Claims
- 1. A method of treating a patient having an infectious disease, comprising the steps of:
- selecting a pharmaceutical composition comprising substantially purified human GM-CSF and a pharmaceutically acceptable carrier; and
- administering said pharmaceutical composition to a human in need thereof.
- 2. The method of claim 1, wherein administering said pharmaceutical composition activates or increases the number of myeloid cells of the human.
- 3. The method of claim 2, wherein administering said pharmaceutical composition activates or increases the number of neutrophils, granulocytes or monocytes.
- 4. The method of claim 1, wherein said pharmaceutically acceptable carrier comprises pharmacological human serum albumin and saline.
- 5. The method of claim 1 or 4, wherein said composition is injected into the human at a daily dosage of 200 to 1000 .mu.g per patient.
- 6. The method according to claim 5, comprising the additional step of selecting as said pharmaceutical composition a composition having an activity of at least about 10 million units per mg in a bone marrow assay.
Parent Case Info
This is a division of application Ser. No. 08/344,806, filed Nov. 23, 1994, which in turn is a continuation of application Ser. No. 08/183,099, filed Jan. 14, 1994, now abandoned, which in turn is a continuation of application Ser. No. 08/023,146, filed Feb. 24, 1993, now abandoned, which in turn is a continuation of application Ser. No. 07/752,250, filed Aug. 28, 1991, now abandoned, which in turn is a continuation of application Ser. No. 07/657,350, filed Feb. 15, 1991, now abandoned, which in turn is a continuation of application Ser. No. 06/652,742, filed Sep. 19, 1994, now abandoned.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
5078996 |
Conlon, III et al. |
Jan 1992 |
|
5147799 |
Bursuker et al. |
Sep 1992 |
|
5162111 |
Grabstein et al. |
Nov 1992 |
|
Non-Patent Literature Citations (11)
Entry |
Yunis, et al., FEBS Letters, 1978, 90:279-82. |
Wu, et al. J. Biol. Chem., 1979, 254:6226-28. |
Gasson, et al. Science, 1984, 226:1339-1342. |
Fojo, et al., Biochemistry, 1978, 17:3109-16. |
Lusis, et al., Blood, 1981, 57:13-21. |
Nicola, et al., Blood, 1979, 54:614-27. |
Fojo, et al., Biophys. Acts., 1977, 494:92-99. |
Price, et al., Biochem. J., 1975, 148:209-17. |
Metcalf, The Hemopoietic Colony Stimulating Factors, Elsevier (1984), pp. 81-84, 215-227, 309-329. |
Wing et al. (1982) J. Clin. Investigation vol. 69 pp. 270-276. |
Lusis et al. (1980) Proc. Natl. Acad. Sci. U.S.A. vol. 77, No. 9, pp. 5346-5350. |
Divisions (1)
|
Number |
Date |
Country |
Parent |
344809 |
Nov 1994 |
|
Continuations (5)
|
Number |
Date |
Country |
Parent |
183099 |
Jan 1994 |
|
Parent |
23146 |
Feb 1993 |
|
Parent |
752250 |
Aug 1991 |
|
Parent |
657350 |
Feb 1991 |
|
Parent |
652742 |
Sep 1984 |
|