The present application relates generally to fluid cassettes with tensioned polymeric membranes for patient heat exchange systems.
Patient temperature control systems have been introduced to prevent fever in patients in the neuro ICU due to suffering from sub-arachnoid hemorrhage or other neurologic malady such as stroke. Also, such systems have been used to induce mild or moderate hypothermia to improve the outcomes of patients suffering from such maladies as stroke, cardiac arrest, myocardial infarction, traumatic brain injury, and high intracranial pressure. Examples of intravascular heat exchange catheters are disclosed in U.S. Pat. Nos. 6,419,643, 6,416,533, 6,409,747, 6,405,080, 6,393,320, 6,368,304, 6,338,727, 6,299,599, 6,290,717, 6,287,326, 6,165,207, 6,149,670, 6,146,411, 6,126,684, 6,306,161, 6,264,679, 6,231,594, 6,149,676, 6,149,673, 6,110,168, 5,989,238, 5,879,329, 5,837,003, 6,383,210, 6,379,378, 6,364,899, 6,325,818, 6,312,452, 6,261,312, 6,254,626, 6,251,130, 6,251,129, 6,245,095, 6,238,428, 6,235,048, 6,231,595, 6,224,624, 6,149,677, 6,096,068, 6,042,559, all of which are incorporated herein by reference.
External patient temperature control systems may be used. Such systems are disclosed in U.S. Pat. Nos. 6,827,728, 6,818,012, 6,802,855, 6,799,063, 6,764,391, 6,692,518, 6,669,715, 6,660,027, 6,648,905, 6,645,232, 6,620,187, 6,461,379, 6,375,674, 6,197,045, and 6,188,930 (collectively, “the external pad patents”), all of which are incorporated herein by reference.
A device includes a frame defining a periphery and an opening, preferably rectilinear and more preferably substantially square, bounded on at least three sides by the periphery. The frame is configured for being closely received between two plates, referred to herein as “cold plates” because in cooling mode they are cold, and has at least a fluid inlet and a fluid outlet both establishing respective fluid passageways through the frame into the opening. The fluid inlet and outlet are configured for fluid communication with respective fluid return and supply lines associated with a patient-engageable heat exchange member. A polymeric membrane assembly is connected to the frame in tension, preferably in biaxial tension (tension in both an x-direction and a y-direction). The membrane assembly blocks the opening and includes a first membrane parallel to a second membrane with a space therebetween. The fluid inlet and fluid outlet of the frame communicate with the space between the membranes.
Without limitation, the heat exchange member can include an intravascular heat exchange catheter or a heat exchange pad externally engageable with a patient or a peritoneal lavage device.
In example embodiments the space between the membranes is expandable when filled with working fluid circulating from the heat exchange member. Each membrane may be no more than two mils (0.002″) thick and may be between one mil and two mils in thickness (0.001″-0.002″).
The opening may be substantially square in that it defines a top, a bottom edge spaced from and parallel to the top, a left side extending between the top and bottom, and a right side extending between the top and bottom and parallel to the left side, with the left and right sides defining a first length, the top and bottom defining a second length, and the first length being equal to the second length±ten percent of the second length. Indeed, the first length can be approximately equal to the second length. However, other shapes such as trapezoidal may be used, in particular with a bottom edge slightly longer than the top edge.
Both membranes of the membrane assembly may be disposed in tension within the opening. Plural posts may be arranged on the frame, and at least portions of the membrane assembly can be stretched over the posts and engaged with the posts to hold the membrane assembly in tension within the opening.
In example implementations the membrane assembly defines a rectilinear border juxtaposed with the frame. The border includes the first and second membranes and at least one reinforcing layer engaged with the first and second membranes and preferably not extending radially inwardly past the border. The membranes may be stretchable to at least 25% elongation. The device may be used in combination with the cold plates and/or the heat exchange member.
In another aspect, an apparatus includes a working fluid chamber defined by two and only two membranes closely spaced from each other, and a hollow frame bordering at least portions of the working fluid chamber and holding the membranes in tension. The hollow frame defines at least one fluid passageway through which fluid can pass into and/or out of the working fluid chamber. When the apparatus is disposed between heat exchange surfaces of a heat exchanger and working fluid fills the working fluid chamber, the working fluid chamber expands against the heat exchange surfaces to facilitate heat exchange with the working fluid.
In another aspect, a method includes stretching first and second polymeric membranes over supports on a first frame half, and engaging the first frame half with a second frame half to establish a cassette receivable between two cold plates. The frame has fluid passageways into a space between the membranes such that the frame is configured for fluid communication with fluid return and supply lines associated with a patient-engageable heat exchange member.
The details of the present invention, both as to its structure and operation, can best be understood in reference to the accompanying drawings, in which like reference numerals refer to like parts, and in which:
Referring initially to
Instead of or in addition to the catheter 12, the system 10 may include one or more pads 18 that are positioned against the external skin of the patient 16 (only one pad 18 shown for clarity). The pad 18 may be, without limitation, any one of the pads disclosed in the external pad patents. The temperature of the pad 18 can be controlled by a pad controller 20 in accordance with principles set forth in the external pad patents to exchange heat with the patient 16, including to induce therapeutic mild or moderate hypothermia in the patient in response to the patient presenting with, e.g., cardiac arrest, myocardial infarction, stroke, high intracranial pressure, traumatic brain injury, or other malady the effects of which can be ameliorated by hypothermia. The pad 18 may receive working fluid from the system 14 through a fluid supply line L3, and return working fluid to the system 14 through a fluid return line L4. Note that in some embodiments, the systems 14, 20 are established in a single assembly.
To cool the patient while awaiting engagement of the catheter 12 and/or pad 18 with the patient, cold fluid 22 in a cold fluid source 24 may be injected into the patient and in particular into the patient's venous system through a pathway 26. Without limitation, the pathway 26 may an IV line, the source 24 may be an IV bag, and the fluid 22 may be chilled saline, e.g., saline at the freezing point or slightly warmer. Or, the source may be a syringe, and the saline can be injected directly into the bloodstream of the patient.
Now referring to
The cold plates 30, 32 may be made of metal, and can be rectilinear as shown and indeed may be nearly square. The cold plates 30, 32 may abut each other along left and right side walls 36, with elongated vertical cassette frame receptacles R1 and R2 being located immediately inboard of the respective side walls 36 and with the slot 34 extending between the walls 36 and terminating at the receptacles R1, R2 as shown. The frame receptacles R1, R2 are wider than the slot 36.
In the example shown, refrigerant inlet and outlet tubes 38, 40 extend through at least one of the cold plates 32 to communicate refrigerant from a compressor into a refrigerant passageway in the cold plate. Each cold plate may have its own refrigerant inlet and outlet tubes, or, in the embodiment shown, only one cold plate may be formed with refrigerant inlet and outlet tubes and the other cold plate either thermally coupled to the cold plate in which the refrigerant flows and/or receiving refrigerant from the other cold plate through passageways formed through one or both of the side walls 36.
In the example shown, the cassette 50 includes a frame 52 defining a periphery and a preferably rectilinear opening bounded as shown on at least three sides by the periphery of the frame. In the non-limiting example shown, the frame includes an elongated parallelepiped-shaped top rail 53 and elongated parallelepiped-shaped left and right side rails 54 parallel to each other and perpendicular to the top rail 32. The example frame 52 may have a metal strip or bottom rail 51 opposite the top rail and connected to the left and right side rails to support the membrane and facilitate placing the membrane in biaxial tension. In any case, the example frame 52 is rectilinear and is configured for being closely received between the two cold plates 30, 32, with the side rails 54 slidably engageable with the frame receptacles R1, R2 between the cold plates 30, 32 and with the below-described membrane assembly passed through the slot 36 to be in close juxtaposition with the refrigerant channels in the cold plates.
In cross-references to
Indeed, a polymeric membrane assembly 64 is connected to the frame 52, blocking the opening that is bounded on four sides by the frame as shown. The membrane assembly includes a first membrane 66 that is parallel to and closely spaced from a second membrane 68, leaving a space therebetween which establishes a working fluid chamber. The fluid inlet 56 and fluid outlet 60 communicate with the space between the membranes 66, 68. At least one and preferably both of the membranes 66, 68 are disposed in tension in the opening. The space between the membranes is expandable when filled with working fluid.
In one example, each membrane is no more than two mils (0.002″) thick and more preferably is between one mil and two mils in thickness (0.001″-0.002″), inclusive. The example preferred membranes 66, 68 are co-extensive with the opening and like the opening are more or less square, with the length of top and bottom edges of the example membranes being approximately equal (within ±10% and more preferably within ±5%) of the lengths of the left and right edges of the membranes. In other embodiments instead of a square (1:1) aspect ratio, an aspect ratio of up to 1:1.5 may be used. The working fluid chamber between the membranes is also rectilinear and in the preferred embodiment no obstructions exist between the membranes, meaning the working fluid chamber is a complete rectilinear, more or less square chamber.
Owing to the thinness of the membranes 66, 68 and the closeness of the cold plates 30, 32 to each other and to the membrane assembly between them when the cassette is engaged with the cold plates, the system shown in the figures affords low impedance of heat transfer between the refrigerant circulating in the cold plates and the working fluid circulating between the membranes 66, 68. The working fluid chamber between the membranes inflates due to backpressure generated by working fluid flow, eliminating or reducing the need for a moving mechanism in the cold plates. Moreover, the narrow slot 34 between the two cold plates provides better heat transfer by reducing the conductive path length between the cold plates and the working fluid. The frame allows for ease of handling, such as insertion and removal of the cassette with/from the cold plates.
With respect to the example working fluid chamber between the membranes 66, 68 having a width-to-length aspect ratio near 1:1 (i.e., square or nearly so), the amount of backpressure required to induce working fluid flow through heat exchanger is reduced compared to a less square configuration. This reduces the amount of work that a working fluid pump must perform, which is desirable for two reasons. One, since the pump may be disposable, lower performance requirements translate into a lower cost disposable and quieter system. For instance, peristaltic roller pumps offer quiet operation and a low-cost disposable element, but operate most efficiently when only modest pressures are required. Two, lowering the working fluid pump work reduces the amount of heat transferred into the working fluid by the pump itself. Also, a low width/length aspect ratio results in slower working fluid velocity which reduces amount of mixing, but this otherwise desirable (from a heat exchange standpoint) effect is negligible in the present example system since the Reynolds numbers are typically <1000, suggesting a laminar flow regime. Furthermore, a low width/length aspect ratio significantly reduces the number of bends (or “corners”) in the fluid flow path. These bends are areas of mixing for the fluid which promotes heat transfer. Without them, a fluid boundary layer builds up. However, this effect is offset herein by maintaining a narrow slot between the cold plates. This way the primary heat transfer mechanism is by conduction, but the conduction path length (and therefore boundary layer) is small, resulting in a relatively high rate of heat transfer.
In preferred examples, the membranes 66, 68 are stretched under tension during assembly to the frame, preferably biaxially (i.e., in tension between the top and bottom rails 53, 51 and also in tension between the left and right side rails 54). This tension can be maintained over the shelf life of the product. Pretensioning minimizes wrinkles in material, which is beneficial because wrinkles can impede working fluid flow and create air gaps which reduce heat transfer between the working fluid and cold plates. Wrinkles can also complicate insertion of the membrane assembly into the narrow slot 34.
To establish pre-tensioning of the membranes, the frame may be made in halves and posts such as threaded fasteners 70 (
In the border portion 74, at least one and preferably more layers of polymer film may be used to reinforce the membranes 66, 68 to establish welded seams through which (at the sides of the membrane assembly) the post holes are formed, allowing for easier fabrication. By placing reinforcing layers on the border portion 74 only, the central “window” of the membrane assembly consists only of a single thin layer membrane between the working fluid and one of the cold plates 30, 32 to minimize impeding heat transfer. A die-cut reinforcement layer may be used which reinforces the entire perimeter with one piece of material.
In some examples, the polymer membranes 66, 68 are highly stretchable, at least greater than 25% elongation. This allows the membranes to change from the empty flat state shown in
Additionally, the membranes may be made of a material which can also be made into tubing. Tubes such as the inlet and outlet tubes 58, 62 shown in
While the particular FLUID CASSETTE WITH TENSIONED POLYMERIC MEMBRANES FOR PATIENT HEAT EXCHANGE SYSTEM is herein shown and described in detail, the scope of the present invention is to be limited by nothing other than the appended claims.
Number | Name | Date | Kind |
---|---|---|---|
1459112 | Mehl | Jun 1923 | A |
1726761 | Palmer | Sep 1929 | A |
1857031 | Schaffer | May 1932 | A |
2223688 | Otoo | Dec 1940 | A |
2663030 | Dahlberg | Dec 1953 | A |
2673987 | Upshaw et al. | Apr 1954 | A |
2987004 | Murray | Jun 1961 | A |
3140716 | Harrison et al. | Jul 1964 | A |
3225191 | Calhoun | Dec 1965 | A |
3228465 | Vadot | Jan 1966 | A |
3369549 | Armao | Feb 1968 | A |
3425419 | Dato | Feb 1969 | A |
3504674 | Swenson | Apr 1970 | A |
3726269 | Webster, Jr. | Apr 1973 | A |
3744555 | Fletcher et al. | Jul 1973 | A |
3751077 | Hiszpanski | Aug 1973 | A |
3834396 | Foster | Sep 1974 | A |
3937224 | Uecker | Feb 1976 | A |
3945063 | Matsuura | Mar 1976 | A |
4038519 | Foucras | Jul 1977 | A |
4065264 | Lewin | Dec 1977 | A |
4103511 | Kress et al. | Aug 1978 | A |
4126132 | Portner et al. | Nov 1978 | A |
4153048 | Magrini | May 1979 | A |
4173228 | Van Steenwyk et al. | Nov 1979 | A |
4181132 | Parks | Jan 1980 | A |
4181245 | Garrett | Jan 1980 | A |
4259961 | Hood, III | Apr 1981 | A |
4298006 | Parks | Nov 1981 | A |
4459468 | Bailey | Jul 1984 | A |
4532414 | Shah et al. | Jul 1985 | A |
4552516 | Stanley | Nov 1985 | A |
4554793 | Harding, Jr. | Nov 1985 | A |
4558996 | Becker | Dec 1985 | A |
4581017 | Sahota | Apr 1986 | A |
4638436 | Badger et al. | Jan 1987 | A |
4653987 | Tsuji et al. | Mar 1987 | A |
4661094 | Simpson | Apr 1987 | A |
4665391 | Spani | May 1987 | A |
4672962 | Hershenson | Jun 1987 | A |
4754752 | Ginsburg et al. | Jul 1988 | A |
4787388 | Hofmann | Nov 1988 | A |
4813855 | Leveen et al. | Mar 1989 | A |
4849196 | Yamada et al. | Jul 1989 | A |
4852567 | Sinofsky | Aug 1989 | A |
4860744 | Johnson et al. | Aug 1989 | A |
4869250 | Bitterly | Sep 1989 | A |
4906237 | Johansson et al. | Mar 1990 | A |
4925376 | Kahler | May 1990 | A |
4941475 | Williams et al. | Jul 1990 | A |
5080089 | Mason et al. | Jan 1992 | A |
5092841 | Spears | Mar 1992 | A |
5103360 | Maeda | Apr 1992 | A |
5106360 | Ishiwara et al. | Apr 1992 | A |
5174285 | Fontenot | Dec 1992 | A |
5192274 | Bierman | Mar 1993 | A |
5195965 | Shantha | Mar 1993 | A |
5211631 | Sheaff | May 1993 | A |
5263925 | Gilmore et al. | Nov 1993 | A |
5269758 | Taheri | Dec 1993 | A |
5281215 | Milder | Jan 1994 | A |
5304214 | DeFord et al. | Apr 1994 | A |
5342301 | Saab | Aug 1994 | A |
5344436 | Fontenot et al. | Sep 1994 | A |
5370675 | Edwards et al. | Dec 1994 | A |
5383856 | Bersin | Jan 1995 | A |
5391030 | Lee | Feb 1995 | A |
5403281 | O'Neill et al. | Apr 1995 | A |
5420962 | Bakke | May 1995 | A |
5433588 | Monk et al. | Jul 1995 | A |
5433740 | Yamaguchi | Jul 1995 | A |
5437673 | Baust et al. | Aug 1995 | A |
5458639 | Tsukashima et al. | Oct 1995 | A |
5466208 | Jackson | Nov 1995 | A |
5476368 | Rabenau | Dec 1995 | A |
5486207 | Mahawili | Jan 1996 | A |
5507792 | Mason | Apr 1996 | A |
5531714 | Dahn et al. | Jul 1996 | A |
5531776 | Ward et al. | Jul 1996 | A |
5624392 | Saab | Apr 1997 | A |
5634907 | Rani et al. | Jun 1997 | A |
5676670 | Kim | Oct 1997 | A |
5693344 | Knight | Dec 1997 | A |
5701905 | Esch | Dec 1997 | A |
5706889 | Bach et al. | Jan 1998 | A |
5709564 | Yamada et al. | Jan 1998 | A |
5709654 | Klatz et al. | Jan 1998 | A |
5716386 | Ward et al. | Feb 1998 | A |
5730720 | Sites et al. | Mar 1998 | A |
5733319 | Neilson et al. | Mar 1998 | A |
5737782 | Matsuura et al. | Apr 1998 | A |
5746585 | McDunn | May 1998 | A |
5759017 | Patton et al. | Jun 1998 | A |
5776079 | Cope et al. | Jul 1998 | A |
5788647 | Eggers | Aug 1998 | A |
5803324 | Silberman | Sep 1998 | A |
5837003 | Ginsburg | Nov 1998 | A |
5857843 | Leason | Jan 1999 | A |
5862675 | Scaringe et al. | Jan 1999 | A |
5875282 | Jordan | Feb 1999 | A |
5879329 | Ginsburg | Mar 1999 | A |
5895418 | Saringer | Apr 1999 | A |
5908407 | Frazee et al. | Jun 1999 | A |
5957963 | Dobak, III | Sep 1999 | A |
5980561 | Kolen et al. | Nov 1999 | A |
5989238 | Ginsburg | Nov 1999 | A |
6019783 | Philips et al. | Feb 2000 | A |
6042559 | Dobak, III | Mar 2000 | A |
6051019 | Dobak, III | Apr 2000 | A |
6059825 | Hobbs et al. | May 2000 | A |
6096068 | Dobak, III et al. | Aug 2000 | A |
6110139 | Loubser | Aug 2000 | A |
6110168 | Ginsburg | Aug 2000 | A |
6117065 | Hastings et al. | Sep 2000 | A |
6117105 | Bresnaham et al. | Sep 2000 | A |
6124452 | Di Magno | Sep 2000 | A |
6126684 | Gobin et al. | Oct 2000 | A |
6146141 | Schumann | Nov 2000 | A |
6146411 | Noda et al. | Nov 2000 | A |
6148634 | Sherwood | Nov 2000 | A |
6149670 | Worthen et al. | Nov 2000 | A |
6149673 | Ginsburg | Nov 2000 | A |
6149676 | Ginsburg | Nov 2000 | A |
6149677 | Dobak, III | Nov 2000 | A |
6149806 | Baer | Nov 2000 | A |
6165207 | Balding | Dec 2000 | A |
6188930 | Carson | Feb 2001 | B1 |
6197045 | Carson | Mar 2001 | B1 |
6224624 | Lasheras | May 2001 | B1 |
6231594 | Dae | May 2001 | B1 |
6231595 | Dobak | May 2001 | B1 |
6235048 | Dobak | May 2001 | B1 |
6238428 | Werneth | May 2001 | B1 |
6245095 | Dobak | Jun 2001 | B1 |
6251129 | Dobak | Jun 2001 | B1 |
6251130 | Dobak | Jun 2001 | B1 |
6254626 | Dobak | Jul 2001 | B1 |
6261312 | Dobak | Jul 2001 | B1 |
6264679 | Keller | Jul 2001 | B1 |
6283940 | Mulholland | Sep 2001 | B1 |
6287326 | Pecor | Sep 2001 | B1 |
6290717 | Philips | Sep 2001 | B1 |
6299599 | Pham et al. | Oct 2001 | B1 |
6306161 | Ginsburg | Oct 2001 | B1 |
6312452 | Dobak | Nov 2001 | B1 |
6325818 | Werneth | Dec 2001 | B1 |
6338727 | Noda et al. | Jan 2002 | B1 |
6364899 | Dobak | Apr 2002 | B1 |
6368304 | Aliberto | Apr 2002 | B1 |
6375674 | Carson | Apr 2002 | B1 |
6379378 | Werneth | Apr 2002 | B1 |
6383144 | Mooney et al. | May 2002 | B1 |
6383210 | Magers | May 2002 | B1 |
6393320 | Lasersohn | May 2002 | B2 |
6405080 | Lasersohn | Jun 2002 | B1 |
6409747 | Gobin et al. | Jun 2002 | B1 |
6416533 | Gobin et al. | Jul 2002 | B1 |
6419643 | Shimada | Jul 2002 | B1 |
6428563 | Keller | Aug 2002 | B1 |
6450990 | Walker et al. | Sep 2002 | B1 |
6461379 | Carson | Oct 2002 | B1 |
6464666 | Augustine et al. | Oct 2002 | B1 |
6464716 | Dobak, III et al. | Oct 2002 | B1 |
6527798 | Ginsburg et al. | Mar 2003 | B2 |
6530946 | Noda et al. | Mar 2003 | B1 |
6544282 | Dae et al. | Apr 2003 | B1 |
6551309 | Le Pivert | Apr 2003 | B1 |
6554791 | Cartledge et al. | Apr 2003 | B1 |
6582387 | Derek | Jun 2003 | B2 |
6605106 | Schwartz | Aug 2003 | B2 |
6610083 | Keller et al. | Aug 2003 | B2 |
6613280 | Myrick | Sep 2003 | B2 |
6620187 | Carson et al. | Sep 2003 | B2 |
6620188 | Ginsburg et al. | Sep 2003 | B1 |
6620189 | Machold | Sep 2003 | B1 |
6622542 | Derek | Sep 2003 | B2 |
6624679 | Tomaivolo et al. | Sep 2003 | B2 |
6635076 | Ginsburg | Oct 2003 | B1 |
6635079 | Ginsburg | Oct 2003 | B2 |
6645232 | Carson et al. | Nov 2003 | B2 |
6648905 | Hoglund | Nov 2003 | B2 |
6660027 | Gruszecki | Dec 2003 | B2 |
6669715 | Hoglund | Dec 2003 | B2 |
6673098 | Machold | Jan 2004 | B1 |
6675835 | Gerner | Jan 2004 | B2 |
6679906 | Hammack et al. | Jan 2004 | B2 |
6685731 | Kushnir et al. | Feb 2004 | B2 |
6685733 | Dae et al. | Feb 2004 | B1 |
6692518 | Carson | Feb 2004 | B2 |
6695874 | Machold et al. | Feb 2004 | B2 |
6706060 | Tzeng et al. | Mar 2004 | B2 |
6716188 | Noda et al. | Apr 2004 | B2 |
6719723 | Wemeth | Apr 2004 | B2 |
6719779 | Daoud | Apr 2004 | B2 |
6726653 | Noda et al. | Apr 2004 | B2 |
6733495 | Bek | May 2004 | B1 |
6740109 | Dobak, III | May 2004 | B2 |
6743201 | Donig et al. | Jun 2004 | B1 |
6764391 | Grant | Jul 2004 | B1 |
6799063 | Carson | Sep 2004 | B2 |
6799342 | Jarmon | Oct 2004 | B1 |
6802855 | Ellingboe | Oct 2004 | B2 |
6818012 | Ellingboe | Nov 2004 | B2 |
6827728 | Ellingboe | Dec 2004 | B2 |
6843099 | Derek | Jan 2005 | B2 |
6843800 | Dobak, III | Jan 2005 | B1 |
6878156 | Noda | Apr 2005 | B1 |
6887263 | Bleam et al. | May 2005 | B2 |
6890347 | Machold | May 2005 | B2 |
6893419 | Noda et al. | May 2005 | B2 |
6969399 | Schock et al. | Nov 2005 | B2 |
6974435 | Derek | Dec 2005 | B2 |
6997942 | Machold | Feb 2006 | B2 |
7070612 | Collins et al. | Jul 2006 | B1 |
7104769 | Davis | Sep 2006 | B2 |
7140850 | Otis | Nov 2006 | B2 |
7175649 | Machold | Feb 2007 | B2 |
7181927 | Collins | Feb 2007 | B2 |
7211106 | Dobak | May 2007 | B2 |
7247165 | Machold | Jul 2007 | B2 |
7258662 | Machold | Aug 2007 | B2 |
7357786 | Bakke | Apr 2008 | B1 |
7377935 | Schock | May 2008 | B2 |
7510569 | Dae et al. | Mar 2009 | B2 |
7516909 | Kaligain | Apr 2009 | B2 |
7645127 | Hagen | Jan 2010 | B2 |
7658755 | Machold | Feb 2010 | B2 |
7666215 | Callister et al. | Mar 2010 | B2 |
7713036 | Kojima et al. | May 2010 | B2 |
7820102 | Myrick | Oct 2010 | B2 |
7822485 | Collins | Oct 2010 | B2 |
7846193 | Dae et al. | Dec 2010 | B2 |
7857781 | Noda et al. | Dec 2010 | B2 |
7892269 | Collins et al. | Feb 2011 | B2 |
7879077 | Machold | Mar 2011 | B2 |
7914564 | Magers | Mar 2011 | B2 |
7959657 | Harsy | Jun 2011 | B1 |
7963986 | Machold | Jun 2011 | B2 |
8105262 | Noda et al. | Jan 2012 | B2 |
8105263 | Noda et al. | Jan 2012 | B2 |
8105264 | Noda et al. | Jan 2012 | B2 |
8109894 | Noda et al. | Feb 2012 | B2 |
8128384 | Mou | Mar 2012 | B2 |
8177824 | Machold | May 2012 | B2 |
8226605 | Faries, Jr. et al. | Jul 2012 | B2 |
8246669 | Machold | Aug 2012 | B2 |
8272857 | Norman et al. | Sep 2012 | B2 |
8366667 | Chan | Feb 2013 | B2 |
8551151 | Machold | Oct 2013 | B2 |
8740959 | Machold | Jun 2014 | B2 |
8784464 | Machold | Jul 2014 | B2 |
8888729 | Noda | Nov 2014 | B2 |
9345614 | Schaefer | May 2016 | B2 |
9474644 | Dabrowiak | Oct 2016 | B2 |
9492633 | Dabrowiak | Nov 2016 | B2 |
9675756 | Kamen | Jun 2017 | B2 |
10022265 | Pamichev | Jul 2018 | B2 |
10085880 | Machold | Oct 2018 | B2 |
20010031946 | Walker et al. | Oct 2001 | A1 |
20010047196 | Ginsburg et al. | Nov 2001 | A1 |
20020004675 | Lasheras | Jan 2002 | A1 |
20020013569 | Sterman et al. | Jan 2002 | A1 |
20020022823 | Luo et al. | Feb 2002 | A1 |
20020096311 | Kushnir | Jul 2002 | A1 |
20020117559 | Kaligian | Aug 2002 | A1 |
20020134134 | Derek | Sep 2002 | A1 |
20020136662 | Myrick | Sep 2002 | A1 |
20020138034 | Derek | Sep 2002 | A1 |
20020145525 | Friedman et al. | Oct 2002 | A1 |
20020183692 | Callister | Dec 2002 | A1 |
20020198579 | Khanna | Dec 2002 | A1 |
20030036495 | Datta | Feb 2003 | A1 |
20030041911 | Gerner | Mar 2003 | A1 |
20030062090 | Secondo | Apr 2003 | A1 |
20030114795 | Durward | Jun 2003 | A1 |
20030135252 | Machold | Jul 2003 | A1 |
20030036496 | Samson et al. | Dec 2003 | A1 |
20030236496 | Elsner | Dec 2003 | A1 |
20040013566 | Myrick | Jan 2004 | A1 |
20040019319 | Derek | Jan 2004 | A1 |
20040024437 | Machold | Feb 2004 | A1 |
20040026068 | Schmidt | Feb 2004 | A1 |
20040089050 | Derek | May 2004 | A1 |
20040089058 | De Hann et al. | May 2004 | A1 |
20040102825 | Daoud | May 2004 | A1 |
20040104018 | Hugh et al. | Jun 2004 | A1 |
20040143311 | Machold | Jul 2004 | A1 |
20040154374 | Derek | Aug 2004 | A1 |
20040171935 | Van Creveld | Sep 2004 | A1 |
20040190255 | Cheon | Sep 2004 | A1 |
20040199230 | Yon | Oct 2004 | A1 |
20040210231 | Boucher et al. | Oct 2004 | A1 |
20040244371 | Takumori | Dec 2004 | A1 |
20040267340 | Cioanta | Dec 2004 | A1 |
20050065584 | Schiff | Mar 2005 | A1 |
20050137662 | Morris | Jun 2005 | A1 |
20050156744 | Pires | Jul 2005 | A1 |
20050209658 | Machold | Sep 2005 | A1 |
20060030917 | Eccleston | Feb 2006 | A1 |
20060064146 | Collins | Mar 2006 | A1 |
20060069418 | Schock et al. | Mar 2006 | A1 |
20060122673 | Callister et al. | Jun 2006 | A1 |
20060210424 | Mallett et al. | Sep 2006 | A1 |
20060241335 | Benkowski | Oct 2006 | A1 |
20060253095 | Stull | Nov 2006 | A1 |
20060293734 | Scott | Dec 2006 | A1 |
20070007640 | Harnden et al. | Jan 2007 | A1 |
20070076401 | Carrez et al. | Apr 2007 | A1 |
20070093710 | Maschke | Apr 2007 | A1 |
20070156006 | Smith | Jul 2007 | A1 |
20070173759 | Augustine | Jul 2007 | A1 |
20070191918 | Machold | Aug 2007 | A1 |
20070203552 | Machold | Aug 2007 | A1 |
20070293919 | Machold | Dec 2007 | A1 |
20080026068 | Brown et al. | Jan 2008 | A1 |
20080082051 | Miller | Apr 2008 | A1 |
20080114430 | Collins | May 2008 | A1 |
20080119916 | Choucair | May 2008 | A1 |
20080230530 | Augustine et al. | Sep 2008 | A1 |
20080262409 | Derrico et al. | Oct 2008 | A1 |
20080267599 | Arnold | Oct 2008 | A1 |
20080269663 | Arnold | Oct 2008 | A1 |
20090065565 | Cao | Mar 2009 | A1 |
20090099518 | Magers | Apr 2009 | A1 |
20090247963 | Bleam et al. | Oct 2009 | A1 |
20090299287 | Carson et al. | Dec 2009 | A1 |
20100036486 | Mazur | Feb 2010 | A1 |
20100049119 | Norman et al. | Feb 2010 | A1 |
20100082000 | Honeck | Apr 2010 | A1 |
20100129248 | Mou | May 2010 | A1 |
20100204765 | Hall | Aug 2010 | A1 |
20100256601 | Lippert | Oct 2010 | A1 |
20110022136 | Scott et al. | Jan 2011 | A1 |
20110046551 | Augustine | Feb 2011 | A1 |
20110137249 | Collins et al. | Jun 2011 | A1 |
20110184253 | Archer et al. | Jul 2011 | A1 |
20110208276 | Machold | Aug 2011 | A1 |
20110208277 | Machold | Aug 2011 | A1 |
20110208278 | Machold et al. | Aug 2011 | A1 |
20110213305 | Jönsson et al. | Sep 2011 | A1 |
20120095536 | Machold | Apr 2012 | A1 |
20120100023 | Hanazuka | Apr 2012 | A1 |
20120158103 | Bledsoe | Jun 2012 | A1 |
20120226338 | Machold | Sep 2012 | A1 |
20130071270 | Zupp | Mar 2013 | A1 |
20130079855 | Helkowski | Mar 2013 | A1 |
20130079856 | Dabrowiak | Mar 2013 | A1 |
20130090708 | Dabrowiak | Apr 2013 | A1 |
20130098880 | Korolev | Apr 2013 | A1 |
20130172805 | Truckai | Jul 2013 | A1 |
20130178923 | Dabrowiak | Jul 2013 | A1 |
20130331774 | Farrell | Dec 2013 | A1 |
20130337732 | Nilliams | Dec 2013 | A1 |
20140081202 | Tsoukalis | Mar 2014 | A1 |
20140094880 | Lim | Apr 2014 | A1 |
20140094882 | Lim | Apr 2014 | A1 |
20140094883 | Lim | Apr 2014 | A1 |
20140276792 | Kaveckis | Sep 2014 | A1 |
20140277302 | Weber | Sep 2014 | A1 |
20140364928 | Machold | Dec 2014 | A1 |
20150223974 | Dabrowiak | Aug 2015 | A1 |
20150230974 | Pistor | Aug 2015 | A1 |
20150230975 | Dabrowiak | Aug 2015 | A1 |
20150314055 | Hogard | Nov 2015 | A1 |
20160022477 | Schaefer | Jan 2016 | A1 |
20160089184 | Truckai | Mar 2016 | A1 |
20160166758 | Norman et al. | Jun 2016 | A1 |
20160228291 | Callister | Aug 2016 | A1 |
20160287432 | Dabrowiak | Oct 2016 | A1 |
20160287433 | Mazzone | Oct 2016 | A1 |
20160287434 | Dabrowiak | Oct 2016 | A1 |
20160287435 | Pamichev | Oct 2016 | A1 |
20170035604 | Dabrowiak | Feb 2017 | A1 |
20180185192 | Mazzone | Jul 2018 | A1 |
20180185193 | Mazzone | Jul 2018 | A1 |
20180207024 | Dabrowiak | Jul 2018 | A1 |
20180214302 | Dabrowiak | Aug 2018 | A1 |
20180214303 | Dabrowiak | Aug 2018 | A1 |
20180311072 | Pamichev | Nov 2018 | A1 |
20180325725 | Dabrowiak | Nov 2018 | A1 |
20190133820 | Jacobsen | May 2019 | A1 |
Number | Date | Country |
---|---|---|
101090685 | Dec 2007 | CN |
19531935 | Feb 1997 | DE |
0663529 | May 1997 | EP |
2040169 | Aug 1980 | GB |
1183185 | Feb 1985 | GB |
2212262 | Jul 1989 | GB |
2383828 | Jul 2003 | GB |
S 61100243 | May 1986 | JP |
09-215754 | Aug 1997 | JP |
10-0127777 | May 1998 | JP |
10-305103 | Nov 1998 | JP |
2001147095 | May 2001 | JP |
2002534160 | Oct 2002 | JP |
2003028582 | Jan 2003 | JP |
2003508150 | Mar 2003 | JP |
2003524507 | Aug 2003 | JP |
2008154751 | Jul 2008 | JP |
2008531114 | Aug 2008 | JP |
2008539034 | Nov 2008 | JP |
2009500066 | Jan 2009 | JP |
2011505929 | Mar 2011 | JP |
2011137621 | Jul 2011 | JP |
2011182849 | Sep 2011 | JP |
2014023604 | Feb 2014 | JP |
2017508509 | Mar 2017 | JP |
2017511716 | Apr 2017 | JP |
1990001682 | Feb 1990 | WO |
WO 1993002730 | Feb 1993 | WO |
1993004727 | Mar 1993 | WO |
1994000177 | Jan 1994 | WO |
1994001177 | Jan 1994 | WO |
95-03680 | Feb 1995 | WO |
1997025011 | Jul 1997 | WO |
1998024491 | Jun 1998 | WO |
1998040017 | Sep 1998 | WO |
2000010494 | Mar 2000 | WO |
2001013809 | Mar 2001 | WO |
0126719 | Apr 2001 | WO |
2001064146 | Sep 2001 | WO |
2001076517 | Oct 2001 | WO |
2001083001 | Nov 2001 | WO |
WO 2005117546 | Dec 2005 | WO |
WO 2006036585 | Apr 2006 | WO |
WO 2009056640 | May 2009 | WO |
WO 2010040819 | Apr 2010 | WO |
2012-175089 | Dec 2012 | WO |
2014160422 | Oct 2014 | WO |
2015119670 | Aug 2015 | WO |
2015119671 | Aug 2015 | WO |
2015122938 | Aug 2015 | WO |
Entry |
---|
Extra Packaging Corp, Polyurethane Properities and Characterisitics, accessed May 9, 2016 at http://www.extrapackaging.com/polyurethane/properites.php. |
American Urethane Inc., “Polyurethane Properties”, available Oct. 12, 2010, http://web.archive.org/web/20101012211957/http://americanurethane.com/polyurethane-properties.html. |
Zenith, Natural Rubber / Styrene Butadiene Rubber Sheets, Available Nov. 1, 2011, Accessed at http://web.archive.org/web/20111101235527/http://www.zenithrubber.com/rubber-sheets/nr-sbr-rubber-sheets.htm. |
Christoph Matthias Pistor, Jeremy Thomas Dabrowiak, Christo Pamichev, “Fluid Cassette with Polymeric Membranes and Integral Inlet and Outlet Tubes for Patient Heat Exchange System” file history of related U.S. Appl. No. 14/180,655, filed Feb. 14, 2014. |
Jeremy Thomas Dabrowiak, Braig Wendell Pendry, Christop Matthias Pistor, “Patient Heat Exchange System with Two or Only Two Fluid Loops” file history of related U.S. Appl. No. 14/180,719, filed Feb. 14, 2014. |
Jeremy Thomas Dabrowiak, “Heat Exchange System for Patient Temperature Control with Multiple Coolant Chambers for Multiple Heat Exchange Modalities” file history of related U.S. Appl. No. 14/175,545, filed Feb. 7, 2014. |
Jeremy Thomas Dabrowiak, Eric Peterson, “Patient Heat Exchange System with Transparent Wall for Viewing Circulating Refrigerant” file history of related U.S. Appl. No. 14/276,202, filed May 13, 2014. |
Austin Reid Hendricks, Christo Petrov Pamichev, Venkata Vishnu Gurukula, Jeremy Thomas Dabrowiak, “Heat Exchange System for Patient Temperature Control with Easy Loading High Performance Peristaltic Pump” file history of related U.S. Appl. No. 14/534,718, filed Nov. 6, 2014. |
F.W. Behmann, E. Bontke, “Die Regelung der Wärmebildung bei künstlicher Hypothermie”, Pffügers Archiv, Bd. 266, S. 408-421 (1958). |
F.W. Behmann, E. Bontke, “Intravasale Kühlung”, Pffügers Archiv, Bd. 263, S. 145-165 (1956). |
Wilhelm Behringer, Stephan Prueckner, Rainer Kenter, Samuel A. Tisherman, Ann Radovsky, Robert Clark, S. William Stezoski, Heremy Henchir, Edwin Klein, Peter Safar, “Rapid Hypothermic Aortic Flush Can Achieve Survival without Brain Damage after 30 Minutes Cardiac Arrest in Dogs”, anesthesiology, V. 93, No. 6, Dec. 2000. |
Dorraine Day Watts, Arthur Trask, Karen Soeken, Philip Predue, Sheilah Dols, Christopher Kaufman; “Hypothermic Coagulopathy in trauma: Effect of Varying levels of Hypothermia on Enzyme Speed, Platelet Function, and Fibrinolytic Activity”. The Journal of Trauma: Injury, Infection, and Critical Care, Vo. 44, No. 5 (1998). |
Jeremy Thomas Dabrowak, Mark Davey, “Serpentine Heat Exchange Assembly for Removable Engagement with Patient Heat Exchange System”, file history of related U.S. Appl. No. 14/675,421, filed Mar. 31, 2015. |
James Mazzone, “Proximal Mounting of Temperature Sensor in Intravascular Temperature Management Catheter”, file history of related U.S. Appl. No. 14/675,452, filed Mar. 31, 2015. |
Jeremy Thomas Dabrowiak, Craig Wendell Pendry, Christoph Matthias Pistor, “Cold Plate Design in Heat Exchanger for Intravascular Temperature Management Catheter and/or Heat Exchange Pad”, file history of related U.S. Appl. No. 14/675,504, filed Mar. 31, 2015. |
Christo Petrov Pamichev, Jeremy Thomas Dabrowiak, “Working Fluid Cassette with Hinged Plenum or Enclosure for Interfacing Heat Exchanger with Intravascular Temperature Management Catheter”, file history of related U.S. Appl. No. 14/676,672, filed Apr. 1, 2015. |
Christo Petrov Pamichev, Jeremy Thomas Dabrowiak, “Heat Exchange System for Patient Temperature Control With Easy Loading High Performance Peristaltic Pump”, file history of related U.S. Appl. No. 14/676,682, filed Apr. 1, 2015. |
Jeremy Thomas Dabrowiak, Craig Wendell Pendry, Christoph Matthias Pistor, “Patient Heat Exchange System with Two and Only Two Fluid Loops”, related U.S. Appl. No. 14/180,719, Non-Final Office Action dated Jun. 7, 2016. |
Christoph Matthias Pistor, Jeremy Thomas Dabrowiak, Craig Wendell Pendry, Christo Pamichev, “Fluid Cassette with Polymeric Membranes and Integral Inlet and Outlet Tubes for Patient Heat Exchange System”, related pending U.S. Appl. No. 14/180,655, applicant's response to non-final office action file Jun. 1, 2016. |
Jeremy Thomas Dabrowiak, Eric Peterson, “Patient Heat Exchange System with Transparent Wall for Viewing Circulating Refrigerant”, related pending U.S. Appl. No. 14/276,202, applicant's response to non-final office action filed Jun. 1, 2016. |
Christoph Matthias Pistor, Jeremy Thomas Dabrowiak, Craig Wendell Pendry, Christo Petrov Pamichev, “Fluid Cassette with Polymeric Membranes and Integral Intel and Outlet Tubes for Patient Heat Exchange System”, related pending U.S. Appl. No. 14/180,655, non-final office action dated May 18, 2016. |
Jeremy Thomas Dabrowiak, Eric Peterson, “Patient Heat Exchange System with Transparent Wall for Viewing Circulating Refrigerant”, related pending U.S. Appl. No. 14/276,202, non-final office action dated May 19, 2016. |
Jeremy Thomas Dabrowiak, Eric Peterson, “Patient Heat Exchange System with Transparent Wall for Viewing Circulating Refrigerant”, related pending U.S. Appl. No. 14/276,202 final office action dated Jul. 15, 2016. |
Austin Reid Hendricks, Christo Petrov Pamichev, Venkata Vishnu Gurukula, Jeremy Thomas Dabrowiak, “Heat Exchange System for Patient Temperature Control with Easy Loading High Performance Peristaltic Pump”, related U.S. Appl. No. 14/534,718, Non-Final Office Action dated Jul. 25, 2016. |
Christoph Matthias Pistor, Jeremy Thomas Dabrowiak, Craig Wendell Pendry, Christo Pamichev, “Fluid Cassette With Polymeric Membranes and Integral Inlet and Outlet Tubes for Patient Heat Exchange System”, related U.S. Appl. No. 14/180,655, Final Office dated Sep. 8, 2016. |
Jeremy Thomas Dabrowiak, Craig Wendell Pendry, Christoph Matthias Pistor, “Patient Heat Exchange System with Two and Only Two Fluid Loops”, related U.S. Appl. No. 14/180,719, Applicant's response to the Non-Final Office Action filed Sep. 7, 2016. |
Jeremy Thomas Dabrowiak, “Heat Exchange System for Patient Temperature Control with Multiple Coolant Chambers for Multiple Heat Exchange Modalities”, related pending U.S. Appl. No. 14/175,545 non-final office action dated Feb. 12, 2016. |
Jeremy Thomas Dabrowiak, “Heat Exchange System for Patient Temperature Control with Multiple Coolant Chambers for Multiple Heat Exchange Modalities”, related pending U.S. Appl. No. 14/175,545 applicants response to non-final office action filed May 2, 2016. |
Baharlou, “Written Opinion of the International Searching Authority”, dated Oct. 12, 2017, from Counterpart PCT application PCT/US2016/024970. |
Dabrowiak “Heat Exchange System for Patient Temperature Control with Multiple Coolant Chambers for Multiple Heat Exchange Modalities”, related pending U.S. Appl. No. 14/175,545 non-final office action dated Feb. 12, 2016. |
Dabrowiak et al., “Fluid Cassette with Tensioned Polymeric Membranes for Patient Heat Exchange System”, related pending U.S. Appl. No. 14/180,613, applicant's response to non-final office action filed Jun. 1, 2016. |
Dabrowiak et al., “Heat Exchange System for Patient Temperature Control with Multiple Coolant Chambers for Multiple Heat Exchange Modalities” file history of related U.S. Appl. No. 14/175,545, filed Feb. 7, 2014. |
Dabrowiak et al., “Patient Heat Exchange System with Transparent Wall for Viewing Circulating Refrigerant” file history of related U.S. Appl. No. 14/276,202, filed May 13, 2014. |
Dabrowiak et al., “Patient Heat Exchange System with Transparent Wall for Viewing Circulating Refrigerant”, related pending U.S. Appl. No. 14/276,202, applicant's response to non-final office action filed Jun. 1, 2016. |
Dabrowiak et al., “Fluid Cassette with Tensioned Polymeric Membranes for Patient Heat Exchange System” file history of related U.S. Appl. No. 14/180,613, filed Feb. 14, 2014. |
Dabrowiak et al., “Fluid Cassette with Tensioned Polymeric Membranes for Patient Heat Exchange System” related pending U.S. Appl. No. 14/180,613, non-final office action dated May 19, 2016. |
Dabrowiak et al., “Fluid Cassette with Tensioned Polymeric Membranes for Patient Heat Exchange System”, related pending U.S. Appl. No. 14/180,613 final office action dated Jul. 15, 2016. |
Dabrowiak et al., “Patient Heat Exchange System with Transparent Wall for Viewing Circulation Refrigerant”, related pending U.S. Appl. No. 14/276,202, applicant's response to non-final office action filed Aug. 21, 2018. |
Dabrowiak et al., “Patient Heat Exchange System With Two and Only Two Fluid Loops”, file history of related U.S. Appl. No. 14/180,719, filed Feb. 14, 2014. |
Dabrowiak et al., “Patient Heat Exchange System with Two and Only Two Fluid Loops”, related U.S. Appl. No. 14/180,719, Non-Final Office Action dated Jun. 7, 2016. |
Dabrowiak et al., “Patient Heat Exchanger System with Transparent Wall for Viewing Circulation Refrigerant”, related pending U.S. Appl. No. 14/276,202, non-final office action dated Feb. 21, 2018. |
Dabrowiak et al., “Patient Heat Exchange System with Two and Only Two Fluid Loops”, related U.S. Appl. No. 14/180,719, Applicant's Response to the Non-Final Office Action filed Sep. 7, 2016. |
Dabrowiak, “Heat Exchange System for Patient Temperature Control With Multiple Coolant Chambers for Multiple Heat Exchange Modalities”, File History of related pending U.S. Appl. No. 15/332,519, filed Oct. 24, 2016. |
Dabrowiak, “Working fluid cassette with hinged plenum or enclosure for interfacing heat exchanger with intravascular temperature management catheter”, filed history of related U.S. Appl. No. 14/676,672, filed Apr. 1, 2015. |
European Office Action in Application No. 16775853.1, dated Nov. 6, 2019, 5 pages. |
International Search Report dated Jun. 25, 2018 in related PCT Application No. PCT/US2018/016752, 4 pages. |
International Search Report dated Jun. 25, 2018 in related PCT Application No. PCT/US2018/016754, 4 pages. |
Japanese Office Action in Application No. 2018-118084, dated Sep. 2, 2019, 10 pages. |
Pistor et al., “Fluid Cassette with Polymeric Membranes and Integral Inlet and Outlet Tubes for Patient Heat Exchange System”, related pending U.S. Appl. No. 14/180,655, applicant's response to non-final office action file Jun. 1, 2016. |
Wittman-Regis, “Written Opinion of the International Searching Authority”, dated Oct. 12, 2017, from counterpart PCT application PCT/US2016/025030. |
Chinese Office Action in Application No. 201480077207.7, dated Jul. 3, 2019, 24 pages. |
Japanese Office Action in Application No. 2018-160938, dated Jul. 19, 2019, 6 pages. |
Number | Date | Country | |
---|---|---|---|
20150230973 A1 | Aug 2015 | US |