TREA

Herbicidal pyrazole sulfonamides

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Information

  • Patent Grant
  • 4747870
  • Patent Number
    4,747,870
  • Date Filed
    Friday, March 13, 1987
    37 years ago
  • Date Issued
    Tuesday, May 31, 1988
    36 years ago
Information
Abstract
This invention relates to certain pyrazole sulfonylurea herbicidal compounds, agriculturally suitable compositions thereof and a method of their use.
Description

BACKGROUND OF THE INVENTION
This invention relates to novel pyrazole sulfonylurea herbicidal compounds, agriculturally suitable compositions thereof and a method of using them to control the growth of undesired vegetation.
New compounds effective for controlling the growth of undesired vegetation are in constant demand. In the most common situation, such compounds are sought to selectively control the growth of weeds in useful crops such as cotton, rice, corn, wheat and soybeans, to name a few. Unchecked weed growth in such crops can cause significant losses, reducing profit to the farmer and increasing costs to the consumer. In other situations, herbicides are desired which will control all plant growth. Examples of areas in which complete control of all vegetation is desired are areas around fuel shortage tanks, ammunition depots and industrial storage areas. There are many products commercially available for these purposes, but the search continues for products which are more effective, less costly and environmentally safe.
The "sulfonylurea" herbicides are an extremely potent class of herbicides discovered within the last few years. A multitude of structural variations exist within the class of herbicides, but they generally consist of a sulfonylurea bridge, --SO.sub.2 NHCONH--, linking two aromatic or heteroaromatic rings.
EP-A No. 95,925 which was published 12/7/83 discloses herbicidal sulfonylurea of formula ##STR1## wherein Q is, in part, ##STR2## R.sub.10 is H, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.4 alkenyl, C.sub.3 -C.sub.4 alkynyl, CO.sub.2 R.sub.24, SO.sub.2 NR.sub.20 R.sub.21 or SO.sub.2 R.sub.22 ;
R.sub.11 is H, C.sub.1 -C.sub.3 alkyl, F, Cl, Br, NO.sub.2, OR.sub.16, CO.sub.2 R.sub.24, S(O).sub.m R.sub.25 or SO.sub.2 NR.sub.20 R.sub.21 ;
provided that when R.sub.10 is other than C.sub.1 -C.sub.3 alkyl, then R.sub.11 is H, Cl, OCH.sub.3, NO.sub.2, or CH.sub.3 ;
R.sub.12 is H or CH.sub.3 ;
R.sub.13 and R.sub.14 are independently H, C.sub.1 -C.sub.3 alkyl, OR.sub.16, F, Cl, Br, NO.sub.2, CO.sub.2 R.sub.24, S(O).sub.m R.sub.25 or SO.sub.2 NR.sub.20 R.sub.21 ;
provided that, when either of R.sub.13 or R.sub.14 is CO.sub.2 R.sub.24, S(O).sub.m R.sub.25 or SO.sub.2 NR.sub.20 R.sub.21, then the other is H, Cl, CH.sub.3, OCH.sub.3 or NO.sub.2 ; and
R.sub.15 is H or CH.sub.3.
EP-A-No.87,780 which was published 9/7/83 discloses herbicidal sulfonylureas of formula ##STR3## wherein A is H, C.sub.1 -C.sub.8 alkyl or optionally substituted phenyl;
B and C are independently H, halogen, NO.sub.2, C.sub.1 -C.sub.8 alkyl, arylalkyl, C.sub.1 -C.sub.8 alkoxy, haloalkyl, CO.sub.2 R, CONR.sub.1 R.sub.2, S(O).sub.n R.sub.3, SO.sub.2 NR.sub.4 R.sub.5, or optionally substituted phenyl.
ZA No. 83/3850 which was published 11/28/83 discloses compounds of formula ##STR4## wherein Q is a five-membered, heterocyclic radical which is bound by way of a carbon atom and contains 2 or 3 heteroatoms and which may be optionally substituted by halogen, pseudohalogen, nitro, alkyl, hydroxyl, haloalkyl, alkoxy, alkylthio, haloalkoxy, haloalkylthio, amino, alkylamino, dialkylamino, alkylcarbonylamino, alkylcarbonyl, alkoxycarbonyl, alkoxyalkyl, alkylthiocarbonyl, carbamoyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylsulfinyl, alkylsulfonyl, alkenyloxy or alkynyloxy; and groups such as phenyl, phenoxy or phenylthio, which are unsubstituted or substituted by halogen, nitro, cyano, alkyl, alkoxy, haloalkyl, alkylcarbonyl, alkoxycarbonyl or haloalkoxy; and also benzyl unsubstituted or substituted by halogen and/or alkyl.
Japanese Patent Application No. 58-70407 (No. SHO 59-219,218, laid open 12/10/84) discloses pyrazole-5-sulfonylureas of formula ##STR5## wherein A is H, lower alkyl or phenyl;
B is H or lower alkyl;
D is H, CO.sub.2 R or COAr, halogen, NO.sub.2 or SO.sub.2 NR.sup.1 R.sup.2 ; and
Ar is phenyl optionally substituted with halogen.
U.S. Pat. No. 4,370,480 discloses herbicidal sulfonylurea of formula ##STR6## wherein R.sub.1 is ##STR7## R is H; C.sub.1 -C.sub.2 alkyl; C.sub.2 -C.sub.6 alkenyl; C.sub.2 -C.sub.6 alkynyl; C.sub.1 -C.sub.4 alkyl substituted with one to four substituents selected from 0-3 F, 0-3 Cl, 0-3 Br, 0-2 OCH.sub.3, 0-1 cyano, 0-1 CO.sub.2 R.sub.1 where R.sub.1 is C.sub.1 -C.sub.3 alkyl; CO.sub.2 R.sub.1, C.sub.2 -C.sub.4 alkenyl substituted with 1-3 Cl; C.sub.3 -C.sub.6 cycloalkyl; C.sub.5 -C.sub.6 cycloalkenyl; C.sub.5 -C.sub.6 cycloalkyl substituted with substituents selected from 1-3 CH.sub.3 or one of CH.sub.3 CH.sub.2, Cl, OCH.sub.3 ; C.sub.4 -C.sub.7 cycloalkylalkyl; ##STR8## where T.sub.1 is ##STR9## or a single bond; and T is O or NOR.sub.1.sup.III
SUMMARY
The compounds of this invention are compounds of Formula I. ##STR10## wherein J is ##STR11## R is H, C.sub.1 -C.sub.3 alkyl, phenyl, SO.sub.2 NR.sub.a R.sub.b, C.sub.1 -C.sub.2 haloalkyl, C.sub.2 -C.sub.4 alkoxyalkyl, C.sub.2 -C.sub.3 cyanoalkyl, C.sub.2 -C.sub.4 alkylthioalkyl, C.sub.2 -C.sub.4 alkylsulfinylalkyl, C.sub.2 -C.sub.4 alkylsulfonylalkyl, CO.sub.2 C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.4 alkylcarbonyl, C.sub.1 -C.sub.2 alkylsulfonyl, C.sub.3 -C.sub.4 alkenyl, C.sub.3 -C.sub.4 alkynyl or C.sub.1 -C.sub.2 alkyl substituted with CO.sub.2 C.sub.1 -C.sub.2 alkyl;
R.sub.1 is H or CH.sub.3 ;
R.sub.2 is H, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 haloalkyl, halogen, nitro, C.sub.1 -C.sub.3 alkoxy, SO.sub.2 NR.sub.c R.sub.d, C.sub.1 -C.sub.3 alkylthio, C.sub.1 -C.sub.3 alkylsulfinyl, C.sub.1 -C.sub.3 alkylsulfonyl, CN, CO.sub.2 R.sub.e, C.sub.1 -C.sub.3 haloalkoxy, C.sub.1 -C.sub.3 haloalkylthio, amino, C.sub.1 -C.sub.2 alkylamino, di(C.sub.1 -C.sub.3 alkyl)amino or C.sub.1 -C.sub.2 alkyl substituted with C.sub.1 -C.sub.2 alkoxy, C.sub.1 -C.sub.2 haloalkoxy, C.sub.1 -C.sub.2 alkylthio, C.sub.1 -C.sub.2 haloalkylthio, CN, OH or SH;
R.sub.a and R.sub.b are independently C.sub.1 -C.sub.2 alkyl;
R.sub.c is H, C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.3 cyanoalkyl, methoxy or ethoxy;
R.sub.d is H, C.sub.1 -C.sub.4 alkyl or C.sub.3 -C.sub.4 alkenyl; or
R.sub.c and R.sub.d may be taken together as --(CH.sub.2).sub.3 --, --(CH.sub.2).sub.4 --, --(CH.sub.2).sub.5 -- or --CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 --;
R.sub.e is C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.4 alkenyl, C.sub.3 -C.sub.4 alkynyl, C.sub.2 -C.sub.4 haloalkyl, C.sub.2 -C.sub.3 cyanoalkyl, C.sub.5 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.7 cycloalkylalkyl or C.sub.2 -C.sub.4 alkoxyalkyl;
R' is C.sub.3 -C.sub.5 cycloalkyl;
E is a single bond or CH.sub.2 ;
W is O or S;
n is 0 or 1;
A is ##STR12## X is H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 haloalkylthio, C.sub.1 -C.sub.4 alkylthio, halogen, C.sub.2 -C.sub.5 alkoxyalkyl, C.sub.2 -C.sub.5 alkoxyalkoxy, amino, C.sub.1 -C.sub.3 alkylamino, di(C.sub.1 -C.sub.3 alkyl)amino or C.sub.3 -C.sub.5 cycloalkyl;
Y is H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 haloalkylthio, C.sub.1 -C.sub.4 alkylthio, C.sub.2 -C.sub.5 alkoxyalkyl, C.sub.2 -C.sub.5 alkoxyalkoxy, amino, C.sub.1 -C.sub.3 alkylamino, di(C.sub.1 -C.sub.3 alkyl)amino, C.sub.3 -C.sub.4 alkenyloxy, C.sub.3 -C.sub.4 alkynyloxy, C.sub.2 -C.sub.5 alkylthioalkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.4 alkynyl azido, cyano, C.sub.2 -C.sub.5 alkylsulfinylalkyl, C.sub.2 -C.sub.5 alkylsulfonylalkyl, ##STR13## or N(OCH.sub.3)CH.sub.3 ; m is 2 or 3;
L.sub.1 and L.sub.2 are independently O or S;
R.sub.3 is H or C.sub.1 -C.sub.3 alkyl;
R.sub.4 and R.sub.5 are independently C.sub.1 -C.sub.3 alkyl;
Z is CH or N;
Z.sub.1 is CH or N;
Y.sub.1 is O or CH.sub.2 ;
X.sub.1 is CH.sub.3, OCH.sub.3, OC.sub.2 H.sub.5 or OCF.sub.2 H;
X.sub.2 is CH.sub.3, C.sub.2 H.sub.5 or CH.sub.2 CF.sub.3 ;
Y.sub.2 is OCH.sub.3, OC.sub.2 H.sub.5, SCH.sub.3, SC.sub.2 H.sub.5, CH.sub.3 or CH.sub.2 CH.sub.3 ;
X.sub.3 is CH.sub.3 or OCH.sub.3 ;
Y.sub.3 is H or CH.sub.3 ;
X.sub.4 is CH.sub.3, OCH.sub.3, OC.sub.2 H.sub.5, CH.sub.2 OCH.sub.3 or Cl; and
Y.sub.4 is CH.sub.3, OCH.sub.3, OC.sub.2 H.sub.5 or Cl;
and their agriculturally suitable salts; provided that
(a) when X is Cl, F, Br or I, then Z is CH and Y is OCH.sub.3, OC.sub.2 H.sub.5, N(OCH.sub.3)CH.sub.3, NHCH.sub.3, N(CH.sub.3).sub.2 or OCF.sub.2 H;
(b) when X or Y is C.sub.1 haloalkoxy, then Z is CH;
(c) X.sub.4 and Y.sub.4 are not simultaneously Cl;
(d) when W is S, then R.sub.1 is H, A is A-1 and Y is CH.sub.3, OCH.sub.3, OC.sub.2 H.sub.5, CH.sub.2 OCH.sub.3, C.sub.2 H.sub.5, CF.sub.3, SCH.sub.3, OCH.sub.2 CH.dbd.CH.sub.2, OCH.sub.2 C.tbd.CH, OCH.sub.2 CH.sub.2 OCH.sub.3, CH(OCH.sub.3).sub.2 or 1,3-dioxolan-2-yl;
(e) when the total number of carbons of X and Y is greater than four, then the number of carbons of R must be less than or equal to two.
In the above definitions, the term "alkyl", used either alone or in compound words such as "alkylthio" or "haloalkyl", denotes straight chain or branched alkyl, e.g. methyl, ethyl, n-propyl, isopropyl or the different butyl isomers.
Alkoxy denotes methoxy, ethoxy, n-propyloxy, isopropyloxy and the different butyl isomers.
Alkenyl denotes straight chain or branched alkenes, e.g. 1-propenyl, 2-propenyl, 3-propenyl and the different butenyl isomers.
Alkynyl denotes straight chain or branched alkynes, e.g. ethynyl, 1-propynyl, 2-propynyl and the different butynyl isomers.
Alkylsulfonyl denotes methylsulfonyl, ethylsulfonyl and the different propylsulfonyl isomers.
Alkylthio, alkylsulfinyl, alkylamino, etc. are defined analogously to the above examples.
Cycloalkyl denotes cyclopropyl, cyclobutyl, and cyclopentyl.
The term "halogen", either alone or in compound words such as "haloalkyl", denotes fluorine, chlorine, bromine or iodine. Further, when used in compound words such as "haloalkyl" said alkyl may be partially halogenated or fully substituted with halogen atoms and said halogen atoms may be the same or different. Examples of haloalkyl include CH.sub.2 CH.sub.2 F, CF.sub.2 CF.sub.3 and CH.sub.2 CHFCl.
The total number of carbon atoms in a substituent group is indicated by the C.sub.i -C.sub.j prefix where i and j are numbers from 1 to 7. For example, C.sub.1 -C.sub.3 alkylsulfonyl would designate methylsulfonyl through propylsulfonyl, C.sub.2 alkoxyalkoxy would designate OCH.sub.2 OCH.sub.3, C.sub.2 cyanoalkyl would designate CH.sub.2 CN and C.sub.3 cyanoalkyl would designate CH.sub.2 CH.sub.2 CN and CH(CN)CH.sub.3.
Compounds of the Invention preferred for reasons of increased ease of synthesis and/or greater herbicidal efficacy are:
1. Compounds of Formula I where
E is a single bond; and
W is O.
2. Compounds of Formula I where
E is CH.sub.2 ; and
W is O.
3. Compounds of Preferred 1 where
R.sub.2 is H, C.sub.1 -C.sub.3 alkyl, halogen, C.sub.1 -C.sub.3 alkyl substituted with 1 to 3 halogen atoms selected from 1 to 3 Cl, 1 to 3 F or 1 Br, OCH.sub.3, SO.sub.2 NHCH.sub.3, SO.sub.2 N(CH.sub.3).sub.2, S(O).sub.n CH.sub.3, CO.sub.2 CH.sub.3, CO.sub.2 CH.sub.2 CH.sub.3, OCF.sub.2 H, CH.sub.2 OCH.sub.3 or CH.sub.2 CN;
X is C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.2 alkoxy, Cl, F, Br, I, OCF.sub.2 H, CH.sub.2 F, CF.sub.3, OCH.sub.2 CH.sub.2 F, OCH.sub.2 CHF.sub.2, OCH.sub.2 CF.sub.3, CH.sub.2 Cl or CH.sub.2 Br; and
Y is H, C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.2 alkoxy, CH.sub.2 OCH.sub.3, CH.sub.2 OCH.sub.2 CH.sub.3, NHCH.sub.3, N(OCH.sub.3)CH.sub.3, N(CH.sub.3).sub.2, CF.sub.3, SCH.sub.3, OCH.sub.2 CH.dbd.CH.sub.2, OCH.sub.2 C.tbd.CH, OCH.sub.2 CH.sub.2 OCH.sub.3, ##STR14## OCF.sub.2 H, OCF.sub.2 Br, SCF.sub.2 H, cyclopropyl, C.tbd.CH or C.tbd.CCH.sub.3 ;
4. Compounds of Preferred 3 where
R is H, C.sub.1 -C.sub.3 alkyl, phenyl, CH.sub.2 CF.sub.3 or CH.sub.2 CH.dbd.CH.sub.2 ;
X is CH.sub.3, OCH.sub.3, OCH.sub.2 CH.sub.3, Cl or OCF.sub.2 H; and
Y is CH.sub.3, OCH.sub.3, C.sub.2 H.sub.5, CH.sub.2 OCH.sub.3, NHCH.sub.3, CH(OCH.sub.3).sub.2 or cyclopropyl.
5. Compounds of Preferred 4 where
A is A-1;
R.sub.2 is H, Cl, Br, OCH.sub.3 or CH.sub.3 ; and
n is 0.
6. Compounds of Preferred 5 where J is J-1.
7. Compounds of Preferred 5 where J is J-2.
8. Compounds of Preferred 5 where J is J-3.
9. Compounds of Preferred 5 where J is J-4.
10. Compounds of Preferred 2 where
R is H, C.sub.1 -C.sub.3 alkyl, phenyl, CH.sub.2 CF.sub.3 or CH.sub.2 CH.dbd.CH.sub.2 ;
R.sub.2 is H, Cl, Br, OCH.sub.3 or CH.sub.3 ;
n is 0;
A is A-1;
X is CH.sub.3, OCH.sub.3, OCH.sub.2 CH.sub.3, Cl or OCF.sub.2 H; and
Y is CH.sub.3, OCH.sub.3, C.sub.2 H.sub.5, CH.sub.2 OCH.sub.3, NHCH.sub.3, CH(OCH.sub.3).sub.2 or cyclopropyl.
A compound of the invention especially preferred for reasons of greatest ease of synthesis and/or greatest herbicidal efficacy is:
4-(Cyclopropylcarbonyl)-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-1-methyl-1H-pyrazole-5-sulfonamide, m.p. 189.degree.-192.degree. C.(d).
The compounds of this invention are highly active as preemergent and/or postemergent herbicides or plant growth regulants with selectivity on rice, corn, wheat, soybeans and barley.
DETAILED DESCRIPTION OF THE INVENTION
Synthesis
Compounds of Formula I can be prepared by one or more of the procedures shown in Equations 1, 4, and 5. J, R.sub.1, and A are as previously defined.
Equation 1 ##STR15##
The reaction of Equation 1 is best carried out in an inert aprotic organic solvent such as dichloromethane, 1,2-dichloroethane, tetrahydrofuran, or acetonitrile, at a temperature between 20.degree. and 85.degree. C. The order of addition is not critical; however, it is often convenient to add the sulfonyl isocyanate or a solution of it in the reaction solvent, to a stirred suspension of the amine.
In some cases, the desired product is insoluble in the reaction solvent at ambient temperature and crystallizes from it in pure form. Products soluble in the reaction solvent are isolated by evaporation of the solvent. Compounds of Formula I then may be purified by trituration of the evaporation residue with solvents such as 1-chlorobutane or ethyl ether and filtration, by recrystallization from mixtures of solvents such as 1,2-dichloroethane, 1-chlorobutane and heptane or by chromatography on silica gel.
Sulfonyl isocyanates (II, W is O) are known in the art and are prepared from the corresponding sulfonamides (IV) by one of the following two general methods.
Equation 2 ##STR16##
The sulfonamide IV is reacted with an alkyl isocyanate (e.g., n-butyl isocyanate) in a solvent whose boiling point is above 135.degree. C., such as xylene. The reaction can optionally be carried out in the presence of a catalytic amount of 1,4-diaza[2.2.2]bicyclooctane (DABCO). The reaction mixture is heated to 135.degree.-140.degree. C. and held at that temperature for 5-60 minutes, after which phosgene is slowly added at such a rate that the temperature remains between 133 and 135.degree. C. When the consumption of phosgene has ceased, the mixture is cooled and filtered to remove insoluble material. Finally, the solvent, alkyl isocyanate, and excess phosgene are evaporated, leaving the sulfonyl isocyanate (II).
If desired, the alkyl isocyanate-sulfonamide adduct can be made and isolated before reaction with the phosgene. In this case the sulfonamide (IV), alkyl isocyanate, and anhydrous base (e.g, K.sub.2 CO.sub.3) in a polar, aprotic solvent (e.g. acetone, butanone, or acetonitrile) are mixed and heated under reflux for 1 to 6 hours. The reaction mixture is then diluted with water, and the pH is adjusted to about 3 with acid (e.g. HCl, H.sub.2 SO.sub.4). The adduct is filtered out and dried, and then reacted with phosgene as described above. This procedure modification is especially useful when sulfonamide (IV) is high melting and has low solubility in the phosgenation solvent.
Sulfonyl isocyanates (II, W is O) can also be prepared by the following method.
Equation 3 ##STR17##
The sulfonamide (IV) is heated at reflux in an excess of thionyl chloride. The reaction is continued until the sulfonamide protons are no longer detectable in the proton magnetic resonance spectrum. From 16 hours to 5 days is typically sufficient for complete conversion to the thionylamide (V) (Equation 3a).
The thionyl chloride is evaporated and the residue is treated with an inert solvent (e.g. toluene) containing at least one equivalent (typically 2-3 equivalents) of phosgene. A catalytic amount of pyridine (typically 0.1 equivalent) is added, and the mixture is heated to about 60.degree.-140.degree. C., with 80.degree.-100.degree. C. preferred. Conversion to the isocyanate (II, W is O) is usually substantially complete within 15 minutes to 3 hours (Equation 3b). The mixture is then cooled and filtered, and the solvent is evaporated, leaving the sulfonyl isocyanate (II, W is O).
Sulfonyl isothiocyanates (II, W is S) are known in the art and are prepared from the corresponding sulfonamides (IV) by reaction with carbon disulfide and potassium hydroxide followed by treatment of the resulting dipotassium salt VI with phosgene. Such a procedure is described in Arch. Pharm. 299, 174 (1966). Many of the compounds of Formula I can be prepared by the procedure shown in Equation 4.
Equation 4 ##STR18##
The reaction of Equations 4 is carried out by contacting phenylcarbamates or phenylthiocarbamates of Formula VI with aminoheterocycles of Formula III in an inert organic solvent such as dioxane or tetrahydrofuran at temperatures of about 20.degree.-100.degree. C. for a period of about one-half to twenty-four hours. The product can be isolated by evaporation of the reaction solvent and purified by methods previously described.
Phenylcarbamates and phenylthiocarbamates of Formula VI can be prepared by the methods described, or modifications thereof known to those skilled in the art, in U.S. Pat. No. 4,443,243.
Alternatively, many of the compounds of formula I can be prepared by the method described in Equation 5.
Equation 5 ##STR19##
The reaction of Equation 5 can be carried out by contacting equimolar amounts of a sulfonamide of Formula IV with a heterocyclic phenylcarbamate or phenylthiocarbamate of Formula VII in the presence of a base such as 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), by methods analogous to those described in South African Patent Application No. 83/0441. The phenylcarbamates and phenylthiocarbamates of Formula VII can be prepared by methods, or modifications thereof known to those skilled in the art, described in South African Patent Application No. 82/5671 and South African Patent Application No. 82/5045.
The sulfonamides IV of this invention may be prepared in a variety of ways some of which are described in Equations 6 through 15.
For Example, the 4-keto-5-sulfonamide isomer 1 may be prepared as outlined in Equation 6.
Equation 6 ##STR20##
Preparation of the intermediates such as bromide 2 may be found in EPA-95,925. Exposure of bromide 2 to nBuLi followed by addition of the resulting anion to cyclopropyl acid chloride affords the protected sulfonamide. Deprotection of the sulfonamide affords the desired sulfonamide 1.
Introduction of various R and R.sub.2 groups to sulfonamides such as 1 may be accomplished in several ways. For example, the sequence in Equation 6 could also be performed on 3-chloro-1-methylpyrazole or 1,3-dimethylpyrazole affording 3 and 4 respectively. Chloride 3 may then be used to further elaborate ##STR21## R.sub.2 as outlined in Equation 7.
Equation 7 ##STR22## The N-substituent of compounds such as 1, 3, 4 and 5 may also be varied by applying the same sequence of reactions as outlined in Equation 6 to various N-substituted pyrazoles. For example, pyrazole may be alkylated with dimethylsulfamoylchloride to afford pyrazole 6. Pyrazole 6 is then converted to sulfonamide 7 as outlined in Equation 8.
Equation 8 ##STR23##
In the case where either R or R.sub.2 are sensitive to nBuLi (i.e. R.sub.2 is CO.sub.2 CH.sub.3 or Br) then the lithiating reagent of choice is lithium diisopropylamide (LDA). Utilizing the same sequence as outlined in Equation 6 but substituting LDA for nBuLi affords sulfonamides such as 8. This is outlined in Equation 9.
Equation 9 ##STR24##
The isomeric 5-keto-4-sulfonamide pyrazoles may be prepared as outlined in Equations 10 and 11.
Equation 10 ##STR25##
In Equation 10 the sequential order of group introduction is reversed to that of Equation 6. The introduction of various R and R.sub.2 groups may be accomplished in the same manor as previously described for the 4-ketoisomer in Equations 7, 8 and 9.
An alternate synthesis of sulfonamides such as 9 is outlined in Equation 11.
Equation 11 ##STR26##
Oxidations of alcohols to ketones such as 12 to 9 are well known in the art. For further discussion pertaining to the oxidation of alcohols to ketones, see R. H. Cornforth, J. W. Cornforth and G. Popjak, Tetrahedron, 18, 1351 (1962).
The isomeric 3-keto-4-sulfonamide such as 13 may be prepared as outlined in Equation 12.
Equation 12 ##STR27##
In the above example of Equation 12, as before, minor variations of starting material allows for the introduction of different R and R.sub.2 groups. The starting pyrazoles 14 or 15 may be prepared via the condensation of a hydrazine with a triketo species as outlined in Equation 13.
Equation 13 ##STR28##
The final pyrazole isomer of the invention such as sulfonamide 16 may be prepared as outlined in Equation 14.
Equation 14 ##STR29##
Again, as described previously, alteration of the starting material allows for the preparation of compounds such as 16 where R and/or R.sub.2 may be varied. For example, utilizing phenylhydrazine and a chloronitrite results in pyrazole 20 and subsequently sulfonamide, 21. This is outlined in Equation 15.
Equation 15 ##STR30##
In all the above examples, substitution of cyclopropyl acid chloride with cyclobutyl or cyclopentyl acid chloride would result in the corresponding 4 or 5-membered ring analogs such as compounds 22, 23, 24, 25 and 26. ##STR31##
For further details pertaining to the synthesis of pyrazoles see EP-A-87,780, South African Patent Application No. 833,350, EP-A-95,925 and T. L. Jacobs, "Heterocyclic Compounds", R. C. Elderfield, ed., Vol. 5, pp. 45-161, Wiley, N.Y., 1957.
For further details pertaining to carbanions see J. Stowell, "Carbanions in Organic Synthesis", Wiley-Interscience, New York, 1979.
The synthesis of heterocyclic amines such as those represented by Formula III has been reviewed in "The Chemistry of Heterocyclic Compounds," a series published by Interscience Publ., New York and London. Aminopyrimidines are described by D. J. Brown in "The Pyrimidines," Vol. XVI of the series mentioned above which is herein incorporated by reference. The 2-amino-1,3,5-triazines of Formula III, where A is A-1 and Z is N, can be prepared according to methods described by E. M. Smolin and L. Rapaport in "s-Triazines and Derivatives," Vol. XIII.
Pyrimidines of Formula III, where A is A-1 and Y is an acetal or thioacetal substituent, can be prepared by methods taught in European Patent Application No. 84,224 (published July 27, 1983).
Pyrimidines of Formula III, wherein A is A-1 and Y is cyclopropyl or OCF.sub.2 H can be synthesized according to the methods taught in U.S. Pat. No. 4,515,626 and U.S. Pat. No. 4,540,782, respectively.
Compounds of Formula III, where A is A-2 or A-3, can be prepared by procedures disclosed in U.S. Pat. No. 4,339,267.
Compounds of formula III, where A is A-4, can be prepared by methods taught in U.S. Pat. No. 4,487,626.
Additional references dealing with the synthesis of bicyclic pyrimidines of Formula III, where A is A-2, A-3, or A-4 are Braker, Sheehan, Spitzmiller and Lott, J. Am. Chem. Soc., 69, 3072 (1947); Mitler and Bhattachanya, Quart. J. Indian Chem. Soc. 4, 152 (1927);
Shrage and Hitchings, J. Org. Chem., 16, 1153 (1951); Caldwell, Kornfeld and Donnell, J. Am. Chem. Soc., 63, 2188 (1941); and Fissekis, Myles and Brown, J. Org. Chem., 29, 2670 (1964).
Compounds of Formula III, where A is A-5, can be prepared by methods taught in U.S. Pat. No. 4,421,550.
Compounds of Formula III, where A is A-6, can be prepared by methods taught in the U.S. Pat. No. 4,496,392.
Compounds of Formula III, where A is A-7 can be prepared by methods taught in EP-A-125,864.
Agriculturally suitable salts of compounds of Formula I are also useful herbicides and can be prepared in a number of ways known to the art. For example, metal salts can be made by contacting compounds of Formula I with a solution of an alkali or alkaline earth metal salt having a sufficiently basic anion (e.g., hydroxide, alkoxide, carbonate or hydroxide). Quaternary amine salts can be made by similar techniques.
Salts of compounds of Formula I can also be prepared by exchange of one cation for another. Cationic exchange can be effected by direct contact of an aqueous solution of a salt of a compound of Formula I (e.g., alkali or quaternary amine salt) with a solution containing the cation to be exchanged. This method is most effective when the desired salt containing the exchanged cation is insoluble in water and can be separated by filtration.
Exchange may also be effected by passing an aqueous solution of a salt of a compound of Formula I (e.g., an alkali metal or quaternary amine salt) through a column packed with a cation exchange resin containing the cation to be exchanged for that of the original salt and the desired product is eluted from the column. This method is particularly useful when the desired salt is water-soluble, e.g., a potassium sodium or calcium salt.
Acid addition salts, useful in this invention can be obtained by reacting a compound of Formula I with a suitable acid, e.g., p-toluenesulfonic acid, trichloroacetic acid or the like.
The preparation of the compounds of this invention is further illustrated by the following specific examples. Unless otherwise indicated, temperatures are in degrees centigrade.





EXAMPLE 1
Preparation of 4-cyclopropylcarbonyl-1-methyl-5-pyrazole t-butyl sulfonamide
To a cooled -78.degree. C., solution of n-BuLi (3.7 g, 57.2 mmol) in approximately 350 ml of tetrahydrofuran is added 1-methyl-4-bromo-5-pyrazole t-butylsulfonamide (7.5 g, 25.4 mmol) dropwise. The solution is stirred for 15 minutes and then added via cannula to freshly distilled cyclopropyl acid chloride (6 g, 57.2 mmol) cooled to -78.degree. C. The resulting solution was quenched with brine, separated, dryed and concentrated in vaccuo. The resulting oil was flash chromatographed (50:50 (v/v)) ethylacetate-hexane to afford 2.7 g of a white solid, m.p. 113.degree.-115.degree. C.,
EXAMPLE 2
Preparation of 4-cyclopropylcarbonyl-1-methyl-5-pyrazolesulfonamide
To a stirring solution of trifluoroacetic acid was added 4-cyclopropyl-1-methyl-5-pyrazole t-butylsulfonamide. The solution was stirred overnight at room temperature. The reaction mixture was concentrated in vaccuo and the resulting solids were triturated with n-butylchloride, m.p. 125.degree.-127.degree. C.; NMR (200 MHz, CDCl.sub.3) 1.1 (m, 2H), 1.3 (m, 2H), 2.4 (m, 1H), 4.2 (s, 3H), 6.4 (br. s, 2H), 8.07 (s, 1H).
EXAMPLE 3
Preparation of 4-(Cyclopropylcarbonyl)-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-1-methyl-1H-pyrazole-5-sulfonamide
To a stirring mixture of the sulfonamide from Example 2 (175 mg, 0.76 mmol) and the phenylcarbamate of 4,6-dimethoxy-2-aminopyrimidine (210 mg, 0.76 mmol) in 3ml of acetonitrile was added diazobicycloundecane (116 mg, 0.76 mmol). The solution was stirred for approximately 10 minutes. Acidification of the reaction mixture and filtration of the resulting solids afforded 300 mg of the desired compound m.p. 189.degree.-192.degree. C. NMR (200 MHz, CDCl.sub.3) 1.0 (m, 2H), 1.1 (m, 2H), 2.4 (m, 1H), 4.0 (s, 6H), 4.35 (s, 1H), 5.80 (s, 1H), 7.4 (br. s, 1H), 8.05 (s, 1H), 12.9 (s, 1H).
TABLES______________________________________Table I ##STR32##Table II ##STR33##Table III ##STR34##Table IV ##STR35##Table V ##STR36##Table VI ##STR37##Table VII ##STR38##______________________________________
TABLE I__________________________________________________________________________R R.sub.1 n R.sub.2 R' X Y Z m.p. (.degree.C.)__________________________________________________________________________CH.sub.3 H 0 H cyclopropyl CH.sub.3 CH.sub.3 CH 162-165CH.sub.3 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 CH 155-157CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CH 189-192CH.sub.3 H 0 H cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 N 134-136CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 N 164-166CH.sub.3 H 0 H cyclopropyl Cl OCH.sub.3 CH 197-199CH.sub.3 H 0 H cyclobutyl CH.sub.3 CH.sub.3 CH 190-194CH.sub.3 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 CH 200-203CH.sub.3 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CH 196-199CH.sub.3 H 0 H cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 N 175-178CH.sub.3 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 N 168-170CH.sub.3 H 0 H cyclobutyl Cl OCH.sub.3 CH 210-212CH.sub.3 H 0 H cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 H cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub. 3 H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 CH 167-169CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 CH 178-180CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 CH 193-195CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 Cl cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 Cl cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 Br cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 Br cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Br cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Br cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 Br cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Br cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Br cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 Br cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 Br cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Br cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Br cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 Br cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Br cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Br cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 Br cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 Br cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Br cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Br cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 Br cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Br cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Br cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 Br cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 Br cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 Br cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 Br cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 Br cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Br cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 Br cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclopentyl OCH.sub. 3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 CH.sub.2 F cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 OCH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 OCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 OCH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 OCH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 OCH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 OCH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 OCH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 OCH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 OCH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3 ).sub.2 CHCH.sub.3 H 0 OCH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 OCH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 OCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 OCH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub. 3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SCH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SCH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclobutyl CH.sub. 3 CH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SCH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SCH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SCH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SCH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SCH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SCH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 SCH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 SCH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 SCH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 SOCH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub. 3 H 0 SO.sub.2 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 CN cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub. 3 H 0 CN cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CN cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CN cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CN cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CN cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CN cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 CN cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CN cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CN cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CN cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CN cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CN cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CN cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 CN cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CN cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CN cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CN cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CN cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CN cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CN cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 CN cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 CN cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 CN cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 CN cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CN cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CN cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CN cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub. 3).sub.2 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 CN cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 CN cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 CN cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 CN cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 CN cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 CN cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 CN cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 CN cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 CN cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 CH.sub.2 CN cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 CN cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 CN cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 CN cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH(OH)CH.sub.3 cyclobutyl CH.sub. 3 OCH.sub.3 NCH.sub.3 H 0 CH(OH)CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH(OH)CH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopropyl CH.sub.2 F CH.sub. 3 CHCH.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.3 OCH NCH.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclopropyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclobutyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclopentyl Cl OCH CHCH.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 CH.sub.3 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHPh H 0 H cyclopropyl CH.sub.3 CH.sub.3 CHPh H 0 H cyclopropyl CH.sub.3 OCH.sub.3 CHPh H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CHPh H 0 H cyclopropyl CH.sub.3 CH.sub.3 NPh H 0 H cyclopropyl CH.sub.3 OCH.sub.3 NPh H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 NPh H 0 H cyclopropyl Cl OCH.sub.3 CHPh H 0 H cyclobutyl CH.sub.3 CH.sub.3 CHPh H 0 H cyclobutyl CH.sub.3 OCH.sub.3 CHPh H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CHPh H 0 H cyclobutyl CH.sub.3 CH.sub.3 NPh H 0 H cyclobutyl CH.sub.3 OCH.sub.3 NPh H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 NPh H 0 H cyclobutyl Cl OCH.sub.3 CHPh H 0 H cyclopentyl CH.sub.3 CH.sub.3 CHPh H 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHPh H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHPh H 0 H cyclopentyl CH.sub.3 CH.sub.3 NPh H 0 H cyclopentyl CH.sub.3 OCH.sub.3 NPh H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NPh H 0 H cyclopentyl Cl OCH.sub.3 CHPh H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHPh H 0 H cyclopropyl cyclopropyl OCH.sub.3 CHPh H 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHPh H 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NPh H 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NPh H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NPh H 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.3 CH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.3 CH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclopropyl Cl OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclobutyl CH.sub.3 CH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclobutyl CH.sub.3 CH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclobutyl Cl OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopentyl CH.sub.3 CH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopentyl CH.sub.3 CH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclopentyl Cl OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopropyl cyclopropyl OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCO.sub.2 CH.sub.3 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl CH.sub.3 CH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl CH.sub.3 CH.sub.3 NSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 NSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 NSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl Cl OCH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclobutyl CH.sub.3 CH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclobutyl CH.sub.3 CH.sub.3 NSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclobutyl CH.sub.3 OCH.sub. 3 NSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 NSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclobutyl Cl OCH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopentyl CH.sub.3 CH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopentyl CH.sub.3 CH.sub.3 NSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 NSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopentyl Cl OCH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl cyclopropyl OCH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.2 F H 0 H cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.2 F H 0 H cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 F H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 F H 0 H cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 F H 0 H cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.2 F H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.2 F H 0 H cyclopropyl Cl OCH.sub.3 CHCH.sub.2 F H 0 H cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.2 F H 0 H cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 F H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 F H 0 H cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 F H 0 H cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 F H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 F H 0 H cyclobutyl Cl OCH.sub.3 CHCH.sub.2 F H 0 H cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 F H 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 F H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 F H 0 H cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 F H 0 H cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.2 F H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 F H 0 H cyclopentyl Cl OCH.sub.3 CHCH.sub.2 F H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 F H 0 H cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 F H 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 F H 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 F H 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 F H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 F H 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl Cl OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclobutyl Cl OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.dbd. CH.sub.2 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopentyl Cl OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub. 2 C.tbd.CH H 0 H cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclopropyl Cl OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclobutyl Cl OCH.sub.3 CHCH.sub.2 .tbd.CH H 0 H cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclopentyl Cl OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 C.tbd.CH H 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHH H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 CHH H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 CHH H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 CHH H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 NH H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 NH H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 NH H 0 Cl cyclopropyl Cl OCH.sub.3 CHH H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 CHH H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 CHH H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 CHH H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 NH H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 NH H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 NH H 0 Cl cyclobutyl Cl OCH.sub.3 CHH H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 CHH H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 CHH H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 CHH H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 NH H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 NH H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 NH H 0 Cl cyclopentyl Cl OCH.sub.3 CHH H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHH H 0 Cl cyclopropyl cyclopropyl OCH.sub.3 CHH H 0 Cl cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHH H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NH H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.3 NH H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NH H 0 Cl cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclobutyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclopentyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclobutyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopentyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl Cl OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclobutyl Cl OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopentyl Cl OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.2 F CH.sub.3 CHPh H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 OHPh H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 CHPh H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 CHPh H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 NPh H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 NPh H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 NPh H 0 Cl cyclopropyl Cl OCH.sub.3 CHPh H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 CHPh H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 CHPh H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 CHPh H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 NPh H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 NPh H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 NPh H 0 Cl cyclobutyl Cl OCH.sub.3 CHPh H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 CHPh H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 CHPh H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 CHPh H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 NPh H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 NPh H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 NPh H 0 Cl cyclopentyl Cl OCH.sub.3 CHPh H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHPh H 0 Cl cyclopropyl cyclopropyl OCH.sub.3 CHPh H 0 Cl cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHPh H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NPh H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.3 NPh H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NPh H 0 Cl cyclopropyl CH.sub.2 F CH.sub.3 CHH H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHH H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHH H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHH H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NH H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NH H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NH H 0 CH.sub.3 cyclopropyl Cl OCH.sub.3 CHH H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHH H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHH H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHH H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NH H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NH H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NH H 0 CH.sub.3 cyclobutyl Cl OCH.sub.3 CHH H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHH H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHH H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHH H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NH H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NH H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NH H 0 CH.sub.3 cyclopentyl Cl OCH.sub.3 CHH H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHH H 0 CH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHH H 0 CH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHH H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NH H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NH H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NH H 0 CH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopenlyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 CH.sub.3 H 0 CH.sub. 3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHPh H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHPh H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHPh H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHPh H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NPh H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NPh H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NPh H 0 CH.sub.3 cyclopropyl Cl OCH.sub.3 CHPh H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHPh H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHPh H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHPh H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NPh H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NPh H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NPh H 0 CH.sub. 3 cyclobutyl Cl OCH.sub.3 CHPh H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHPh H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHPh H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHPh H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NPh H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NPh H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NPh H 0 CH.sub.3 cyclopentyl Cl OCH.sub.3 CHPh H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHPh H 0 CH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHPh H 0 CH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHPh H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NPh H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NPh H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NPh H 0 CH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.dbd. CH.sub.2 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd. CH H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 1 H cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 1 H cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 H cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 H cyclopropyl CH.sub.3 CH.sub. 3 NCH.sub.3 H 1 H cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 1 H cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 H cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 1 H cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 1 H cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 H cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 H cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 1 H cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 1 H cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 H cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 1 H cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 1 H cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 H cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 H cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 1 H cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 1 H cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 H cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 1 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub. 3 H 1 H cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 1 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 1 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 1 H cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 1 H cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 1 Cl cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 1 Cl cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 Cl cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 Cl cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 1 Cl cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 1 Cl cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 Cl cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 1 Cl cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 1 Cl cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 Cl cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 Cl cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 1 Cl cyclobutyl CH.sub.3 OCH.sub. 3 NCH.sub.3 H 1 Cl cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 Cl cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 1 Cl cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 1 Cl cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 Cl cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 Cl cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 1 Cl cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 1 Cl cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 Cl cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 1 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 1 Cl cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 1 Cl cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 1 Cl cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 1 Cl cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 1 Cl cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cylopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 1 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 1 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 CH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 1 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 1 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 CH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 1 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 1 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 CH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 1 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 1 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 1 CH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 CH.sub.3 0 H cylopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.3 0 H cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.3 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.3 0 H cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.3 0 H cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.3 0 H cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub. 3 0 H cyclopropyl Cl OCH.sub.3 CHCH.sub.3 CH.sub.3 0 H cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.3 0 H cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.3 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.3 0 H cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.3 0 H cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.3 0 H cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.3 0 H cyclobutyl Cl OCH.sub.3 CHCH.sub.3 CH.sub.3 0 H cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.3 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.3 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.3 0 H cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.3 0 H cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.3 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.3 0 H cyclopentyl Cl OCH.sub.3 CHCH.sub.3 CH.sub.3 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 CH.sub.3 0 H cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub. 3 CH.sub.3 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 CH.sub.3 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 CH.sub.3 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.3 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 CH.sub.3 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 H cylopropyl CH.sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 H cyclopropyl CH.sub.2 CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 H cyclopropyl OCF.sub.2 H CH.sub.3 CHCH.sub.3 H 0 H cyclopropyl OCF.sub.2 H OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl OCH.sub.2 CF.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl CH.sub.2 F OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl CH.sub.2 Cl OCH.sub.3 NCH.sub.3 H 0 H cyclopropyl SCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl SCH.sub.2 F OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl Br OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl CH.sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopropyl OCH.sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl OCH.sub.2 OCH.sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 H cyclopropyl N(CH.sub.3).sub.2 OCH.sub.3 NCH.sub.3 H 0 H cyclopropyl NHCH.sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 H cyclopropyl CH.sub.3 CH.sub.2 SCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl OCH.sub.3 CH.sub.2 SO.sub.2 CH.sub.3 CHCH.sub.3 H 0 H cyclopropyl NH.sub.2 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 H cyclopropyl CH.sub.3 OCH.sub.2 CH.dbd.CH.sub.2 CHCH.sub.3 H 0 H cyclopropyl CH.sub.2 CH.sub.3 OCF.sub.2 H CHCH.sub.3 H 0 H cyclopropyl OCF.sub.2 H OCF.sub.2 H CHCH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.dbd.CH.sub.2 CHCH.sub.3 H 0 H cyclopropyl OCH.sub.3 C(O)CH.sub.3 NCH.sub.3 H 0 H cyclopropyl CH.sub.3 N(OCH.sub.3)CH.sub.3 NCH.sub.3 H 0 H cyclopropyl OCH(CH.sub.3).sub.2 OCF.sub.2 H CHCH.sub.3 H 0 H cylobutyl CH.sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.2 CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 H cyclobutyl OCF.sub.2 H CH.sub.3 CHCH.sub.3 H 0 H cyclobutyl OCF.sub.2 H OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl OCH.sub.2 CF.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.2 F OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.2 Cl OCH.sub.3 NCH.sub.3 H 0 H cyclobutyl SCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl SCH.sub.2 F OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl Br OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclobutyl OCH.sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl OCH.sub.2 OCH.sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 H cyclobutyl N(CH.sub.3).sub.2 OCH.sub.3 NCH.sub.3 H 0 H cyclobutyl NHCH.sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 H 0 H cyclobutyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 H cyclobutyl CH.sub.3 CH.sub.2 SCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl OCH.sub.3 CH.sub.2 SO.sub.2 CH.sub.3 CHCH.sub.3 H 0 H cyclobutyl NH.sub.2 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 H cyclobutyl CH.sub.3 OCH.sub.2 CH.dbd.CH.sub.2 CHCH.sub.3 H 0 H cyclobutyl CH.sub.2 CH.sub.3 OCF.sub.2 H CHCH.sub.3 H 0 H cyclobutyl OCF.sub.2 H OCF.sub.2 H CHCH.sub.3 H 0 H cyclobutyl OCH.sub.3 OCH.dbd.CH.sub.2 CHCH.sub.3 H 0 H cyclobutyl OCH.sub.3 C(O)CH.sub.3 NCH.sub.3 H 0 H cyclobutyl CH.sub.3 N(OCH.sub.3)CH.sub.3 NCH.sub.3 H 0 H cyclobutyl OCH(CH.sub.3).sub.2 OCF.sub.2 H CH__________________________________________________________________________
TABLE II__________________________________________________________________________R R.sub.1 n R.sub.2 R' X Y Z m.p. (.degree.C.)__________________________________________________________________________CH.sub.3 H 0 H cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 H cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 H cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 Cl cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 Cl cyclopropyl CH.sub.2 F CH.sub. 3 CHCH.sub.3 H 0 CH.sub.2 F cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub. 2 F cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 CH.sub.2 F cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub. 3).sub.2 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 SOCH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 CN cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CN cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CN cyclopropyl OCH.sub.3 OCH.sub. 3 CHCH.sub.3 H 0 CN cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CN cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CN cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CN cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 CN cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CN cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CN cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CN cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CN cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CN cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CN cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 CN cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CN cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CN cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CN cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CN cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CN cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CN cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 CN cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 CN cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 CN cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 CN cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CN cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CN cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CN cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub. 2 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl cyclopropyl OCH.sub. 3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl CH.sub.3 OCH NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclopropyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclobutyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclopentyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 CH.sub.3 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.3 CH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.3 CH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclopropyl Cl OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclobutyl CH.sub.3 CH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclobutyl CH.sub.3 CH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclobutyl CH.sub.3 OCH.sub. 3 NCO.sub.2 CH.sub.3 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclobutyl Cl OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopentyl CH.sub.3 CH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopentyl CH.sub.3 CH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclopentyl Cl OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopropyl cyclopropyl OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCO.sub.2 CH.sub.3 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub. 3 NCO.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.2 F H 0 H cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.2 F H 0 H cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 F H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 F H 0 H cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 F H 0 H cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.2 F H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.2 F H 0 H cyclopropyl Cl OCH.sub.3 CHCH.sub.2 F H 0 H cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.2 F H 0 H cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 F H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 F H 0 H cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 F H 0 H cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 F H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 F H 0 H cyclobutyl Cl OCH.sub.3 CHCH.sub.2 F H 0 H cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 F H 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 F H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 F H 0 H cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 F H 0 H cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.2 F H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 F H 0 H cyclopentyl Cl OCH.sub.3 CHCH.sub.2 F H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 F H 0 H cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 F H 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 F H 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 F H 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 F H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 F H 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclopropyl Cl OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclobutyl Cl OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclopentyl CH.sub.3 OCH.sub. 3 NCH.sub.2 C.tbd.CH H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclopentyl Cl OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 C.tbd.CH H 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub. 3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclobutyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3CH.sub.2 CH.sub.3 H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclopentyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl Cl OCH.sub. 3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclobutyl Cl OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopentyl Cl OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.2 F CH.sub.3 CHH H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 CHH H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 CHH H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 CHH H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 NH H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 NH H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 NH H 0 Cl cyclopropyl Cl OCH.sub.3 CHH H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 CHH H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 CHH H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 CHH H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 NH H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 NH H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 NH H 0 Cl cyclobutyl Cl OCH.sub.3 CHH H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 CHH H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 CHH H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 CHH H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 NH H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 NH H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 NH H 0 Cl cyclopentyl Cl OCH.sub.3 CHH H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHH H 0 Cl cyclopropyl cyclopropyl OCH.sub.3 CHH H 0 Cl cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHH H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NH H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.3 NH H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NH H 0 Cl cyclopropyl CH.sub.2 F CH.sub.3 CHPh H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHPh H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHPh H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHPh H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NPh H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NPh H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NPh H 0 CH.sub.3 cyclopropyl Cl OCH.sub.3 CHPh H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHPh H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHPh H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHPh H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NPh H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NPh H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NPh H 0 CH.sub.3 cyclobutyl Cl OCH.sub.3 CHPh H 0 CH.sub. 3 cyclopentyl CH.sub.3 CH.sub.3 CHPh H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHPh H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHPh H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NPh H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NPh H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NPh H 0 CH.sub.3 cyclopentyl Cl OCH.sub.3 CHPh H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHPh H 0 CH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHPh H 0 CH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHPh H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NPh H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NPh H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NPh H 0 CH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub. 3 NCH.sub.2 Cl H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHH H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHH H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHH H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHH H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NH H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NH H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NH H 0 CH.sub.3 cyclopropyl Cl OCH.sub. 3 CHH H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHH H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHH H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHH H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NH H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NH H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NH H 0 CH.sub.3 cyclobutyl Cl OCH.sub.3 CHH H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHH H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHH H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHH H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NH H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NH H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NH H 0 CH.sub.3 cyclopentyl Cl OCH.sub.3 CHH H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHH H 0 CH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHH H 0 CH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHH H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NH H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NH H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NH H 0 CH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 1 Cl cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 1 Cl cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 Cl cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 Cl cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 1 Cl cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 1 Cl cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 Cl cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 1 Cl cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 1 Cl cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 Cl cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 Cl cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 1 Cl cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 1 Cl cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 Cl cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 1 Cl cyclopentyl CH.sub.3 CH.sub. 3 CHCH.sub.3 H 1 Cl cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 Cl cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 Cl cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 1 Cl cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 1 Cl cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 Cl cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 1 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 1 Cl cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 1 Cl cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 1 Cl cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 1 Cl cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 1 Cl cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 CH.sub.3 0 H cylopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.3 0 H cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.3 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.3 0 H cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.3 0 H cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.3 0 H cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.3 0 H cyclopropyl Cl OCH.sub.3 CHCH.sub.3 CH.sub.3 0 H cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.3 0 H cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.3 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.3 0 H cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.3 0 H cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.3 0 H cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.3 0 H cyclobutyl Cl OCH.sub.3 CHCH.sub.3 CH.sub.3 0 H cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.3 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.3 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.3 0 H cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.3 0 H cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.3 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.3 0 H cyclopentyl Cl OCH.sub.3 CHCH.sub.3 CH.sub.3 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CH.sub.-CH.sub.3 CH.sub.3 0 H cyclopropyl cyclopropyl OCH.su b.3 CHCH.sub.3 CH.sub.3 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 CH.sub.3 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 CH.sub.3 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.3 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 CH.sub.3 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 H cylobutyl CH.sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.2 CF.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 H cyclobutyl OCF.sub.2 H CH.sub.3 CHCH.sub.3 H 0 H cyclobutyl OCF.sub.2 H OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl OCH.sub.2 CF.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.2 F OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.2 Cl OCH.sub.3 NCH.sub.3 H 0 H cyclobutyl SCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl SCH.sub.2 F OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl Br OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclobutyl OCH.sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl OCH.sub.2 OCH.sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 H cyclobutyl N(CH.sub.3).sub.2 OCH.sub.3 NCH.sub.3 H 0 H cyclobutyl NHCH.sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 H 0 H cyclobutyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 H cyclobutyl CH.sub.3 CH.sub.2 SCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl OCH.sub.3 CH.sub.2 SO.sub.2 CH.sub.3 CHCH.sub.3 H 0 H cyclobutyl NH.sub.2 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 H cyclobutyl CH.sub.3 OCH.sub.2 CH.dbd.CH.sub.2 CHCH.sub.3 H 0 H cyclobutyl CH.sub.2 CH.sub.3 OCF.sub.2 H CHCH.sub.3 H 0 H cyclobutyl OCF.sub.2 H OCF.sub.2 H CHCH.sub.3 H 0 H cyclobutyl OCH.sub.3 OCH.dbd.CH.sub.2 CHCH.sub.3 H 0 H cyclobutyl OCH.sub.3 C(O)CH.sub.3 NCH.sub.3 H 0 H cyclobutyl CH.sub.3 N(OCH.sub.3)CH.sub.3 NCH.sub.3 H 0 H cyclobutyl OCH(CH.sub.3).sub.2 OCF.sub.2 H CH__________________________________________________________________________
TABLE III__________________________________________________________________________R R.sub.1 n R.sub.2 R' X Y Z m.p. (.degree.C.)__________________________________________________________________________CH.sub.3 H 0 H cyclopropyl CH.sub.3 CH.sub.3 CH 157-159CH.sub.3 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 CH 179-182CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CH 159-161CH.sub.3 H 0 H cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 N 185-187CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 N 196-198CH.sub.3 H 0 H cyclopropyl Cl OCH.sub.3 CH 202-205CH.sub.3 H 0 H cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 H cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 H cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub. 3 H 0 CH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 Cl cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 Cl cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 Br cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 Br cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Br cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Br cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 Br cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Br cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Br cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 Br cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 Br cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Br cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Br cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 Br cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Br cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Br cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 Br cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 Br cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Br cyclopentyl OCH.sub.3 OCH.sub. 3 CHCH.sub.3 H 0 Br cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 Br cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Br cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Br cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 Br cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 Br cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 Br cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 Br cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 Br cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Br cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 Br cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 OCH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 OCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub. 3 NCH.sub.3 H 0 OCH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 OCH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 OCH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 OCH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 OCH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 OCH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 OCH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 OCH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 OCH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 OCH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 OCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 OCH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SCH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SCH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclobutyl CH.sub.3 CH.sub. 3 NCH.sub.3 H 0 SCH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SCH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SCH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SCH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SCH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SCH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 SCH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 SCH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 SCH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub. 3 H 0 SCH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 CH.sub. 3 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 SO.sub.2 CH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CO.sub.2 CH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 CN cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 CN cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 CN cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 CN cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 CN cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 CN cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub. 3 H 0 CH.sub.2 CN cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 CN cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 CN cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 CN cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 CN cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 CH.sub.2 CN cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 CN cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 CN cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 CN cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub. 3 H 0 CH(OH)CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH(OH)CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH(OH)CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH(OH)CH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH(OH)CH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHPh H 0 H cyclopropyl CH.sub.3 CH.sub.3 CHPh H 0 H cyclopropyl CH.sub.3 OCH.sub.3 CHPh H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CHPh H 0 H cyclopropyl CH.sub.3 CH.sub.3 NPh H 0 H cyclopropyl CH.sub.3 OCH.sub.3 NPh H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 NPh H 0 H cyclopropyl Cl OCH.sub.3 CHPh H 0 H cyclobutyl CH.sub.3 CH.sub.3 CHPh H 0 H cyclobutyl CH.sub.3 OCH.sub.3 CHPh H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CHPh H 0 H cyclobutyl CH.sub.3 CH.sub.3 NPh H 0 H cyclobutyl CH.sub.3 OCH.sub.3 NPh H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 NPh H 0 H cyclobutyl Cl OCH.sub.3 CHPh H 0 H cyclopentyl CH.sub.3 CH.sub.3 CHPh H 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHPh H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHPh H 0 H cyclopentyl CH.sub.3 CH.sub.3 NPh H 0 H cyclopentyl CH.sub.3 OCH.sub.3 NPh H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NPh H 0 H cyclopentyl Cl OCH.sub.3 CHPh H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHPh H 0 H cyclopropyl cyclopropyl OCH.sub.3 CHPh H 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHPh H 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NPh H 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NPh H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NPh H 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl CH.sub.3 CH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl CH.sub.3 CH.sub.3 NSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 NSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 NSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl Cl OCH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclobutyl CH.sub.3 CH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclobutyl CH.sub.3 CH.sub.3 NSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 NSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 NSO.sub.2 N(CH.sub.3).sub. 2 H 0 H cyclobutyl Cl OCH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopentyl CH.sub.3 CH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopentyl CH.sub.3 CH.sub.3 NSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 NSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopentyl Cl OCH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl cyclopropyl OCH.sub.3 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NSO.sub.2 N(CH.sub.3).sub.2 H 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl Cl OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclobutyl Cl OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopentyl Cl OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHH H 0 H cyclopropyl CH.sub.3 CH.sub.3 CHH H 0 H cyclopropyl CH.sub.3 OCH.sub.3 CHH H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CHH H 0 H cyclopropyl CH.sub.3 CH.sub.3 NH H 0 H cyclopropyl CH.sub.3 OCH.sub.3 NH H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 NH H 0 H cyclopropyl Cl OCH.sub.3 CHH H 0 H cyclobutyl CH.sub.3 CH.sub.3 CHH H 0 H cyclobutyl CH.sub.3 OCH.sub.3 CHH H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CHH H 0 H cyclobutyl CH.sub.3 CH.sub.3 NH H 0 H cyclobutyl CH.sub.3 OCH.sub.3 NH H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 NH H 0 H cyclobutyl Cl OCH.sub.3 CHH H 0 H cyclopentyl CH.sub.3 CH.sub.3 CHH H 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHH H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHH H 0 H cyclopentyl CH.sub.3 CH.sub.3 NH H 0 H cyclopentyl CH.sub.3 OCH.sub.3 NH H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NH H 0 H cyclopentyl Cl OCH.sub.3 CHH H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHH H 0 H cyclopropyl cyclopropyl OCH.sub.3 CHH H 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHH H 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NH H 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NH H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NH H 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclobutyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopentyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 CH.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.2 F CH.sub.3 CHPh H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 CHPh H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 CHPh H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 CHPh H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 NPh H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 NPh H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 NPh H 0 Cl cyclopropyl Cl OCH.sub.3 CHPh H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 CHPh H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 CHPh H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 CHPh H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 NPh H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 NPh H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 NPh H 0 Cl cyclobutyl Cl OCH.sub.3 CHPh H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 CHPh H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 CHPh H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 CHPh H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 NPh H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 NPh H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 NPh H 0 Cl cyclopentyl Cl OCH.sub.3 CHPh H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHPh H 0 Cl cyclopropyl cyclopropyl OCH.sub.3 CHPh H 0 Cl cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHPh H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NPh H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.3 NPh H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NPh H 0 Cl cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub. 3 NCH.sub.2 CH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub. 2 H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 CH.dbd.CH.sub.2 H 0 CH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 C.tbd.CH H 0 CH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 1 H cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 1 H cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 H cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 H cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 1 H cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 1 H cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 H cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 1 H cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 1 H cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 H cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 H cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 1 H cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 1 H cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 H cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 1 H cyclopentyl CH.sub.3 CH.sub. 3 CHCH.sub.3 H 1 H cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 H cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 H cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 1 H cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 1 H cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 H cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 1 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 1 H cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 1 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 1 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 1 H cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 1 H cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 1 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 1 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 CH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 1 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 1 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 CH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 CH cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 1 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 1 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 CH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 1 CH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 1 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 1 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 1 CH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 H cyclopropyl CH.sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 H cyclopropyl CH.sub.2 CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 H cyclopropyl OCF.sub.2 H CH.sub.3 CHCH.sub.3 H 0 H cyclopropyl OCF.sub.2 H OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl OCH.sub.2 CF.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl CH.sub.2 F OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl CH.sub.2 Cl OCH.sub.3 NCH.sub.3 H 0 H cyclopropyl SCH.sub.3 OCH.sub. 3 CHCH.sub.3 H 0 H cyclopropyl SCH.sub.2 F OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl Br OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl CH.sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopropyl OCH.sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl OCH.sub.2 OCH.sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 H cyclopropyl N(CH.sub.3).sub.2 OCH.sub.3 NCH.sub.3 H 0 H cyclopropyl NHCH.sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 H cyclopropyl CH.sub.3 CH.sub.2 SCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl OCH.sub.3 CH.sub.2 SO.sub.2 CH.sub.3 CHCH.sub.3 H 0 H cyclopropyl NH.sub.2 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 H cyclopropyl CH.sub.3 OCH.sub.2 CH.dbd.CH.sub.2 CHCH.sub.3 H 0 H cyclopropyl CH.sub.2 CH.sub.3 OCF.sub.2 H CHCH.sub.3 H 0 H cyclopropyl OCF.sub.2 H OCF.sub.2 H CHCH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.dbd.CH.sub.2 CHCH.sub.3 H 0 H cyclopropyl OCH.sub.3 C(O)CH.sub.3 NCH.sub.3 H 0 H cyclopropyl CH.sub.3 N(OCH.sub.3)CH.sub.3 NCH.sub.3 H 0 H cyclopropyl OCH(CH.sub.3).sub.2 OCF.sub.2 H CH__________________________________________________________________________
TABLE IV__________________________________________________________________________R R.sub.1 n R.sub.2 R' X Y Z m.p. (.degree.C.)__________________________________________________________________________CH.sub.3 H 0 H cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 H cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 H cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub. 3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 Cl cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 Cl cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 F cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 CH.sub.2 F cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 F cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 SO.sub.2 N(CH.sub.3).sub.2 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub. 3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 SOCH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 SOCH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 SOCH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 CN cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CN cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CN cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CN cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CN cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CN cyclopropyl OCH.sub. 3 OCH.sub.3 NCH.sub.3 H 0 CN cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 CN cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CN cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CN cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CN cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CN cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CN cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CN cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 CN cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CN cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CN cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CN cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CN cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CN cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CN cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 CN cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 CN cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 CN cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 CN cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CN cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CN cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CN cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub. 2 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub. 3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 N(CH.sub.3).sub.2 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl CH.sub.3 OCH NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 CH.sub.2 OCH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclopropyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclobutyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclopentyl Cl OCH CHCH.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 CH.sub.3 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.3 CH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.3 CH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub. 3 NCO.sub.2 CH.sub.3 H 0 H cyclopropyl Cl OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclobutyl CH.sub.3 CH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclobutyl CH.sub.3 CH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclobutyl Cl OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopentyl CH.sub.3 CH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopentyl CH.sub.3 CH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NCO.sub.2 CH.sub. 3 H 0 H cyclopentyl Cl OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopropyl cyclopropyl OCH.sub.3 CHCO.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCO.sub.2 CH.sub.3 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCO.sub.2 CH.sub.3 H 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.2 F H 0 H cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.2 F H 0 H cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 F H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 F H 0 H cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 F H 0 H cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.2 F H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.2 F H 0 H cyclopropyl Cl OCH.sub.3 CHCH.sub.2 F H 0 H cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.2 F H 0 H cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 F H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 F H 0 H cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 F H 0 H cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 F H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 F H 0 H cyclobutyl Cl OCH.sub.3 CHCH.sub.2 F H 0 H cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 F H 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 F H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 F H 0 H cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 F H 0 H cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.2 F H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 F H 0 H cyclopentyl Cl OCH.sub.3 CHCH.sub.2 F H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 F H 0 H cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 F H 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 F H 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 F H 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 F H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 F H 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclopropyl Cl OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclobutyl Cl OCH.sub.3 CHCH.sub.2 .tbd.CH H 0 H cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclopentyl Cl OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 C.tbd.CH H 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 C.tbd.CH H 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 C.tbd.CH H 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclobutyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclopentyl Cl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl Cl OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub. 3 CH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclobutyl Cl OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopentyl Cl OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 SO.sub.2 CH.sub.3 H 0 Cl cyclopropyl CH.sub.2 F CH.sub.3 CHH H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 CHH H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 CHH H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 CHH H 0 Cl cyclopropyl CH.sub.3 CH.sub.3 NH H 0 Cl cyclopropyl CH.sub.3 OCH.sub.3 NH H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.3 NH H 0 Cl cyclopropyl Cl OCH.sub.3 CHH H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 CHH H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 CHH H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 CHH H 0 Cl cyclobutyl CH.sub.3 CH.sub.3 NH H 0 Cl cyclobutyl CH.sub.3 OCH.sub.3 NH H 0 Cl cyclobutyl OCH.sub.3 OCH.sub.3 NH H 0 Cl cyclobutyl Cl OCH.sub.3 CHH H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 CHH H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 CHH H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 CHH H 0 Cl cyclopentyl CH.sub.3 CH.sub.3 NH H 0 Cl cyclopentyl CH.sub.3 OCH.sub.3 NH H 0 Cl cyclopentyl OCH.sub.3 OCH.sub.3 NH H 0 Cl cyclopentyl Cl OCH.sub.3 CHH H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHH H 0 Cl cyclopropyl cyclopropyl OCH.sub.3 CHH H 0 Cl cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHH H 0 Cl cyclopropyl NHCH.sub. 3 OCH.sub.2 CH.sub.3 NH H 0 Cl cyclopropyl NHCH.sub.3 OCH.sub.3 NH H 0 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NH H 0 Cl cyclopropyl CH.sub.2 F CH.sub.3 CHPh H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHPh H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHPh H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHPh H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NPh H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NPh H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NPh H 0 CH.sub.3 cyclopropyl Cl OCH.sub.3 CHPh H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHPh H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHPh H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHPh H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NPh H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NPh H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NPh H 0 CH.sub.3 cyclobutyl Cl OCH.sub.3 CHPh H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHPh H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHPh H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHPh H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NPh H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NPh H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NPh H 0 CH.sub.3 cyclopentyl Cl OCH.sub.3 CHPh H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHPh H 0 CH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHPh H 0 CH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHPh H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NPh H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NPh H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NPh H 0 CH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl Cl OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclobutyl Cl OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclopentyl Cl OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.2 Cl H 0 CH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHH H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 CHH H 0 CH.sub.3 cyclopropyl CH.sub. 3 OCH.sub.3 CHH H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 CHH H 0 CH.sub.3 cyclopropyl CH.sub.3 CH.sub.3 NH H 0 CH.sub.3 cyclopropyl CH.sub.3 OCH.sub.3 NH H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.3 NH H 0 CH.sub.3 cyclopropyl Cl OCH.sub.3 CHH H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 CHH H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 CHH H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 CHH H 0 CH.sub.3 cyclobutyl CH.sub.3 CH.sub.3 NH H 0 CH.sub.3 cyclobutyl CH.sub.3 OCH.sub.3 NH H 0 CH.sub.3 cyclobutyl OCH.sub.3 OCH.sub.3 NH H 0 CH.sub.3 cyclobutyl Cl OCH.sub.3 CHH H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 CHH H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 CHH H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 CHH H 0 CH.sub.3 cyclopentyl CH.sub.3 CH.sub.3 NH H 0 CH.sub.3 cyclopentyl CH.sub.3 OCH.sub.3 NH H 0 CH.sub.3 cyclopentyl OCH.sub.3 OCH.sub.3 NH H 0 CH.sub.3 cyclopentyl Cl OCH.sub.3 CHH H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHH H 0 CH.sub.3 cyclopropyl cyclopropyl OCH.sub.3 CHH H 0 CH.sub.3 cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHH H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NH H 0 CH.sub.3 cyclopropyl NHCH.sub.3 OCH.sub.3 NH H 0 CH.sub.3 cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NH H 0 CH.sub.3 cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 1 Cl cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 1 Cl cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 Cl cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 Cl cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 1 Cl cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 1 Cl cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 Cl cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 1 Cl cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 1 Cl cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 Cl cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 Cl cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 1 Cl cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 1 Cl cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 Cl cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 1 Cl cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 1 Cl cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 Cl cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 1 Cl cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 1 Cl cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 1 Cl cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 Cl cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 1 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 1 Cl cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 1 Cl cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 1 Cl cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 1 Cl cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 1 Cl cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 1 Cl cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 CH 0 H cylopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 CH 0 H cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 CH 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH 0 H cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 CH 0 H cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 CH 0 H cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 CH 0 H cyclopropyl Cl OCH.sub.3 CHCH.sub.3 CH 0 H cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 CH 0 H cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 CH 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH 0 H cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 CH 0 H cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 CH 0 H cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 CH 0 H cyclobutyl Cl OCH.sub.3 CHCH.sub.3 CH 0 H cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 CH 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 CH 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH 0 H cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 CH 0 H cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 CH 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 CH 0 H cyclopentyl Cl OCH.sub.3 CHCH.sub.3 CH 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 CH 0 H cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 CH 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 CH 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 CH 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 CH 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 CH 0 H cyclopropyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.2 CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.2 F CH.sub.3 CHCH.sub.3 H 0 H cyclobutyl OCF.sub.2 H CH.sub.3 CHCH.sub.3 H 0 H cyclobutyl OCF.sub.2 H OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl OCH.sub.2 CF.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.2 F OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.2 Cl OCH.sub.3 NCH.sub.3 H 0 H cyclobutyl SCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl SCH.sub.2 F OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl Br OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclobutyl OCH.sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl OCH.sub.2 OCH.sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 H cyclobutyl N(CH.sub.3).sub. 2 OCH.sub.3 NCH.sub.3 H 0 H cyclobutyl NHCH.sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 H 0 H cyclobutyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 H cyclobutyl CH.sub.3 CH.sub.2 SCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl OCH.sub.3 CH.sub.2 SO.sub.2 CH.sub.3 CHCH.sub.3 H 0 H cyclobutyl NH.sub.2 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 H cyclobutyl CH.sub.3 OCH.sub.2 CH.dbd.CH.sub.2 CHCH.sub.3 H 0 H cyclobutyl CH.sub.2 CH.sub.3 OCF.sub.2 H CHCH.sub.3 H 0 H cyclobutyl OCF.sub.2 H OCF.sub.2 H CHCH.sub.3 H 0 H cyclobutyl OCH.sub.3 OCH.dbd.CH.sub.2 CHCH.sub.3 H 0 H cyclobutyl OCH.sub.3 C(O)CH.sub.3 NCH.sub.3 H 0 H cyclobutyl CH.sub.3 N(OCH.sub.3)CH.sub.3 NCH.sub.3 H 0 H cyclobutyl OCH(CH.sub.3).sub.2 OCF.sub.2 H CH__________________________________________________________________________
TABLE V__________________________________________________________________________ m.p.R R.sub.1 R.sub.2 R' n A X.sub.1 Y.sub.1 X.sub.2 Y.sub.2 X.sub.3 Y.sub.3 (.degree.C.)__________________________________________________________________________CH.sub.3 H H cyclopropyl 0 A-2 CH.sub.3 O -- -- -- --CH.sub.3 H H cyclopropyl 0 A-2 OCH.sub.3 O -- -- -- --CH.sub.3 H H cyclopropyl 0 A-2 OCH.sub.3 CH.sub.2 -- -- -- --CH.sub.3 H H cyclopropyl 0 A-2 OCH.sub.2 CH.sub.3 O -- -- -- --CH.sub.3 H H cyclopropyl 0 A-3 CH.sub.3 -- -- -- -- --CH.sub.3 H H cyclopropyl 0 A-3 OCH.sub.3 -- -- -- -- --CH.sub.3 H H cyclopropyl 0 A-3 OCH.sub.2 CH.sub.3 -- -- -- -- --CH.sub.3 H H cyclopropyl 0 A-3 OCF.sub.2 H -- -- -- -- --CH.sub.3 H H cyclopropyl 0 A-4 CH.sub.3 -- -- -- -- HCH.sub.3 H H cyclopropyl 0 A-4 CH.sub.3 -- -- -- -- CH.sub.3CH.sub.3 H H cyclopropyl 0 A-4 OCH.sub.3 -- -- -- -- HCH.sub.3 H H cyclopropyl 0 A-4 OCH.sub.3 -- -- -- -- CH.sub.3CH.sub.3 H H cyclopropyl 0 A-4 OCF.sub.2 H -- -- -- -- HCH.sub.3 H H cyclopropyl 0 A-5 -- -- CH.sub.3 OCH.sub.3 -- --CH.sub.3 H H cyclopropyl 0 A-5 -- -- CH.sub.3 OCH.sub.2 CH.sub.3 -- --CH.sub.3 H H cyclopropyl 0 A-5 -- -- CH.sub.3 SCH.sub.3 -- --CH.sub.3 H H cyclopropyl 0 A-5 -- -- CH.sub.2 CH.sub.3 OCH.sub.3 -- --CH.sub.3 H H cyclopropyl 0 A-6 -- -- -- -- CH.sub.3 --CH.sub. 3 H H cyclopropyl 0 A-6 -- -- -- -- OCH.sub.3 --__________________________________________________________________________ m.p.R R.sub.1 R.sub.2 R' n A X.sub.4 Y.sub.4 Z.sub.1 (.degree.C.)__________________________________________________________________________CH.sub.3 H H cyclopropyl 0 A-7 CH.sub.3 CH.sub.3 CH__________________________________________________________________________ m.p.R R.sub.1 R.sub.2 R' n A X.sub.1 Y.sub.1 X.sub.2 Y.sub.2 X.sub.3 Y.sub.3 (.degree.C.)__________________________________________________________________________CH.sub.3 H CH.sub.3 cyclopropyl 0 A-2 CH.sub.3 O -- -- -- --CH.sub.3 H CH.sub.3 cyclopropyl 0 A-2 OCH.sub.3 O -- -- -- --CH.sub.3 H CH.sub.3 cyclopropyl 0 A-2 OCH.sub.3 CH.sub.2 -- -- -- --CH.sub.3 H CH.sub.3 cyclopropyl 0 A-2 OCH.sub.2 CH.sub.3 O -- -- -- --CH.sub. 3 H CH.sub.3 cyclopropyl 0 A-3 CH.sub.3 -- -- -- -- --CH.sub.3 H CH.sub.3 cyclopropyl 0 A-3 OCH.sub.3 -- -- -- -- --CH.sub.3 H CH.sub.3 cyclopropyl 0 A-3 OCH.sub.2 CH.sub.3 -- -- -- -- --CH.sub.3 H CH.sub.3 cyclopropyl 0 A-3 OCF.sub.2 H -- -- -- -- --CH.sub.3 H CH.sub.3 cyclopropyl 0 A-4 CH.sub.3 -- -- -- -- HCH.sub.3 H CH.sub.3 cyclopropyl 0 A-4 CH.sub.3 -- -- -- -- CH.sub.3CH.sub.3 H CH.sub.3 cyclopropyl 0 A-4 OCH.sub.3 -- -- -- -- HCH.sub.3 H CH.sub.3 cyclopropyl 0 A-4 OCH.sub.3 -- -- -- -- CH.sub.3CH.sub.3 H CH.sub.3 cyclopropyl 0 A-4 OCF.sub.2 H -- -- -- -- HCH.sub.3 H CH.sub.3 cyclopropyl 0 A-5 -- -- CH.sub.3 OCH.sub.3 -- --CH.sub.3 H CH.sub.3 cyclopropyl 0 A-5 -- -- CH.sub.3 OCH.sub.2 CH.sub.3 -- --CH.sub.3 H CH.sub.3 cyclopropyl 0 A-5 -- -- CH.sub.3 SCH.sub.3 -- --CH.sub.3 H CH.sub.3 cyclopropyl 0 A-5 -- -- CH.sub.2 CH.sub.3 OCH.sub.3 -- --CH.sub.3 H CH.sub.3 cyclopropyl 0 A-6 -- -- -- -- CH.sub.3 --CH.sub.3 H CH.sub.3 cyclopropyl 0 A-6 -- -- -- -- OCH.sub.3 --CH.sub.3 H H cyclobutyl 0 A-2 CH.sub.3 O -- -- -- --CH.sub.3 H H cyclobutyl 0 A-2 OCH.sub.3 O -- -- -- --CH.sub.3 H H cyclobutyl 0 A-2 OCH.sub.3 CH.sub.2 -- -- -- --CH.sub.3 H H cyclobutyl 0 A-2 OCH.sub.2 CH.sub.3 O -- -- -- --CH.sub.3 H H cyclobutyl 0 A-3 CH.sub.3 -- -- -- -- --CH.sub.3 H H cyclobutyl 0 A-3 OCH.sub.3 -- -- -- -- --CH.sub.3 H H cyclobutyl 0 A-3 OCH.sub.2 CH.sub.3 -- -- -- -- --CH.sub.3 H H cyclobutyl 0 A-3 OCF.sub.2 H -- -- -- -- --CH.sub.3 H H cyclobutyl 0 A-4 CH.sub.3 -- -- -- -- HCH.sub.3 H H cyclobutyl 0 A-4 CH.sub.3 -- -- -- -- CH.sub.3CH.sub.3 H H cyclobutyl 0 A-4 OCH.sub.3 -- -- -- -- HCH.sub.3 H H cyclobutyl 0 A-4 OCH.sub.3 -- -- -- -- CH.sub.3CH.sub.3 H H cyclobutyl 0 A-4 OCF.sub.2 H -- -- -- -- HCH.sub.3 H H cyclobutyl 0 A-5 -- -- CH.sub.3 OCH.sub.3 -- --CH.sub.3 H H cyclobutyl 0 A-5 -- -- CH.sub.3 OCH.sub.2 CH.sub.3 -- --CH.sub.3 H H cyclobutyl 0 A-5 -- -- CH.sub.3 SCH.sub.3 -- --CH.sub.3 H H cyclobutyl 0 A-5 -- -- CH.sub.2 CH.sub.3 OCH.sub.3 -- --CH.sub.3 H H cyclobutyl 0 A-6 -- -- -- -- CH.sub.3 --CH.sub.3 H H cyclobutyl 0 A-6 -- -- -- -- OCH.sub.3 --__________________________________________________________________________
TABLE VI__________________________________________________________________________ m.p.R R.sub.1 n R.sub.2 R' X Y Z (.degree.C.)__________________________________________________________________________CH.sub.3 H 0 H cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 H cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 H cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 H cyclopropyl CH.sub.2 F CH.sub.3 CH__________________________________________________________________________
TABLE VII__________________________________________________________________________ m.p.R R.sub.1 n R.sub.2 R' X Y Z (.degree.C.)__________________________________________________________________________CH.sub.3 H 0 H cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 H cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopropyl Cl OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclobutyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 H cyclobutyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclobutyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclobutyl Cl OCH.sub.3 CHCH.sub.3 H 0 H cyclopentyl CH.sub.3 CH.sub.3 CHCH.sub.3 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 H 0 H cyclopentyl CH.sub.3 CH.sub.3 NCH.sub.3 H 0 H cyclopentyl CH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopentyl OCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopentyl Cl OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 CHCH.sub.3 H 0 H cyclopropyl cyclopropyl OCH.sub.3 CHCH.sub.3 H 0 H cyclopropyl OCH.sub.3 CH(OCH.sub.3).sub.2 CHCH.sub.3 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 H cyclopropyl NHCH.sub.3 OCH.sub.3 NCH.sub.3 H 0 H cyclopropyl OCH.sub.3 OCH.sub.2 CH.sub.3 NCH.sub.3 H 0 H cyclopropyl CH.sub.2 F CH.sub.3 CH__________________________________________________________________________
FORMULATIONS
Useful formulations of the compounds of Formula I can be prepared in conventional ways. They include dusts, granules, pellets, solutions, suspensions, emulsions, wettable powders, emulsifiable concentrates and the like. Many of these may be applied directly. Sprayable formulations can be extended in suitable media and used at spray volumes of from a few liters to several hundred liters per hectare. High strength compositions are primarily used as intermediates for further formulation. The formulations, broadly, contain about 0.1% to 99% by weight of active ingredient(s) and at least one of (a) about 0.1% to 20% surfactant(s) and (b) about 1% to 99.9% solid or liquid inert diluent(s). More specifically, they will contain these ingredients in the following approximate proportions:
______________________________________ Active Weight Percent* Ingredient Diluent(s) Surfactant(s)______________________________________Wettable Powders 20-90 0-74 1-10Oil Suspensions, 3-50 40-95 0-15Emulsions, Solutions,(including EmulsifiableConcentrates)Aqueous Suspension 10-50 40-84 1-20Dusts 1-25 70-99 0-5Granules and Pellets 0.1-95 5-99.9 0-15High Strength 90-99 0-10 0-2Compositions______________________________________ *Active ingredient plus at least one of a Surfactant or a Diluent equals 100 weight percent.
Lower or higher levels of active ingredient can, of course, be present depending on the intended use and the physical properties of the compound. Higher ratios of surfactant to active ingredient are sometimes desirable, and are achieved by incorporation into the formulation or by tank mixing.
Typical solid diluents are described in Watkins, et al., "Handbook of insecticide Dust Diluents and Carriers", 2nd Ed., Dorland Books, Caldwell, N.J., but other solids, either mined or manufactured, may be used. The more absorptive diluents are preferred for wettable powders and the denser ones for dusts. Typical liquid diluents and solvents are described in Marsden, "Solvents Guide,"2nd Ed., Interscience, New York, 1950. Solubility under 0.1% is preferred for suspension concentrates; solution concentrates are preferably stable against phase separation at 0.degree. C. "McCutcheon's Detergents and Emulsifiers Annual", MC Publishing Corp., Ridgewood, N.J., as well as Sisely and Wood, "Encyclopedia of Surface Active Agents", Chemical Publishing Co., Inc., New York, 1964, list surfactants and recommended uses. All formulations can contain minor amounts of additives to reduce foaming, caking, corrosion, microbiological growth, etc.
The methods of making such compositions are well known. Solutions are prepared by simply mixing the ingredients. Fine solid compositions are made by blending and, usually, grinding as in a hammer or fluid energy mill. Suspensions are prepared by wet milling (see, for example, Littler, U.S. Pat. No. 3,060,084). Granules and pellets may be made by spraying the active material upon preformed granular carriers or by agglomeration techniques. See J. E. Browning, "Agglomeration", Chemical Engineering, Dec. 4, 1967, pp. 147ff. and "Perry's Chemical Engineer's Handbook", 5th Ed., McGraw-Hill, N.Y., 1973, pp. 8-57ff.
For further information regarding the art of formulation, see for example:
H. M. Loux, U.S. Pat. No. 3,235,361, Feb. 15, 1966, Col. 6, line 16 through Col. 7, line 19 and Examples 10 through 41;
R. W. Luckenbaugh, U.S. Pat. No. 3,309,192, Mar. 14, 1967, Col. 5, line 43 through Col. 7, line 62 and Examples 8, 12, 15, 39, 41, 52, 53, 58, 132, 138-140, 162-164, 166, 167 and 169-182;
H. Gysin and E. Knusli, U.S. Pat. No. 2,891,855, June 23, 1959, Col. 3, line 66 through Col. 5, line 17 and Examples 1-4;
G. C. Klingman, "Weed Control as a Science", John Wiley and sons, Inc., New York, 1961, pp. 81-96; and
J. D. Fryer and S. A. Evans, "Weed Control Handbook", 5th Ed., Blackwell Scientific Publications, Oxford, 1968, pp. 101-103.
In the following Examples, all parts are by weight unless otherwise indicated.
EXAMPLE 4
Wettable Powder
______________________________________4-(Cyclopropylcarbonyl)-N--[(4,6-dimethoxypyrimidin 80%2-yl)aminocarbonyl]-1-methyl-1-H--pyrazole-5-sulfonamidesodium alkylnaphthalenesulfonate 2%sodium ligninsulfonate 2%synthetic amorphous silica 3%kaolinite 13%______________________________________
The ingredients are blended, hammer-milled until all the solids are essentially under 50 microns, reblended, and packaged.
EXAMPLE 5
Wettable Powder
______________________________________4-(Cyclopropylcarbonyl)-N--[(4,6-dimethoxypyrimidin 50%2-yl)aminocarbonyl]-1-methyl-1-H--pyrazole-5-sulfonamidesodium alkylnaphthalenesulfonate 2%low viscosity methyl cellulose 2%diatomaceous earth 46%______________________________________
The ingredients are blended, coarsely hammer-milled and then air-milled to produce particles essentially all below 10 microns in diameter. The product is reblended before packaging.
EXAMPLE 6
Granule
______________________________________Wettable Powder of Example 4 5%attapulgite granules 95%(U.S.S. 20 to 40 mesh; 0.84-0.42 mm)______________________________________
A slurry of wettable powder containing 25% solids is sprayed on the surface of attapulgite granules in a double-cone blender. The granules are dried and packaged.
EXAMPLE 7
Extruded Pellet
______________________________________4-(Cyclopropylcarbonyl)-N--[(4,6-dimethoxypyrimidin 25%2-yl)aminocarbonyl]-1-methyl-1-H--pyrazole-5-sulfonamideanhydrous sodium sulfate 10%crude calcium ligninsulfonate 5%sodium alkylnaphthalenesulfonate 1%calcium/magnesium bentonite 59%______________________________________
The ingredients are blended, hammer-milled and then moistened with about 12% water. The mixture is extruded as cylinders about 3 mm diameter which are cut to produce pellets about 3 mm long. These may be used directly after drying, or the dried pellets may be crushed to pass a U.S.S. No. 20 sieve (0.84 mm openings). The granules held on a U.S.S. No. 40 sieve (0.42 mm openings) may be packaged for use and the fines recycled.
EXAMPLE 8
Low Strength Granule
______________________________________4-(Cyclopropylcarbonyl)-N--[(4,6-dimethoxypyrimidin 0.1%2-yl)aminocarbonyl]-1-methyl-1-H--pyrazole-5-sulfonamideattapulgite granules 99.9%(U.S.S. 20 to 40 mesh)______________________________________
The active ingredient is dissolved in a solvent and the solution is sprayed upon dedusted granules in a double-cone blender. After spraying of the solution has been completed, the material is warmed to evaporate the solvent. The material is allowed to cool and then packaged.
EXAMPLE 9
Granule
______________________________________4-(Cyclopropylcarbonyl)-N--[(4,6-dimethoxypyrimidin 80%2-yl)aminocarbonyl]-1-methyl-1-H--pyrazole-5-sulfonamidewetting agent 1%crude ligninsulfonate salt (containing 10%5 to 20% of the natural sugars)attapulgite clay 9%______________________________________
The ingredients are blended and milled to pass through a 100 mesh screen. This material is then added to a fluid bed granulator, the air flow is adjusted to gently fluidize the material, and a fine spray of water is sprayed onto the fluidized material. The fluidization and spraying are continued until granules of the desired size range are made. The spraying is stopped, but fluidization is continued, optionally with heat, until the water content is reduced to the desired level, generally less than 1%. The material is then discharged, screened to the desired size range, generally 14 to 100 mesh (1410 to 149 microns), and packaged for use.
EXAMPLE 10
Low Strength Granule
______________________________________4-(Cyclopropylcarbonyl)-N--[(4,6-dimethoxypyrimidin 1%2-yl)aminocarbonyl]-1-methyl-1-H--pyrazole-5-sulfonamideN,N--dimethylformamide 9%attapulgite granules 90%(U.S.S. 20 to 40 sieve)______________________________________
The active ingredient is dissolved in the solvent and the solution is sprayed upon dedusted granules in a double cone blender. After spraying of the solution has been completed, the blender is allowed to run for a short period and then the granules are packaged.
EXAMPLE 11
Aqueous Suspension
______________________________________4-(Cyclopropylcarbonyl)-N--[(4,6-dimethoxypyrimidin 40%2-yl)aminocarbonyl]-1-methyl-1-H--pyrazole-5-sulfonamidepolyacrylic acid thickener 0.3%dodecylphenol polyethylene glycol ether 0.5%disodium phosphate 1%monosodium phosphate 0.5%polyvinyl alcohol 1.0%water 56.7%______________________________________
The ingredients are blended and ground together in a sand mill to produce particles essentially all under 5 microns in size.
EXAMPLE 12
Solution
______________________________________4-(Cyclopropylcarbonyl)-N--[(4,6-dimethoxypyrimidin 5%2-yl)aminocarbonyl]-1-methyl-1-H--pyrazole-5-sulfonamidewater 95%______________________________________
The salt is added directly to the water with stirring to produce the solution, which may then be packaged for use.
EXAMPLE 13
High Strength Concentrate
______________________________________4-(Cyclopropylcarbonyl)-N--[(4,6-dimethoxypyrimidin 99%2-yl)aminocarbonyl]-1-methyl-1-H--pyrazole-5-sulfonamidesilica aerogel 0.5%synthetic amorphous silica 0.5%______________________________________
The ingredients are blended and ground in a hammer-mill to produce a material essentially all passing a U.S.S. No. 50 screen (0.3 mm opening). The concentrate may be formulated further if necessary.
EXAMPLE 14
Wettable Powder
______________________________________4-(Cyclopropylcarbonyl)-N--[(4,6-dimethoxypyrimidin 90%2-yl)aminocarbonyl]-1-methyl-1-H--pyrazole-5-sulfonamidedioctyl sodium sulfosuccinate 0.1%synthetic fine silica 9.9%______________________________________
The ingredients are blended and ground in a hammer-mill to produce particles essentially all below 100 microns. The material is sifted through a U.S.S. No. 50 screen and then packaged.
EXAMPLE 15
Wettable Powder
______________________________________4-(Cyclopropylcarbonyl)-N--[(4,6-dimethoxypyrimidin 40%2-yl)aminocarbonyl]-1-methyl-1-H--pyrazole-5-sulfonamidesodium ligninsulfonate 20%montmorillonite clay 40%______________________________________
The ingredients are thoroughly blended, coarsely hammer-milled and then air-milled to produce particles essentially all below 10 microns in size. The material is reblended and then packaged.
EXAMPLE 16
Oil Suspension
______________________________________4-(Cyclopropylcarbonyl)-N--[(4,6-dimethoxypyrimidin 35%2-yl)aminocarbonyl]-1-methyl-1-H--pyrazole-5-sulfonamideblend of polyalcohol carboxylic 6%esters and oil soluble petroleumsulfonatesxylene 59%______________________________________
The ingredients are combined and ground together in a sand mill to produce particles essentially all below 5 microns. The product can be used directly, extended with oils, or emulsified in water.
EXAMPLE 17
Dust
______________________________________4-(Cyclopropylcarbonyl)-N--[(4,6-dimethoxypyrimidin 10%2-yl)aminocarbonyl]-1-methyl-1-H--pyrazole-5-sulfonamideattapulgite 10%Pyrophyllite 80%______________________________________
The active ingredient is blended with attapulgite and then passed through a hammer-mill to produce particles substantially all below 200 microns. The ground concentrate is then blended with powdered pyrophyllite until homogeneous.
UTILITY
Test results indicate that the compounds of the present invention are highly active preemergent or post-emergent herbicides or plant growth regulants. Many of them have utility for broad-spectrum pre- and/or post-emergence weed control in areas where complete control of all vegetation is desired, such as around fuel shortage tanks, ammunition depots, industrial storage areas, parking lots, drive-in theaters, around billboards, highway and railroad structures. Some of the compounds have utility for selective weed control in crops such as rice, wheat, barley, soybeans and corn. Some compounds of the invention are especially selective to wheat and rice. Alternatively, the subject compounds are useful to modify plant growth.
The rates of application for the compounds of the invention are determined by a number of factors, including their use as plant growth modifiers or as herbicies, the crop species involved, the types of weeds to be controlled, weather and climate, formulations selected, mode of application, amount of foliage present, etc. In general terms, the subject compounds should be applied at levels of around 0.001 to 10 kg/ha, the lower rates being suggested for use on lighter soils and/or those having a low organic matter content, for plant growth modification or for situations where only short-term persistence is required.
The compounds of the invention may be used in combination with any other commercial herbicide, examples of which are those of the triazine, triazole, imidazolinone, uracil, urea, amide, diphenylether, carbamate and bipyridylium types as well as other sulfonylureas. The compound of this invention is also especially useful in combination with the following herbicides.
______________________________________Common Name Chemical Name______________________________________alachlor 2-chloro-2',6'-diethyl-N--(methoxy- methyl)-acetanilideatrazine 2-chloro-4-(ethylamino)-6-(isopropyl- amino)- -s-triazinebutylate S--ethyl-diisobutylthiocarbamatecyanazine 2-[[4-chloro-6-(ethylamino)- -s-triazin-2- yl]amino]-2-methylpropionitriledicamba 3,6-dichloro- -o-anisic acidEPTC S--ethyl dipropylthiocarbamatelinuron 3-(3,4-dichlorophenyl)-1-methoxy-1- methylureametolachlor 2-chloro-N--(2-ethyl-6-methylphenyl)-N-- (2-methoxy-1-methylethyl)acetamidemetribuzin 4-amino-6-tert-butyl-3-(methylthio)-as- triazine-5(4H)--onetridiphane 2-(3,5-dichlorophenyl)-2-(2,2,2-tri- chloroethyl)oxirane2,4-D (2,4-dichlorophenoxy)acetic acidthiobencarb S--4-chlorobenzyldiethylthiocarbamatemolinate S--ethyl N,N--hexamethylenethiocarbamatebutachlor N--(butoxymethyl-2-chloro-2',6'-di- ethylacetanilidenaproanilide N--phenyl-2-(l-naphthyloxy)propionamidepyrazolate 4-(2,4-dichlorobenzoyl)-1,3-dimethyl- pyrazol-5-yl-4-toluenesulfonatepretilachlor 2-chloro-2',6'-diethyl-N--( -n-propoxy- ethyl)acetanilideoxidiazon 3-[2,4-dichloro-5-(1-methylethoxy)- phenyl]-5-(1,1-dimethylethyl)-1,3,4- oxadizol-2(3H)--one______________________________________Trade Name orCode Number Chemical Name______________________________________Harmony .RTM. 3-[[(4-methoxy-6-methyl-1,3,5-triazin- 2-yl)aminocarbonyl]aminosulfonyl]-2- thiophenecarboxylic acid, methyl esterCinch .RTM. exo-1-methyl-4-(1-methylethyl)-2-[(2- methylphenyl)methoxy]-7-oxabicyclo- [2.2.1]heptaneMy-93 S--(1-methyl-1-phenethyl)piperidine-1- carbothioateCH-83 S--(2-methylpropyl)-hexanhydro-1H--aze- pine-1-carbothioic acid, esterX-52 2,4-dichlorophenyl-3-methoxy-4-nitro- phenyl etherSC-2957 S--benzyl-N-- ethyl-N--propylthiocarbamateHW-52 N--(2,3-dichlorophenyl)-4-(ethoxy- methoxy)benzamideNTN-801 2-(benzothiazol-2-yl)-N--methyl-N-- phenylacetamideSL-49 2-[4-[(2,4-dichlorophenyl)carbonyl]- 1,3-dimethyl-1H--pyrazol-5-yloxy]-1- phenylethanoneBAS-514 3,7-dichloro-8-quinoline carboxylic acid______________________________________
The herbicidal properties of the subject compounds were discovered in a number of greenhouse tests. The test procedures and results follow.
______________________________________CompoundNumber X Y Z______________________________________ ##STR39##1 CH.sub.3 CH.sub.3 CH2 CH.sub.3 OCH.sub.3 CH3 OCH.sub.3 OCH.sub.3 CH4 CH.sub.3 OCH.sub.3 N5 OCH.sub.3 OCH.sub.3 N6 Cl OCH.sub.3 CH______________________________________ ##STR40##7 CH.sub.3 CH.sub.3 CH8 CH.sub.3 OCH.sub.3 CH9 OCH.sub.3 OCH.sub.3 CH10 CH.sub.3 OCH.sub.3 N11 OCH.sub.3 OCH.sub.2 N12 Cl OCH.sub.3 CH______________________________________ ##STR41##13 CH.sub.3 CH.sub.3 CH14 OCH.sub.3 CH.sub.3 CH15 OCH.sub.3 OCH.sub.3 CH______________________________________
TEST A
Seeds of crabgrass (Digitaria spp.), barnyardgrass (Echinochloa crusgalli), giant foxtail (Setaria faberi), wild oats (Avena fatua), cheatgrass (Bromus secalinus), velvetleaf (Abutilon theophrasti), morningglory (Ipomoea spp.), cocklebur (Xanthium pennsylvanicum), sorghum, corn soybean, sugarbeet, cotton, rice, wheat, barley and purple nutsedge (Cyperus rotundus) tubers were planted and treated preemergence with the test chemicals dissolved in a non-phytotoxic solvent. At the same time, these crop and weed species were treated with a soil/foliage application. At the time of treatment, the plants ranged in height from 2 to 18 cm. Treated plants and controls were maintained in a greenhouse for sixteen days, after which all species were compared to controls and visually rated for response to treatment. The ratings, summarized in Table A, are based on a numerical scale extending from 0=no injury, to 10=complete kill. The accompanying descriptive symbols have the following meanings:
C=chlorosis/necrosis
B=burn
D=defoliation
E=emergence inhibition
G=growth retardation
H=formative effect
U=unusual pigmentation
X=axillary stimulation
S=albinism
6Y=abscised buds or flowers
TABLE A Compound 1 Compound 2 Compound 3 Compound 4 Compound 5 Compound 6 CMPD 7 CMPD 8 CMPD 9 Rate kg/ha 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.01 0.05 0.01 0.05 0.01 0.05 POSTEMERGENCE Morningglory 9C 3C,8G 10C 10C 10C 10C 9C 3C,8G 5C,9G 3C,8H 10C 2C,4G 5C,9G 10C 10C 10C 2C,6G 10C Cocklebur 9C 5C,9G 10C 10C 10C 10C 9C 4C,9G 9H 3C,9H 9C 2C,8H 3C,6G 10C 10C 10C 10C 10C Velvetleaf 10C 9C 10C 10C 10C 10C 9C 3C,7H 2G 0 9C 3C,7H 4C,9H 9C 10C 10C 9C 10C Nutsedge 9G 3C,8G 5C,9G 9G 9G 9G 9G 2C,5G 9G 0 9G 9G 3C,7G 9C 9C 9C 8G 9C Crabgrass 3G 0 2G 0 2C,5G 2G 2C,5G 0 4G 0 0 0 2G 3C,7G 7G 4C,9G 4G 3C,9G Barnyardgrass 3H 0 5C,9H 3C,5H 5C,9H 6C,9H 3C,8H 0 9H 2H 2C,5H 0 4C,9H 9C 4C,9H 9C 9H 9C Cheatgrass 3C,7G 0 3C,9G 8G 2C,8G 7G 9G 0 3C,9G 0 2C,5G 0 9C 10C 10C 9C 9C 10C Wild Oats 0 0 2C,2G 0 0 0 0 0 0 0 0 0 3C,5G 3C,9G 2C,3G 4C,9G 2C,5G 2C,8G Sicklepod -- -- -- -- -- -- -- -- -- -- -- -- Wheat 0 0 0 0 2G 0 3G 0 0 0 0 0 7G 9G 5G 9G 2G 6G Corn 0 0 9H 2C,6G 9H 9H 3C,9H 3C,7H 3C,9H 2H 2G 0 3C,7H 3C,9G 4C,9H 6C,9G 9G 5C,9G Soybean 3H 0 3C,6H 3H 3C,5H 5H 3C,6H 2H 3C,6H 3C,3H 2C 0 4C,9G 5C,9G 4C,9G 9C 9C 5C,9G Rice 3G 0 3G 0 3G 0 3G 0 5C,9G 0 0 0 9C 9C 4C,8G 9C 4C,9G 5C,9G Sorghum 9G 3C,9H 4C,9G 4C,9G 9H 5H 2C,9H 2C,8G 4C,9G 3C,7H 3C,8H 2G 3C,9G 9C 5C,9G 9C 9G 5C,9G Sugar beet 9C 10C 9C 10C 9C 9C 5C,9H 4C,8H 4C,9H 4C,8G 5C,9G 8G 9C 9C 10C 9C 10C 9C Cotton 10C 3C,9H 10C 10C 10C 9C 4C,9G 8H 10C 5C,9G 9C 7G 4C,9G 10C 5C,9G 10C 4C,9G 10C Giant Foxtail 3C,6G 4C,9G 4C,8G 5C,9G 3C,7G 5C,9G Barley 3C,6G 2C,8G 3C,7G 6C,9G 2C,4G 3C,7G PREEMERGENCE Morningglory 8H 0 3C,7H 5G 9G 7G 9G 7H 3C,8G 2C,5H 2C,5H 0 7H 9G 3C,8H 8H 7G 8G Cocklebur 7H 2C,3H 9H 7H 9H -- 7H -- 7H 2C 2C,5H 0 9H 3C,5G 3C,7H 1H 8H Velvetleaf 7H 0 5C,9G 5H 9G 2H 2C,5H 2H 0 0 3C,7G 0 3C,6H 3C,9G 3C,5G 3C,9G 7H 4C,9G Nutsedge 10E 3C,8G 10E 10E 10E 10E 8G 5G 9G 9G 10E 0 3C,8G 10E 10E 10E 9G 10E Crabgrass 0 0 3C 0 3G 0 2C,3G 0 0 0 0 0 3G 3G 6G 4C,9G 3G 6G Barnyardgrass 2G 0 3C,7G 3G 9H 7H 4G 2H 3H 0 5G 0 3C,6G 4C,9H 3C,8G 9H 3C,7H 9H Cheatgrass 7G 0 9G 8G 9H 7G 7G 0 5G 0 3G 0 3C,7G 9G 9H 10E 8G 9H Wild Oats 0 0 1C 0 0 0 0 0 0 0 0 0 2C,4G 4C,8H 3C,3G 3C,7G 0 6G Sicklepod -- -- -- -- -- -- -- -- -- -- -- -- Wheat 0 2G 0 0 0 0 0 0 0 0 0 0 3G 3C,8H 2G 7G 0 2G Corn 3G 0 2C,9G 3C,7G 9G 5G 9H 3C,9H 9H 2C,8H 2C,6G 2G 3C,4G 4C,9H 3C,7G 3C,9H 3C,7G 8G Soybean 1H 0 3C,6H 2C,3H 2C,5H 0 3C,6H 3C,5H 3C,6H 3C,3H 0 0 3C,5G 3C,7H 4C,8H 9H 2C,4G 9H Rice 6G 5G 5G 2G 2G 0 6G 1C 3C,9H 5G 2G 0 9H 10E 9H 10H 9H 9H Sorghum 3C,9H 3C,8G 9G 8H 2C,9H 2G 9H 3C,9H 3C,9H 2C,8G 2C,7H 0 3C,8H 10E 3C,9H 10H 3C,8G 9H Sugar beet 3C,9G 3C,7H 4C,9G 4C,9G 9G 7G 5C,9G 8H 9G 8H 9G 5G 7G 9G 4C,9G 4C,9G 9G 9C Cotton 8G 0 9G 7H 9G 7G 2C,7H 2C,2G 3C,7H 0 3G 0 3C,6G 9G 3C,7H 9G 2G 6G Giant Foxtail 3C,5G 4C,8H 3C,8G 9H 3C,5G 9H Barley 3C,7G 9G 3C,8G 9G 2C,4G 7G CMPD 10 CMPD 11 CMPD 12 COMPD 13 COMPD 14 COMPD 15 Rate kg/ha 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 POSTEMERGENCE Morningglory 3C,7H 10C 3C,7H 10C 4C,8G 9C 2C,5G 3C,8G 3C,8G 9C 6G 10C Cocklebur 10C 10C 3C,8H 10C 10C 10C 5C,9G 10C 10C 10C 10C 10C Velvetleaf 3C,7H 6C,9H 6G 7G 9C 10C 4C,8H 10C 9C 10C 10C 10C Nutsedge 7G 9C 4G 5G 4C,9G 5C,9G 3C,7G 4C,9G 9G 10C 4C,9G 10C Crabgrass 3C,8G 9C 5C,8G 9C 2G 2C,5G 0 0 0 0 2G 3C,7G Barnyardgrass 9C 9C 5C,9H 10C 3C,7G 4C,9H 0 0 2H 2C,5G 3G 2C,7G Cheatgrass 9C 5C,9G 6C,9G 9C 7G 9C 3G 8G 8G 8G 6G 4C,9G Wild Oats 4C,8G 4C,9G 6C,9G 5C,9G 0 2C,2G 0 2G 0 3C,7G 0 0 Sicklepod Wheat 2C,8G 5C,9G 3C,9G 6C,9G 0 2C,4G 0 2G 0 5G 0 0 Corn 5C,9G 9C 9C 9C 2G 3C,7H 0 0 0 0 0 2C,2H Soybean 4C,9G 9C 5C,9G 6C,9G 3C,5H 4C,9G 1H 5H 2C,5H 3C,7H 3C,8H 5C,9G Rice 9C 9C 9C 9C 6G 9C 0 5G 0 2G 0 2G Sorghum 9C 10C 9C 9C 3C,9H 9G 0 0 0 2G 0 0 Sugar beet 9C 10C 9C 10C 9C 9C 9C 10C 4C,9G 9C 10C 10C Cotton 2C,9H 10C 5C,9H 5C,9G 4C,9G 10C 7G 4C,9G 9C 5C,9G 5C,9G 5C,9G Giant Foxtail 6C,9G 9C 5C,9G 9C 3C,3G 4C,8H 0 3G 0 3G 3G 4C,7G Barley 2C,6G 4C,9G 7G 9C 0 2C,3G 0 2G 0 3G 0 0 PREEMERGENCE Morningglory 2C,5H 9G 3C,3H 8G 3C,5G 5H 2G 8G 5G 9G 7G 8G Cocklebur 2C 3C,7H 0 3C,3H -- 2C,3H 9H 2C,4H 7H Velvetleaf 7H 3C,9G 0 5H 2H 5H 0 3C,8H 5H 4C,9G 3H 8G Nutsedge 4C,9G 10E 2C 10E 9G 10E 0 9G 10E 10E 5G 10E Crabgrass 4C,9G 9H 3C,8G 4C,8G 0 7G 0 0 0 2G 2C,3G 2C,5G Barnyardgrass 4C,9H 4C,9H 3C,7H 9H 4H 9H 0 2C,2H 0 5G 0 5G Cheatgrass 9H 10E 8H 10E 8G 9H 0 7G 0 8G 4G 9G Wild Oats 3C,7H 4C,8H 3C,6G 3C,7G 0 3G 0 3G 0 3G 0 0 Sicklepod Wheat 7G 2C,9H 7G 9H 0 3G 0 3G 0 4G 0 0 Corn 2C,8G 9G 3C,9G 3C,9G 2C 3C,9G 0 2G 0 3G 0 2G Soybean 3C,7H 9H 3C,7H 9H 3C,4H 3C,7H 0 0 0 6H 0 6H Rice 5C,9H 10E 9H 10E 8H 9H 0 0 0 0 0 0 Sorghum 9H 10H 5C,9H 10H 3C,8H 5C,9H 0 0 0 0 0 0 Sugar beet 9G 5C,9G 3G 3C,8G 8G 8G 7G 9G 7G 9G 9C 9G Cotton 5G 9G 4H 7H 4G 8G 0 7H 0 8G -- 4H Giant Foxtail 4c,9G 4C,9H 3C,8H 4C,9H 3G 9H 0 2G 0 3G 0 3G Barley 9G 4C,9H 9G 9G 4G 3C,5G 0 2G 0 0 0 2G
TEST B
Postemergence
Three round pans (25 cm diameter by 12.5 cm deep) were filled with Sassafras sandy loam soil. One pan was planted with nutsedge (Cyperus rotundus) tubers, crabgrass (Digitaria sanquinalis), sicklepod (Cassia obtusifolia), jimsonweed (Datura stramonium), velvetleaf (Abutilon theophrasti), lambsquarters (Chenopodium album), rice (Oryza sativa), and teaweed (Sida spinosa). The second pot was planted with green foxtail (Setaria viridis), cocklebur (Xanthium pensylvanicum), morningglory (Iopmoea hederacea), cotton (Gossypium hirsutum), johnsongrass (Sorghum halepense), barnyardgrass (Echinochloa crusgalli), corn (Zea mays), soybean (Glycine max), and giant foxtrail (Setaria faberi). The third pot was planted with wheat (Triticum aestivum), barley (Hordeum vulgare), wild buckwheat (Polygonum convolvulus L.), cheatgrass (Bromus secalinus L.), sugarbeet (Beta vulgaris), wild oat (Avena fatua L.), viola (Viola arvensis), blackgrass (Alopecurus myosuroides), and rape (Brassica napus). The plants were grown for approximately fourteen days, then sprayed post-emergence with the chemicals dissolved in a non-phytotoxic solvent.
Premergence
Three round pans (25 cm diameter by 12.5 cm deep) were filled with Sassafras sandy loan soil. One pan was planted with nutsedge tubers, crabgrass, sicklepod, jimsonweed, velvetleaf, lambsquarters, rice and teaweed. The second pot was planted with green foxtail, cocklebur, morningglory, cotton, johnsongrass, barnyardgrass, corn soybean, and giant foxtail. The third pot was planted with wheat, barley, wild buckwheat, cheatgrass, sugarbeet, wild oat, viola, blackgrass, and rape. The three pans were sprayed preemergence with the chemicals dissolved in a non-phytotoxic solvent.
Treated plants and controls were maintained in the greenhouse for approximately 24 days, then all rated plants were compared to controls and visually rated for plant response.
Response ratings are based on a scale of 0 to 100 where 0=no effect, and 100=completed control. A dash (-) response means no test.
Response ratings are contained in Table B.
TABLE B__________________________________________________________________________ CMPD 3 CMPD 10__________________________________________________________________________RATE RATE = G/HA 0001. 0004. 0016. 0062. 0.25 0001. 0004. 0016.__________________________________________________________________________POSTEMERGENCEGIANT FOXTAIL 0 30 60 80 0 20 50 80VELVETLEAF 60 100 100 100 30 40 60 80SUGAR BEETS 100 100 100 70 80 90 100CRABGRASS 0 30 50 70 0 0 60 60TEAWEED 30 50 70 90 60 60 70 80JIMSONWEED 30 50 70 100 0 40 70 80RICE 0 0 0 100 30 50 80 100COCKLEBUR 100 100 100 100 40 50 80 100COTTON 30 60 100 100 0 20 80 80SOYBEAN 0 0 20 60 70 100BARNYARD GRASS 0 0 60 100 20 60 70 100WILD OATS 0 0 0 0 50 80 90MORNINGGLORY 30 50 70 90 0 30 70 80WHEAT 0 0 0 0 20 50 90CASSIA 0 30 50 70 60 80 90JOHNSONGRASS 0 0 0 50 30 70 90 100NUTSEDGE 100 100 100 100 20 40 60 60CORN 0 30 50 0 40 90 90WILD BUCKWHEAT 30 50 70 0 50 90 90BLACK GRASS 0 30 50 20 70 80 100RAPESEED 100 100 100 40 80 90 100BARLEY 0 0 0 20 60 90 100GREEN FOXTAIL 0 0 30 60 30 60 70 90CHEAT GRASS 0 0 30 0 30 60 70BUCKWHEATVIOLA 70 90 100 0 40 90 100LAMBSQUARTER 50 70 90 100 40 70 90 100__________________________________________________________________________RATE RATE = G/HA 0004. 0016. 0062. 0.250 0001. 0004. 0016. 0062.__________________________________________________________________________PREEMERGENCEGIANT FOXTAIL 30 60 100 100 50 70 80 90VELVETLEAF 50 70 80 100 30 50 70 90SUGAR BEETS 60 70 80 90 70 90 100 100CRABGRASS 30 50 80 100 50 70 80 100TEAWEED 30 50 70 90 40 50 70 80JIMSONWEED 40 70 80 90 50 70 80 90RICE 0 0 30 80 90 100 100 100COCKLEBUR 50 70 80 90 60 70 80 90COTTON 0 30 60 80 20 40 60 80SOYBEAN 0 20 50 70 20 40 70 90BARNYARD GRASS 0 40 70 90 30 60 90 100WILD OATS 0 0 0 0 40 50 70 90MORNINGGLORY 30 70 80 90 30 50 60 70WHEAT 0 0 0 0 20 30 60 100CASSIA 30 50 60 80 80 90 100 100JOHNSONGRASS 30 50 70 90 70 80 90 100NUTSEDGE 100 100 100 100 0 30 60 90CORN 0 20 60 80 0 60 80 100WILD BUCKWHEAT 50 70 80 90 30 60 80 90BLACK GRASS 0 30 60 90 50 70 80 100RAPESEED 80 90 100 100 60 70 80 90BARLEY 0 0 0 0 20 40 90 100GREEN FOXTAIL 30 50 100 100 60 80 100 100CHEAT GRASS 0 30 60 90 50 80 100 100BUCKWHEATVIOLA 70 90 100 100 60 70 80 100LAMBSQUARTER 80 100 100 100 70 80 90 100__________________________________________________________________________
TEST C
Sixteen cm diameter Wagner pots, equipped with a stoppered drain opening near the bottom of the side wall, were partially filled with Woodstown sandy loam. About 1500 mls of water were added to each pot to bring the water level to a point 3 cm above the soil surface. Japonica and Indica rice seedlings were transplanted. Also, a number of barnyardgrass (Echinochloa crusgalli) seeds were added to each pot. At the same time, seedlings or tubers of the following species were transplanted into the muddy soil: water plantain (Alisma trivale), Scirpus (Scirpus mucranatus), and Cyperus (Cyperus difformis). The weed species selected for this test are of economic importance in major rice-growning areas. The chemical treatments were applied directly to the paddy water after being formulated in a non-phytotoxic solvent within hours after transplanting of two additional species: water chestnut (Eleocharis spp.) and arrowhead (Saqittaria latifolia). Shortly after treatment, the drain hole was opened to drop the water level by two cm. Water was then added to restore the water level to its original height. The following day the draining and refilling process was repeated. The pots were then maintained in the greenhouse. Rates of application and plant response ratings made 21 days after treatment are summarized in Table C.
TABLE C______________________________________RATE RATE = G/HA CMPD 3SOIL 0004. 0008. 0016.______________________________________BARNYARD GRASS 45 60 65WATER CHESTNUT 75 95 92ARROWHEAD 85 90 95SCIRPUS (SEDGE) 82 85 92CYPRESS (SEDGE) 92 95 100WATER PLANTAIN 87 100 100RICE JAP EFF 0 5 10RICE INDICA EFF 0 0 5______________________________________
Claims
  • 1. A compound of the formula ##STR42## wherein J is ##STR43## R is H, C.sub.1 -C.sub.3 alkyl, phenyl, SO.sub.2 NR.sub.a R.sub.b, C.sub.1 -C.sub.2 haloalkyl, C.sub.2 -C.sub.4 alkoxyalkyl, C.sub.2 -C.sub.3 cyanoalkyl, C.sub.2 -C.sub.4 alkylthioalkyl, C.sub.2 -C.sub.4 alkylsulfinylalkyl, C.sub.2 -C.sub.4 alkylsulfonylalkyl, CO.sub.2 C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.4 alkylcarbonyl, C.sub.1 -C.sub.2 alkylsulfonyl, C.sub.3 -C.sub.4 alkenyl, C.sub.3 -C.sub.4 alkynyl or C.sub.1 -C.sub.2 alkyl substituted with CO.sub.2 C.sub.1 -C.sub.2 alkyl;
  • R.sub.1 is H or CH.sub.3 ;
  • R.sub.2 is H, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 haloalkyl, halogen, nitro, C.sub.1 -C.sub.3 alkoxy, SO.sub.2 NR.sub.c R.sub.d, C.sub.1 -C.sub.3 alkylthio, C.sub.1 -C.sub.3 alkylsulfinyl, C.sub.1 -C.sub.3 alkylsulfonyl, CN, CO.sub.2 R.sub.e, C.sub.1 -C.sub.3 haloalkoxy, C.sub.1 -C.sub.3 haloalkylthio, amino, C.sub.1 -C.sub.2 alkylamino, di(C.sub.1 -C.sub.3 alkyl)amino or C.sub.1 -C.sub.2 alkyl substituted with C.sub.1 -C.sub.2 alkoxy, C.sub.1 -C.sub.2 haloalkoxy, C.sub.1 -C.sub.2 alkylthio, C.sub.1 -C.sub.2 haloalkylthio, CN, OH or SH;
  • R.sub.a and R.sub.b are independently C.sub.1 -C.sub.2 alkyl;
  • R.sub.c is H, C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.3 cyanoalkyl, methoxy or ethoxy;
  • R.sub.d is H, C.sub.1 -C.sub.4 alkyl or C.sub.3 -C.sub.4 alkenyl; or
  • R.sub.c and R.sub.d may be taken together as --(CH.sub.2).sub.3 --, --(CH.sub.2).sub.4 --, --(CH.sub.2).sub.5 -- or --CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 --;
  • R.sub.e is C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.4 alkenyl, C.sub.3 -C.sub.4 alkynyl, C.sub.2 -C.sub.4 haloalkyl, C.sub.2 -C.sub.3 cyanoalkyl, C.sub.5 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.7 cycloalkylalkyl or C.sub.2 -C.sub.4 alkoxyalkyl;
  • R' is C.sub.3 -C.sub.5 cycloalkyl;
  • E is a single bond or CH.sub.2 ;
  • W is O or S;
  • n is 0 or 1;
  • A is ##STR44## X is H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 haloalkylthio, C.sub.1 -C.sub.4 alkylthio, halogen, C.sub.2 -C.sub.5 alkoxyalkyl, C.sub.2 -C.sub.5 alkoxyalkoxy, amino, C.sub.1 -C.sub.3 alkylamino, di(C.sub.1 -C.sub.3 alkyl)amino or C.sub.3 -C.sub.5 cycloalkyl;
  • Y is H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 haloalkylthio, C.sub.1 -C.sub.4 alkylthio, C.sub.2 -C.sub.5 alkoxyalkyl, C.sub.2 -C.sub.5 alkoxyalkoxy, amino, C.sub.1 -C.sub.3 alkylamino, di(C.sub.1 -C.sub.3 alkyl)amino, C.sub.3 -C.sub.4 alkenyloxy, C.sub.3 -C.sub.4 alkynyloxy, C.sub.2 -C.sub.5 alkylthioalkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.4 alkynyl, azido, cyano, C.sub.2 -C.sub.5 alkylsulfinylalkyl, C.sub.2 -C.sub.5 alkylsulfonylalkyl, ##STR45## or N(OCH.sub.3)CH.sub.3 ; m is 2 or 3;
  • L.sub.1 and L.sub.2 are independently O or S;
  • R.sub.3 is H or C.sub.1 -C.sub.3 alkyl;
  • R.sub.4 and R.sub.5 are independently C.sub.1 -C.sub.3 alkyl;
  • Z is CH;
  • and their agriculturally suitable salts; provided that
  • (a) when X is Cl, F, Br or I, then Y is OCH.sub.3, OC.sub.2 H.sub.5, N(OCH.sub.3)CH.sub.3, NHCH.sub.3, N(CH.sub.3).sub.2 or OCF.sub.2 H;
  • (b) when W is S, then R.sub.1 is H and Y is CH.sub.3, OCH.sub.3, OC.sub.2 H.sub.5, CH.sub.2 OCH.sub.3, C.sub.2 H.sub.5, CF.sub.3, SCH.sub.3, OCH.sub.2 CH.dbd.CH.sub.2, OCH.sub.2 C.tbd.CH, OCH.sub.2 CH.sub.2 OCH.sub.3, CH(OCH.sub.3).sub.2 or 1,3-dioxolan-2-yl;
  • (c) when the total number of carbons of X and Y is greater than four, then the number of carbons of R must be less than or equal to two.
  • 2. Compounds of claim 1 where
  • E is a single bond; and
  • W is O.
  • 3. Compounds of claim 1 where
  • E is CH.sub.2 ; and
  • W is O.
  • 4. Compounds of claim 2 where
  • R.sub.2 is H, C.sub.1 -C.sub.3 alkyl, halogen, C.sub.1 -C.sub.3 alkyl substituted with 1 to 3 halogen atoms selected from 1 to 3 Cl, 1 to 3 F or 1 Br, OCH.sub.3, SO.sub.2 NHCH.sub.3, SO.sub.2 N(CH.sub.3).sub.2, S(O).sub.n CH.sub.3, CO.sub.2 CH.sub.3, CO.sub.2 CH.sub.2 CH.sub.3, OCF.sub.2 H, CH.sub.2 OCH.sub.3 or CH.sub.2 CN;
  • X is C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.2 alkoxy, Cl, F, Br, I, OCF.sub.2 H, CH.sub.2 F, CF.sub.3, OCH.sub.2 CH.sub.2 F, OCH.sub.2 CHF.sub.2, OCH.sub.2 CF.sub.3, CH.sub.2 Cl or CH.sub.2 Br; and
  • Y is H, C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.2 alkoxy, CH.sub.2 OCH.sub.3, CH.sub.2 OCH.sub.2 CH.sub.3, NHCH.sub.3, N(OCH.sub.3)CH.sub.3, N(CH.sub.3).sub.2, CF.sub.3, SCH.sub.3, OCH.sub.2 CH.dbd.CH.sub.2, OCH.sub.2 C.tbd.CH, OCH.sub.2 CH.sub.2 OCH.sub.3, CH.sub.2 SCH.sub.3, ##STR46## OCF.sub.2 H, OCF.sub.2 Br, SCF.sub.2 H, cyclopropyl, C.tbd.CH or C.tbd.CCH.sub.3.
  • 5. Compounds of claim 4 where
  • R is H, C.sub.1 -C.sub.3 alkyl, phenyl, CH.sub.2 CF.sub.3 or CH.sub.2 CH.dbd.CH.sub.2 ;
  • X is CH.sub.3, OCH.sub.3, OCH.sub.2 CH.sub.3, Cl or OCF.sub.2 H; and
  • Y is CH.sub.3, OCH.sub.3, C.sub.2 H.sub.5, CH.sub.2 OCH.sub.3, NHCH.sub.3, CH(OCH.sub.3).sub.2 or cyclopropyl.
  • 6. Compounds of claim 5 where
  • R.sub.2 is H, Cl, Br, OCH.sub.3 or CH.sub.3 ; and n is O.
  • 7. Compounds of claim 6 where J is J-1.
  • 8. Compounds of claim 6 where J is J-2.
  • 9. Compounds of claim 6 where J is J-3.
  • 10. Compounds of claim 6 where J is J-4.
  • 11. Compounds of claim 3 where
  • R is H, C.sub.1 C.sub.3 alkyl, phenyl, CH.sub.2 CF.sub.3 or CH.sub.2 CH.dbd.CH.sub.2 ;
  • R.sub.2 is H, Cl, Br, OCH.sub.3 or CH.sub.3 ;
  • n is O;
  • X is CH.sub.3, OCH.sub.3, OCH.sub.2 CH.sub.3, Cl or OCF.sub.2 H; and
  • Y is CH.sub.3, OCH.sub.3, C.sub.2 H.sub.5, CH.sub.2 OCH.sub.3, NHCH.sub.3, CH(OCH.sub.3).sub.2 or cyclopropyl.
  • 12. The compound of claim 1 which is
  • 4-(Cyclopropylcarbonyl)-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-1-methyl-1H-pyrazole-5-sulfonamide.
  • 13. An agriculturally suitable composition for controlling the growth of undesired vegetation comprises an effective amount of a compound of claim 1 and at least one of the following; surfactant, solid or liquid diluent.
  • 14. An agriculturally suitable composition for controlling the growth of undesired vegetation comprises an effective amount of a compound of claim 2 and at least one of the following; surfactant, solid or liquid diluent.
  • 15. An agriculturally suitable composition for controlling the growth of undesired vegetation comprises an effective amount of a compound of claim 3 and at least one of the following; surfactant, solid or liquid diluent.
  • 16. An agriculturally suitable composition for controlling the growth of undesired vegetation comprises an effective amount of a compound of claim 4 and at least one of the following; surfactant, solid or liquid diluent.
  • 17. An agriculturally suitable composition for controlling the growth of undesired vegetation comprises an effective amount of a compound of claim 5 and at least one of the following; surfactant, solid or liquid diluent.
  • 18. An agriculturally suitable composition for controlling the growth of undesired vegetation comprises an effective amount of a compound of claim 6 and at least one of the following; surfactant, solid or liquid diluent.
  • 19. An agriculturally suitable composition for controlling the growth of undesired vegetation comprises an effective amount of a compound of claim 7 and at least one of the following; surfactant, solid or liquid diluent.
  • 20. An agriculturally suitable composition for controlling the growth of undesired vegetation comprises an effective amount of a compound of claim 8 and at least one of the following; surfactant, solid or liquid diluent.
  • 21. An agriculturally suitable composition for controlling the growth of undesired vegetation comprises an effective amount of a compound of claim 9 and at least one of the following; surfactant, solid or liquid diluent.
  • 22. An agriculturally suitable composition for controlling the growth of undesired vegetation comprises an effective amount of a compound of claim 10 and at least one of the following; surfactant, solid or liquid diluent.
  • 23. An agriculturally suitable composition for controlling the growth of undesired vegetation comprises an effective amount of a compound of claim 11 and at least one of the following; surfactant, solid or liquid diluent.
  • 24. An agriculturally suitable composition for controlling the growth of undesired vegetation comprises an effective amount of a compound of claim 12 and at least one of the following; surfactant, solid or liquid diluent.
  • 25. A method for controlling the growth of desired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim 1.
  • 26. A method for controlling the growth of desired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim 2.
  • 27. A method for controlling the growth of desired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim 3.
  • 28. A method for controlling the growth of desired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim 4.
  • 29. A method for controlling the growth of desired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim 5.
  • 30. A method for controlling the growth of desired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim 6.
  • 31. A method for controlling the growth of desired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim 7.
  • 32. A method for controlling the growth of desired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim 8.
  • 33. A method for controlling the growth of desired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim 9.
  • 34. A method for controlling the growth of desired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim 10.
  • 35. A method for controlling the growth of desired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim 11.
  • 36. A method for controlling the growth of desired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim 12.
RELATED APPLICATIONS

This is a continuation-in-part of U.S. Ser. No. 859,275 filed May 2, 1986, now abandoned.

US Referenced Citations (1)
Number Name Date Kind
4370480 Levitt et al. Jan 1983
Foreign Referenced Citations (4)
Number Date Country
87780 Sep 1983 EPX
95925 Dec 1983 EPX
58-70407 Dec 1984 JPX
833850 Dec 1983 ZAX
Continuation in Parts (1)
Number Date Country
Parent 859275 May 1986