Patent Grant
8652163
This invention relates generally to devices for intravascular interventional therapeutic treatment or vascular surgery for treatment of defects in the vasculature, and more particularly concerns a system and method for delivering intravascular interventional devices, such as for treatment of aneurysms.
Vascular interventional devices such as vasoocclusive devices are typically placed within the vasculature of the human body by use of a catheter. Vascular interventional devices such as stents can be placed within an occluded vessel to facilitate blood flow through the vessel, and vasoocclusive devices are typically either placed within a blood vessel to block the flow of blood through the vessel by forming an embolus, or are placed within an aneurysm stemming from the vessel to form an embolus within the aneurysm. Stents can have a wide variety of configurations, but generally need to be placed and then released at a desired location within a blood vessel. Vasoocclusive devices used for these procedures can also have a wide variety of configurations, and aneurysms have been treated with external surgically placed clips, detachable vasoocclusive balloons and embolus generating vasoocclusive devices such as one or more vasoocclusive coils.
The delivery of such vasoocclusive devices have typically been accomplished by a variety of means, including via a catheter in which the device is pushed through an opening at the distal end of the catheter by a pusher to deploy the device. The vasoocclusive devices can be produced in such a way that they will pass through the lumen of a catheter in a linear shape and take on a complex shape as originally formed after being deployed into the area to be treated, such as an aneurysm.
One conventional releasable balloon catheter used to embolize vascular lesions has a tube portion made of a material such as a hydrophilic polymer, located between the catheter and the balloon, that can be melted by heating the tube, or can be dissolved in the blood when heated, and electrodes are provided for heating the tube. Another conventional technique for separating a balloon from a balloon catheter involves the melting and breaking of a connecting member between the balloon and the catheter body, when power is supplied to electrodes provided for heating the connecting member. When the connecting member is heated to temperatures of about 70° C. and slight tension is applied, the balloon can be separated from the main catheter body.
An implant delivery assembly is also known that is used for delivery of implants such as embolic coils, utilizing a shape memory decoupling mechanism activated when exposed to body temperature. A cooling solution is flushed through the catheter during introduction and placement of the implant in order to prevent premature release of the implant prior to the time that the implant is to be released. Another implant delivery assembly includes an electrical heating system for heating the coupling mechanism to a temperature at which the shape memory material returns to its original shape, to deploy the implant.
Another device is known in which a device to be implanted is detached by application of a high-frequency current which melts and severs a resin that is used to retain the device to be implanted until the device is to be deployed. In another known device, an electrolytically severable link is dissolved by activation of a power source electrically coupled to the electrolytically severable link to detach the device to be implanted.
In another conventional technique, a conductive guidewire delivers a high frequency current through the guidewire to melt and sever a joint to detach an implanted device from the guidewire. The patient is grounded during the procedure, and current is introduced via the guidewire, rather than with a two way current path.
Such devices that release the interventional device by melting or dissolving the intermediate section between the catheter tip and implanted device may cause thermal damage of surrounding tissues during detachment that can cause embolization in the bloodstream, and may also potentially release undesirable particles of materials into the bloodstream that can also cause embolization in the bloodstream. There is therefore a need for a precise method of deploying therapeutic interventional devices without compromising the position of the implant, without causing thermal damage to surrounding tissues, and without releasing undesirable particles of materials into the bloodstream and risking the formation of emboli in the bloodstream. The present invention meets these and other needs.
Briefly, and in general terms, the present invention provides for an apparatus for deployment of an intravascular therapeutic device, such as a vasoocclusive device, a microcoil, at least one electrode, a stent, or a coated coil, for example, using an elongated, flexible pusher member. The therapeutic device is connected to a first connector member mounted to the flexible pusher member with an elongated second connector member connected between the first connector member and the therapeutic device. At least one of the first and second connector members includes a severable portion that is capable of being severed, such as by melting or degradation, by heat. A heat source is provided for heating and breaking the severable portion of the first or second connector member to release the therapeutic device. The first connector member may be formed from a molded thermoplastic material, such as high density polyethylene, and the elongated second connector member may be a connector fiber, or a ribbon, for example. The elongated second connector member may also be formed from a thermoplastic material, such as high density polyethylene. The heat source is advantageously contained substantially within the pusher member, which provides a sufficient amount of thermal insulation to eliminate the potential for thermal damage to surrounding tissues during detachment of the therapeutic device. Since the severable first connecting member is heated and broken at a location fully contained within the pusher member, the potential for releasing undesirable particles of materials into the bloodstream and consequent embolization in the bloodstream is virtually eliminated.
The invention accordingly provides for an apparatus for release and deployment of a therapeutic device within the vasculature of a patient, the apparatus including an elongated, flexible pusher member having an interior lumen, a first connector member mounted to the elongated, flexible pusher member. In one aspect, the first connector member may have a severable portion capable of being broken by heating disposed within the elongated, flexible pusher member. An elongated second connector member is connected to the therapeutic device and detachably connected to the first connector member. The elongated second connector member thereby connects the therapeutic device to the pusher member for placement of the therapeutic device within the vasculature, and in one aspect, the elongated second connector member may have a severable portion capable of being broken by heating disposed within the elongated, flexible pusher member.
In one aspect, a heat source may be disposed in the interior lumen of the pusher member adjacent to the first connector member for heating the severable portion of the first connector member to cause the severable portion of the first connector member to break and release the elongated second connector member for detaching and deploying the therapeutic device from the flexible pusher member when a desired placement of the therapeutic device within the vasculature is achieved.
In another aspect, the first connector member may be formed from a molded thermoplastic, such as high density polyethylene, for example. The first connector member may be molded in the form of a rod extending across the interior diameter of the interior lumen of the pusher member, a post, a ring, or other similar suitable configurations. In another aspect, the heat source may include an electrical resistance heat source coil. Alternatively, the heat source may include an induction ring, and may be included in the first connector member, for severing the elongated second connector member. A control unit is typically connected to the heat source to supply electrical current to the heat source. The flexible pusher member typically includes a heat insulating shaft having an entry port communicating with the interior lumen of the pusher member, and the heat source is disposed in the interior lumen of the pusher member adjacent to the entry port. The flexible pusher member has a distal tip, and in one aspect, the heat source may be spaced apart from the distal tip of the flexible pusher member.
In other aspects, the elongated second connector member may be a connector fiber, or may be a ribbon. The therapeutic device may be a vasoocclusive device, a microcoil, at least one electrode, a stent, or a coated coil, for example.
These and other aspects and advantages of the invention will become apparent from the following detailed description and the accompanying drawings, which illustrate by way of example the features of the invention.
While vasoocclusive devices have conventionally been delivered to a portion of a patient's vasculature to be treated through a delivery catheter by means of a pusher device, such conventional methods can involve separation of the vasoocclusive device from the pusher device in ways that result in injury to the vasculature, such as by causing thermal damage of surrounding tissues during detachment that can cause embolization in the bloodstream, or by release of undesirable particles of materials into the bloodstream that can cause embolization in the bloodstream.
With reference to
In a first embodiment illustrated in
A first connector member 58 is mounted to the elongated, flexible pusher member, and has a severable portion 60 disposed within the elongated, flexible pusher member that is capable of being broken by heating. The first connector member is typically formed from a molded thermoplastic material, such as high density polyethylene. In the first embodiment, the first connector member may be molded in the form of a rod 61 extending across and connected between opposing sides of the interior diameter of the interior lumen of the pusher member, as is shown in
In a second embodiment illustrated in
In a third embodiment illustrated in
In each embodiment, the therapeutic device includes an elongated second connector member 66 connected to the therapeutic device, such as by being looped through an end coil 68 of a microcoil therapeutic device, for example. The elongated second connector member may alternatively be tied or bonded to the therapeutic device, such as by heat bonding, or by an adhesive such as a cyanoacrylate adhesive, for example. The elongated second connector member is typically looped around the first connector member when the first connector member is a rod or post, or through the first connector member, when the first connector member is a ring. The elongated second connector member may be a connector fiber, or a ribbon, that may be made of polyethylene, or another suitable fiber material, for example. In a presently preferred embodiment, the elongated second connector member is formed of polyethylene, and is typically about 0.015 to 0.030 inches in diameter, although the elongated second connector member can be as thin as about 0.0005 inches in diameter, and can be formed from a variety of thermoplastic materials with high tensile strength. The elongated second connector member may also optionally be formed of a suitable high tensile strength material, for example.
In the foregoing embodiments, a heat source such as a resistive heat source coil 70 is disposed in the interior lumen of the pusher member adjacent to the severable portion of the first connector member for heating the severable portion of the first connector member to cause the severable portion of the first connector member to break and release the elongated second connector member, to thereby detach and deploy the therapeutic device from the flexible pusher member when a desired placement of the therapeutic device within the vasculature is achieved. The heat source may be spaced apart from the distal end of the pusher member. The heat source is connected by electrical connectors 72 to a control unit 74 which supplies electrical current to the resistive heat source coil to cause the severable connector member to break and release the therapeutic device. Alternatively, the heat source may deliver heat to the severable connector member by other means, such as thermo-mechanical, electromagnetic or RF energy, for example. The lumen of the pusher member advantageously provides an insulative space and wall thickness to contain the heating of the severable connector member to avoid thermal damage to surrounding tissues, and to help contain pieces of the severable connector member that may be formed during heating of the severable connector member to deploy the therapeutic device. The therapeutic device is thus detachably connected to the first connector member by the elongated second connector member, for placement of the therapeutic device within the vasculature.
In a fourth embodiment illustrated in
It will be apparent from the foregoing that while particular forms of the invention have been illustrated and described, various modifications can be made without departing from the spirit and scope of the invention. Accordingly, it is not intended that the invention be limited, except as by the appended claims.
This is a continuation of application Ser. No. 12/814,397 filed 11 Jun. 2010, now U.S. Pat. No. 8,298,256, which is a continuation of application Ser. No. 11/726,074 filed 21 Mar. 2007, now U.S. Pat. No. 7,740,637, which is a continuation-in-part of application Ser. No. 11/020,936, filed 22 Dec. 2004, now U.S. Pat. No. 7,198,613, which is a continuation of application Ser. No. 10/290,777, filed 7 Nov. 2002, now U.S. Pat. No. 6,966,892, which is a continuation of application Ser. No. 09/501,466, filed 9 Feb. 2000, now U.S. Pat. No. 6,478,773.
| Number | Name | Date | Kind |
|---|---|---|---|
| 1341052 | Gale | May 1920 | A |
| 2078182 | MacFarland | Apr 1937 | A |
| 2549335 | Rahthus | Apr 1951 | A |
| 3334629 | Cohn | Aug 1967 | A |
| 3485234 | Stevens | Dec 1969 | A |
| 3649224 | Anderson et al. | Mar 1972 | A |
| 3868956 | Alfidi et al. | Mar 1975 | A |
| 4327734 | White, Jr. | May 1982 | A |
| 4341218 | U | Jul 1982 | A |
| 4346712 | Handa et al. | Aug 1982 | A |
| 4402319 | Handa et al. | Sep 1983 | A |
| 4441495 | Hicswa | Apr 1984 | A |
| 4494531 | Gianturco | Jan 1985 | A |
| 4512338 | Balko et al. | Apr 1985 | A |
| 4545367 | Tucci | Oct 1985 | A |
| 4553545 | Maass et al. | Nov 1985 | A |
| 4611594 | Grayhack et al. | Sep 1986 | A |
| 4629458 | Pinchuk | Dec 1986 | A |
| 4638803 | Rand | Jan 1987 | A |
| RE32348 | Pevsner | Feb 1987 | E |
| 4655771 | Wallsten | Apr 1987 | A |
| 4662068 | Polonsky | May 1987 | A |
| 4670286 | Nyilas et al. | Jun 1987 | A |
| 4718907 | Karwoski et al. | Jan 1988 | A |
| 4732152 | Wallsten et al. | Mar 1988 | A |
| 4748986 | Morrison et al. | Jun 1988 | A |
| 4768507 | Fischell et al. | Sep 1988 | A |
| 4795458 | Regan | Jan 1989 | A |
| 4798606 | Pinchuk | Jan 1989 | A |
| 4800882 | Gianturco | Jan 1989 | A |
| 4813925 | Anderson, Jr. et al. | Mar 1989 | A |
| 4820298 | Leveen et al. | Apr 1989 | A |
| 4830003 | Wolff et al. | May 1989 | A |
| 4850960 | Grayzel | Jul 1989 | A |
| 4856516 | Hillstead | Aug 1989 | A |
| 4873978 | Ginsburg | Oct 1989 | A |
| 4944746 | Iwata et al. | Jul 1990 | A |
| 4950258 | Kawai et al. | Aug 1990 | A |
| 4954126 | Wallsten | Sep 1990 | A |
| 4957479 | Roemer | Sep 1990 | A |
| 4957501 | Lahille et al. | Sep 1990 | A |
| 4969890 | Sugita et al. | Nov 1990 | A |
| 4990155 | Wilkoff | Feb 1991 | A |
| 4994069 | Ritchart et al. | Feb 1991 | A |
| 4994071 | MacGregor | Feb 1991 | A |
| 5002556 | Ishida et al. | Mar 1991 | A |
| 5015253 | MacGregor | May 1991 | A |
| 5019090 | Pinchuk | May 1991 | A |
| 5026377 | Burton et al. | Jun 1991 | A |
| 5035706 | Giantureo et al. | Jul 1991 | A |
| 5037377 | Alonso | Aug 1991 | A |
| 5041084 | DeVries et al. | Aug 1991 | A |
| 5041126 | Gianturco | Aug 1991 | A |
| 5061275 | Wallsten et al. | Oct 1991 | A |
| 5064435 | Porter | Nov 1991 | A |
| 5071407 | Termin et al. | Dec 1991 | A |
| 5101094 | Keller et al. | Mar 1992 | A |
| 5104404 | Wolff | Apr 1992 | A |
| 5108407 | Geremia et al. | Apr 1992 | A |
| 5109867 | Twyford, Jr. | May 1992 | A |
| 5122136 | Guglielmi et al. | Jun 1992 | A |
| 5122137 | Lennox | Jun 1992 | A |
| 5133364 | Palermo et al. | Jul 1992 | A |
| 5133731 | Butler et al. | Jul 1992 | A |
| 5133732 | Wiktor | Jul 1992 | A |
| 5141502 | Macaluso, Jr. | Aug 1992 | A |
| 5143085 | Wilson | Sep 1992 | A |
| 5147370 | McNamara et al. | Sep 1992 | A |
| 5151105 | Kwan-Gett | Sep 1992 | A |
| 5152784 | Tsilibary | Oct 1992 | A |
| 5160341 | Brenneman et al. | Nov 1992 | A |
| 5171273 | Silver et al. | Dec 1992 | A |
| 5176625 | Brisson | Jan 1993 | A |
| 5176661 | Evard et al. | Jan 1993 | A |
| 5181921 | Makita et al. | Jan 1993 | A |
| 5183085 | Timmermans | Feb 1993 | A |
| 5186992 | Kite, III | Feb 1993 | A |
| 5188621 | Samson | Feb 1993 | A |
| 5192290 | Hilal | Mar 1993 | A |
| 5197977 | Hoffman, Jr. et al. | Mar 1993 | A |
| 5203772 | Hammerslag et al. | Apr 1993 | A |
| 5211658 | Clouse | May 1993 | A |
| 5217484 | Marks | Jun 1993 | A |
| 5222969 | Gillis | Jun 1993 | A |
| 5222970 | Reeves | Jun 1993 | A |
| 5224953 | Morgentaler | Jul 1993 | A |
| 5226911 | Chee et al. | Jul 1993 | A |
| 5226913 | Pinchuk | Jul 1993 | A |
| 5228453 | Sepetka | Jul 1993 | A |
| 5234437 | Sepetka | Aug 1993 | A |
| 5234456 | Silvestrini | Aug 1993 | A |
| 5238004 | Sahatjian et al. | Aug 1993 | A |
| 5250071 | Palermo | Oct 1993 | A |
| 5256146 | Ensminger et al. | Oct 1993 | A |
| 5258042 | Mehta | Nov 1993 | A |
| 5261916 | Engelson | Nov 1993 | A |
| 5275173 | Samson et al. | Jan 1994 | A |
| 5304194 | Chee et al. | Apr 1994 | A |
| 5304198 | Samson | Apr 1994 | A |
| 5312415 | Palermo | May 1994 | A |
| 5314472 | Fontaine | May 1994 | A |
| 5322501 | Mahmud-Durrani | Jun 1994 | A |
| 5334217 | Das | Aug 1994 | A |
| 5336205 | Zenzen et al. | Aug 1994 | A |
| 5341818 | Abrams et al. | Aug 1994 | A |
| 5342387 | Summers | Aug 1994 | A |
| 5350397 | Palermo et al. | Sep 1994 | A |
| 5354295 | Guglielmi et al. | Oct 1994 | A |
| 5354309 | Schnepp-Pesch et al. | Oct 1994 | A |
| 5368049 | Raman et al. | Nov 1994 | A |
| 5373856 | Grenouillet | Dec 1994 | A |
| 5382259 | Phelps et al. | Jan 1995 | A |
| 5383887 | Nadal | Jan 1995 | A |
| 5395390 | Simon et al. | Mar 1995 | A |
| 5405377 | Cragg | Apr 1995 | A |
| 5409015 | Palermo | Apr 1995 | A |
| 5411475 | Atala et al. | May 1995 | A |
| 5413597 | Krajicek | May 1995 | A |
| 5415664 | Pinchuk | May 1995 | A |
| 5417708 | Hall et al. | May 1995 | A |
| 5423829 | Pham et al. | Jun 1995 | A |
| 5433723 | Lindenberg et al. | Jul 1995 | A |
| 5441516 | Wang et al. | Aug 1995 | A |
| 5443478 | Purdy | Aug 1995 | A |
| 5443498 | Fontaine | Aug 1995 | A |
| 5484449 | Amundson et al. | Jan 1996 | A |
| 5500013 | Buscemi et al. | Mar 1996 | A |
| 5514115 | Frantzen et al. | May 1996 | A |
| 5514176 | Bosley, Jr. | May 1996 | A |
| 5520194 | Miyata et al. | May 1996 | A |
| 5522822 | Phelps et al. | Jun 1996 | A |
| 5522836 | Palermo | Jun 1996 | A |
| 5523092 | Hanson et al. | Jun 1996 | A |
| 5527336 | Rosenbluth et al. | Jun 1996 | A |
| 5540701 | Sharkey et al. | Jul 1996 | A |
| 5549624 | Mirigian et al. | Aug 1996 | A |
| 5562641 | Flomenblit et al. | Oct 1996 | A |
| 5562698 | Parker | Oct 1996 | A |
| 5569245 | Guglielmi et al. | Oct 1996 | A |
| 5578074 | Mirigian | Nov 1996 | A |
| 5582619 | Ken | Dec 1996 | A |
| 5603694 | Brown et al. | Feb 1997 | A |
| 5607445 | Summers | Mar 1997 | A |
| 5609627 | Goicoechea et al. | Mar 1997 | A |
| 5613981 | Boyle et al. | Mar 1997 | A |
| 5624461 | Mariant | Apr 1997 | A |
| 5637113 | Tartaglia et al. | Jun 1997 | A |
| 5638827 | Palmer et al. | Jun 1997 | A |
| 5639277 | Mariant et al. | Jun 1997 | A |
| 5643254 | Scheldrup et al. | Jul 1997 | A |
| 5643339 | Kavteladze et al. | Jul 1997 | A |
| 5645564 | Northrup et al. | Jul 1997 | A |
| 5649949 | Wallace et al. | Jul 1997 | A |
| 5653726 | Kieturakis | Aug 1997 | A |
| 5653727 | Wiktor | Aug 1997 | A |
| 5666968 | Imran et al. | Sep 1997 | A |
| 5667522 | Flomenblit et al. | Sep 1997 | A |
| 5676697 | McDonald | Oct 1997 | A |
| 5690643 | Wijay | Nov 1997 | A |
| 5690666 | Berenstein et al. | Nov 1997 | A |
| 5690671 | McGurk et al. | Nov 1997 | A |
| 5693085 | Buirge et al. | Dec 1997 | A |
| 5702373 | Samson | Dec 1997 | A |
| 5702414 | Richter et al. | Dec 1997 | A |
| 5713907 | Hogendijk et al. | Feb 1998 | A |
| 5722989 | Fitch et al. | Mar 1998 | A |
| 5725546 | Samson | Mar 1998 | A |
| 5733329 | Wallace et al. | Mar 1998 | A |
| 5743905 | Eder et al. | Apr 1998 | A |
| 5746765 | Kleshinski et al. | May 1998 | A |
| 5746769 | Ton et al. | May 1998 | A |
| 5749883 | Halpern | May 1998 | A |
| 5749891 | Ken et al. | May 1998 | A |
| 5749894 | Engelson | May 1998 | A |
| 5749918 | Hogendijk et al. | May 1998 | A |
| 5749921 | Lenker et al. | May 1998 | A |
| 5759161 | Ogawa et al. | Jun 1998 | A |
| 5788653 | Lorenzo | Aug 1998 | A |
| 5797957 | Palmer et al. | Aug 1998 | A |
| 5800455 | Palermo | Sep 1998 | A |
| 5800526 | Anderson et al. | Sep 1998 | A |
| 5814062 | Sepetka et al. | Sep 1998 | A |
| 5824059 | Wijay | Oct 1998 | A |
| 5911737 | Lee et al. | Jun 1999 | A |
| 5944733 | Engelson | Aug 1999 | A |
| 5947963 | Guglielmi | Sep 1999 | A |
| 5964771 | Beyar et al. | Oct 1999 | A |
| 5984929 | Bashiri et al. | Nov 1999 | A |
| 5989242 | Saadat et al. | Nov 1999 | A |
| 6059815 | Lee et al. | May 2000 | A |
| 6102933 | Lee et al. | Aug 2000 | A |
| 6139520 | McCrory et al. | Oct 2000 | A |
| 6159165 | Ferrera et al. | Dec 2000 | A |
| 6168570 | Ferrera | Jan 2001 | B1 |
| 6224610 | Ferrera | May 2001 | B1 |
| 6270495 | Palermo | Aug 2001 | B1 |
| 6296622 | Debeer et al. | Oct 2001 | B1 |
| 6338736 | Boosfeld et al. | Jan 2002 | B1 |
| 6478773 | Gandhi et al. | Nov 2002 | B1 |
| 6500149 | Gandhi et al. | Dec 2002 | B2 |
| 6616617 | Ferrera et al. | Sep 2003 | B1 |
| 6656173 | Palermo | Dec 2003 | B1 |
| 6835185 | Ramzipoor et al. | Dec 2004 | B2 |
| 6966892 | Gandhi et al. | Nov 2005 | B2 |
| 7198613 | Gandhi et al. | Apr 2007 | B2 |
| 7422569 | Wilson et al. | Sep 2008 | B2 |
| 7575582 | Gandhi et al. | Aug 2009 | B2 |
| 7578826 | Gandhi et al. | Aug 2009 | B2 |
| 7740637 | Gandhi et al. | Jun 2010 | B2 |
| 7776054 | Gandhi et al. | Aug 2010 | B2 |
| 7780680 | Gandhi et al. | Aug 2010 | B2 |
| 20010029352 | Gandhi et al. | Oct 2001 | A1 |
| 20020138025 | Gellman et al. | Sep 2002 | A1 |
| 20050043755 | Wilson et al. | Feb 2005 | A1 |
| 20060020333 | Lashinski et al. | Jan 2006 | A1 |
| 20060025801 | Lulo et al. | Feb 2006 | A1 |
| 20060265001 | Marks | Nov 2006 | A1 |
| 20070060938 | Dziadik et al. | Mar 2007 | A1 |
| 20070167911 | Gandhi et al. | Jul 2007 | A1 |
| Number | Date | Country |
|---|---|---|
| 4102550 | Aug 1981 | DE |
| 19704269 | Nov 1997 | DE |
| 183372 | Jun 1986 | EP |
| 278937 | Aug 1988 | EP |
| 382014 | Aug 1990 | EP |
| 518704 | Dec 1992 | EP |
| 627201 | Dec 1994 | EP |
| 717961 | Dec 1995 | EP |
| 592182 | Jul 1925 | FR |
| 2066839 | Jul 1981 | GB |
| 998981 | May 1980 | JP |
| 6030225 | Apr 1981 | JP |
| 6420841 | Jan 1989 | JP |
| 64020841 | Jan 1989 | JP |
| 2255157 | Oct 1990 | JP |
| 5501022 | Feb 1993 | JP |
| 7265431 | Oct 1995 | JP |
| 11197250 | Jul 1999 | JP |
| 9105300 | Apr 1991 | WO |
| 9214408 | Sep 1992 | WO |
| 9416629 | Aug 1994 | WO |
| 9518585 | Jul 1995 | WO |
| 9521592 | Aug 1995 | WO |
| 9701368 | Jan 1997 | WO |
| 9730642 | Aug 1997 | WO |
| 9748351 | Dec 1997 | WO |
| 9822042 | May 1998 | WO |
| 9822175 | May 1998 | WO |
| 9837816 | Sep 1998 | WO |
| 9929260 | Jun 1999 | WO |
| 0158366 | Aug 2001 | WO |
| 2005032337 | Apr 2005 | WO |
| 2006076537 | Jul 2006 | WO |
| Entry |
|---|
| JPO, Final Notification of Reasons for Rejection in Japanese Patent Application No. 2001-557480 (translation), Dispatched Sep. 19, 2010, Japan Patent Office, Tokyo, Japan. |
| Athanasoulis, Christos A., M.D., “Therapeutic Applications of Angiography”, The New England Journal of Medicine, May 15, 1980, pp. 1117-1125 (1 of 2). |
| Athanasoulis, Christos A., M.D., “Therapeutic Applications of Angiography”, The New England Journal of Medicine, May 22, 1980, pp. 1174-1179 (2 of 2). |
| Berenstein, Alex, M.D. et al., “Catheter and Material Selection for Transarterial Embolization: Technical Considerations” Radiology, Sep. 1979; pp. 631-639. |
| Battista, O.A. et al.. “Colloidal Macromolecular Phenomena. Part II. Novel Microcrystals of Polymers”, Journal of Applied Polymer Science 1967, pp. 481-498. |
| Hilal, Sadek K., M.D. et al. “Therapeutic Percutaneous Embolization for Extra-Axial Vascular Lesions of the Head, Neck and Spine”, Journal of Neurological Surgery, Sep. 1975; pp. 275-287. |
| Kaufman, Stephen L., M.D. et al., “Transcatheter Embolization with Microfibrillar Collagen in Swine”, Investigative Radiology, May-Jun. 1978, pp. 200-204. |
| Kumar, Ashok J. et al., “Preoperative Embolization of Hypervascular Head and Neck Neoplasms Using Microfibrillar Collagen”, Journal of Neuroradiology (1982), pp. 163-168. |
| Latchaw, Richard E., M.D. et al., “Polyvinyl Foam Embolization of Vascular and Neoplastic Lesions of the Head, Neck and Spine”, Radiology (1979), pp. 669-679. |
| Reuter, Stewart R., M.D. et al., “Selective Arterial Embolization for Control of Massive Upper Gastrointestinal Bleeding”, American Journal of Radiology, Sep. 1975, pp. 119-126. |
| Roberson, Glenn H. et al., “Therapeutic Embolization of Juvenile Angiofibroma”, American Journal of Radiology, Oct. 1979, pp. 657-663. |
| Gianturco, C., M.D. et al. “Mechanical Devices for Arterial Occlusion”, Am. J Roentgenol Jul. 1975, pp. 428-435. |
| Wallace, Sidney, M.D. et al., “Therapeutic Vascular Occlusion Utilizing Steel Coil Technique: Clinical Applications”, Am. J Roentgenol (1976); pp. 381-387. |
| Anderson, James H. et al., “Transcatheter Intravascular Coil Occlusion of Experimental Arteriovenous Fistulas”, Am. J. Roentgenol, Nov. 1977, pp. 795-798. |
| Anderson, James H. et al., “‘Mini’ Gianturco Stainless Steel Coils for Transcatheter Vascular Occlusion”, Radiology, Aug. 1978, pp. 301-303. |
| Chuang, Vincent P., M.D., et al., “A New Improved Coil for Tapered-Tip Catheter for Arterial Occlusion” by May 1980, pp. 507-509. |
| Hawkins, Jeffrey, M.D. et al., “Retrievable Gianturco-Coil Introducer”, Radiology, Jan. 1986, 262-264. |
| Wallace, Sidney, M.D. et al., “Arterial Occlusion of Pelvic Bone Tumors”, Cancer, Oct. 1979, pp. 322-325 & 661-663. |
| International Search Report, May 3, 2001, 6 pages. |
| Number | Date | Country | |
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| 20130023922 A1 | Jan 2013 | US |
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| Number | Date | Country | |
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