Claims
- 1. A method of testing for nephritis which is accompanied by a mesangial proliferative lesion or renal insufficiency in a patient suspected of having nephritis, by administering to said patient or to a culture of excised kidney cells from said patient, an aqueous solution, suspension or emulsion of a p-substituted aniline or a pharmaceutically acceptable salt thereof having the following formula: ##STR2## wherein X represents --COOH, --CONH.sub.2, --CONHCH.sub.3, --CON(CH.sub.3).sub.2, --CONHCH.sub.2 COOH, --CONHC(R)HCOOH, --CONH(CH.sub.2).sub.2-3 COOH, --SO.sub.3 H, --SO.sub.2 NH.sub.2, --SO.sub.2 NHCH.sub.3, --SO.sub.2 N(CH.sub.3).sub.2, --SO.sub.2 NHCH.sub.2 COOH, --SO.sub.2 NHC(R)HCOOH, --SO.sub.2 NH(CH.sub.2)2-3COOH, --PO.sub.3 H, --OH, --OCOCH.sub.3, --O-sulfonate ester, --O-glucuronate ester, --COCH.sub.2 NH.sub.2, 1-tetrazol-5-yl, and --(CH.sub.2).sub.1-2 -Y, wherein Y is the same as X and R represents a side chain of a proteinaceous amino acid; measuring the amount of N-acetylated p-substituted aniline derivative produced and comparing this value against a pre-established standard to evaluate the activity of acetyltransferase in the patient and thereby to determine whether a nephritic condition is indicated.
- 2. The method of claim 1 wherein the substituted aniline is p-aminohippuric acid or the sodium salt thereof.
- 3. The method of claim 1 wherein the substituted aniline is p-aminobenzoic acid or the sodium salt thereof.
- 4. The method of claim 1 wherein the activity of acetyltransferase is evaluated by measuring the amount of N-acetylated aniline compound present in the patient's blood and/or urine.
Priority Claims (1)
Number |
Date |
Country |
Kind |
5-292475 |
Oct 1993 |
JPX |
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Parent Case Info
This application is a division of application Ser. No. 08/327,827 filed Oct. 24, 1994 now abandoned.
Non-Patent Literature Citations (2)
Entry |
Pacifici et al., Xenobiotica, 1988, vol. 18, No. 7, 849-856. |
Cribb et al., The Journal of Pharmacology and Experimental Therapeutics, 259: 1241-1246 (1991). |
Divisions (1)
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Number |
Date |
Country |
Parent |
327827 |
Oct 1994 |
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