Monosulfactams

Abstract

Antibacterial activity is exhibited by monocyclic .beta.-lactam antibiotics having in the 1-position an --O--SO.sub.3 H activating group and in the 3-position an acylamino group of the formula ##STR1## wherein R.sub.3 and R.sub.4 are each independently hydrogen or alkyl.

Description

Claims

1. A compound having the formula ##STR38## or a pharmaceutically acceptable salt thereof, wherein R.sub.1 and R.sub.2 are the same or different and each is hydrogen or alkyl, or R.sub.1 and R.sub.2 together are --(CH.sub.2).sub.n --wherein n is 2, 3, 4, 5 or 6; and

R.sub.3 and R.sub.4 are the same or different and each is hydrogen or alkyl of 1 to 3 carbon atoms.

2. A compound in accordance with claim 1 wherein R.sub.1 and R.sub.2 are the same or different and each is hydrogen or alkyl.

3. A compound in accordance with claim 1 wherein R.sub.1 and R.sub.2 are the same or different and each is hydrogen or methyl.

4. A compound in accordance with claim 1 wherein one of R.sub.1 and R.sub.2 is hydrogen and the other is methyl or ethyl.

5. A compound in accordance with claim 1 wherein R.sub.1 and R.sub.2 are each methyl.

6. A compound in accordance with claim 1 wherein R.sub.1 and R.sub.2 are each hydrogen.

7. A compound in accordance with claim 1 wherein R.sub.1 and R.sub.2 together are --(CH.sub.2).sub.n --.

8. A compound in accordance with claim 1 wherein R.sub.3 and R.sub.4 are each hydrogen.

9. A compound in accordance with claim 1 wherein R.sub.3 is alkyl of 1 to 3 carbon atoms and R.sub.4 is hydrogen.

10. A compound in accordance with claim 1 wherein R.sub.3 and R.sub.4 are each alkyl of 1 to 3 carbon atoms.

11. The compound in accordance with claim 1, [3S(Z)]-2-[[[1-(2-amino-4-thiazolyl)-2-[[4,4-dimethyl-2-oxo-1-(sulfooxy)-3-azetidinyl]amino]-2-oxoethylidene]amino]oxy]-2-propenoic acid.

12. The compound in accordance with claim 1, (.+-.)-(Z)-2-[[[1-(2-amino-4-thiazolyl)-2-oxo-2-[[2-oxo-1-(sulfooxy)-1-azaspiro[3.3]hept-3-yl]amino]ethylidene]amino]oxy]-2-propenoic acid.