MECHANISTIC BASED GENOTOXICITY ASSAY

Information

• Research Project
• 2649388

• ApplicationId

  2649388

• Core Project Number

  R43ES009473

• Full Project Number

  1R43ES009473-01

• Serial Number

  9473

• FOA Number

• Sub Project Id

• Project Start Date

  5/1/1998 - 27 years ago

• Project End Date

  4/30/1999 - 26 years ago

• Program Officer Name

• Budget Start Date

  5/1/1998 - 27 years ago

• Budget End Date

  4/30/1999 - 26 years ago

• Fiscal Year

  1998

• Support Year

  1

• Suffix

• Award Notice Date

  4/23/1998 - 27 years ago

Organizations

• SYMBIOTECH, INC.

This proposal aims to develop a mechanistic-based genotoxicity assay that is rapid and inexpensive and measures three genotoxicity endpoints. The assay involves three genetically engineered strains of yeast, one for each endpoint. The strains are designed to assess the effect of suspected toxins on a particular yeast mechanism, thus the assay is mechanistic-based. The assay can be used in place of standard mutagenicity assays and provides mode-of-action data that could prove valuable in human risk assessment of carcinogenicity. PROPOSED COMMERCIAL APPLICATION The assay proposed herein is rapid and inexpensive and has advantages over commercially available assays with similar properties. The assay will be useful to industries, the EPA, NIH, DOD and other government agencies where toxic chemicals are employed.

IC Name

• Activity

  R43

• Administering IC

  ES

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  114

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  ZRG5

• Study Section Name

• Organization Name

  SYMBIOTECH, INC.

• Organization Department

• Organization DUNS

• Organization City

  WALLINGFORD

• Organization State

  CT

• Organization Country

  UNITED STATES

• Organization Zip Code

  06492

• Organization District

  UNITED STATES