Claims
- 1. A method of treating a biological composition suspected of containing a pathogen, comprising, in the following order:
a) providing, in any order, i) a compound of the formula selected from the group consisting of 15I) a substituent A on the benzene ring is selected from the group consisting of:
—(CH2)u—NH2, —(CH2)w—J—(CH2)z—NH2, —(CH2)w—J—(CH2)x—K—(CH2)z—NH2, and —(CH2)w—J—(CH2)x—K—(CH2)y—L—(CH2)z—NH2; wherein J, K, and L are independently selected from the group consisting of O and NH, in which u is a whole number from 1 to 10, w is a whole number from 1 to 5, x is a whole number from 2 to 5, y is a whole number from 2 to 5, and z is a whole number from 2 to 6; and II) substituents B, R1, R2, R4, and R5 on the benzene ring, 3-, 4-, 4′- and 5′-carbon atoms respectively, are independently selected from the group consisting of —H and —(CH2)vCH3, where v is a whole number from 0 to 5; and all salts thereof; ii) a light source for photoactivating said compound; and iii) a biological composition suspected of containing a pathogen; b) adding said compound to said biological composition; and c) photoactivating said compound, so as to inactivate the pathogen, if present.
- 2. The method of claims 1, wherein said biological composition is a blood product.
- 3. The method of claim 2, wherein said blood product comprises plasma.
- 4. The method of claim 2, wherein said blood product comprises a plasma fraction.
- 5. The method of claim 2, wherein said blood product comprises platelets.
- 6. The method of claim 2, wherein said pathogen is selected from the group consisting of viruses and bacteria.
REFERENCE TO RELATED APPLICATIONS
[0001] This application is a continuation of application Ser. No. 09/500,680, filed Feb. 9, 2000, which is a continuation of application Ser. No. 09/196,935, filed on Nov. 20, 1998, which issued as U.S. Pat. No. 6,133,460, which claims priority to U.S. Provisional Patent Application Serial No. 60/066,224, filed Nov. 20, 1997; the disclosure of which is hereby incorporated by reference.
STATEMENT OF RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH
[0002] This invention was made with United States government support under SBIR Grant No. 1 R43 HL51796-01 from the NIH. The United States Government has certain rights in this invention.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60066224 |
Nov 1997 |
US |
Continuations (2)
|
Number |
Date |
Country |
Parent |
09500680 |
Feb 2000 |
US |
Child |
10208583 |
Jul 2002 |
US |
Parent |
09196935 |
Nov 1998 |
US |
Child |
09500680 |
Feb 2000 |
US |