Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge

Description

TECHNICAL FIELD

Lancing devices are well known in the medical health-care products industry for piercing the skin to produce blood for analysis. Biochemical analysis of blood samples is a diagnostic tool for determining clinical information. Many point-of-care tests are performed using capillary whole blood, the most common being monitoring blood glucose level in diabetics. Typically, a drop of blood is obtained by making a small incision in the fingertip, creating a small wound, which generates a small blood droplet on the surface of the skin.

BACKGROUND ART

Early methods of lancing included piercing or slicing the skin with a needle or razor. Current methods utilize lancet drivers that contain a multitude of spring, cam and mass actuators to drive the lancet. These include cantilever springs, diaphragms, coil springs, as well as gravity plumbs to actuate the lancet. Typically, the device is pre-cocked, or the user cocks the device. The device is held against the skin and the user mechanically triggers the ballistic launch of the lancet.

The problem with current devices is that they require two hands to operate, one to hold the device and push a button which activates the device, and the other hand to provide a finger for lancing. After lancing, the finger needs to be free to move to another device for collection of the blood droplet and subsequent analysis.

Generally, known methods of blood sampling require several steps. First, a measurement session is set up by gathering various paraphernalia such as lancets, launchers, test strips, instrument, etc. Second, the patient must assemble the paraphernalia by loading a sterile lancet, loading a test strip, and arming the launcher.

Third, the patient must place their finger against the lancet launcher and using the other hand activate the launcher. Fourth, the patient must put down the launcher and place the bleeding finger against a test strip, which may or may not have been loaded into the instrument. The patient must insure blood has been loaded onto the test strip and the instrument has been calibrated prior to such loading. Finally, the patient must dispose of all the blood contaminated paraphernalia including the lancet. What has been needed is a blood sampling device and method that simplifies the blood sampling procedure.

DISCLOSURE OF INVENTION

Embodiments of the present invention are related to medical health-care products and to methods for obtaining blood for chemical analysis. More particularly, embodiments of the invention relate to devices and methods for piercing the skin (lancing) with a sensor to detect the presence of a patient's finger and activate the lancet automatically. In some embodiments, the cartridge and lancet are disposable.

In accordance with embodiments of the invention, a patient will be able to obtain a sample of blood in an ergonomic, convenient way using a method and apparatus which integrates lancing, sample collection, and analysis. The presence of patients finger on the ergonomic sampling area is sensed by monitoring the pressure applied by the finger on the cartridge which houses the lancet. The application of a predetermined pressure is measured by a piezoelectric or electrical circuit.

Advantages can be achieved in a blood sampling device by integrating the lancing and blood sample collection procedure so that the device can capture and transport the capillary blood from the wound created by the lancet to a desired active area, such as a strip for analyzing glucose. This can be done in embodiments of the invention by integrating the lancet, conduit and reservoir into a disposable cartridge which can be inserted into a hand-held sampling device with instrumentation for analyzing the blood sample.

In the use of an embodiment of the invention, a finger is placed over an ergonomically contoured sampling area and pressure is applied with the finger so that a sensor will activate the lancet, which will, in turn, lance the finger and allow the blood sample to be collected in the conduit and transported to the reservoir for analysis in a single step from the patient's perspective.

BRIEF DESCRIPTION OF DRAWING

The objects, advantages and features of this invention will be more readily appreciated from the following detailed description, when read in conjunction with the accompanying drawing, in which:

FIG. 1 is a drawing of the cartridge which houses the lancet.

FIG. 2 is a drawing of the chamber in the sampling device where the cartridge is loaded.

FIG. 3 is a drawing of the cartridge loaded into the sampling device.

FIG. 4 is a drawing of an alternate lancet configuration.

FIG. 5 is a drawing of the orifice and ergonomically contoured sampling area.

FIG. 6 is a drawing of the lancing event.

BEST MODE FOR CARRYING OUT THE INVENTION

Reference will now be made to embodiments of the invention, examples of which are illustrated in the accompanying drawings. Wherever possible, the same reference numbers will be used throughout the drawings to refer to the same or like parts.

FIG. 1 shows the disposable cartridge (10) which houses the lancet (12).

Disposable means that the cartridge is used for one lancing cycle and is then discarded.

The lancet (12) has a distal end (16) which connects to the driver (40) and a proximal end (14) which lances the skin. The proximal end (14) is embedded within the conduit (18). Embedded means completely shielded by the cartridge when it is not lancing. The distal end (16) extends into the cavity (20). The reservoir (22) has a narrow opening (24) on the ergonomically contoured surface (26) which is adjacent to the proximal end (14) of the lancet (12). The term ergonomically contoured is generally defined to mean shaped to snugly fit a finger placed on the surface. The term reservoir is generally defined to mean an area which allows pooling of the blood sample. The term narrow is generally defined to mean a reduction in diameter of the reservoir so as to exploit capillary forces to better channel the blood into the rest of the reservoir. The term adjacent, as used in the context of the proximity of the proximal end (16) and narrow opening (24), is generally defined to mean that the proximal end (16) and the narrow opening (24) are located in the same general area. The cartridge (10) is capable of channeling the blood sample, which means transporting through small passages (not shown), to an active area (28) which corresponds to the device's system for analyzing the blood. This system can consist of a chemical, physical, optical, electrical or other means of analyzing the blood sample. The lancet and reservoir embodiment illustrated are integrated into the cartridge in a single packaged unit.

FIG. 2 shows the chamber (30) in the sampling device where the cartridge is loaded. The cartridge is loaded on a socket (32) suspended with springs (34) and sits in slot (36). The launcher (38) is attached to the socket (32). The launcher has a proximal end (40) and a distal end (42). The launcher is any mechanical (such as spring or cam driven) or electrical (such as electromagnetically or electronically driven) means for advancing, stopping, and retracting the lancet. There is a clearance (44) between the distal end of the launcher (42) and the sensor (46) which is attached to the chamber (30). The socket (32) also contains the system for analyzing the blood (48) which corresponds to the active area (28) on the cartridge (10) when it is loaded into the socket (32).

FIG. 3 shows a cartridge (10) loaded into the socket (32). The active area (28) and system for analyzing the blood (48) overlap. The launcher (38) fits into the cavity (20). The proximal end (40) of the launcher (38) abuts the distal end (16) of the lancet (12). The patient's finger (50) sits on the ergonomically contoured surface (26).

FIG. 4 shows a drawing of an alternate lancet configuration where the lancet (12) and launcher (38) are oriented to lance the side of the finger (50) as it sits on the ergonomically contoured surface (26).

FIG. 5 illustrates with exploded detail the orifice (52) and ergonomically contoured surface (26). The conduit (18) has an orifice (52) which opens on a blood well (54). The narrow opening (24) of the reservoir (22) also opens on the blood well (54). The diameter of the narrow opening (24) is significantly greater than the diameter of the orifice (52) which is substantially the same diameter as the diameter of the lancet (12). After the lancet is retracted, the blood flowing from the finger (50) will collect in the blood well (54). The lancet (12) will have been retracted into the orifice (52) effectively blocking the passage of blood down the orifice (52). The blood will flow from the blood well (54) through the narrow opening (24) into the reservoir (22).

FIG. 6 shows a drawing of the lancing event. The patient applies pressure by pushing down with the finger (50) on the ergonomically contoured surface (26). This applies downward pressure on the cartridge (10) which is loaded into the socket (32).

As the socket (32) is pushed downward it compresses the springs (34). The sensor (46) makes contact with the distal end (42) of the launcher (38) and thereby detects the presence of the finger on the ergonomically contoured surface. Detection means sensing using electrical means. The sensor is a piezoelectric device which detects this pressure and sends a signal to circuit (56) which actuates the launcher (38) and advances and then retracts the lancet (12) lancing the finger (50). In another embodiment, the sensor (46) is an electric contact which closes a circuit when it contacts the launcher (38) activating the launcher (38) to advance and retract the lancet (12) lancing the finger (50).

Activating means beginning the lancing event, which consists of advancing, stopping, and retracting the lancet.

An embodiment of the invention is a method of sampling which reduces the number of steps that must be taken by a patient to obtain a sample and analysis of the sample. First, the patient loads a cartridge with an embedded sterile lancet into the device. Second, the patient initiates a lancing cycle by turning on the power to the device or by placing the finger to be lanced on the ergonomically contoured surface and pressing down. Initiation means arming the device. This initiation prompts the sensor.

Prompting means that the sensor is made operational and given control to activate the launcher. Prompting is a safety precaution to avoid unintentionally launching the lancet.

The sensor is unprompted when the lancet is retracted after its lancing cycle to avoid multiple lancing events that would cause unnecessary pain and obstruct the collection of the blood sample. The lancing cycle consists of arming, advancing, stopping and retracting the lancet, and collecting the blood sample in the reservoir. The cycle is complete once the blood sample has been collected in the reservoir. Third, the patient presses down on the cartridge which forces the launcher to make contact with the sensor and activates the launcher. The lancet then pierces the skin and the reservoir collects the blood sample. The patient is then optionally informed to remove the finger by an audible signal such as a buzzer or a beeper, and/or a visual signal such as an LED or a display screen. The patient can then dispose of all the contaminated parts by removing the cartridge and disposing of it. In another embodiment, multiple cartridges may be loaded into the sampling device in the form of a cassette. The patient is informed by the device as to when to dispose of the entire cassette after the analysis is complete.

Other embodiments of the invention will be apparent to those skilled in the art from consideration of the specification and practice of the invention disclosed herein.

It is intended that the specification and examples be considered as exemplary only, with a true scope and spirit of the invention being indicated by the following claims.

Claims

1. A method of sampling comprising of the steps of: loading a disposable cartridge with an embedded lancet into a lancing device;placing a piece of skin on a surface of said cartridge, the surface being ergonomically contoured to a finger;initiating a lancing cycle by prompting a sensor on said lancing device;activating a launcher;lancing said skin to obtain a blood sample;unprompting said sensor upon retraction of said lancet;collecting said blood sample; anddisposing said cartridge.
2. A method of sampling according to claim 1 further comprising of the step of: analyzing said blood sample.
3. A method of sampling according to claim 1 further comprising of the step of: informing a user to remove said skin when said lancing cycle is complete.
4. A method of sampling according to claim 3 wherein: informing said user further comprises giving an audible signal when said lancing cycle is complete.
5. A method of sampling according to claim 3 wherein: informing said user further comprises giving a visual signal when said lancing cycle is complete.
6. A method of sampling according to claim 1 wherein: activating said launcher comprises applying pressure through said skin to said surface.
7. A method of sampling comprising of the steps of: loading a disposable cartridge with an embedded lancet into a lancing device;initiating a lancing cycle and activating a sensor on said lancing device by placing a piece of skin on a surface of said cartridge, the surface being ergonomically contoured to a finger;lancing the skin surface of the finger to obtain a blood sample;unprompting said sensor upon retraction of said lancet;collecting said blood sample; andtransferring said cartridge for analysis.
8. A method of sampling according to claim 7 further comprising of the step of: analyzing said blood sample.
9. A method of sampling according to claim 7 further comprising of the step of: informing a user to remove said skin when said lancing cycle is complete.
10. A method of sampling according to claim 9 wherein: informing said user further comprises giving an audible signal when said lancing cycle is complete.
11. A method of sampling according to claim 9 wherein: informing said user further comprises giving a visual signal when said lancing cycle is complete.
12. A method of sampling according to claim 7 wherein: activating said launcher comprises applying pressure through said skin to said surface.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a divisional of U.S. Ser. No. 10/363,510 filed Sep. 29, 2003 (now U.S. Pat. No. 7,749,174, which is a §3.71 filing of PCT/US02/19060 filed Jun. 12, 2002, which in turn claims the benefit of U.S. Ser. No. 60/297,860 filed Jun. 12, 2001. All applications above are fully incorporated herein by reference.

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5342382	Brinkerhoff	Aug 1994	A
5344703	Kovar	Sep 1994	A
5350392	Purcell	Sep 1994	A
5352351	White	Oct 1994	A
5354287	Wacks	Oct 1994	A
5354447	Uenoyama	Oct 1994	A
5356420	Czernecki	Oct 1994	A
5360410	Wacks	Nov 1994	A
5365699	Armstrong	Nov 1994	A
5366469	Steg	Nov 1994	A
5366470	Ramel	Nov 1994	A
5366609	White	Nov 1994	A
5368047	Suzuki	Nov 1994	A
5370509	Golding	Dec 1994	A
5371687	Holmes	Dec 1994	A
5372135	Mendelson	Dec 1994	A
5375397	Ferrand	Dec 1994	A
5378628	Graetzel	Jan 1995	A
5382346	Uenoyama	Jan 1995	A
5383885	Bland	Jan 1995	A
5389534	Gentzekow	Feb 1995	A
5390450	Goenka	Feb 1995	A
5393903	Graetzel	Feb 1995	A
5395339	Talonn	Mar 1995	A
5395387	Burns	Mar 1995	A
5397334	Schenk	Mar 1995	A
5401376	Foos	Mar 1995	A
5402798	Swierczek	Apr 1995	A
5405283	Goenka	Apr 1995	A
5405510	Betts	Apr 1995	A
5405511	White	Apr 1995	A
5407545	Hirose	Apr 1995	A
5407554	Saurer	Apr 1995	A
5407818	Gentzekow	Apr 1995	A
5409583	Yoshioka	Apr 1995	A
5409664	Allen	Apr 1995	A
5410059	Fraser	Apr 1995	A
5415169	Siczek	May 1995	A
5418142	Kiser	May 1995	A
5423847	Strong et al.	Jun 1995	A
5424545	Block	Jun 1995	A
5426032	Phillips	Jun 1995	A
5436161	Bergstrom	Jul 1995	A
5437999	Diebold	Aug 1995	A
5438271	White	Aug 1995	A
5443701	Willner	Aug 1995	A
5445920	Saito	Aug 1995	A
D362719	Kaplan	Sep 1995	S
5453360	Yu	Sep 1995	A
5454828	Schraga	Oct 1995	A
5456875	Lambert	Oct 1995	A
5459325	Hueton	Oct 1995	A
5460182	Goodman	Oct 1995	A
5462533	Daugherty	Oct 1995	A
5464418	Schraga	Nov 1995	A
5465722	Fort	Nov 1995	A
5471102	Becker	Nov 1995	A
5472427	Rammler	Dec 1995	A
5474084	Cunniff	Dec 1995	A
5476474	Davis	Dec 1995	A
5480387	Gabriel	Jan 1996	A
5487748	Marshall	Jan 1996	A
D367109	Ryner	Feb 1996	S
5490505	Diab	Feb 1996	A
5496274	Graves	Mar 1996	A
5496453	Uenoyama	Mar 1996	A
5498542	Corey	Mar 1996	A
5501836	Myerson	Mar 1996	A
5501893	Laermer	Mar 1996	A
5507288	Bocker	Apr 1996	A
5507629	Jarvik	Apr 1996	A
5508171	Walling	Apr 1996	A
5509410	Hill	Apr 1996	A
5510266	Bonner et al.	Apr 1996	A
5512159	Yoshioka	Apr 1996	A
5514152	Smith	May 1996	A
5515170	Matzinger	May 1996	A
5518006	Mawhirt	May 1996	A
D371198	Savage	Jun 1996	S
5524636	Sarvazyan	Jun 1996	A
5525511	D'Costa	Jun 1996	A
5525518	Lundsgaard	Jun 1996	A
5526120	Jina	Jun 1996	A
5527333	Nikkels	Jun 1996	A
5527334	Kanner	Jun 1996	A
5529074	Greenfield	Jun 1996	A
5540676	Freiburg	Jul 1996	A
5540709	Ramel	Jul 1996	A
5543326	Heller	Aug 1996	A
5545174	Schenk	Aug 1996	A
5545291	Smith	Aug 1996	A
5547702	Gleisner	Aug 1996	A
D373419	Muramatsu	Sep 1996	S
5554153	Costello	Sep 1996	A
5554166	Lange	Sep 1996	A
5558834	Chu	Sep 1996	A
5562384	Alvite	Oct 1996	A
5562696	Nobles	Oct 1996	A
5563031	Yu	Oct 1996	A
5563042	Phillips	Oct 1996	A
5569286	Peckham	Oct 1996	A
5569287	Tezuka	Oct 1996	A
5571132	Mawhirt	Nov 1996	A
5575284	Athan	Nov 1996	A
5575403	Charlton	Nov 1996	A
5575895	Ikeda	Nov 1996	A
5582697	Ikeda	Dec 1996	A
5584846	Mawhirt	Dec 1996	A
5591139	Lin	Jan 1997	A
5593852	Heller	Jan 1997	A
5599501	Carey	Feb 1997	A
5605837	Karimi	Feb 1997	A
D378612	Clark	Mar 1997	S
5608006	Myerson	Mar 1997	A
5609749	Yamauchi	Mar 1997	A
5611809	Marshall	Mar 1997	A
5611810	Arnold	Mar 1997	A
5613978	Harding	Mar 1997	A
5616135	Thorne	Apr 1997	A
5617851	Lipkovker	Apr 1997	A
5618297	Hart	Apr 1997	A
5620579	Genshaw	Apr 1997	A
5620863	Tomasco	Apr 1997	A
5624458	Lipscher	Apr 1997	A
5624459	Kortenbach	Apr 1997	A
5624537	Turner	Apr 1997	A
D379516	Rutter	May 1997	S
5628764	Schraga	May 1997	A
5628765	Morita	May 1997	A
5628890	Carter	May 1997	A
5628961	Davis	May 1997	A
5630828	Mawhirt	May 1997	A
5630986	Charlton	May 1997	A
5632410	Moulton	May 1997	A
5640954	Pfeiffer	Jun 1997	A
D381591	Rice	Jul 1997	S
5643306	Schraga	Jul 1997	A
5643308	Markman	Jul 1997	A
5645555	Davis	Jul 1997	A
5647851	Pokras	Jul 1997	A
5650062	Ikeda	Jul 1997	A
5653863	Genshaw	Aug 1997	A
5657760	Ying et al.	Aug 1997	A
5658444	Black	Aug 1997	A
5660791	Brenneman	Aug 1997	A
D383550	Larson	Sep 1997	S
5662127	De Vaughn	Sep 1997	A
5662672	Pambianchi	Sep 1997	A
5666966	Horie	Sep 1997	A
5676143	Simonsen	Oct 1997	A
5678306	Bozeman	Oct 1997	A
5680858	Hansen	Oct 1997	A
5680872	Sesekura	Oct 1997	A
5682233	Brinda	Oct 1997	A
5682884	Hill	Nov 1997	A
5683562	Schaffar	Nov 1997	A
5691898	Rosenberg	Nov 1997	A
5692514	Bowman	Dec 1997	A
5695947	Guo	Dec 1997	A
5700695	Yassinzadeh	Dec 1997	A
5705045	Park	Jan 1998	A
5707384	Kim	Jan 1998	A
5708247	McAleer	Jan 1998	A
5709668	Wacks	Jan 1998	A
5709699	Warner	Jan 1998	A
5710011	Forrow	Jan 1998	A
5714123	Sohrab	Feb 1998	A
5714390	Hallowitz	Feb 1998	A
5719034	Kiser	Feb 1998	A
5720862	Hamamoto	Feb 1998	A
5720924	Eikmeier	Feb 1998	A
D392391	Douglas	Mar 1998	S
D392740	Yung	Mar 1998	S
5723284	Ye	Mar 1998	A
5727548	Hill	Mar 1998	A
5729905	Mathiasmeier	Mar 1998	A
5730753	Morita	Mar 1998	A
5733085	Shida	Mar 1998	A
5733300	Pambianchi	Mar 1998	A
D393716	Brenneman	Apr 1998	S
D393717	Brenneman	Apr 1998	S
5735868	Lee	Apr 1998	A
5736103	Pugh	Apr 1998	A
5738244	Charlton	Apr 1998	A
5741228	Lambrecht	Apr 1998	A
5741634	Nozoe	Apr 1998	A
RE35803	Lange	May 1998	E
5746217	Erickson	May 1998	A
5746761	Turchin	May 1998	A
5746898	Preidel	May 1998	A
5753429	Pugh	May 1998	A
5753452	Smith	May 1998	A
5755228	Wilson	May 1998	A
5755733	Morita	May 1998	A
5758643	Wong	Jun 1998	A
5759364	Charlton	Jun 1998	A
5762770	Pritchard	Jun 1998	A
5770086	Indriksons	Jun 1998	A
5770369	Meade	Jun 1998	A
5772586	Heinonen	Jun 1998	A
5772677	Mawhirt	Jun 1998	A
5773270	D'Orazio	Jun 1998	A
5776157	Thorne	Jul 1998	A
5776719	Douglas	Jul 1998	A
5779365	Takaki	Jul 1998	A
5780304	Matzinger	Jul 1998	A
5782770	Mooradian	Jul 1998	A
5782852	Foggia	Jul 1998	A
5788651	Weilandt	Aug 1998	A
5788652	Rahn	Aug 1998	A
5789255	Yu	Aug 1998	A
5794219	Brown	Aug 1998	A
5795725	Buechler	Aug 1998	A
5795774	Matsumoto	Aug 1998	A
5797940	Mawhirt	Aug 1998	A
5797942	Schraga	Aug 1998	A
5798030	Raguse	Aug 1998	A
5798031	Charlton	Aug 1998	A
5800781	Gavin	Sep 1998	A
5801057	Smart	Sep 1998	A
5807375	Gross	Sep 1998	A
5810199	Charlton	Sep 1998	A
D399566	Sohrab	Oct 1998	S
5820551	Hill	Oct 1998	A
5822715	Worthington	Oct 1998	A
5823973	Racchini	Oct 1998	A
5824491	Priest	Oct 1998	A
5827181	Dias	Oct 1998	A
5828943	Brown	Oct 1998	A
5829589	Nguyen	Nov 1998	A
5830219	Bird	Nov 1998	A
5832448	Brown	Nov 1998	A
5840020	Heinonen	Nov 1998	A
5840171	Birch	Nov 1998	A
5843691	Douglas	Dec 1998	A
5843692	Phillips	Dec 1998	A
5846216	Gonzales	Dec 1998	A
5846486	Pugh	Dec 1998	A
5846490	Yokota	Dec 1998	A
5849174	Sanghera	Dec 1998	A
5853373	Griffith	Dec 1998	A
5854074	Charlton	Dec 1998	A
D403975	Douglas	Jan 1999	S
5855377	Murphy	Jan 1999	A
5855801	Lin	Jan 1999	A
5856174	Lipshutz	Jan 1999	A
5856195	Charlton	Jan 1999	A
5857967	Frid	Jan 1999	A
5857983	Douglas	Jan 1999	A
5858804	Zanzucchi	Jan 1999	A
5860922	Gordon et al.	Jan 1999	A
5863800	Eikmeier	Jan 1999	A
5866353	Berneth	Feb 1999	A
5868135	Kaufman	Feb 1999	A
5868772	LeVaughn	Feb 1999	A
5869972	Birch	Feb 1999	A
5871494	Simons	Feb 1999	A
5872713	Douglas	Feb 1999	A
5873887	King	Feb 1999	A
5876351	Rohde	Mar 1999	A
5876957	Douglas	Mar 1999	A
5879163	Brown	Mar 1999	A
5879310	Sopp	Mar 1999	A
5879311	Duchon	Mar 1999	A
5879373	Roeper	Mar 1999	A
5880829	Kauhaniemi	Mar 1999	A
5882494	van Antwerp	Mar 1999	A
5885211	Eppstein	Mar 1999	A
5886056	Hershkowitz	Mar 1999	A
5887133	Brown	Mar 1999	A
5890128	Diaz	Mar 1999	A
RE36191	Solomon	Apr 1999	E
5891053	Sesekura	Apr 1999	A
5893848	Negus	Apr 1999	A
5893870	Talen	Apr 1999	A
5897493	Brown	Apr 1999	A
5897569	Kellogg	Apr 1999	A
5899855	Brown	May 1999	A
5899915	Saadat	May 1999	A
5900130	Benvegnu	May 1999	A
5902731	Ouyang	May 1999	A
5906921	Ikeda	May 1999	A
D411619	Duchon	Jun 1999	S
5908416	Costello	Jun 1999	A
5911937	Hekal	Jun 1999	A
5912134	Shartle	Jun 1999	A
5913310	Brown	Jun 1999	A
5916156	Hildenbrand	Jun 1999	A
5916229	Evans	Jun 1999	A
5916230	Brenneman	Jun 1999	A
5918603	Brown	Jul 1999	A
5919711	Boyd	Jul 1999	A
5921963	Erez	Jul 1999	A
5922188	Ikeda	Jul 1999	A
5922530	Yu	Jul 1999	A
5922591	Anderson	Jul 1999	A
RE36268	Szuminsky	Aug 1999	E
5931794	Pitesky	Aug 1999	A
5933136	Brown	Aug 1999	A
5935075	Casscells et al.	Aug 1999	A
5938635	Kuhle	Aug 1999	A
5938679	Freeman	Aug 1999	A
5940153	Castaneda	Aug 1999	A
5942102	Hodges	Aug 1999	A
5942189	Wolfbeis	Aug 1999	A
5947957	Morris	Sep 1999	A
5951300	Brown	Sep 1999	A
5951492	Douglas	Sep 1999	A
5951493	Douglas	Sep 1999	A
5951582	Thorne	Sep 1999	A
5951836	McAleer	Sep 1999	A
5954738	LeVaughn	Sep 1999	A
5956501	Brown	Sep 1999	A
5957846	Chiang	Sep 1999	A
5958199	Miyamoto	Sep 1999	A
5959098	Goldberg	Sep 1999	A
5960403	Brown	Sep 1999	A
5961451	Reber	Oct 1999	A
5964718	Duchon	Oct 1999	A
5965380	Heller	Oct 1999	A
5968063	Chu	Oct 1999	A
5968760	Phillips	Oct 1999	A
5968836	Matzinger	Oct 1999	A
5971941	Simons	Oct 1999	A
5972199	Heller	Oct 1999	A
5972294	Smith	Oct 1999	A
5972715	Celentano	Oct 1999	A
5974124	Schlueter	Oct 1999	A
5976085	Kimball	Nov 1999	A
5983193	Heinonen	Nov 1999	A
5985116	Ikeda	Nov 1999	A
5985559	Brown	Nov 1999	A
5986754	Harding	Nov 1999	A
5993400	Rincoe	Nov 1999	A
5993434	Dev	Nov 1999	A
D417504	Love	Dec 1999	S
5997476	Brown	Dec 1999	A
5997561	Boecker	Dec 1999	A
5997817	Crismore	Dec 1999	A
5997818	Hackner	Dec 1999	A
6001067	Shults	Dec 1999	A
6007497	Huitema	Dec 1999	A
D418602	Prokop	Jan 2000	S
6014577	Henning	Jan 2000	A
6015392	Douglas	Jan 2000	A
6018289	Sekura	Jan 2000	A
6020110	Williams	Feb 2000	A
6022324	Skinner	Feb 2000	A
6022366	Schraga	Feb 2000	A
6022748	Charych	Feb 2000	A
6023629	Tamada	Feb 2000	A
6023686	Brown	Feb 2000	A
6027459	Shain et al.	Feb 2000	A
6030399	Ignotz	Feb 2000	A
6030827	Davis	Feb 2000	A
6030967	Marui	Feb 2000	A
6032059	Henning	Feb 2000	A
6032119	Brown	Feb 2000	A
6033421	Theiss	Mar 2000	A
6033866	Guo	Mar 2000	A
6036924	Simons	Mar 2000	A
6037178	Leiner	Mar 2000	A
6041253	Kost	Mar 2000	A
6045567	Taylor	Apr 2000	A
6046055	Wolfbeis	Apr 2000	A
6048352	Douglas	Apr 2000	A
D424696	Ray	May 2000	S
6056701	Duchon	May 2000	A
6059815	Lee	May 2000	A
6060327	Keen	May 2000	A
6061128	Zweig	May 2000	A
6063039	Cunningham	May 2000	A
6066103	Duchon	May 2000	A
6066243	Anderson	May 2000	A
6066296	Brady	May 2000	A
6067463	Jeng	May 2000	A
6068615	Brown	May 2000	A
D426638	Ray	Jun 2000	S
6070761	Bloom	Jun 2000	A
6071249	Cunningham	Jun 2000	A
6071250	Douglas	Jun 2000	A
6071251	Cunningham et al.	Jun 2000	A
6071294	Simons	Jun 2000	A
6071391	Gotoh	Jun 2000	A
6074360	Haar	Jun 2000	A
6077408	Miyamoto	Jun 2000	A
6080106	Lloyd	Jun 2000	A
6080172	Fujiwara	Jun 2000	A
D428150	Ruf	Jul 2000	S
6083196	Trautman	Jul 2000	A
6083710	Heller	Jul 2000	A
6084660	Shartle	Jul 2000	A
6085576	Sunshine	Jul 2000	A
6086544	Hibner	Jul 2000	A
6086545	Roe	Jul 2000	A
6086562	Jacobsen	Jul 2000	A
6090078	Erskine	Jul 2000	A
6091975	Daddona	Jul 2000	A
6093146	Filangeri	Jul 2000	A
6093156	Cunningham	Jul 2000	A
D428993	Lubs	Aug 2000	S
6099484	Douglas	Aug 2000	A
6099802	Pugh	Aug 2000	A
6100107	Lei	Aug 2000	A
6101478	Brown	Aug 2000	A
6102933	Lee	Aug 2000	A
6103033	Say	Aug 2000	A
6103509	Sode	Aug 2000	A
6104940	Watanabe	Aug 2000	A
6106751	Talbot	Aug 2000	A
6107083	Collins	Aug 2000	A
6113578	Brown	Sep 2000	A
6117155	Lee	Sep 2000	A
6117630	Reber	Sep 2000	A
6118126	Zanzucchi	Sep 2000	A
6119033	Spigelman	Sep 2000	A
6120462	Hibner	Sep 2000	A
6120676	Heller	Sep 2000	A
6121009	Heller	Sep 2000	A
6122536	Sun	Sep 2000	A
6126804	Andresen	Oct 2000	A
6126899	Woudenberg	Oct 2000	A
6129823	Hughes	Oct 2000	A
6132449	Lum	Oct 2000	A
6133837	Riley	Oct 2000	A
6134461	Say	Oct 2000	A
6136013	Marshall	Oct 2000	A
6139562	Mauze	Oct 2000	A
6143164	Heller	Nov 2000	A
6144837	Quy	Nov 2000	A
6144976	Silva et al.	Nov 2000	A
6149203	Hanlon	Nov 2000	A
6151586	Brown	Nov 2000	A
6152875	Hakamata	Nov 2000	A
6152942	Brenneman	Nov 2000	A
6153069	Pottgen	Nov 2000	A
RE36991	Yamamoto	Dec 2000	E
6155267	Nelson	Dec 2000	A
6155992	Henning et al.	Dec 2000	A
6156051	Schraga	Dec 2000	A
6157442	Raskas	Dec 2000	A
6159147	Lichter	Dec 2000	A
6159424	Kauhaniemi	Dec 2000	A
6161095	Brown	Dec 2000	A
6162397	Jurik	Dec 2000	A
6162611	Heller	Dec 2000	A
6167362	Brown	Dec 2000	A
6167386	Brown	Dec 2000	A
6168563	Brown	Jan 2001	B1
6168957	Matzinger	Jan 2001	B1
6171325	Mauze	Jan 2001	B1
6172743	Kley et al.	Jan 2001	B1
6175752	Say	Jan 2001	B1
6176847	Humphreys	Jan 2001	B1
6176865	Mauze	Jan 2001	B1
6177000	Peterson	Jan 2001	B1
6177931	Alexander	Jan 2001	B1
6183489	Douglas	Feb 2001	B1
6186145	Brown	Feb 2001	B1
6190612	Berger	Feb 2001	B1
6191852	Paffhausen	Feb 2001	B1
6192891	Gravel	Feb 2001	B1
6193673	Viola	Feb 2001	B1
6193873	Ohara	Feb 2001	B1
6194900	Freeman	Feb 2001	B1
6197040	LeVaughn	Mar 2001	B1
6197257	Raskas	Mar 2001	B1
6200773	Ouyang	Mar 2001	B1
6203504	Latterell	Mar 2001	B1
6206841	Cunningham et al.	Mar 2001	B1
6210133	Aboul-Hosn	Apr 2001	B1
6210272	Brown	Apr 2001	B1
6210369	Wilmot	Apr 2001	B1
6210420	Mauze	Apr 2001	B1
6210421	Bocker	Apr 2001	B1
6212417	Ikeda	Apr 2001	B1
6214626	Meller	Apr 2001	B1
6214804	Felgner	Apr 2001	B1
6218571	Zheng	Apr 2001	B1
6219574	Cormier	Apr 2001	B1
6221023	Matsuba	Apr 2001	B1
6221238	Grundig	Apr 2001	B1
6225078	Ikeda	May 2001	B1
6228100	Schraga	May 2001	B1
6230051	Cormier	May 2001	B1
6230501	Bailey	May 2001	B1
6231531	Lum	May 2001	B1
6233471	Berner	May 2001	B1
6233539	Brown	May 2001	B1
6234772	Wampler	May 2001	B1
6240393	Brown	May 2001	B1
D444235	Roberts	Jun 2001	S
6241862	McAleer	Jun 2001	B1
6242207	Douglas	Jun 2001	B1
6245060	Loomis	Jun 2001	B1
6245215	Douglas	Jun 2001	B1
6246992	Brown	Jun 2001	B1
6248065	Brown	Jun 2001	B1
6251083	Yum	Jun 2001	B1
6251121	Saadat	Jun 2001	B1
6251260	Heller	Jun 2001	B1
6251344	Goldstein	Jun 2001	B1
D444557	Levaughn	Jul 2001	S
6254831	Barnard	Jul 2001	B1
6256533	Vuzhakov	Jul 2001	B1
6258111	Ross	Jul 2001	B1
6258229	Winarta	Jul 2001	B1
6258254	Miyamoto	Jul 2001	B1
6261241	Burbank	Jul 2001	B1
6261245	Kawai	Jul 2001	B1
6261519	Harding	Jul 2001	B1
6264635	Wampler	Jul 2001	B1
6268161	Han	Jul 2001	B1
6268162	Phillips	Jul 2001	B1
6269314	Iitawaki	Jul 2001	B1
6270455	Brown	Aug 2001	B1
6270637	Crismore	Aug 2001	B1
6272359	Kivela	Aug 2001	B1
6272364	Kurnik	Aug 2001	B1
6275717	Gross	Aug 2001	B1
6280254	Wu	Aug 2001	B1
6281006	Heller	Aug 2001	B1
6283926	Cunningham	Sep 2001	B1
6283982	Levaughn	Sep 2001	B1
6284478	Heller	Sep 2001	B1
6285448	Kuenstner	Sep 2001	B1
6285454	Douglas	Sep 2001	B1
6289254	Shimizu	Sep 2001	B1
6290683	Erez	Sep 2001	B1
6294897	Champlin	Sep 2001	B1
6295506	Heinonen	Sep 2001	B1
6299578	Kurnik	Oct 2001	B1
6299596	Ding	Oct 2001	B1
6299757	Feldman	Oct 2001	B1
6302844	Walker	Oct 2001	B1
6302855	Lav	Oct 2001	B1
6305804	Rice	Oct 2001	B1
6306104	Cunningham	Oct 2001	B1
6306152	Verdonk	Oct 2001	B1
6306347	Mason	Oct 2001	B1
6309351	Kurnik	Oct 2001	B1
6309535	Williams	Oct 2001	B1
6312612	Sherman	Nov 2001	B1
6315738	Nishikawa	Nov 2001	B1
6318970	Backhouse	Nov 2001	B1
6319210	Douglas	Nov 2001	B1
6322574	Lloyd	Nov 2001	B1
6322808	Trautman	Nov 2001	B1
6322963	Bauer	Nov 2001	B1
6329161	Heller	Dec 2001	B1
6330426	Brown	Dec 2001	B2
6331163	Kaplan	Dec 2001	B1
6332871	Douglas	Dec 2001	B1
6334363	Testud	Jan 2002	B1
6334778	Brown	Jan 2002	B1
6334856	Allen	Jan 2002	B1
6335203	Patel	Jan 2002	B1
6336900	Alleckson	Jan 2002	B1
6338790	Feldman	Jan 2002	B1
6346120	Yamazaki	Feb 2002	B1
6349229	Watanabe	Feb 2002	B1
6350273	Minagawa	Feb 2002	B1
6350451	Horn	Feb 2002	B1
6352514	Douglas	Mar 2002	B1
6352523	Brown	Mar 2002	B1
6353753	Flock	Mar 2002	B1
6364889	Kheiri et al.	Apr 2002	B1
6364890	Lum	Apr 2002	B1
6368273	Brown	Apr 2002	B1
6375469	Brown	Apr 2002	B1
6375627	Mauze	Apr 2002	B1
6379301	Worthington	Apr 2002	B1
6379317	Kintzig	Apr 2002	B1
6379324	Gartstein	Apr 2002	B1
6379969	Mauze et al.	Apr 2002	B1
6381577	Brown	Apr 2002	B1
D456910	Clark	May 2002	S
6387709	Mason	May 2002	B1
6391005	Lum	May 2002	B1
6395227	Kiser	May 2002	B1
6398522	Skill	Jun 2002	B2
6398562	Butler	Jun 2002	B1
6399394	Dahm	Jun 2002	B1
6402701	Kaplan	Jun 2002	B1
6402704	McMorrow	Jun 2002	B1
6409740	Kuhr	Jun 2002	B1
6413410	Hodges	Jul 2002	B1
6413411	Pottgen	Jul 2002	B1
6415821	Kamholz	Jul 2002	B2
6420128	Ouyang	Jul 2002	B1
6421633	Heinonen	Jul 2002	B1
6423014	Churchill	Jul 2002	B1
6428664	Bhullar	Aug 2002	B1
6436055	Roe	Aug 2002	B1
6436256	Williams	Aug 2002	B1
6436721	Kuo	Aug 2002	B1
6440645	Yon-Hin	Aug 2002	B1
6444115	Hodges	Sep 2002	B1
6447119	Stewart et al.	Sep 2002	B1
6447265	Antaki	Sep 2002	B1
6451040	Purcell	Sep 2002	B1
6453810	Rossmeisl	Sep 2002	B1
6458258	Taniike	Oct 2002	B2
6461496	Feldman	Oct 2002	B1
6462162	van Antwerp	Oct 2002	B2
6464649	Duchon	Oct 2002	B1
6471903	Sherman	Oct 2002	B2
6472220	Simons	Oct 2002	B1
6475360	Hodges	Nov 2002	B1
6475372	Ohara	Nov 2002	B1
6475436	Schabbach	Nov 2002	B1
6475750	Han	Nov 2002	B1
6477394	Rice	Nov 2002	B2
6477424	Thompson	Nov 2002	B1
6484046	Say	Nov 2002	B1
6485439	Roe	Nov 2002	B1
6485461	Mason	Nov 2002	B1
6485923	Yani	Nov 2002	B1
6488827	Shartle	Dec 2002	B1
6488891	Mason	Dec 2002	B2
6489133	Phillips	Dec 2002	B2
6491709	Sharma	Dec 2002	B2
6491870	Patel	Dec 2002	B2
6494830	Wessel	Dec 2002	B1
6497845	Sacherer	Dec 2002	B1
6501404	Walker	Dec 2002	B2
6501976	Sohrab	Dec 2002	B1
6503209	Hakky et al.	Jan 2003	B2
6503210	Hirao	Jan 2003	B1
6503231	Prausnitz	Jan 2003	B1
6503290	Jarosinski	Jan 2003	B1
6503381	Gotoh	Jan 2003	B1
6506165	Sweeney	Jan 2003	B1
6506168	Fathallah	Jan 2003	B1
6506575	Knappe	Jan 2003	B1
6508785	Eppstein	Jan 2003	B1
6512986	Harmon	Jan 2003	B1
6514270	Schraga	Feb 2003	B1
6514460	Fendrock	Feb 2003	B1
6519241	Theimer	Feb 2003	B1
6520326	McIvor	Feb 2003	B2
6521110	Hodges	Feb 2003	B1
6521182	Shartle	Feb 2003	B1
6527521	Noda	Mar 2003	B2
6527716	Epstein	Mar 2003	B1
6527778	Athanasiou	Mar 2003	B2
6529377	Nelson	Mar 2003	B1
6530892	Kelly	Mar 2003	B1
6530937	Schraga	Mar 2003	B1
6531322	Jurik	Mar 2003	B1
6533949	Yeshurun	Mar 2003	B1
6537207	Rice	Mar 2003	B1
6537242	Palmer	Mar 2003	B1
6537264	Cormier et al.	Mar 2003	B1
6537292	Lee	Mar 2003	B1
6540672	Simonsen	Apr 2003	B1
6540675	Aceti	Apr 2003	B2
6540762	Bertling	Apr 2003	B1
6540891	Stewart	Apr 2003	B1
6541266	Modzelewski	Apr 2003	B2
6547954	Ikeda	Apr 2003	B2
6549796	Sohrab	Apr 2003	B2
6551494	Heller	Apr 2003	B1
6553244	Lesho	Apr 2003	B2
6554381	Locher	Apr 2003	B2
6555061	Leong	Apr 2003	B1
D475136	Taniguchi	May 2003	S
6558320	Causey	May 2003	B1
6558361	Yeshurun	May 2003	B1
6558402	Chelak	May 2003	B1
6558528	Matzinger	May 2003	B1
6560471	Heller	May 2003	B1
6561978	Conn	May 2003	B1
6561989	Whitson	May 2003	B2
6562210	Bhullar	May 2003	B1
6565509	Say	May 2003	B1
6565808	Hudak	May 2003	B2
6569157	Shain	May 2003	B1
6571651	Hodges	Jun 2003	B1
6572566	Effenhauser	Jun 2003	B2
6572822	Jurik	Jun 2003	B2
6574490	Abbink	Jun 2003	B2
6575905	Knobbe	Jun 2003	B2
6576101	Heller	Jun 2003	B1
6576117	Iketaki	Jun 2003	B1
6576416	Haviland	Jun 2003	B2
6579690	Bonnecaze et al.	Jun 2003	B1
6582573	Douglas	Jun 2003	B2
6584338	Van Muiswinkel	Jun 2003	B1
D477670	Jurik	Jul 2003	S
6586199	Ouyang	Jul 2003	B2
6587705	Kim	Jul 2003	B1
6589260	Schmelzeisen-Redeker	Jul 2003	B1
6589261	Abulhaj	Jul 2003	B1
6591124	Sherman	Jul 2003	B2
6591125	Buse	Jul 2003	B1
6592744	Hodges	Jul 2003	B1
6592745	Feldman	Jul 2003	B1
6595919	Berner	Jul 2003	B2
6599407	Taniike	Jul 2003	B2
6599693	Webb	Jul 2003	B1
6599769	Kondo	Jul 2003	B2
6601534	Hebrank	Aug 2003	B2
6602205	Erickson	Aug 2003	B1
6602268	Kuhr	Aug 2003	B2
6602678	Kwon	Aug 2003	B2
6604050	Trippel	Aug 2003	B2
6607362	Lum	Aug 2003	B2
6607494	Fowler	Aug 2003	B1
6607658	Heller	Aug 2003	B1
6612111	Hodges	Sep 2003	B1
6616616	Fritz	Sep 2003	B2
6616819	Liamos	Sep 2003	B1
6618934	Feldman	Sep 2003	B1
6620112	Klitmose	Sep 2003	B2
6620310	Ohara	Sep 2003	B1
6623501	Heller	Sep 2003	B2
6626851	Hirao	Sep 2003	B2
6632349	Hodges	Oct 2003	B1
6635222	Kent	Oct 2003	B2
6638415	Hodges	Oct 2003	B1
6638772	Douglas	Oct 2003	B1
6641533	Causey	Nov 2003	B2
6645142	Braig	Nov 2003	B2
6645219	Roe	Nov 2003	B2
6645368	Beatty	Nov 2003	B1
6649416	Kauer	Nov 2003	B1
6650915	Routt	Nov 2003	B2
6652720	Mansouri	Nov 2003	B1
6652734	Hodges	Nov 2003	B1
6652814	House	Nov 2003	B1
D484600	Kaar	Dec 2003	S
6656697	Ouyang	Dec 2003	B1
6656702	Yugawa	Dec 2003	B1
6659966	Essenpreis	Dec 2003	B2
6660018	Lum	Dec 2003	B2
6662439	Bhullar	Dec 2003	B1
6669669	Flaherty	Dec 2003	B2
6671527	Peterson	Dec 2003	B2
D484980	Hartwein	Jan 2004	S
6673617	Patel	Jan 2004	B2
6676995	Dick	Jan 2004	B2
6679841	Bojan	Jan 2004	B2
6679852	Schmelzeisen-Redeker	Jan 2004	B1
6682933	Patel	Jan 2004	B2
6689411	Dick	Feb 2004	B2
6706000	Perez	Mar 2004	B2
6706049	Moerman	Mar 2004	B2
6706159	Moerman	Mar 2004	B2
6706232	Hasegawa	Mar 2004	B2
6709692	Sudor	Mar 2004	B2
6713660	Roe	Mar 2004	B1
6716577	Yu	Apr 2004	B1
6719887	Hasegawa	Apr 2004	B2
6719923	Stiene	Apr 2004	B2
6721586	Kiser	Apr 2004	B2
6723046	Lichtenstein	Apr 2004	B2
6723111	Abulhaj	Apr 2004	B2
6723371	Chih-hui	Apr 2004	B2
6723500	Yu	Apr 2004	B2
6726818	Cui et al.	Apr 2004	B2
6729546	Roustaei	May 2004	B2
6730494	Toranto	May 2004	B1
6731966	Spigelman	May 2004	B1
6733493	Gruzdev	May 2004	B2
6736777	Kim	May 2004	B2
6738654	Sohrab	May 2004	B2
6740215	Nakaminami	May 2004	B1
6743211	Prausnitz	Jun 2004	B1
6743597	Guo	Jun 2004	B1
6743635	Neel	Jun 2004	B2
6746872	Zheng	Jun 2004	B2
6749618	Levaughn	Jun 2004	B2
6749740	Liamos	Jun 2004	B2
6749792	Olsen	Jun 2004	B2
6749887	Dick	Jun 2004	B1
6751491	Lew	Jun 2004	B2
6752817	Flora	Jun 2004	B2
6753187	Cizdziel	Jun 2004	B2
6759190	Lin	Jul 2004	B2
6764496	Schraga	Jul 2004	B2
6764581	Forrow	Jul 2004	B1
6767441	Cai	Jul 2004	B1
6773671	Lewis	Aug 2004	B1
6776888	Yamamoto	Aug 2004	B2
6780645	Hayter	Aug 2004	B2
6780647	Fujiwara	Aug 2004	B2
6783502	Orloff	Aug 2004	B2
6783537	Kuhr	Aug 2004	B1
6784274	van Antwerp	Aug 2004	B2
6786874	Grace	Sep 2004	B2
6787013	Chang	Sep 2004	B2
6787109	Haar	Sep 2004	B2
6790327	Ikeda	Sep 2004	B2
6790599	Madou	Sep 2004	B1
6792791	Sato	Sep 2004	B2
6793632	Sohrab	Sep 2004	B2
6793633	Douglas	Sep 2004	B2
6793802	Lee	Sep 2004	B2
6797150	Kermani	Sep 2004	B2
6800488	Khan	Oct 2004	B2
6801041	Karinka	Oct 2004	B2
6801804	Miller	Oct 2004	B2
6802199	Hilgers	Oct 2004	B2
6802811	Slepian	Oct 2004	B1
6802957	Jung	Oct 2004	B2
6805780	Ryu	Oct 2004	B1
6808499	Churchill	Oct 2004	B1
6808908	Yao	Oct 2004	B2
6808937	Ligler	Oct 2004	B2
6809807	Erickson	Oct 2004	B1
6811406	Grube	Nov 2004	B2
6811557	Schraga	Nov 2004	B2
6811659	Vachon	Nov 2004	B2
6811753	Hirao	Nov 2004	B2
6811792	Roser	Nov 2004	B2
6812031	Carlsson	Nov 2004	B1
6814843	Bhullar	Nov 2004	B1
6814844	Bhullar	Nov 2004	B2
6814845	Wilson	Nov 2004	B2
6815186	Clark	Nov 2004	B2
6816742	Kim	Nov 2004	B2
6818180	Douglas	Nov 2004	B2
6821483	Phillips	Nov 2004	B2
6823750	Hodges	Nov 2004	B2
6825047	Woudenberg	Nov 2004	B1
6827250	Uhland	Dec 2004	B2
6827829	Kawanaka	Dec 2004	B2
6829507	Lidman	Dec 2004	B1
6830551	Uchigaki	Dec 2004	B1
6830668	Musho	Dec 2004	B2
6830669	Miyazaki	Dec 2004	B2
6830934	Harding	Dec 2004	B1
6833540	MacKenzie	Dec 2004	B2
6835184	Sage	Dec 2004	B1
6835553	Han	Dec 2004	B2
6835570	Patel	Dec 2004	B2
6837858	Cunningham	Jan 2005	B2
6837976	Cai	Jan 2005	B2
6837988	Leong	Jan 2005	B2
6840912	Kloepfer	Jan 2005	B2
6841052	Musho	Jan 2005	B2
6843254	Tapper	Jan 2005	B2
6843902	Penner	Jan 2005	B1
6844149	Goldman	Jan 2005	B2
6847451	Pugh	Jan 2005	B2
6849052	Uchigaki	Feb 2005	B2
6849168	Crumly	Feb 2005	B2
6849216	Rappin	Feb 2005	B2
6849456	Patel	Feb 2005	B2
6850790	Berner	Feb 2005	B2
6852119	Abulhaj	Feb 2005	B1
6852212	Maxwell	Feb 2005	B2
6852500	Hoss	Feb 2005	B1
6853854	Proniewiez	Feb 2005	B1
6855243	Khan	Feb 2005	B2
6856125	Kermani	Feb 2005	B2
6856928	Harmon	Feb 2005	B2
6858015	List	Feb 2005	B2
6858401	Phillips	Feb 2005	B2
6859738	Bush	Feb 2005	B2
6862466	Ackerman	Mar 2005	B2
6862534	Sterling	Mar 2005	B2
6863800	Karinka	Mar 2005	B2
6863801	Hodges	Mar 2005	B2
6865408	Abbink	Mar 2005	B1
6866641	Marshall	Mar 2005	B2
6866675	Perez	Mar 2005	B2
6866758	Bhullar	Mar 2005	B2
6866822	House	Mar 2005	B1
6869418	Marano-Ford	Mar 2005	B2
6872200	Mann	Mar 2005	B2
6872297	Mansouri	Mar 2005	B2
6872298	Kermani	Mar 2005	B2
6872299	Kermani	Mar 2005	B2
6872358	Hagen	Mar 2005	B2
6875208	Santini	Apr 2005	B2
6875223	Argauer	Apr 2005	B2
6875327	Miyazaki	Apr 2005	B1
6875613	Shartle	Apr 2005	B2
6878120	Roe	Apr 2005	B2
6878251	Hodges	Apr 2005	B2
6878255	Wang	Apr 2005	B1
6878262	Taniike	Apr 2005	B2
6880968	Haar	Apr 2005	B1
6881203	Delmore	Apr 2005	B2
6881322	Tokunaga	Apr 2005	B2
6881378	Zimmer	Apr 2005	B1
6881541	Petersen	Apr 2005	B2
6881550	Phillips	Apr 2005	B2
6881551	Heller	Apr 2005	B2
6881578	Otake	Apr 2005	B2
6882940	Potts	Apr 2005	B2
6884592	Matzinger	Apr 2005	B2
6885196	Taniike	Apr 2005	B2
6885883	Parris	Apr 2005	B2
6887202	Currie	May 2005	B2
6887239	Elstrom	May 2005	B2
6887253	Schraga	May 2005	B2
6887254	Curie	May 2005	B1
6887426	Phillips	May 2005	B2
6887709	Leong	May 2005	B2
6889069	Routt	May 2005	B2
6890319	Crocker	May 2005	B1
6890421	Ohara	May 2005	B2
6890484	Bautista	May 2005	B2
6891936	Kai	May 2005	B2
6892085	McIvor	May 2005	B2
6893396	Schulze	May 2005	B2
6893545	Gotoh	May 2005	B2
6893552	Wang	May 2005	B1
6895263	Shin	May 2005	B2
6895264	Rice	May 2005	B2
6895265	Silver	May 2005	B2
6896793	Erdosy	May 2005	B2
6897788	Khair	May 2005	B2
6902905	Burson	Jun 2005	B2
6904301	Raskas	Jun 2005	B2
6905733	Russel	Jun 2005	B2
6908008	Pugh	Jun 2005	B2
6908535	Rankin	Jun 2005	B2
6908591	MacPhee	Jun 2005	B2
6908593	Shartle	Jun 2005	B1
6911130	Brenneman	Jun 2005	B2
6911131	Miyazaki	Jun 2005	B2
6911621	Bhullar	Jun 2005	B2
6911937	Sparrow	Jun 2005	B1
6913210	Baasch	Jul 2005	B2
6913668	Matzinger	Jul 2005	B2
6916410	Katsuki	Jul 2005	B2
6918874	Hatch	Jul 2005	B1
6918901	Theeuwes	Jul 2005	B1
6918918	Schraga	Jul 2005	B1
6922576	Raskas	Jul 2005	B2
6922578	Eppstein	Jul 2005	B2
6923764	Aceti	Aug 2005	B2
6923894	Huang	Aug 2005	B2
6923936	Swanson	Aug 2005	B2
6924093	Haviland	Aug 2005	B2
6925317	Samuels	Aug 2005	B1
6925393	Kalatz	Aug 2005	B1
6929631	Brugger	Aug 2005	B1
6929649	Pugh	Aug 2005	B2
6929650	Fukuzawa	Aug 2005	B2
6931327	Goode	Aug 2005	B2
6931328	Braig	Aug 2005	B2
6939310	Matzinger	Sep 2005	B2
6939312	Hodges	Sep 2005	B2
6939450	Karinka	Sep 2005	B2
6939685	Ouyang	Sep 2005	B2
6940591	Sopp	Sep 2005	B2
6942518	Liamos	Sep 2005	B2
6942769	Cheng	Sep 2005	B2
6942770	Cai	Sep 2005	B2
6944486	Braig	Sep 2005	B2
6945943	Pugh	Sep 2005	B2
6946067	Hodges	Sep 2005	B2
6946098	Miekka	Sep 2005	B2
6946299	Neel	Sep 2005	B2
6949111	Schraga	Sep 2005	B2
6949221	Kiser	Sep 2005	B2
6951631	Catt	Oct 2005	B1
6951728	Qian	Oct 2005	B2
6952603	Gerber	Oct 2005	B2
6952604	DeNuzzio	Oct 2005	B2
6953693	Neel	Oct 2005	B2
6954662	Freger	Oct 2005	B2
6958072	Schraga	Oct 2005	B2
6958129	Galen	Oct 2005	B2
6958809	Sterling	Oct 2005	B2
6959211	Rule	Oct 2005	B2
6959247	Neel	Oct 2005	B2
6960287	Charlton	Nov 2005	B2
6960289	Hodges	Nov 2005	B2
6960323	Guo	Nov 2005	B2
6964871	Bell	Nov 2005	B2
6965791	Hitchcock	Nov 2005	B1
6966880	Boecker	Nov 2005	B2
6966977	Hasegawa	Nov 2005	B2
6967105	Nomura	Nov 2005	B2
6968375	Brown	Nov 2005	B1
6969359	Duchon	Nov 2005	B2
6969450	Taniike	Nov 2005	B2
6969451	Shin	Nov 2005	B2
6973706	Say	Dec 2005	B2
6975893	Say	Dec 2005	B2
6977032	Hasegawa	Dec 2005	B2
6977722	Wohlstadter et al.	Dec 2005	B2
6979544	Keen	Dec 2005	B2
6979571	Modzelewski	Dec 2005	B2
6982027	Yagi	Jan 2006	B2
6982431	Modlin	Jan 2006	B2
6983176	Gardner	Jan 2006	B2
6983177	Rule	Jan 2006	B2
6984307	Zweig	Jan 2006	B2
6986777	Kim	Jan 2006	B2
6986869	Tuohy	Jan 2006	B2
6988996	Roe	Jan 2006	B2
6989243	Yani	Jan 2006	B2
6989891	Braig	Jan 2006	B2
6990365	Parker	Jan 2006	B1
6990366	Say	Jan 2006	B2
6990367	Kiser	Jan 2006	B2
6990849	Bohm	Jan 2006	B2
6991918	Keith	Jan 2006	B2
6991940	Carroll	Jan 2006	B2
6994825	Haviland	Feb 2006	B2
6997317	Catelli	Feb 2006	B2
6997343	May	Feb 2006	B2
6997344	Brown	Feb 2006	B2
6997936	Marshall	Feb 2006	B2
6998247	Monfre	Feb 2006	B2
6998248	Yani	Feb 2006	B2
6999810	Berner	Feb 2006	B2
7001343	Erickson	Feb 2006	B2
7001344	Freeman	Feb 2006	B2
7003337	Harjunmaa	Feb 2006	B2
7003340	Say	Feb 2006	B2
7003341	Say	Feb 2006	B2
7004928	Aceti	Feb 2006	B2
7005048	Watanabe	Feb 2006	B1
7005273	Heller	Feb 2006	B2
7005459	Hekal	Feb 2006	B2
7005857	Stiene	Feb 2006	B2
7006857	Braig	Feb 2006	B2
7006858	Silver	Feb 2006	B2
7008384	Tapper	Mar 2006	B2
7010432	Kermani	Mar 2006	B2
7011630	Desai	Mar 2006	B2
7011954	Ouyang	Mar 2006	B2
7014615	Erickson	Mar 2006	B2
7015262	Leong	Mar 2006	B2
7016713	Gardner	Mar 2006	B2
7018568	Tierney	Mar 2006	B2
7018848	Douglas	Mar 2006	B2
7022217	Hodges	Apr 2006	B2
7022218	Taniike	Apr 2006	B2
7022286	Lemke	Apr 2006	B2
7024236	Ford	Apr 2006	B2
7024248	Penner	Apr 2006	B2
7024399	Sumner	Apr 2006	B2
7025425	Kovatchev	Apr 2006	B2
7025774	Freeman	Apr 2006	B2
7027848	Robinson	Apr 2006	B2
7029444	Shin	Apr 2006	B2
7033322	Silver	Apr 2006	B2
7033371	Alden	Apr 2006	B2
7039560	Kawatahara	May 2006	B2
7041057	Faupel	May 2006	B1
7041063	Abreu	May 2006	B2
7041068	Freeman	May 2006	B2
7041210	Hodges	May 2006	B2
7041254	Haviland	May 2006	B2
7041468	Drucker	May 2006	B2
7043287	Khalil	May 2006	B1
7043821	Hodges	May 2006	B2
7044911	Drinan	May 2006	B2
7045046	Chambers	May 2006	B2
7045054	Buck	May 2006	B1
7045097	Kovacs	May 2006	B2
7045310	Buck	May 2006	B2
7045361	Heiss	May 2006	B2
7047070	Wilkinson	May 2006	B2
7047795	Sato	May 2006	B2
7049087	Jenny	May 2006	B2
7049130	Carroll	May 2006	B2
7050843	Shartle	May 2006	B2
7051495	Lang	May 2006	B2
7052268	Powell	May 2006	B2
7052591	Gao	May 2006	B2
7052652	Zanzucchi	May 2006	B2
7052864	Durkop	May 2006	B2
7054682	Young	May 2006	B2
7054759	Fukunaga	May 2006	B2
D522656	Orr	Jun 2006	S
D523555	Loerwald	Jun 2006	S
7056425	Hasegawa	Jun 2006	B2
7056495	Roser	Jun 2006	B2
7058437	Buse	Jun 2006	B2
7059352	Bohm	Jun 2006	B2
7060059	Keith	Jun 2006	B2
7060168	Taniike	Jun 2006	B2
7060192	Yuzhakov	Jun 2006	B2
7061593	Braig	Jun 2006	B2
7063234	Giraud	Jun 2006	B2
7063774	Bhullar	Jun 2006	B2
7063775	Yamaoka	Jun 2006	B2
7063776	Huang	Jun 2006	B2
7066884	Custer	Jun 2006	B2
7066885	Erickson	Jun 2006	B2
7070564	Matzinger	Jul 2006	B2
7070680	Bae	Jul 2006	B2
7073246	Bhullar	Jul 2006	B2
7074307	Simpson	Jul 2006	B2
7074308	Mao	Jul 2006	B2
7077328	Krishnaswamy	Jul 2006	B2
7077828	Kuhr	Jul 2006	B2
7078480	Nagel	Jul 2006	B2
7079252	Debreezeny	Jul 2006	B1
7081188	Cho	Jul 2006	B1
7083712	Morita	Aug 2006	B2
7086277	Tess	Aug 2006	B2
7087149	Muguruma	Aug 2006	B1
7090764	Iyengar	Aug 2006	B2
7096053	Loeb	Aug 2006	B2
7096124	Sterling	Aug 2006	B2
7097631	Trautman	Aug 2006	B2
7098038	Fukuoka	Aug 2006	B2
7103578	Beck	Sep 2006	B2
7105066	Schraga	Sep 2006	B2
7107253	Sumner	Sep 2006	B1
7108680	Rohr	Sep 2006	B2
7108778	Simpson	Sep 2006	B2
7109271	Liu	Sep 2006	B2
7110112	Uchida	Sep 2006	B2
7110803	Shults	Sep 2006	B2
7112265	McAleer	Sep 2006	B1
7112451	Takahashi	Sep 2006	B2
7113172	Hohl	Sep 2006	B2
7115362	Douglas	Oct 2006	B2
7118351	Effenhauser	Oct 2006	B2
7118667	Lee	Oct 2006	B2
7118668	Edelbrock	Oct 2006	B1
7118916	Matzinger	Oct 2006	B2
7118919	Yatscoff	Oct 2006	B2
7120483	Russell	Oct 2006	B2
7122102	Wogoman	Oct 2006	B2
7122110	Deng	Oct 2006	B2
7122111	Tokunaga	Oct 2006	B2
7125481	Musho	Oct 2006	B2
7129038	Gopalan	Oct 2006	B2
RE39390	Hasegawa	Nov 2006	E
D531725	Loerwald	Nov 2006	S
7131342	Hodges	Nov 2006	B2
7131984	Sato	Nov 2006	B2
7132041	Deng	Nov 2006	B2
7133710	Acosta	Nov 2006	B2
7134550	Groth	Nov 2006	B2
7134999	Brauker	Nov 2006	B2
7135100	Lau	Nov 2006	B1
7137957	Erickson	Nov 2006	B2
7138041	Su	Nov 2006	B2
7138089	Aitken	Nov 2006	B2
7141034	Eppstein	Nov 2006	B2
7141058	Briggs	Nov 2006	B2
7144404	Whitson	Dec 2006	B2
7144485	Hsu	Dec 2006	B2
7144495	Teodorezyk	Dec 2006	B2
7144496	Meserol	Dec 2006	B2
7144709	Ouyang	Dec 2006	B2
7147825	Matsuda	Dec 2006	B2
7150755	Levaughn	Dec 2006	B2
7150975	Tamada	Dec 2006	B2
7150995	Xie	Dec 2006	B2
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Related Publications (1)

	Number	Date	Country
	20070249962 A1	Oct 2007	US

Provisional Applications (1)

	Number	Date	Country
	60297860	Jun 2001	US

Divisions (1)

	Number	Date	Country
Parent	10363510		US
Child	11768633		US

Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge

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