Biochemical Surface Modification of Plasma-Treated Orthopedic Biomaterials

Information

• NSF Award
• 9610073

Owner

• UNIVERSITY OF KENTUCKY, A CORP. OF KY

• Award Id

  9610073

• Award Effective Date

  10/1/1997 - 28 years ago

• Award Expiration Date

  9/30/1999 - 26 years ago

• Award Amount

  $ 110,085.00

• Award Instrument

  Continuing grant

9610073 Puleo This research is directed at the development and understanding of methods for biochemical surface modification of bioinert orthopedic and dental implant materials. Specifically, biomaterials with plasma-deposited thin films will be used to deliver and retain osteoinductive bone morphogenetic protein (BMP) at the cell-biomaterial interface so as to induce expression of the osteoblast phenotype and thus promote mineralization. The specific aims of the research are to: (1) quantify the benefit to the amount and/or stability/retention of BMP-2 provided by immobilization on plasma treated metallic biomaterials, (2) characterize the bioactivity of BMP-conjugated biomaterials by assessing expression of osteoblastic traits in vitro using two pluripotent mesenchymal cell types, (3) determine the individual and combined roles of weakly and strongly bound BMP-2 in promoting osteoinduction in vitro. This research could provide knowledge to help promote early fixation and compensate for gaps between bone and implant in orthopedic and dental applications. ***

• Program Officer

  Janice M. Jenkins

• Min Amd Letter Date

  9/19/1997 - 28 years ago

• Max Amd Letter Date

  10/8/1998 - 27 years ago

• ARRA Amount

• Name

  University of Kentucky

• City

  Lexington

• State

  KY

• Country

  United States

• Address

  201 Kinkead Hall

• Postal Code

  405060001

• Phone Number

  8592579420

• First Name

  David

• Last Name

  Puleo

• Email Address

  puleo@uky.edu

• Start Date

  9/19/1997 12:00:00 AM

• Name

  Health

• Code

  203000

• Text

  BIOMEDICAL ENGINEERING

• Code

  5345

• Text

  UNASSIGNED

• Code

  0

• Text

  RES EXPER FOR UNDERGRAD-SUPPLT

• Code

  9251

• Text

  OTHER RESEARCH OR EDUCATION