3-Chloro-4-trifluoromethoxy-benzyloxy)-2-propionylamino-benzoic acid,5-(2,4-Bis-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Chloro-2-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2-fluoro-4-trifluoromethyl-benzyloxy)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-difluoro-benzyloxy)-benzoic acid,5-(4-Chloro-2-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-2-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Chloro-4-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-dichloro-benzyloxy)-benzoic acid,5-(2-Bromo-4-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-fluoro-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2,4-Dichloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-2-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2,4-Bis-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Fluoro-2-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(4-fluoro-2-trifluoromethyl-phenoxymethyl)-benzoic acid,5-(2-Chloro-4-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Chloro-4-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-dichloro-phenoxymethyl)-benzoic acid,5-(4-Fluoro-3-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Chloro-3-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Chloro-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Bromo-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-3-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Chloro-4-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(4-fluoro-3-trifluoromethyl-phenoxymethyl)-benzoic acid,5-(2,4-Difluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Chloro-2-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-2-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-2-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2,4-Dibromo-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2,4-Bis-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-2-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-difluoro-phenoxymethyl)-benzoic acid,5-(4-Chloro-2-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-2-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Bromo-2-chloro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-trifluoromethyl-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-fluoro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(2-Bromo-4-chloro-phenoxymethyl)-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-(2,4-dibromo-phenoxymethyl)-benzoic acid,5-[(E)-2-(2,4-Dichloro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Fluoro-2-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Bis-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2-Chloro-4-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Difluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Chloro-2-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2-Fluoro-4-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(4-fluoro-2-trifluoromethyl-phenyl)-vinyl]-benzoic acid,5-[(E)-2-(4-Chloro-2-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-[(E)-2-(4-Chloro-3-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Fluoro-3-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3-Chloro-4-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3-Fluoro-4-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3-Chloro-4-trifluoromethoxy-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3,4-Dichloro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Chloro-2-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Bis-trifluoromethyl-phenye-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(2-fluoro-4-trifluoromethyl-phenyl)-vinyl]-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(2,4-difluoro-phenyl)-vinyl]-benzoic acid,5-[(E)-2-(4-Chloro-2-fluoro-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-[(E)-2-(2-Chloro-4-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-[(E)-2-(2-Chloro-4-fluoro-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid,2-(Cyclopropanecarbonyl-amino)-5-[(E)-2-(2,4-dichloro-phenyl)-vinyl]-benzoic acid, and pharmaceutically acceptable salts thereof.
  • 65. The method according to claim 48, wherein the compound is selected from the group consisting of 5-(4-Bromo-2-trifluoromethyl-benzyloxy)-2-(cyclopropanecarbonyl-amino)-benzoic acid,5-(4-Chloro-2-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2-Bromo-4-trifluoromethyl-benzyloxy)-2-propionylamino-benzoic acid,5-(2,4-Dichloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-2-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2,4-Bis-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Fluoro-2-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Fluoro-3-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Chloro-3-trifluoromethyl-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Chloro-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Bromo-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-(4-Bromo-3-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(3-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Dichloro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Fluoro-2-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Bis-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2-Chloro-4-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Difluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Chloro-2-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Chloro-3-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Fluoro-3-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3-Chloro-4-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3-Fluoro-4-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3-Chloro-4-trifluoromethoxy-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(3,4-Dichloro-phenyl)-vinyl]-2-propionylamino-benzoic acid, and pharmaceutically acceptable salts thereof.
  • 66. The method according to claim 48, wherein the compound is selected from the group consisting of 5-(2-Chloro-4-fluoro-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Chloro-4-trifluoromethoxy-phenoxymethyl)-2-propionylamino-benzoic acid,5-(2-Bromo-4-chloro-phenoxymethyl)-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Bis-trifluoromethyl-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2-Chloro-4-fluoro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(2,4-Dichloro-phenyl)-vinyl]-2-propionylamino-benzoic acid,5-[(E)-2-(4-Chloro-2-trifluoromethyl-phenyl)-vinyl]-2-(cyclopropanecarbonyl-amino)-benzoic acid, and
  • 67. The method according to claim 48, wherein the disorder or condition is selected from the group consisting of autoimmune diseases, inflammatory diseases, organ transplant rejection, and malignant neoplasia.
  • 68. The method according to claim 48, wherein the disorder or condition is selected from the group consisting of acute and chronic inflammation, rheumatoid arthritis, multiple sclerosis, type-1 diabetes, inflammatory bowel disease, and psoriasis.
  • 69. The method according to claim 48, wherein the compound exhibits an in vitro metabolic stability towards oxidation by cytochrome P450 characterized by a half-life (t1/2) of longer than about 70 minutes.
  • 70. The method according to claim 69, wherein the compound is characterized by a half-life (t1/2) of longer than about 100 minutes.
  • 71. The method according to claim 70, wherein the compound is characterized by a half-life (t1/2) of longer than about 200 minutes.
  • 72. A method of preparing a compound according to claim 1, wherein X in formula (I) is OCH2, by
  • 73. The method according to claim 72, wherein Y in formulae (II), (IV) and (VI) is a C1-C6 alkyl group, the method optionally comprising hydrolyzing the ester moiety C(O)OY to a carboxylic acid moiety and optionally reacting the carboxylic acid moiety with a suitable base so as to transform the carboxylic acid moiety into a carboxylic acid salt of a pharmaceutically acceptable cation.
  • 74. The method according to claim 72, wherein said reacting steps occur in a polar aprotic solvent in the presence of an alkali metal carbonate.
  • 75. The method according to claim 72, wherein the reaction of the compound of formula (VI) with the styrene compound of formula (VII) occurs in the presence of a palladium catalyst.
  • 76. The method according to claim 72, wherein the compound of formula (IV) is made by
  • 77. The method according to claim 76, wherein the compound of formula (VIII) is made by
  • 78. The method according to claim 72, wherein the compound of formula (II) or formula (VI), generically represented as formula IX, is made by
  • 79. The method according to claim 72, wherein A is selected from the group consisting of bromide, chloride, mesyloxy, and tosyloxy.
  • 80. The method according to claim 72, wherein the compound of formula (V) is made by
Priority Claims (1)
Number Date Country Kind
0700281-9 Feb 2007 SE national
CROSS REFERENCE TO RELATED APPLICATIONS

This application is a continuation of PCT Application No. PCT/SE2008/050126, filed Jan. 31, 2008, and also claims the benefit of U.S. Provisional Application Ser. No. 60/899,660, filed Feb. 6, 2007, and Swedish Application No. 0700281-9, filed Feb. 6, 2007, all of which are incorporated herein by reference in their entirety and for all purposes.

Provisional Applications (1)
Number Date Country
60899660 Feb 2007 US
Continuations (1)
Number Date Country
Parent PCT/SE2008/050126 Jan 2008 US
Child 12535358 US