Claims
- 1. A compound of the formula
- wherein X is oxygen or sulfur; wherein R is hydrogen, a straight or branched alkyl group having from 1 to 8 carbon atoms or benzyl; wherein R.sub.1 is selected from
- (a) phenyl which is unsubstituted or is substituted with from 1 to 3 substituents selected from
- phenyl,
- an alkyl group having from 1 to 6 carbon atoms and which is straight or branched,
- an alkoxy group having from 1 to 6 carbon atoms and which is straight or branched;
- phenoxy,
- hydroxy,
- fluorine,
- chlorine,
- bromine,
- trifluoromethyl,
- --COOH,
- --COOalkyl wherein alkyl has from 1 to 4 carbon atoms and is straight or branched,
- --(CH.sub.2).sub.p NR.sub.3 R.sub.4 wherein p is zero or one, and each of R.sub.3 and R.sub.4 is selected from hydrogen or a straight or branched alkyl group having 1 to 4 carbon atoms;
- (b) 1- or 2-naphthyl which is unsubstituted or is substituted with from 1 to 3 substituents selected from
- phenyl,
- an alkyl group having from 1 to 6 carbon atoms and which is straight or branched,
- an alkoxy group having from 1 to 6 carbon atoms and which is straight or branched;
- phenoxy,
- hydroxy,
- fluorine,
- chlorine,
- bromine,
- nitro,
- trifluoromethyl,
- --COOH,
- --COOalkyl wherein alkyl has from 1 to 4 carbon atoms and is straight or branched,
- --(CH.sub.2).sub.p NR.sub.3 R.sub.4 wherein p, R.sub.3, and R.sub.4 have the meanings defined above;
- wherein R.sub.2 is selected from
- (a) phenyl which is unsubstituted or is substituted with from 1 to 3 substituents selected from
- phenyl,
- an alkyl group having from 1 to 6 carbon atoms and which is straight or branched,
- an alkoxy group having from 1 to 6 carbon atoms and which is straight or branched;
- phenoxy,
- hydroxy,
- fluorine,
- chlorine,
- bromine,
- trifluoromethyl,
- --COOH,
- --COOalkyl wherein alkyl has from 1 to 4 carbon atoms and is straight or branched,
- --(CH.sub.2).sub.p NR.sub.3 R.sub.4 wherein p is zero or one, and each of R.sub.3 and R.sub.4 is selected from hydrogen or a straight or branched alkyl group having 1 to 4 carbon atoms;
- (b) 1- or 2-naphthyl which is unsubstituted or is substituted with from 1 to 3 substituents selected from
- phenyl,
- an alkyl group having from 1 to 6 carbon atoms and which is straight or branched,
- an alkoxy group having from 1 to 6 carbon atoms and which is straight or branched;
- phenoxy,
- hydroxy,
- fluorine,
- chlorine,
- bromine,
- nitro,
- trifluoromethyl,
- --COOH,
- --COOalkyl wherein alkyl has from 1 to 4 carbon atoms and is straight or branched,
- --(CH.sub.2).sub.p NR.sub.3 R.sub.4 wherein p, R.sub.3, and R.sub.4 have the meanings defined above;
- (c) the group ##STR11## wherein t is zero or 1 to 4; w is zero or 1 to 4 with the proviso that the sum of t and w is not greater than 5; R.sub.5 and R.sub.6 are independently selected from hydrogen or alkyl having from 1 to 6 carbon atoms, or when R.sub.5 is hydrogen, R.sub.6 can be selected from the groups defined for R.sub.7 ; and R.sub.7 is phenyl or phenyl substituted with from 1 to 3 substituents selected from a straight or branched alkyl group having from 1 to 6 carbon atoms, straight or branched alkoxy group having from 1 to 6 carbon atoms, phenoxy, hydroxy, fluorine, chlorine, bromine, nitro, trifluoromethyl, --COOH, COOalkyl wherein alkyl has from 1 to 4 carbon atoms, or --(CH.sub.2).sub.p NR.sub.3 R.sub.4 wherein P, R.sub.3, and R.sub.4 have the meanings defined above; or
- (d) a straight or branched hydrocarbon chain having from 1 to 20 carbon atoms and which is saturated or contains from 1 to 3 double bonds; and pharmaceutically acceptable acid salts thereof with the proviso that:
- (i) one of R1 or R2 is phenyl or substituted phenyl and
- (ii) the following compounds are excluded: ##STR12##
- 2. A compound of claim 1 wherein R.sub.1 is phenyl.
- 3. A compound of claim 1, wherein R.sub.1 is phenyl disubstituted in the 2,6-positions.
- 4. A compound of claim 1 wherein R.sub.2 is phenyl.
- 5. A compound of claim 1 wherein R.sub.2 is phenyl disubstituted in the 2,6-positions.
- 6. A compound of claim 1 wherein each of R.sub.1 and R.sub.2 is phenyl.
- 7. A compound of claim 1 wherein each phenyl disubstituted in the 2,6-positions.
- 8. A compound of claim 1 which is:
- 2,6-Bis(1-methylethyl)phenyl[[2,6-bis(1-methylethyl)phenoxy]sulfonyl]carbamate,
- 2,6-Bis(1,1-dimethylethyl)-4-methylphenyl (phenoxysulfonyl)carbamate,
- 2,6-Bis(1,1-dimethylethyl)-4-methylphenyl[(hexyloxy)sulfonyl]carbamate,
- 2,6-Bis(1,1-dimethylethyl)-4-methylphenyl[(dodecyloxy-sulfonyl]carbamate,
- 2,6-Bis(1-methylethyl)phenyl[(hexyloxy)sulfonyl]carbamate,
- 2,6-Bis(1-methylethyl)phenyl](dodecyloxy)sulfonyl]carbamate,
- 2,6-Bis(1,1-dimethylethyl)phenyl[[2,6-bis(1-methylethyl)phenoxy]sulfonyl]carbamate.
- 9. A compound of claim 1 which is 2,6-bis(1-methylethyl)phenyl[[2,6-bis(1-methylethyl)phenoxy]sulfonyl]carbamate, monosodium salt.
CROSS-REFERENCE TO RELATED APPLICATION
This application is a continuation of application Ser. No. 738,772, filed Aug. 1, 1991 which is a continuation-in-part of application Ser. No. 606,006, filed Oct. 30, 1990, both now abandoned.
Foreign Referenced Citations (1)
Number |
Date |
Country |
940292 |
Mar 1956 |
DEX |
Continuations (1)
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Number |
Date |
Country |
Parent |
738772 |
Aug 1991 |
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Continuation in Parts (1)
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Number |
Date |
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Parent |
606006 |
Oct 1990 |
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