Claims
- 1. A compound of the formula (I)
- 2. The compound according to claim 1 wherein:
J is chosen from C1-10 alkyl, aryl or C3-7 cycloalkyl each optionally substituted by Rb; R2 is independently chosen from C1-6 alkyl which may optionally be partially or fully halogenated, acetyl, aroyl, C1-4 alkoxy, which may optionally be partially or fully halogenated, halogen, methoxycarbonyl, phenylsulfonyl and —SO2—CF3; n is 1-4; Ra and Rb are each independently chosen from hydrogen, C1-5 alkyl, C2-5 alkenyl, C2-5 alkynyl, C3-8 cycloalkylC0-2 alkyl, aryl, C1-5 alkoxy, C1-5 alkylthio, amino, C1-5 alkylamino, C1-5 dialkylamino, C1-5 acyl, C1-5 alkoxycarbonyl, C1-5 acyloxy, C1-5 acylamino, C1-5 sulphonylamino, hydroxy, halogen, trifluoromethyl, nitro, nitrile or Ra and Rb are chosen from; heterocycle chosen from pyrrolidinyl, pyrrolinyl, morpholinyl, thiomorpholinyl, thiomorpholinyl sulfoxide, thiomorpholinyl sulfone, dioxalanyl, piperidinyl, piperazinyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrofuranyl, 1,3-dioxolanone, 1,3-dioxanone, 1,4-dioxanyl, piperidinonyl, tetrahydropyrimidonyl, pentamethylene sulfide, pentamethylene sulfoxide, pentamethylene sulfone, tetramethylene sulfide, tetramethylene sulfoxide and tetramethylene sulfone and heteroaryl chosen from aziridinyl, thienyl, furanyl, isoxazolyl, oxazolyl, thiazolyl, thiadiazolyl, tetrazolyl, pyrazolyl, pyrrolyl, imidazolyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, pyranyl, quinoxalinyl, indolyl, benzimidazolyl, benzoxazolyl, benzothiazolyl, benzothienyl, quinolinyl, quinazolinyl, naphthyridinyl, indazolyl, triazolyl, pyrazolo[3,4-b]pyrimidinyl, purinyl, pyrrolo[2,3-b]pyridinyl, pyrazolo[3,4-b]pyridinyl, tubercidinyl, oxazo[4,5-b]pyridinyl and imidazo[4,5-b]pyridinyl; R7 is hydrogen; and each X is O.
- 3. The compound according to claim 2 wherein
R5 is chosen from —O—, —S—, —NH—, C(O), a linear chain chosen from —NH(CR7F8)n—, —(CR7R8)n—, —O(CR7R8)n—, —C(O)—O(CR7R9)n—, —S(CR7R9)n—, C(O)(CR7R9)n— and —C(O)NH(CR7R8)n—, wherein n is 1-3 and each of the aforementioned R5 is further substituted by Ra.
- 4. The compound according to claim 3 wherein
Ar1 is chosen from cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl, phenyl, naphthyl, tetrahydronaphthyl, indanyl and indenyl, each Ar1 is substituted with one R1, and independently substituted with two R2 groups; R1 is NO2, NH2, C1-3acylNH— or the formula: J-S(O)m—N(Rc)—; J is C1-10 alkyl; R2 is independently chosen from C1-6 alkyl which may optionally be partially or fully halogenated and C1-3 alkoxy, which may optionally be partially or fully halogenated; R3 and R4 are each independently chosen from hydrogen, C1-3 alkyl and chloro; R6 is chosen from hydrogen and amino; R5 is: —NH—, C(O), a linear chain chosen from —NH(CR7R8)n—, —(CR7R8)n—, —O(CR7R8)n—, —C(O)—O(CR7R8)n—, C(O)(CR7R8)n— and —C(O)NH(CR7R8)n— wherein n is 1-2 and each of the aforementioned R5 is further substituted by Ra, Ra and Rb are each independently chosen from hydrogen, C1-5 alkyl, C3-7 cycloalkylC0-2 alkyl, aryl, C1-5 alkoxy, amino, C1-5 alkylamino, C1-3 dialkylamino, C1-3 acyl, C1-5 alkoxycarbonyl, C1-3 acyloxy, C1-3 acylamino, C1-3 sulphonylamino, hydroxy, halogen, trifluoromethyl, nitro, nitrile; or Ra is chosen from pyrrolidinyl, pyrrolinyl, morpholinyl, thiomorpholinyl, thiomorpholinyl sulfoxide, thiomorpholinyl sulfone, piperidinyl, piperazinyl, piperidinonyl, tetrahydropyrimidonyl, aziridinyl, isoxazolyl, oxazolyl, thiazolyl, thiadiazolyl, tetrazolyl, pyrazolyl, pyrrolyl, imidazolyl, pyridinyl, pyrimidinyl, pyrazinyl and pyridazinyl.
- 5. The compound according to claim 4 wherein
Ar1 is 220R1 is the formula: J-S(O)2—NH—; J is C1-5 alkyl; R2 is independently chosen from C1-5 alkyl which may optionally be partially or fully halogenated and C1-2 alkoxy, which may optionally be partially or fully halogenated; R3 is hydrogen; R4 is chosen from hydrogen and methyl; R8 is chosen from hydrogen, methyl, ethyl, CH2OH and CH2OCH3. In yet another embodiment, there are provided compounds of the formula (I) as described immediately above and wherein R3 is hydrogen; R4 is methyl; Ra is chosen from hydrogen, C1-5 alkyl, C3-6 cycloalkylC0-2 alkyl, phenyl, C1-5 alkoxy, amino, C1-5 alkylamino, C1-3 dialkylamino, C1-3 acyl, C1-5 alkoxycarbonyl, C1-3 acyloxy, C1-3 acylamino, hydroxy, halogen; or Ra is chosen from morpholinyl, thiomorpholinyl, thiomorpholinyl sulfoxide, thiomorpholinyl sulfone, piperidinyl, piperidinonyl, pyridinyl, pyrimidinyl, pyrazinyl and pyridazinyl.
- 6. The compound according to claim 5 wherein
Ra is chosen from hydrogen, C1-5 alkyl, C3-6 cycloalkyl, phenyl, C1-5 alkoxy, C1-5 alkoxycarbonyl, C1-3 acyloxy, C1-3 acylamino, hydroxy, halogen; or Ra is chosen morpholinyl, piperidinyl and pyridinyl.
- 7. The compound according to claim 6 wherein
Ar1 is 221R5 is —NH(CR7R8)n—Ra, wherein Ra is chosen from phenyl, morpholinyl, piperidinyl, pyridinyl, cyclopropyl, cyclohexyl, C1-5 alkyl and C1-3 alkoxy.
- 8. A compound chosen from
1-[5-(3-Methanesulfonylamino-2-methoxy-5-trifluoromethyl-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid methyl ester 1-[5-(5-tert-Butyl-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-H-1,2,3-triazole-4-carboxylic acid ((R)-1-phenyl-ethyl)-amide 1-[5-(5-tert-Butyl-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid (2-morpholin-4-yl-ethyl)-amide 1-[5-(5-tert-Butyl-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid benzylamide 1-[5-(5-tert-Butyl-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid methyl ester 1-[3-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid ((R)-1-phenyl-ethyl)-amide 1-[3-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid benzylamide 1-[3-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid (2,2-dimethyl-propyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2,3-dimethyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid (2-morpholin-4-yl-ethyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2,3-dimethyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid benzylamide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2,3-dimethyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid methyl ester 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-chloro-phenyl]-1H-1,2,3-triazole-4-carboxylic acid ((R)-1-phenyl-ethyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-chloro-phenyl]-1H-1,2,3-triazole-4-carboxylic acid ((R)-1-phenyl-propyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-chloro-phenyl]-1H-1,2,3-triazole-4-carboxylic acid (2,2-dimethyl-propyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-chloro-phenyl]-1H-1,2,3-triazole-4-carboxylic acid (pyridin-3-ylmethyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-chloro-phenyl]-1H-1,2,3-triazole-4-carboxylic acid ethyl ester 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-chloro-phenyl]-1H-1,2,3-triazole-4-carboxylic acid methyl ester 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-fluoro-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid benzylamide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-fluoro-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid (2,2-dimethyl-propyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-3-fluoro-2-methyl-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid (2,2-dimethyl-propyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid ((R)-1,2,2-trimethyl-propyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid (1-pyridin-3-yl-ethyl)-amide 1-{5-[3-Methanesulfonylamino-2-methoxy-5-(2,2,2-trifluoro-1-trifluoromethyl-ethyl)-phenylcarbamoyl]-2-methyl-phenyl}-H-[1,2,3]triazole-4-carboxylic acid ((R)-1-phenyl-ethyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid ((R)-1-cyclohexyl-ethyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid ((R)-1-phenyl-propyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid ((S)-1,2,2-trimethyl-propyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid ((S)-1-cyclohexyl-ethyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid ((S)-1-phenyl-ethyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid ((S)-2-dimethylamino-1-phenyl-ethyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid ((R)-3-dimethylamino-1-phenyl-propyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid ((S)-2-methoxy-1-phenyl-ethyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid (1-methyl-1-phenyl-ethyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid (2,2-dimethyl-propyl)-amide 1-[5-(3-Amino-5-tert-butyl-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid (2,2-dimethyl-propyl)-amide 1-{5-[3-Methanesulfonylamino-2-methoxy-5-(1-methyl-cyclopropyl)-phenylcarbamoyl]-2-methyl-phenyl}-1H-[1,2,3]triazole-4-carboxylic acid (2,2-dimethyl-propyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid (2-hydroxy-2-methyl-propyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid (2-morpholin-4-yl-ethyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid (2-piperidin-1-yl-ethyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid (3-dimethylamino-2,2-dimethyl-propyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid (piperidin-4-ylmethyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid (1-methyl-piperidin-4-ylmethyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid ((S)-1-ethyl-pyrrolidin-2-ylmethyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid ((R)-1-ethyl-pyrrolidin-2-ylmethyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid (1-methyl-piperidin-3-ylmethyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid (2-dimethylamino-2-methyl-propyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid (pyridin-3-ylmethyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid (pyridin-4-ylmethyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid 3-methyl-benzylamide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid benzylamide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid phenylamide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid p-tolylamide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid m-tolylamide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid o-tolylamide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid pyridin-4-ylamide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid benzyl-methyl-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid ((S)-2-dimethylamino-1-phenyl-ethyl)-methyl-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid cyclohexylmethyl-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid cyclopentylamide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid cyclopentylmethyl-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid cyclopropylamide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid cyclopropylmethyl-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid ethyl ester 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid methyl ester 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid methylamide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid tert-butylamide 1-{5-[3-Methanesulfonylamino-2-methoxy-5-(2,2,2-trifluoro-1-trifluoromethyl-ethyl)-phenylcarbamoyl]-2-methyl-phenyl}-1H-1,2,3-triazole-4-carboxylic acid ethyl ester 3-(4-Benzoyl-1,2,3-triazol-1-yl)-N-(5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenyl)-4-methyl-benzamide 3-{1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carbonyl}-benzoic acid methyl ester 4-[({1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carbonyl}-amino)-methyl]-piperidine-1-carboxylic acid tert-butyl ester 3-[({1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-[1,2,3]triazole-4-carbonyl}-amino)-methyl]-piperidine-1-carboxylic acid tert-butyl ester 5-Amino-1-[5-(5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid (pyridin-3-ylmethyl)-amide 5-Amino-1-[5-(5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid ((R)-1-phenyl-ethyl)-amide 5-Amino-1-[5-(5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid (2,2-dimethyl-propyl)-amide 5-Amino-1-[5-(5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid ((S)-1,2,2-trimethyl-propyl)-amide 5-Amino-1-[5-(5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid (3-dimethylamino-2,2-dimethyl-propyl)-amide 5-Amino-1-[5-(5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid methyl ester N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-3-(4-cyclohexanecarbonyl-1,2,3-triazol-1-yl)-4-methyl-benzamide N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-3-[4-((S)-3-hydroxy-2-phenyl-propionyl)-1,2,3-triazol-1-yl]4-methyl-benzamide N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-3-[4-(2,6-dichloro-benzoyl)-1,2,3-triazol-1-yl]4-methyl-benzamide N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-3-[4-(2,6-dimethyl-benzoyl)-1,2,3-triazol-1-yl]-4-methyl-benzamide N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-4-methyl-3-[4-((R)-2-phenyl-propionyl)-1,2,3-triazol-1-yl]-benzamide N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-4-methyl-3-[4-(2-methyl-benzoyl)-1,2,3-triazol-1-yl]-benzamide and N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-4-methyl-3-[4-(morpholine-4-carbonyl)-1,2,3-triazol-1-yl]-benzamide or the pharmaceutically acceptable salts, acids, esters or isomers thereof.
- 9. A compound chosen from
1-[5-(5-tert-Butyl-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid ((R)-1-phenyl-ethyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-chloro-phenyl]-1H-1,2,3-triazole-4-carboxylic acid ((R)-1-phenyl-ethyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-chloro-phenyl]-1H-1,2,3-triazole-4-carboxylic acid ((R)-1-phenyl-propyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid ((R)-1,2,2-trimethyl-propyl)-amide 1-[5-(3-Amino-5-tert-butyl-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid (2,2-dimethyl-propyl)-amide 1-{5-[3-Methanesulfonylamino-2-methoxy-5-(1-methyl-cyclopropyl)-phenylcarbamoyl]-2-methyl-phenyl}-1H-[1,2,3]triazole-4-carboxylic acid (2,2-dimethyl-propyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid ((R)-1-cyclohexyl-ethyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid ((R)-1-phenyl-propyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid (1-pyridin-3-yl-ethyl)-amide 1-{5-[3-Methanesulfonylamino-2-methoxy-5-(2,2,2-trifluoro-1-trifluoromethyl-ethyl)-phenylcarbamoyl]-2-methyl-phenyl)}-1H-[1,2,3]triazole-4-carboxylic acid ((R)-1-phenyl-ethyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid ((S)-2-methoxy-1-phenyl-ethyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid (2-hydroxy-2-methyl-propyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid (3-dimethylamino-2,2-dimethyl-propyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid cyclohexylmethyl-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid cyclopentylamide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid cyclopentylmethyl-amide 5-Amino-1-[5-(5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid (pyridin-3-ylmethyl)-amide 5-Amino-1-[5-(5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid ((R)-1-phenyl-ethyl)-amide 5-Amino-1-[5-(5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid (2,2-dimethyl-propyl)-amide 5-Amino-1-[5-(5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid ((S)-1,2,2-trimethyl-propyl)-amide 5-Amino-1-[5-(5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid (3-dimethylamino-2,2-dimethyl-propyl)-amide 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid o-tolylamide N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-3-(4-cyclohexanecarbonyl-1,2,3-triazol-1-yl)-4-methyl-benzamide N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-3-[4-((S)-3-hydroxy-2-phenyl-propionyl)-1,2,3-triazol-1-yl]-4-methyl-benzamide N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-4-methyl-3-[4-((R)-2-phenyl-propionyl)-1,2,3-triazol-1-yl]-benzamide and 1-[5-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid ((S)-2-dimethylamino-1-phenyl-ethyl)-amide or the pharmaceutically acceptable salts, acids, esters or isomers thereof.
- 10. A method of treating a disease or condition chosen from:
osteoarthritis, atherosclerosis, contact dermatitis, bone resorption diseases, reperfusion injury, asthma, multiple sclerosis, Guillain-Barre syndrome, Crohn's disease, ulcerative colitis, psoriasis, graft versus host disease, systemic lupus erythematosus and insulin-dependent diabetes mellitus, rheumatoid arthritis, toxic shock syndrome, Alzheimer's disease, diabetes, inflammatory bowel diseases, acute and chronic pain, stroke, myocardial infarction, alone or following thrombolytic therapy, thermal injury, adult respiratory distress syndrome (ARDS), multiple organ injury secondary to trauma, acute glomerulonephritis, dermatoses with acute inflammatory components, acute purulent meningitis, syndromes associated with hemodialysis, leukopherisis, granulocyte transfusion associated syndromes, necrotizing entrerocolitis, complications including restenosis following percutaneous transluminal coronary angioplasty, traumatic arthritis, sepsis, chronic obstructive pulmonary disease and congestive heart failure said method comprising administering to a patient a pharmaceutically effective amount of a compound according to claim 1.
- 11. A method of treating an oncological disease said method comprising administering to a patient a pharmaceutically effective amount of a compound according to claim 1.
- 12. A process of making a compound of the formula:
- 13. A pharmaceutical composition containing a pharmaceutically effective amount of a compound according to claim 1 and one or more pharmaceutically acceptable carriers and/or adjuvants.
RELATED APPLICATION DATA
[0001] This application claims benefit to U.S. provisional application No. 60/430,519 filed Nov. 27, 2002.
Provisional Applications (1)
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Number |
Date |
Country |
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60430519 |
Nov 2002 |
US |