cytotoxic response

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AHUMAN NECESSITIES A61Medical science A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

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A61K2039/572cytotoxic response

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Patents Grantslast 30 patents

Information Patent Grant
Cancer stem cell targeted cancer vaccines
- Patent number 12,357,678
- Issue date Jul 15, 2025
- Stemline Therapeutics, Inc.
- Ivan Bergstein
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Immunomodulating polynucleotides, antibody conjugates thereof, and...
- Patent number 12,351,598
- Issue date Jul 8, 2025
- TALLAC THERAPEUTICS, INC.
- Sukumar Sakamuri
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Combination vaccine
- Patent number 12,337,031
- Issue date Jun 24, 2025
- CureVac SE
- Karl-Josef Kallen
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Viral vector
- Patent number 12,337,030
- Issue date Jun 24, 2025
- VALO THERAPEUTICS OY
- Vincenzo Cerullo
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Oncolytic virus platform to treat cancers with myxoma virus
- Patent number 12,331,079
- Issue date Jun 17, 2025
- Arizona Board of Regents on behalf of Arizona State University
- Douglas Grant McFadden
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Dead antigen stimulated immature heterogenous dendritic cells as th...
- Patent number 12,329,807
- Issue date Jun 17, 2025
- MegaNano Biotech, Inc.
- Chuanhai Cao
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Compositions and methods for making antibody conjugates
- Patent number 12,324,842
- Issue date Jun 10, 2025
- The Trustees of the University of Pennsylvania
- Andrew Tsourkas
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Exosome-targeted DNA vaccine
- Patent number 12,319,727
- Issue date Jun 3, 2025
- EXORPHIA, INC.
- Ken Ishii
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Peptides and combination of peptides for use in immunotherapy again...
- Patent number 12,297,245
- Issue date May 13, 2025
- Immatics Biotechnologies GmbH
- Colette Song
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Multispecific antigen-binding molecules and uses thereof
- Patent number 12,297,257
- Issue date May 13, 2025
- REGENERON PHARMACEUTICALS, INC.
- Julian Andreev
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Compositions and methods for targeted immunomodulatory antibodies a...
- Patent number 12,295,968
- Issue date May 13, 2025
- The Johns Hopkins University
- Atul Bedi
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Cancer vaccines targeting MUC16 and uses thereof
- Patent number 12,285,473
- Issue date Apr 29, 2025
- Inovio Pharmaceuticals, Inc.
- Jian Yan
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Peptides and combination of peptides for use in immunotherapy again...
- Patent number 12,281,146
- Issue date Apr 22, 2025
- Immatics Biotechnologies GmbH
- Colette Song
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Peptides and scaffolds for use in immunotherapy against head and ne...
- Patent number 12,275,775
- Issue date Apr 15, 2025
- Immatics Biotechnologies GmbH
- Andrea Mahr
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Biomaterials for modulating immune responses
- Patent number 12,274,744
- Issue date Apr 15, 2025
- President and Fellows of Harvard College
- David J. Mooney
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
In immunotherapy against lung cancer, including NSCLC, SCLC and oth...
- Patent number 12,275,768
- Issue date Apr 15, 2025
- Immatics Biotechnologies GmbH
- Colette Song
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Peptides and scaffolds for use in immunotherapy against head and ne...
- Patent number 12,275,776
- Issue date Apr 15, 2025
- Immatics Biotechnologies GmbH
- Andrea Mahr
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Use of toll-like receptor 2 (TLR-2) agonist for modulating human im...
- Patent number 12,268,739
- Issue date Apr 8, 2025
- Children's Medical Center Corporation
- David J. Dowling
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Cytotoxic immunostimulating particles and uses thereof
- Patent number 12,263,215
- Issue date Apr 1, 2025
- BIONTECH SE
- Steve Pascolo
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
T cell manufacturing compositions and methods
- Patent number 12,258,581
- Issue date Mar 25, 2025
- BIONTECH US INC.
- Marit M. Van Buuren
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Panel comprising Borrelia MHC multimers
- Patent number 12,258,373
- Issue date Mar 25, 2025
- Immudex ApS
- Liselotte Brix
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Bispecific antibody construct directed to MUC17 and CD3
- Patent number 12,258,404
- Issue date Mar 25, 2025
- Amgen Inc.
- Tobias Raum
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Methods and compositions for transducing lymphocytes and regulating...
- Patent number 12,258,574
- Issue date Mar 25, 2025
- Exuma Biotech Corp.
- Gregory Ian Frost
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Production of engineered T-cells by sleeping beauty transposon coup...
- Patent number 12,258,397
- Issue date Mar 25, 2025
- Seattle Children's Hospital
- Michael C. Jensen
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Peptides and combination of peptides for use in immunotherapy again...
- Patent number 12,247,057
- Issue date Mar 11, 2025
- Immatics Biotechnologies GmbH
- Colette Song
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Anti-CTLA-4 antibodies and methods of use thereof
- Patent number 12,246,066
- Issue date Mar 11, 2025
- Agenus Inc.
- Marc van Dijk
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Method of making exosomes from tumor cell/antigen presenting cell h...
- Patent number 12,241,091
- Issue date Mar 4, 2025
- Institute of Process Engineering, Chinese Academy of Sciences
- Guanghui Ma
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Polymersomes comprising a soluble encapsulated antigen as well as m...
- Patent number 12,239,736
- Issue date Mar 4, 2025
- ACM BIOLABS PTE LTD
- Madhavan Nallani
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Peptides and combination of peptides for use in immunotherapy again...
- Patent number 12,240,877
- Issue date Mar 4, 2025
- Immatics Biotechnologies GmbH
- Colette Song
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Peptides and combination of peptides for use in immunotherapy again...
- Patent number 12,240,878
- Issue date Mar 4, 2025
- Immatics Biotechnologies GmbH
- Colette Song
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Patents Applicationslast 30 patents

Information Patent Application
FUSION PROTEIN FOR INDUCING IMMUNE RESPONSE AND TREATING CANCER
- Publication number 20250235523
- Publication date Jul 24, 2025
- TAIVITAL BIOPHARMACEUTICAL CO. LTD
- YIPEI LIN
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
METHODS AND COMPOSITIONS FOR TRANSDUCING LYMPHOCYTES AND REGULATING...
- Publication number 20250236889
- Publication date Jul 24, 2025
- Exuma Biotech Corp.
- Gregory Ian FROST
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
PDL1 PEPTIDES FOR USE IN CANCER VACCINES
- Publication number 20250230218
- Publication date Jul 17, 2025
- IO Biotech ApS
- Mads Hald ANDERSEN
- C07 - ORGANIC CHEMISTRY
Information Patent Application
CANCER VACCINES TARGETING MUC16 AND USES THEREOF
- Publication number 20250222086
- Publication date Jul 10, 2025
- INOVIO PHARMACEUTICALS, INC.
- Jian YAN
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
PROTEIN AND PEPTIDE VACCINES TARGETING METHANOGENS
- Publication number 20250222082
- Publication date Jul 10, 2025
- Arkea Bio Corp.
- Matthew Dunn
- A23 - FOODS OR FOODSTUFFS THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
Information Patent Application
PEPTIDES AND SCAFFOLDS FOR USE IN IMMUNOTHERAPY AGAINST HEAD AND NE...
- Publication number 20250223335
- Publication date Jul 10, 2025
- Immatics Biotechnologies GmbH
- Andrea MAHR
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MRNAS ENCODING CHECKPOINT CANCER VACCINES AND USES THEREOF
- Publication number 20250213664
- Publication date Jul 3, 2025
- ModernaTX, Inc.
- Joshua P. Frederick
- C07 - ORGANIC CHEMISTRY
Information Patent Application
ANTIGENIC PEPTIDES FOR PREVENTION AND TREATMENT OF CANCER
- Publication number 20250205324
- Publication date Jun 26, 2025
- ENTEROME S.A.
- Laurent CHENE
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUS M-SEGMENT NUCLEIC ACID VACCIN...
- Publication number 20250205327
- Publication date Jun 26, 2025
- THE UNITED STATES GOVERNMENT, AS REPRESENTED BY THE SECRETARY OF THE ARMY
- Aura R. GARRISON
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
TREATMENT AND PREVENTION OF CONDITIONS ASSOCIATED WITH RESPIRATORY...
- Publication number 20250195638
- Publication date Jun 19, 2025
- UNIVERSITY OF HOUSTON SYSTEM
- Navin Varadarajan
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
T CELL MANUFACTURING COMPOSITIONS AND METHODS
- Publication number 20250188414
- Publication date Jun 12, 2025
- BIONTECH US INC.
- Marit M. VAN BUUREN
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
POLYMERSOMES COMPRISING A SOLUBLE ENCAPSULATED ANTIGEN AS WELL AS M...
- Publication number 20250186346
- Publication date Jun 12, 2025
- ACM BIOLABS PTE LTD
- Madhavan NALLANI
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
COMBINATION THERAPY FOR TREATMENT OF DISEASE
- Publication number 20250179169
- Publication date Jun 5, 2025
- MEREO BIOPHARMA 5, INC.
- Christopher Lamond MURRIEL
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
NOVEL BISPECIFIC ANTIGEN BINDING MOLECULES CAPABLE OF SPECIFIC BIND...
- Publication number 20250179205
- Publication date Jun 5, 2025
- HOFFMANN-LA ROCHE INC.
- Peter BRUENKER
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
VACCINE COMPRISING NATURAL KILLER CELLS LOADED WITH LIGANDS OF NATU...
- Publication number 20250170179
- Publication date May 29, 2025
- CELLID CO., LTD.
- Chang-Yuil KANG
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MESSENGER RIBONUCLEIC ACIDS FOR ENHANCING IMMUNE RESPONSES AND METH...
- Publication number 20250170235
- Publication date May 29, 2025
- ModernaTX, Inc.
- Eric Yi-Chun HUANG
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
EPICHAPEROME INHIBITION TO IMPROVE T CELL RESPONSES
- Publication number 20250152702
- Publication date May 15, 2025
- Monica L. Guzman
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
CONSENSUS SEQUENCE OF THE ANTIGEN TELOMERASE AND THE USE THEREOF IN...
- Publication number 20250152687
- Publication date May 15, 2025
- Evvivax S. R. L.
- Luigi AURISICCHIO
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
NOVEL LIVE MULTI-ANTIGENIC RECOMBINANT VACCINE AGAINST TUBERCULOSIS
- Publication number 20250152690
- Publication date May 15, 2025
- The Regents of the University of California
- Marcus A. Horwitz
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
PEPTIDES AND COMBINATION OF PEPTIDES AND SCAFFOLDS FOR USE IN IMMUN...
- Publication number 20250154459
- Publication date May 15, 2025
- Immatics Biotechnologies GmbH
- Andrea MAHR
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
AFRICAN SWINE FEVER VACCINE COMPOSITION
- Publication number 20250152695
- Publication date May 15, 2025
- Plumbline Life Sciences, Inc.
- Eun Jin KIM
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
AUTOLOGOUS CELL BASED SARS-COV-2 VACCINES
- Publication number 20250152697
- Publication date May 15, 2025
- ORGENESIS INC.
- Oren MOSKOVICH
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITIONS CONTAINING POLYNUCLEOTIDE AMPHIPHILES AND METHODS OF U...
- Publication number 20250134992
- Publication date May 1, 2025
- Elicio Therapeutics, Inc.
- Peter C. DEMUTH
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
NK CELLS WITH AN INCREASED ANTIBODY-DEPENDENT CELLULAR TOXICITY (AD...
- Publication number 20250136940
- Publication date May 1, 2025
- The United States of America, as Represented by the Secretary, Dept. of Healt...
- Richard W. Childs
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Novel Epstein Barr Virus Immunotherapies
- Publication number 20250127884
- Publication date Apr 24, 2025
- The Wistar Institute of Anatomy and Biology
- David Weiner
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CMV EPITOPES
- Publication number 20250127874
- Publication date Apr 24, 2025
- The Council of the Queensland Institute of Medical Research
- Rajiv KHANNA
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ASSESSMENT AND TREATMENT OF CHRONIC HEPATITIS B
- Publication number 20250127886
- Publication date Apr 24, 2025
- Brii Biosciences, Inc.
- Zhi Hong
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF AUTOIM...
- Publication number 20250121043
- Publication date Apr 17, 2025
- UTI Limited Partnership
- Pedro Santamaria
- G01 - MEASURING TESTING
Information Patent Application
METHODS OF IDENTIFYING SUBJECTS RESPONSIVE TO TREATMENT FOR AN AUTO...
- Publication number 20250110122
- Publication date Apr 3, 2025
- The General Hospital Corporation
- Denise L. FAUSTMAN
- G01 - MEASURING TESTING
Information Patent Application
INTRACELLULAR DELIVERY OF BIOMOLECULES TO INDUCE TOLERANCE
- Publication number 20250108071
- Publication date Apr 3, 2025
- StemCell Technologies Canada Inc.
- Jonathan B. GILBERT
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

cytotoxic response

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Cancer stem cell targeted cancer vaccines

Immunomodulating polynucleotides, antibody conjugates thereof, and...

Combination vaccine

Viral vector

Oncolytic virus platform to treat cancers with myxoma virus

Dead antigen stimulated immature heterogenous dendritic cells as th...

Compositions and methods for making antibody conjugates

Exosome-targeted DNA vaccine

Peptides and combination of peptides for use in immunotherapy again...

Multispecific antigen-binding molecules and uses thereof

Compositions and methods for targeted immunomodulatory antibodies a...

Cancer vaccines targeting MUC16 and uses thereof

Peptides and combination of peptides for use in immunotherapy again...

Peptides and scaffolds for use in immunotherapy against head and ne...

Biomaterials for modulating immune responses

In immunotherapy against lung cancer, including NSCLC, SCLC and oth...

Peptides and scaffolds for use in immunotherapy against head and ne...

Use of toll-like receptor 2 (TLR-2) agonist for modulating human im...

Cytotoxic immunostimulating particles and uses thereof

T cell manufacturing compositions and methods

Panel comprising Borrelia MHC multimers

Bispecific antibody construct directed to MUC17 and CD3

Methods and compositions for transducing lymphocytes and regulating...

Production of engineered T-cells by sleeping beauty transposon coup...

Peptides and combination of peptides for use in immunotherapy again...

Anti-CTLA-4 antibodies and methods of use thereof

Method of making exosomes from tumor cell/antigen presenting cell h...

Polymersomes comprising a soluble encapsulated antigen as well as m...

Peptides and combination of peptides for use in immunotherapy again...

Peptides and combination of peptides for use in immunotherapy again...

Patents Applicationslast 30 patents

FUSION PROTEIN FOR INDUCING IMMUNE RESPONSE AND TREATING CANCER

METHODS AND COMPOSITIONS FOR TRANSDUCING LYMPHOCYTES AND REGULATING...

PDL1 PEPTIDES FOR USE IN CANCER VACCINES

CANCER VACCINES TARGETING MUC16 AND USES THEREOF

PROTEIN AND PEPTIDE VACCINES TARGETING METHANOGENS

PEPTIDES AND SCAFFOLDS FOR USE IN IMMUNOTHERAPY AGAINST HEAD AND NE...

MRNAS ENCODING CHECKPOINT CANCER VACCINES AND USES THEREOF

ANTIGENIC PEPTIDES FOR PREVENTION AND TREATMENT OF CANCER

CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUS M-SEGMENT NUCLEIC ACID VACCIN...

TREATMENT AND PREVENTION OF CONDITIONS ASSOCIATED WITH RESPIRATORY...

T CELL MANUFACTURING COMPOSITIONS AND METHODS

POLYMERSOMES COMPRISING A SOLUBLE ENCAPSULATED ANTIGEN AS WELL AS M...

COMBINATION THERAPY FOR TREATMENT OF DISEASE

NOVEL BISPECIFIC ANTIGEN BINDING MOLECULES CAPABLE OF SPECIFIC BIND...

VACCINE COMPRISING NATURAL KILLER CELLS LOADED WITH LIGANDS OF NATU...

MESSENGER RIBONUCLEIC ACIDS FOR ENHANCING IMMUNE RESPONSES AND METH...

EPICHAPEROME INHIBITION TO IMPROVE T CELL RESPONSES

CONSENSUS SEQUENCE OF THE ANTIGEN TELOMERASE AND THE USE THEREOF IN...

NOVEL LIVE MULTI-ANTIGENIC RECOMBINANT VACCINE AGAINST TUBERCULOSIS

PEPTIDES AND COMBINATION OF PEPTIDES AND SCAFFOLDS FOR USE IN IMMUN...

AFRICAN SWINE FEVER VACCINE COMPOSITION

AUTOLOGOUS CELL BASED SARS-COV-2 VACCINES

COMPOSITIONS CONTAINING POLYNUCLEOTIDE AMPHIPHILES AND METHODS OF U...

NK CELLS WITH AN INCREASED ANTIBODY-DEPENDENT CELLULAR TOXICITY (AD...

Novel Epstein Barr Virus Immunotherapies

CMV EPITOPES

ASSESSMENT AND TREATMENT OF CHRONIC HEPATITIS B

COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF AUTOIM...

METHODS OF IDENTIFYING SUBJECTS RESPONSIVE TO TREATMENT FOR AN AUTO...

INTRACELLULAR DELIVERY OF BIOMOLECULES TO INDUCE TOLERANCE