The broader impact/commercial potential of this Small Business Innovation Research Phase II project is the reduction of deaths and long-term disabilities in people suffering from bleeding in the brain caused by intracerebral hemorrhage (ICH) or traumatic brain injury. Currently, physicians detect worsening bleeding through a clinical exam where a patient shows outward signs of deterioration in their neurological status. By the time these signs of additional bleeding appear, much of the damage to the brain has already occurred. About a third of people who suffer a severe traumatic brain injury either die or are left disabled. For hemorrhagic stroke, 60% die and 70% of survivors are left with significant disabilities. A device which transmits and receives very low power radiofrequency signals has been created that can be put on a patients head. The presence of blood outside of the brain's vessels and arteries creates a characteristic change in the radio signal used by the device. Using radio waves to non-invasively detect brain bleeds will allow treatment to start sooner, which will save lives, reduce disabilities and lower the cost of treating severe brain injuries.<br/><br/>The proposed project tests (i) the ability of the device to detect and characterize small changes in ICH size and location over time and (ii) the ability to display changes in the bleed in a meaningful way to physicians. An algorithm for determining the size and location of the hemorrhage will be tested using both a phantom model that mimics the human brain and an IACUC-approved pig ICH model. Multiple hemorrhage volumes and locations will be used to test the algorithm's ability to detect hemorrhage volume changes within 1 mL, location within 1 cm, and distinguish changes due to the hemorrhage from physiological changes in a living pig's brain. Signal measurements taken before, during, and after infusion of blood will be captured at each time point to test the accuracy of the algorithm. Software will be developed to display the information from the algorithm in three-dimensions while giving doctors and nurses control over thresholds for triggering an alarm and how often the device scans. To test the software, the data collected during the pig experiments will be used to determine how accurate the display matches the location and size of the hemorrhage from CT images collected during testing.