Claims
- 1. A method for the inactivation of prekallikrein activator during the production of blood product preparations from human or animal plasma comprising the steps of (1) obtaining said preparations in a fractionation process by the enrichment in fractions of plasma proteins, (2) adding dissolved chymotrypsin or immobilized chymotrypsin to said fractions at any stage of said fractionation process and (3) removing the respective one of said dissolved chymotrypsin and immobilized chymotrypsin from said preparations before completion thereof.
- 2. A method for the inactivation of prekallikrein activator during the production of albumin preparations from human or animal plasma comprising the steps of (1) obtaining said preparations in a fractionation process by the enrichment in fractions of plasma proteins, (2) adding an aqueous chymotrypsin solution to an aqueous solution of enriched plasma proteins at any stage of said fractionation process, (3) precipitating said plasma proteins by a protein precipitating agent so as to be separated from said chymotrypsin solution, and (4) processing said plasma proteins to finished preparations.
- 3. A method for the inactivation of prekallikrein activator during the production of albumin preparations comprising the steps of (1) obtaining said preparations in a fractionation process by the enrichment in fractions of plasma proteins, (2) adding chymotrypsin immobilized on Sepharose to an aqueous solution of enriched plasma proteins at any stage of said fractionation process, (3) removing solid substances from said solution to separate said chymotrypsin and to obtain protein-containing solutions, and (4) processing said protein-containing solutions to finished preparations.
Priority Claims (1)
Number |
Date |
Country |
Kind |
494/88 |
Feb 1988 |
AUX |
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Parent Case Info
This application is a continuation of application Ser. No. 07/315,163, filed Feb. 24, 1989, now U.S. Pat. No. 5,094,949.
US Referenced Citations (9)
Foreign Referenced Citations (1)
Number |
Date |
Country |
2218148 |
Sep 1971 |
DEX |
Non-Patent Literature Citations (1)
Entry |
B. M. Alving et al., The New England Journal of Medicine, vol. 299, p. 66 (1978). |
Continuations (1)
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Number |
Date |
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Parent |
315163 |
Feb 1989 |
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