Double-stranded nucleic acids or oligonucleotides

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A61K31/713

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AHUMAN NECESSITIES A61Medical science A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES A61K31/00Medicinal preparations containing organic active ingredients

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A61K31/713Double-stranded nucleic acids or oligonucleotides

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Patents Grantslast 30 patents

Information Patent Grant
Biodegradable lipids for the delivery of active agents
- Patent number 12,364,762
- Issue date Jul 22, 2025
- Alnylam Pharmaceuticals, Inc.
- Martin Maier
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Dosages of immunoconjugates of antibodies and SN-38 for improved ef...
- Patent number 12,364,761
- Issue date Jul 22, 2025
- Immunomedics, Inc.
- Serengulam V. Govindan
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Branched lipid conjugates of siRNA for specific tissue delivery
- Patent number 12,365,894
- Issue date Jul 22, 2025
- UNIVERSITY OF MASSACHUSETTS
- Anastasia Khvorova
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Nucleic acid-polypeptide compositions and uses thereof
- Patent number 12,364,769
- Issue date Jul 22, 2025
- AVIDITY BIOSCIENCES, INC.
- Andrew John Geall
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Silver-/gold-compounds and methods thereof
- Patent number 12,357,657
- Issue date Jul 15, 2025
- The University of Hong Kong
- Hongzhe Sun
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Use of APE1/Ref-1 inhibitors for treatment of retinal diseases
- Patent number 12,350,247
- Issue date Jul 8, 2025
- Indiana University Research and Technology Corporation
- Mark R. Kelley
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Nucleic acid-polypeptide compositions and uses thereof
- Patent number 12,351,637
- Issue date Jul 8, 2025
- AVIDITY BIOSCIENCES, INC.
- Andrew John Geall
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Cationic lipids containing silicon
- Patent number 12,350,383
- Issue date Jul 8, 2025
- ARBUTUS BIOPHARMA CORPORATION
- Michael J. Abrams
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Biodegradable lipids for the delivery of active agents
- Patent number 12,350,338
- Issue date Jul 8, 2025
- Alnylam Pharmaceuticals, Inc.
- Martin Maier
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Polypeptides directed against viral infection and uses thereof
- Patent number 12,350,286
- Issue date Jul 8, 2025
- QUADRUMIX BIOTECHNOLOGY INC.
- Trushar R. Patel
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Inflammasome-targeted RNA interference approach to treating kidney...
- Patent number 12,343,407
- Issue date Jul 1, 2025
- Memorial Sloan Kettering Cancer Center
- Michael R. McDevitt
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Synthetic lethality and the treatment of cancer
- Patent number 12,343,341
- Issue date Jul 1, 2025
- PACYLEX PHARMACEUTICALS INC.
- Luc G. Berthiaume
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Biodegradable lipids for the delivery of active agents
- Patent number 12,343,398
- Issue date Jul 1, 2025
- Alnylam Pharmaceuticals, Inc.
- Martin Maier
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Factor XII (hageman factor) (F12), kallikrein B, plasma (fletcher f...
- Patent number 12,338,439
- Issue date Jun 24, 2025
- Alnylam Pharmaceuticals, Inc.
- Akin Akinc
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Compounds and methods for trans-membrane delivery of molecules
- Patent number 12,337,036
- Issue date Jun 24, 2025
- Aposense Ltd.
- Ilan Ziv
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Methods and compositions for administration of iron
- Patent number 12,329,772
- Issue date Jun 17, 2025
- American Regent, Inc.
- Mary Jane Helenek
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Compositions and methods for delivery of biomacromolecule agents
- Patent number 12,324,843
- Issue date Jun 10, 2025
- The Regents of the University of Michigan
- James J. Moon
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Methods for reducing post-operative cognitive dysfunction (POCD)
- Patent number 12,325,744
- Issue date Jun 10, 2025
- THE KENNEDY TRUST FOR RHEUMATOLOGY RESEARCH
- Mervyn Maze
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Methods and compositions for modulating gene expression using oligo...
- Patent number 12,319,914
- Issue date Jun 3, 2025
- Larry J. Smith
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Exosome-targeted DNA vaccine
- Patent number 12,319,727
- Issue date Jun 3, 2025
- EXORPHIA, INC.
- Ken Ishii
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods and compositions for genomic integration
- Patent number 12,319,925
- Issue date Jun 3, 2025
- Myeloid Therapeutics, Inc.
- Daniel Getts
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Use of TLR agonist and anti-CD47 agent to enhance phagocytosis of c...
- Patent number 12,318,448
- Issue date Jun 3, 2025
- The Board of Trustees of the Leland Stanford Junior University
- Irving L. Weissman
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Ionizable compounds and compositions and uses thereof
- Patent number 12,319,643
- Issue date Jun 3, 2025
- Nitto Denko Corporation
- Roger Adami
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Branched tail lipid compounds and compositions for intracellular de...
- Patent number 12,312,293
- Issue date May 27, 2025
- ModernaTX, Inc.
- Kerry E. Benenato
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Compositions and methods for nanoparticle lyophile forms
- Patent number 12,311,055
- Issue date May 27, 2025
- Nitto Denko Corporation
- Roger Adami
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Therapeutic double stranded RNA and methods for producing the same
- Patent number 12,312,376
- Issue date May 27, 2025
- AIM ImmunoTech Inc.
- Thomas K. Equels
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Antibody-drug conjugates and uses thereof
- Patent number 12,310,958
- Issue date May 27, 2025
- Immunomedics, Inc.
- David M. Goldenberg
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Compositions and methods for monitoring, diagnosis, prognosis, dete...
- Patent number 12,303,494
- Issue date May 20, 2025
- GLAX Health LLC
- Shivani Shrivastava
- G01 - MEASURING TESTING
Information Patent Grant
BBB-crossing lipid ligand of hetero nucleic acid
- Patent number 12,305,169
- Issue date May 20, 2025
- National University Corporation Tokyo Medical and Dental University
- Takanori Yokota
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Tetragalnac and peptide containing conjugates and methods for deliv...
- Patent number 12,304,925
- Issue date May 20, 2025
- SIRNA Therapeutics, Inc.
- David Tellers
- C07 - ORGANIC CHEMISTRY

Patents Applicationslast 30 patents

Information Patent Application
EXON SKIPPING COMPOSITIONS FOR TREATING MUSCULAR DYSTROPHY
- Publication number 20250236869
- Publication date Jul 24, 2025
- Sarepta Therapeutics, Inc.
- Richard K. BESTWICK
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Methods and Compositions for Inhibiting the Growth and/or prolifera...
- Publication number 20250235470
- Publication date Jul 24, 2025
- Fred Hutchinson Cancer Center
- Masafumi TOYOSHIMA
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
Use of Trinucleotide Repeat RNAs To Treat Cancer
- Publication number 20250230444
- Publication date Jul 17, 2025
- Northwestern University
- Marcus E. Peter
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITIONS AND METHODS FOR TREATMENT OF SEPSIS-RELATED DISORDERS
- Publication number 20250228886
- Publication date Jul 17, 2025
- John Mansell
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
PRODUCTS AND METHODS FOR INHIBITION OF EXPRESSION OF DYNAMIN-1 VARI...
- Publication number 20250230443
- Publication date Jul 17, 2025
- Research Institute at Nationwide Children's Hospital
- Scott Quenton Harper
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
PROTECTION OF BIOLOGICAL SPECIES FROM DEGRADATION
- Publication number 20250228773
- Publication date Jul 17, 2025
- SISAF LTD
- Roghieh Suzanne SAFFIE-SIEBERT
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
DELIVERY OF HYDROPHOBIC ACTIVE AGENT PARTICLES
- Publication number 20250229008
- Publication date Jul 17, 2025
- SURMODICS, INC.
- Joram Slager
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITIONS AND METHODS FOR TREATING LIVER DISEASES WITH SIRNAS TA...
- Publication number 20250228885
- Publication date Jul 17, 2025
- The Board of Regents of the University of Texas System
- Hao Zhu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
FABP4 AS A THERAPEUTIC TARGET IN SKIN DISEASES
- Publication number 20250221962
- Publication date Jul 10, 2025
- TICURE LTD.
- Tali GARIN-SHKOLNIK
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
IMMUNE ENHANCEMENT OF CANCER TREATMENT
- Publication number 20250221932
- Publication date Jul 10, 2025
- Spark Therapeutics, Inc.
- Xavier ANGUELA
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
TARGETED DELIVERY
- Publication number 20250213604
- Publication date Jul 3, 2025
- Judo Bio Inc.
- Steven L. Robinette
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
LIVER PROTECTIVE MARC VARIANTS AND USES THEREOF
- Publication number 20250215486
- Publication date Jul 3, 2025
- The General Hospital Corporation
- Sekar Kathiresan
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITIONS AND METHODS FOR IMMUNE CELL MODULATION IN ADOPTIVE IMM...
- Publication number 20250215396
- Publication date Jul 3, 2025
- FATE THERAPEUTICS, INC.
- Jonathan Rosen
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Compounds and Methods for Inhibiting LPA
- Publication number 20250215044
- Publication date Jul 3, 2025
- Ionis Pharmaceuticals, Inc.
- Dieter Kubli
- C07 - ORGANIC CHEMISTRY
Information Patent Application
MANNOSE-TARGETED COMPOSITIONS
- Publication number 20250215042
- Publication date Jul 3, 2025
- GENEVANT SCIENCES GMBH
- Richard J. Holland
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
RNA CONTAINING COMPOSITION FOR TREATMENT OF TUMOR DISEASES
- Publication number 20250213724
- Publication date Jul 3, 2025
- CureVac SE
- Mariola FOTIN-MLECZEK
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Anti-NGF Antibodies and Methods Thereof
- Publication number 20250206831
- Publication date Jun 26, 2025
- Zoetis Services LLC
- Sebastian C. J. Steiniger
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
AMPHIREGULIN GENE-SPECIFIC DOUBLE-STRANDED OLIGONUCLEOTIDE AND COMP...
- Publication number 20250207137
- Publication date Jun 26, 2025
- Bioneer Corporation
- Tae-Rim KIM
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MODIFIED RNA AGENTS WITH REDUCED OFF-TARGET EFFECT
- Publication number 20250205272
- Publication date Jun 26, 2025
- Alnylam Pharmaceuticals, Inc.
- Mark K. SCHLEGEL
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Anti-NGF Antibodies and Methods Thereof
- Publication number 20250206832
- Publication date Jun 26, 2025
- Zoetis Services LLC
- Sebastian C. J. Steiniger
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS AND PRODUCTS FOR NUCLEIC ACID PRODUCTION AND DELIVERY
- Publication number 20250195622
- Publication date Jun 19, 2025
- FACTOR BIOSCIENCE INC.
- Matthew Angel
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITIONS AND METHODS OF TREATING MUSCLE ATROPHY AND MYOTONIC DY...
- Publication number 20250195676
- Publication date Jun 19, 2025
- Avidity Biosciences, Inc.
- Andrew John GEALL
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
RNA FRAMEWORK FOR GENE EDITING AND GENE EDITING METHOD
- Publication number 20250197883
- Publication date Jun 19, 2025
- Yunpeng SUI
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
NONCOVALENTLY BRANCHED OLIGONUCLEOTIDE COMPOSITIONS
- Publication number 20250188471
- Publication date Jun 12, 2025
- Atalanta Therapeutics, Inc.
- Matthew HASSLER
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
KETOHEXOKINASE (KHK) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
- Publication number 20250188475
- Publication date Jun 12, 2025
- Alnylam Pharmaceuticals, Inc.
- Kevin Fitzgerald
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ENHANCING ESTROGEN RECEPTOR ALPHA IN OSTEOARTHRITIS
- Publication number 20250188149
- Publication date Jun 12, 2025
- University of Pittsburgh of the Commonwealth System of Higher Education
- Hang Lin
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
POTENTIATION OF DURABLE ANTITUMOR IMMUNITY BY MULTIFACTORIAL IMMUNE...
- Publication number 20250186486
- Publication date Jun 12, 2025
- Baylor College of Medicine
- William K. DECKER
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SYNTHETIC LETHALITY AND THE TREATMENT OF CANCER
- Publication number 20250179589
- Publication date Jun 5, 2025
- PACYLEX PHARMACEUTICALS INC.
- Luc G. Berthiaume
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS FOR INCREASING PLATELET COUNT BY INHIBITING BILIVERDIN IXBE...
- Publication number 20250170277
- Publication date May 29, 2025
- The Research Foundation for the State University of New York
- Wadie F. BAHOU
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHOD OF TREATING CANCER USING WRS INHIBITORS
- Publication number 20250171559
- Publication date May 29, 2025
- Korea Research Institute of Bioscience and Biotechnology
- Tae-Don KIM
- G01 - MEASURING TESTING

Double-stranded nucleic acids or oligonucleotides

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Biodegradable lipids for the delivery of active agents

Dosages of immunoconjugates of antibodies and SN-38 for improved ef...

Branched lipid conjugates of siRNA for specific tissue delivery

Nucleic acid-polypeptide compositions and uses thereof

Silver-/gold-compounds and methods thereof

Use of APE1/Ref-1 inhibitors for treatment of retinal diseases

Nucleic acid-polypeptide compositions and uses thereof

Cationic lipids containing silicon

Biodegradable lipids for the delivery of active agents

Polypeptides directed against viral infection and uses thereof

Inflammasome-targeted RNA interference approach to treating kidney...

Synthetic lethality and the treatment of cancer

Biodegradable lipids for the delivery of active agents

Factor XII (hageman factor) (F12), kallikrein B, plasma (fletcher f...

Compounds and methods for trans-membrane delivery of molecules

Methods and compositions for administration of iron

Compositions and methods for delivery of biomacromolecule agents

Methods for reducing post-operative cognitive dysfunction (POCD)

Methods and compositions for modulating gene expression using oligo...

Exosome-targeted DNA vaccine

Methods and compositions for genomic integration

Use of TLR agonist and anti-CD47 agent to enhance phagocytosis of c...

Ionizable compounds and compositions and uses thereof

Branched tail lipid compounds and compositions for intracellular de...

Compositions and methods for nanoparticle lyophile forms

Therapeutic double stranded RNA and methods for producing the same

Antibody-drug conjugates and uses thereof

Compositions and methods for monitoring, diagnosis, prognosis, dete...

BBB-crossing lipid ligand of hetero nucleic acid

Tetragalnac and peptide containing conjugates and methods for deliv...

Patents Applicationslast 30 patents

EXON SKIPPING COMPOSITIONS FOR TREATING MUSCULAR DYSTROPHY

Methods and Compositions for Inhibiting the Growth and/or prolifera...

Use of Trinucleotide Repeat RNAs To Treat Cancer

COMPOSITIONS AND METHODS FOR TREATMENT OF SEPSIS-RELATED DISORDERS

PRODUCTS AND METHODS FOR INHIBITION OF EXPRESSION OF DYNAMIN-1 VARI...

PROTECTION OF BIOLOGICAL SPECIES FROM DEGRADATION

DELIVERY OF HYDROPHOBIC ACTIVE AGENT PARTICLES

COMPOSITIONS AND METHODS FOR TREATING LIVER DISEASES WITH SIRNAS TA...

FABP4 AS A THERAPEUTIC TARGET IN SKIN DISEASES

IMMUNE ENHANCEMENT OF CANCER TREATMENT

TARGETED DELIVERY

LIVER PROTECTIVE MARC VARIANTS AND USES THEREOF

COMPOSITIONS AND METHODS FOR IMMUNE CELL MODULATION IN ADOPTIVE IMM...

Compounds and Methods for Inhibiting LPA

MANNOSE-TARGETED COMPOSITIONS

RNA CONTAINING COMPOSITION FOR TREATMENT OF TUMOR DISEASES

Anti-NGF Antibodies and Methods Thereof

AMPHIREGULIN GENE-SPECIFIC DOUBLE-STRANDED OLIGONUCLEOTIDE AND COMP...

MODIFIED RNA AGENTS WITH REDUCED OFF-TARGET EFFECT

Anti-NGF Antibodies and Methods Thereof

METHODS AND PRODUCTS FOR NUCLEIC ACID PRODUCTION AND DELIVERY

COMPOSITIONS AND METHODS OF TREATING MUSCLE ATROPHY AND MYOTONIC DY...

RNA FRAMEWORK FOR GENE EDITING AND GENE EDITING METHOD

NONCOVALENTLY BRANCHED OLIGONUCLEOTIDE COMPOSITIONS

KETOHEXOKINASE (KHK) iRNA COMPOSITIONS AND METHODS OF USE THEREOF

ENHANCING ESTROGEN RECEPTOR ALPHA IN OSTEOARTHRITIS

POTENTIATION OF DURABLE ANTITUMOR IMMUNITY BY MULTIFACTORIAL IMMUNE...

SYNTHETIC LETHALITY AND THE TREATMENT OF CANCER

METHODS FOR INCREASING PLATELET COUNT BY INHIBITING BILIVERDIN IXBE...

METHOD OF TREATING CANCER USING WRS INHIBITORS