Integrated Studies of Vertebrate Renal Taurine Transport

Information

• NSF Award
• 9306555

Owner

• University of Oklahoma Health Sciences Center

• Award Id

  9306555

• Award Effective Date

  9/1/1993 - 32 years ago

• Award Expiration Date

  2/28/1998 - 27 years ago

• Award Amount

  $ 164,999.00

• Award Instrument

  Continuing grant

9306555 Benyajati The goal of this proposal is to elucidate the mechanisms and regulation of the transport of taurine in vertebrate kidneys. Taurine is an abundant amino acid which functions as an intracellular osmolyte, important in the regulation of cell volume. The snake kidney can simultaneously reabsorb and secrete taurine and membrane and membrane vesicle preparations have been used to study the transport mechanisms in this species. The experiments in this proposal will test the hypothesis that secretion of taurine across the kidney cells occurs under conditions of low osmolality, low NaCl/and or high K+concentration in the extracellular fluid. These studies will be done in intact animals, isolated units of the kidney (nephrons) and isolated membranes. Conditions of renal transport in vivo will be correlated with the specific transport characteristics at the membrane level in vitro. These studies will provide new information on the mechanisms by which taurine preforms its functions, and will also aid in understanding osmoregulation at the cellular and organismic levels. ***

• Program Officer

  Ione Hunt Von Herbing

• Min Amd Letter Date

  8/10/1993 - 32 years ago

• Max Amd Letter Date

  5/30/1995 - 30 years ago

• ARRA Amount

• Name

  University of Oklahoma Health Sciences Center

• City

  Oklahoma City

• State

  OK

• Country

  United States

• Address

  865 Research Parkway

• Postal Code

  731043609

• Phone Number

  4052712090

• First Name

  Siribhinya

• Last Name

  Benyajati

• Start Date

  9/1/1993 12:00:00 AM

• Name

  Health

• Code

  203000

• Name

  Life Science Biological

• Code

  61

• Text

  ANIMAL SYSTEMS PHYSIOLOGY

• Code

  1146

• Text

  INTEGRATIVE ANIMAL BIOLOGY

• Code

  1155

• Text

  UNASSIGNED

• Code

  0

• Text

  OTHER RESEARCH OR EDUCATION