This invention pertains to implantable medical devices such as cardiac rhythm management devices. In particular, the invention relates to a method and system incorporated into such a device for gathering clinically useful physiological data.
Implantable cardiac rhythm management devices are commonplace today for the treatment of chronic or recurring cardiac arrhythmias. For example, cardiac pacemakers are implantable devices that replace or supplement a heart's compromised ability to pace itself (i.e., bradycardia) due to chronotropic incompetence or a conduction system defect by delivering electrical pacing pulses to the heart. Implantable cardioverter/defibrillators (ICD's) are devices that deliver electrical energy to the heart in order to reverse excessively rapid heart rates (tachycardia) including life threatening cardiac arrhythmias such as ventricular fibrillation. Since some patients have conditions that necessitate pacing and also render them vulnerable to life-threatening arrhythmias, implantable cardiac devices have been developed that combine both functions in a single device.
Cardiac rhythm management devices are typically implanted subcutaneously or submuscularly in a patient's chest and have leads threaded intravenously into the heart to connect the device to electrodes used for sensing and pacing. Leads may also be positioned on the epicardium by various means. A programmable electronic controller causes shocks to be delivered when fibrillation is detected or pacing pulses to be output in response to lapsed time intervals and sensed electrical activity. Pacemakers sense intrinsic cardiac electrical activity by means of internal electrodes disposed near the chamber to be sensed.
Modern cardiac rhythm management devices also typically have the capability to communicate data via a data link with an external programming device. Such data is transmitted to the pacemaker in order to program its mode of operation as well as define other operating parameters. Data transmitted from the pacemaker can be used to verify the operating parameters as well as relay information regarding the condition of both the pacemaker and the patient. Pacemaker patients are monitored at regular intervals as part of routine patient care and to check the condition of the device. Among the data which may typically be telemetered from the pacemaker are its programming parameters and an electrogram representing the electrical activity of the heart as sensed by the pacemaker.
Pacemakers have also been developed which monitor a patient's exertion level while the device is functioning in order to adjust the pacing rate. Such devices, referred to as rate-adaptive pacemakers, may use various measurable physiological parameters for this purpose that are related to exertion level including minute ventilation, body activity, electrogram intervals, and body temperature. Because of their continuous access to the patient and their communications capabilities, cardiac rhythm management devices and other similar implantable devices may also offer an ideal platform for gathering and storing clinically useful information which can later be transmitted to an external device.
The present invention is a method and system for monitoring temperature in an implantable medical device such as a cardiac pacemaker or implantable cardioverter/defibrillator. Data from these monitoring operations can then be stored in the memory of the device for later retrieval using an external programmer. In one embodiment, temperature measurements are collected at specified regular intervals to ascertain trends in the patient's temperature that may be useful in diagnosing certain medical conditions. The collection intervals may be made shorter or longer in order to detect fast or slow trends, respectively. Temperature data may also be collected to reflect average temperature variations over specified periods (e.g., daily) and at specific times of the day. Averages of temperature measurements taken over a period of time can also be used to compensate for component drift in the temperature sensor by calibrating the temperature sensor to match an average temperature which is assumed to be consistently maintained by the body.
In another embodiment, temperature measurements are associated with contemporaneous physiological measurements such as heart rate, respiratory rate, and body activity as well as any device activity to aid the clinician in interpreting the data. Detection of certain events such as arrhythmias or initiation of particular device activities may be used to trigger measurement of temperature and possibly other physiological variables.
Body temperature measurements may be taken using a temperature sensor incorporated into an intravenous lead or otherwise external to the device. Alternatively, temperature sensing circuitry internal to the device housing may be employed to provide the temperature measurement. Because device activity can affect its internal temperature, the system may require that temperature measurements using an internal sensor only be taken during periods in which the device is not actively delivering therapy. In a particular embodiment of an internal sensor, a proportional-to-absolute-temperature (PTAT) current typically used by the device electronics to generate a reference voltage is employed as a temperature sensor. Incorporating a temperature sensor within the device housing allows a clinician to determine if the temperature is within an acceptable range before allowing the device to become operational in a patient and also allows monitoring of temperature before implantation to determine if temperature extremes have occurred during storage which may adversely affect device operation. As the internal temperature of an electronic device may change during certain activities, such as delivery of shock pulses in the case of an implantable cardioverter/defibrillator, either no temperature data is collected during such activities or such data is flagged accordingly.
Another embodiment of the invention involves efficient storage and transmission of temperature data. Because of the limited range of temperature measurements taken within the human body, the range and resolution of stored temperature data can be adjusted so that less storage space is needed and data can be transmitted more efficiently. A non-linear range can also be used so that different resolutions are used with different temperatures.
A temperature sensor 50 communicates with the microprocessor via a sensor interface 51. The sensor 50 may be a resistive temperature detector driven by a current source that converts temperature changes in the patient's body into electrical signals. The sensor 50 may be incorporated into an external lead (e.g., an intravenous lead) or may be internal to the housing of the device. An example of such an internal sensor is described more fully below. The sensor interface 51 includes sampling circuitry for sampling the sensor output and an analog-to-digital converter for digitizing the samples that are then processed and stored by the microprocessor.
In accordance with the invention, the controller 10 is configured to store temperature measurements collected at specified regular intervals and/or collected when triggered by sensed events or initiation of particular device activity. For example, temperature measurements may be collected and stored at specified times on a daily basis with an associated time stamp. Other physiological measurements may also be simultaneously collected and associated with a temperature measurement, including measurements of heart rate, respiratory rate, minute ventilation, or body activity. A temperature measurement may also be triggered by other sensor activity such as when a measured exertion level measurement reaches a specified limit value or upon detection of a specified cardiac rhythm.
One use of periodic temperature measurements is to calculate a trend from the measurements indicating temperature changes over a specified period of time. The device can also be programmed to enable trending for a combination of heart rate, accelerometer measurements, respiratory rate, temperature, or other such inputs. Besides varying which inputs to trend, and the trending rate (e.g. fast/slow) can also be selectively varied, and each of the trended inputs could be sampled at an independent rate. For example, the heart rate could be sampled once every 16 seconds while the temperature is only sampled once every 15 minutes. The fast trending rate for the temperature could be once every 15 minutes and the slow trending rate could be once every hour. This trending data could then be read from the device on a daily or weekly interval depending on the trending rate. Another option is to gather trending information around some critical point in time. For example trending data could be gathered only around cardiac events or around patient activated times. Even if trending is not programmed, the basal temperature can still be recorded on a daily basis. This can be done by measuring the temperature at set time (e.g. 3 am) or after the patient activity is at a minimum (e.g. 2 hours at lower rate limit). This basal temperature data could be kept for the last 30 days or other specified time period.
Temperature sensors can drift over time due to component drift or such things as flicker noise. For example, when a PG is first calibrated it may read 98.8 deg as 98.7 degrees, and over time the error will vary. Over the life of the product the temperature error could be as much as a few degrees. As long as the error is known it can be subtracted from the indicated measurement in order to find the actual temperature. One method to do this automatically is to take advantage of the consistent average temperature of the human body. For example, if over a week the average temperature measured is 97.0 degrees, it could be assumed that the error term is −1.8 degrees. All the temperature measurements for the period can then be scaled up by 1.8 degrees. The temperature sensor can also be calibrated by programming the device with an actual temperature when measured by other means.
Temperature data collected as described above may be transmitted via the telemetry data link to an external programmer. After the temperature data has been transmitted, it can be further processed and graphically displayed. The further processing could include any of the following: adjusting temperature data to account for drift error in the measurement (i.e. autocalibration), comparing the temperature data to other previous data to determine trends, combining temperature data with device activity or other sensors, and plotting temperature verses a daily cycle or monthly cycle.
The temperature sensor 50 may either be incorporated into an intravenous lead or located within a housing for the sensor. The sensor may be of any convenient type such as a thermistor, resistive temperature detector, or thermocouple. A particular embodiment of a temperature sensing circuit internal to the device housing utilizes the proportional-to-absolute-temperature (PTAT) current typically generated by the device electronics. A PTAT current is normally used to generate a reference voltage with a bandgap reference voltage circuit, but also provides a convenient way of measuring the device temperature. Except when heat is being generated by the device, the device temperature is equilibrated with the body temperature so that the PTAT current varies with body temperature.
Incorporating the temperature sensor within the device housing means that the sensor is subject to heating caused by, for example, high currents when the device is delivering shock therapy or reforming the electrolytic capacitors used to deliver shock therapy. Temperature measurements may therefore be prohibited from being collected during such activity or within a specified time window afterward. Alternatively, such temperature measurements may be flagged accordingly.
Having a temperature sensor incorporated into the device housing also allows monitoring of temperatures before implantation such as when the device is being stored for long periods of time. During storage of the device, for example, the temperature may be measured once per hour with an alarm flag set if the temperature ever leaves safe storage temperature limits. The flag can be announced whenever the device is interrogated. Minimum and maximum storage temperatures can also be logged. The device can also be configured to issue an alarm if the present device temperature is not inside the safe operational temperature limits. This can happen because the storage temperature limits are broader than the operational temperature limits. If for example, the device has been brought in from a very cold environment (such as outside winter temperatures) and has not had sufficient time to warm up, the device could be outside of the operational temperature limits but still within safe storage limits.
Another aspect of the invention involves the manner in which temperature data is represented which impacts both the required storage space and transmission bandwidth. One method of compressing the storage space and transmission bandwidth of temperature data is to assume a fixed offset or to use a nonlinear compression scheme. For example, if an 8 bit linear scale is used to store temperature data, then the scale could be from 0 to 127.5 degrees with 0.5 degree resolution which is too coarse a resolution. With 0.1 degree resolution, the temperature range would only be 0.0 to 25.5 degrees, which is too small. If a 90 degree offset were to be used, the temperature range would become 90.0 to 115.5 degrees with a 0.1 degree resolution. This means that the 8 bit number represents the difference between 90 degrees and the actual temperature reading (e.g. a temperature of 98 degrees would be represented as 180, so 90+180/10=98). This would yield good temperature resolution over a limited range. The range and resolution could be adjusted for recording different types of information (e.g. −40 degree offset, 1 degree resolution as a coarse temperature range). An example of a nonlinear range would be to use a different resolution depending on the temperature. For example temperatures between −40 to 90 and 116 to 178 could have resolutions of 2 degree, and temperatures between 90 and 115.4 could have resolutions of 0.2 degrees.
Although the invention has been described in conjunction with the foregoing specific embodiment, many alternatives, variations, and modifications will be apparent to those of ordinary skill in the art. Such alternatives, variations, and modifications are intended to fall within the scope of the following appended claims.
This application is a continuation of U.S. patent application Ser. No. 12/210,508, filed on Sep. 15, 2008, now U.S. Pat. No. 8,055,338, which is a continuation of U.S. patent application Ser. No. 10/718,134, filed on Nov. 20, 2003, now U.S. Pat. No. 7,426,413, which is a division of U.S. patent application Ser. No. 09/823,260, filed on Mar. 30, 2001, now U.S. Pat. No. 6,662,048, the specifications of which are incorporated herein by reference.
Number | Name | Date | Kind |
---|---|---|---|
4341982 | Lahti et al. | Jul 1982 | A |
4441498 | Nordling | Apr 1984 | A |
4488824 | Salem | Dec 1984 | A |
4519401 | Ko et al. | May 1985 | A |
4542532 | McQuilkin | Sep 1985 | A |
4542535 | Bates et al. | Sep 1985 | A |
4543954 | Cook et al. | Oct 1985 | A |
4562841 | Brockway et al. | Jan 1986 | A |
4634294 | Christol et al. | Jan 1987 | A |
4803987 | Calfee et al. | Feb 1989 | A |
4944299 | Silvian | Jul 1990 | A |
4945909 | Fearnot et al. | Aug 1990 | A |
5005574 | Fearnot et al. | Apr 1991 | A |
5025808 | Hafner | Jun 1991 | A |
5029582 | Lekholm | Jul 1991 | A |
5089019 | Grandjean | Feb 1992 | A |
5109853 | Taicher et al. | May 1992 | A |
5113869 | Nappholz et al. | May 1992 | A |
5314453 | Jeutter | May 1994 | A |
5336244 | Weijand | Aug 1994 | A |
5342408 | deCoriolis et al. | Aug 1994 | A |
5350412 | Hoegnelid et al. | Sep 1994 | A |
5370666 | Lindberg et al. | Dec 1994 | A |
5476485 | Weinberg et al. | Dec 1995 | A |
5476488 | Morgan et al. | Dec 1995 | A |
5486200 | Lindemans | Jan 1996 | A |
5516285 | Yacker et al. | May 1996 | A |
5535752 | Halperin et al. | Jul 1996 | A |
5579876 | Adrian et al. | Dec 1996 | A |
5593430 | Renger | Jan 1997 | A |
5598847 | Renger | Feb 1997 | A |
5650759 | Hittman et al. | Jul 1997 | A |
5683432 | Goedeke et al. | Nov 1997 | A |
5697958 | Paul et al. | Dec 1997 | A |
5752977 | Grevious et al. | May 1998 | A |
5766232 | Grevious et al. | Jun 1998 | A |
5807397 | Barreras | Sep 1998 | A |
5833603 | Kovacs et al. | Nov 1998 | A |
5843139 | Goedeke et al. | Dec 1998 | A |
5861019 | Sun et al. | Jan 1999 | A |
5904708 | Goedeke | May 1999 | A |
5919210 | Lurie et al. | Jul 1999 | A |
6009350 | Renken | Dec 1999 | A |
6093146 | Filangeri | Jul 2000 | A |
6115583 | Brummer et al. | Sep 2000 | A |
6115634 | Donders et al. | Sep 2000 | A |
6115636 | Ryan | Sep 2000 | A |
6169925 | Villaseca et al. | Jan 2001 | B1 |
6240317 | Villaseca et al. | May 2001 | B1 |
6254548 | Ishikawa et al. | Jul 2001 | B1 |
6263246 | Goedeke et al. | Jul 2001 | B1 |
6275737 | Mann | Aug 2001 | B1 |
6309350 | VanTassel et al. | Oct 2001 | B1 |
6310512 | Briskin et al. | Oct 2001 | B1 |
6329920 | Morrison et al. | Dec 2001 | B1 |
6388628 | Dettloff et al. | May 2002 | B1 |
6398727 | Bui et al. | Jun 2002 | B1 |
6424867 | Snell et al. | Jul 2002 | B1 |
6427088 | Bowman, IV et al. | Jul 2002 | B1 |
6434429 | Kraus et al. | Aug 2002 | B1 |
6443891 | Grevious | Sep 2002 | B1 |
6456256 | Amundson et al. | Sep 2002 | B1 |
6470215 | Kraus et al. | Oct 2002 | B1 |
6490487 | Kraus et al. | Dec 2002 | B1 |
6531982 | White et al. | Mar 2003 | B1 |
6564104 | Nelson et al. | May 2003 | B2 |
6564105 | Starkweather et al. | May 2003 | B2 |
6574509 | Kraus et al. | Jun 2003 | B1 |
6574510 | Von Arx et al. | Jun 2003 | B2 |
6577900 | Silvian | Jun 2003 | B1 |
6577901 | Thompson et al. | Jun 2003 | B2 |
6582365 | Hines et al. | Jun 2003 | B1 |
6585644 | Lebel et al. | Jul 2003 | B2 |
6600952 | Snell et al. | Jul 2003 | B1 |
6602191 | Quy | Aug 2003 | B2 |
6614406 | Amundson et al. | Sep 2003 | B2 |
6622043 | Kraus et al. | Sep 2003 | B1 |
6622050 | Thompson | Sep 2003 | B2 |
6659948 | Lebel et al. | Dec 2003 | B2 |
6662048 | Balczewski et al. | Dec 2003 | B2 |
6675045 | Mass et al. | Jan 2004 | B2 |
6687546 | Lebel et al. | Feb 2004 | B2 |
6708065 | Von Arx et al. | Mar 2004 | B2 |
6809701 | Amundson et al. | Oct 2004 | B2 |
7069086 | Von Arx | Jun 2006 | B2 |
7426413 | Balczewski et al. | Sep 2008 | B2 |
20010027331 | Thompson | Oct 2001 | A1 |
20010047125 | Quy | Nov 2001 | A1 |
20020013614 | Thompson | Jan 2002 | A1 |
20020065539 | Von Arx et al. | May 2002 | A1 |
20020147388 | Mass et al. | Oct 2002 | A1 |
20030018369 | Thompson et al. | Jan 2003 | A1 |
20030028902 | Cubley et al. | Feb 2003 | A1 |
20030114897 | Von Arx et al. | Jun 2003 | A1 |
20030114898 | Von Arx et al. | Jun 2003 | A1 |
20030149459 | Von Arx et al. | Aug 2003 | A1 |
20040102815 | Balczewski et al. | May 2004 | A1 |
20040260363 | Arx et al. | Dec 2004 | A1 |
20050134520 | Rawat et al. | Jun 2005 | A1 |
20090012574 | Balczewski et al. | Jan 2009 | A1 |
Number | Date | Country |
---|---|---|
0168640 | Jan 1986 | EP |
1050265 | Nov 2000 | EP |
5-54066 | Jul 1994 | JP |
7-22702 | Apr 1995 | JP |
8-503648 | Apr 1996 | JP |
WO-9509028 | Apr 1995 | WO |
WO-0247545 | Jun 2002 | WO |
Entry |
---|
“U.S. Appl. No. 09/823,260, Non-Final Office Action mailed Dec. 17, 2002”, 10 pgs. |
“U.S. Appl. No. 09/823,260, Notice of Allowance mailed Jul. 15, 2003”, 5 pgs. |
“U.S. Appl. No. 09/823,260, Response filed Apr. 17, 2003 to Non-Final Office Action mailed Dec. 17, 2002”, 8 pgs. |
“U.S. Appl. No. 10/718,/134, Notice of Allowance mailed May 16, 2008”, 8 pgs. |
“U.S. Appl. No. 10/718,134, Final Office Action mailed Dec. 10, 2007”, 7 pgs. |
“U.S. Appl. No. 10/718,134, Non-Final Office Action mailed Jun. 1, 2007”, 7 pgs. |
“U.S. Appl. No. 10/718,134, Response filed Oct. 1, 2007 to Office Action mailed Jul. 1, 2007”, 8 pgs. |
“U.S. Appl. No. 10/718,134, Response filed Feb. 11, 2008 to Final Office Action mailed Dec. 10, 2007”, 7 pages. |
“U.S. Appl. No. 12/210,508, Final Office Action mailed May 4, 2011”, 5 pgs. |
“U.S. Appl. No. 12/210,508, Non Final Office Action mailed Dec. 7, 2010”, 8 pgs. |
“U.S. Appl. No. 12/210,508, Notice of Allowance mailed Jul. 19, 2011”, 5 pgs. |
“U.S. Appl. No. 12/210,508, Response filed Apr. 7, 2011 to Non Final Office Action mailed Dec. 7, 2010”, 9 pgs. |
“U.S. Appl. No. 12/210,508, Response filed Jul. 5, 2011 to Final Office Action mailed May 4, 2011”, 5 pgs. |
“European Application Serial No. 02723654.6, Examination Report mailed Apr. 22, 2005”, 4 pgs. |
“European Application Serial No. 02723654.6, Examination Report mailed May 26, 2006”, 3 pgs. |
“European Application Serial No. 02723654.6, Response filed Oct. 25, 2005 to Examination Report mailed Apr. 22, 2005”, 8 pgs. |
“European Application Serial No. 02723654.6, Response filed Nov. 22, 2006 to Examination Report mailed May 26, 2006”, 4 pgs. |
“European Application Serial No. 03785021.1, Examination Notification Art. 94(3) mailed Dec. 9, 2010”, 6 pgs. |
“European Application Serial No. 03785021.1, Office Action Response Filed Apr. 19, 2011”, 3. |
“International Application Serial No. PCT/US02/09644, International Preliminary Examination Report mailed Feb. 12, 2003”, 3 pgs. |
“International Application Serial No. PCT/US02/09644, International Search Report mailed Jul. 25, 2002”, 4 pgs. |
“International Application Serial No. PCT/US02/09644, Written Opinion mailed Nov. 12, 2002”, 2 pgs. |
“International Application Serial No. PCT/US03/24778, International Search Report mailed May 3, 2004”, 8 pgs. |
“Japanese Application No. 2004-527861, Notice of Allowance mailed Jun. 16, 2010”, 3 pgs. |
“Japanese Application Serial No. 2004-527861, Amended Claims filed Nov. 16, 2009”, (w/ English Translation of Amended Claims), 10 pgs. |
“Japanese Application Serial No. 2004-527861, Office Action mailed Jul. 30, 2009”, (w/ English Translation), 7 pgs. |
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20120046708 A1 | Feb 2012 | US |
Number | Date | Country | |
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Parent | 09823260 | Mar 2001 | US |
Child | 10718134 | US |
Number | Date | Country | |
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Parent | 12210508 | Sep 2008 | US |
Child | 13287751 | US | |
Parent | 10718134 | Nov 2003 | US |
Child | 12210508 | US |