Double-stranded nucleic acids or oligonucleotides

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A61K31/713

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AHUMAN NECESSITIES A61Medical science A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES A61K31/00Medicinal preparations containing organic active ingredients

Current Industry

A61K31/713Double-stranded nucleic acids or oligonucleotides

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Patents Grantslast 30 patents

Information Patent Grant
Liver protective MARC variants and uses thereof
- Patent number 12,215,382
- Issue date Feb 4, 2025
- The General Hospital Corporation
- Sekar Kathiresan
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Anti-tissue factor antibodies, antibody-drug conjugates, and relate...
- Patent number 12,215,167
- Issue date Feb 4, 2025
- ICONIC THERAPEUTICS LLC
- Jan-Willem Theunissen
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Immunoregulatory agent
- Patent number 12,213,984
- Issue date Feb 4, 2025
- Kyushu University, National University Corporation
- Yoshinori Fukui
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Compositions and methods for transport across the blood brain barrier
- Patent number 12,208,143
- Issue date Jan 28, 2025
- OPHIDION INC.
- Andreas Walz
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Exosome-targeted DNA vaccine
- Patent number 12,209,115
- Issue date Jan 28, 2025
- EXORPHIA, INC.
- Ken Ishii
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods and products for nucleic acid production and delivery
- Patent number 12,201,675
- Issue date Jan 21, 2025
- Factor Bioscience Inc.
- Matthew Angel
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Nanostructured lipid carriers and stable emulsions and uses thereof
- Patent number 12,201,722
- Issue date Jan 21, 2025
- ACCESS TO ADVANCED HEALTH INSTITUTE
- Christopher B. Fox
- Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC
Information Patent Grant
NXTAR-derived oligonucleotides and uses thereof
- Patent number 12,194,057
- Issue date Jan 14, 2025
- Washington University
- Nupam Mahajan
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Nucleic acid and other compositions and methods for the modulation...
- Patent number 12,195,753
- Issue date Jan 14, 2025
- The Board of Trustees of the University of Illinois
- Aleksei Aksimentiev
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Antibodies directed to Tie-2 and methods of use
- Patent number 12,195,542
- Issue date Jan 14, 2025
- Unity Biotechnology, Inc.
- Jason Damiano
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
SiRNA delivery system compound as well as preparation method and ap...
- Patent number 12,194,145
- Issue date Jan 14, 2025
- Zhimin Wang
- B82 - NANO-TECHNOLOGY
Information Patent Grant
Cellular delivery of DNA intercalating agents
- Patent number 12,195,531
- Issue date Jan 14, 2025
- Code Biotherapeutics, Inc.
- Robert C. Getts
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Composition for regulating cell division comprising FCHO1 modulator...
- Patent number 12,186,365
- Issue date Jan 7, 2025
- Seoul National University R&DB Foundation
- Myung Haing Cho
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Compositions and methods for dengue virus chimeric constructions in...
- Patent number 12,186,363
- Issue date Jan 7, 2025
- TAKEDA VACCINES, INC.
- Dan T. Stinchcomb
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Tolerogenic liposomes and methods of use thereof
- Patent number 12,178,908
- Issue date Dec 31, 2024
- AnTolRx, Inc.
- Aditi Jhaveri
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Use of PIWI-interacting RNA piR-hsa-211106
- Patent number 12,180,476
- Issue date Dec 31, 2024
- Wenhua Xu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Alpha-v beta-6 integrin ligands and uses thereof
- Patent number 12,173,086
- Issue date Dec 24, 2024
- Arrowhead Pharmaceuticals, Inc.
- Aaron Almeida
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Nano-plasmonic molecular probes and methods of use
- Patent number 12,173,355
- Issue date Dec 24, 2024
- Duke University
- Tuan Vo-Dinh
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Sequence specific antimicrobials
- Patent number 12,168,040
- Issue date Dec 17, 2024
- The Rockefeller University
- David Bikard
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Compositions and methods for the delivery of nucleic acids
- Patent number 12,161,659
- Issue date Dec 10, 2024
- Case Western Reserve University
- Zheng-Rong Lu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Combination cancer therapy with pentaaza macrocyclic ring complex a...
- Patent number 12,156,863
- Issue date Dec 3, 2024
- Galera Labs, LLC
- Robert A. Beardsley
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Methods for promoting entry of an agent into a cell
- Patent number 12,150,951
- Issue date Nov 26, 2024
- TECREA LIMITED
- Liam Good
- B82 - NANO-TECHNOLOGY
Information Patent Grant
Direct and selective inhibition of MDM4 for treatment of cancer
- Patent number 12,139,712
- Issue date Nov 12, 2024
- VIB VZW
- Jean-Christophe Marine
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods for treating hair loss disorders
- Patent number 12,138,490
- Issue date Nov 12, 2024
- The Trustees of Columbia University In the City of New York
- Angela M. Christiano
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Cell-penetrating peptides for antisense delivery
- Patent number 12,138,312
- Issue date Nov 12, 2024
- Sarepta Therapeutics, Inc.
- Justin M. Wolfe
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Physiologically active substance carrier
- Patent number 12,138,346
- Issue date Nov 12, 2024
- LEMONEX INC.
- Cheolhee Won
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Control of replication and transcription of self-replicating RNA in...
- Patent number 12,139,721
- Issue date Nov 12, 2024
- Massachusetts Institute of Technology
- Darrell J. Irvine
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
MicroRNA-198 as a tumor suppressor in ovarian cancer
- Patent number 12,134,769
- Issue date Nov 5, 2024
- Baylor College of Medicine
- Qizhi Yao
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Increasing gene expression
- Patent number 12,134,772
- Issue date Nov 5, 2024
- Advantage Therapeutics, Inc.
- Ci-Di Chen
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Compositions and methods for delivery of RNA
- Patent number 12,133,894
- Issue date Nov 5, 2024
- HDT BIO CORP.
- Amit Khandhar
- B82 - NANO-TECHNOLOGY

Patents Applicationslast 30 patents

Information Patent Application
THERAPEUTIC AGENT FOR REFRACTORY VIRAL INFECTIONS
- Publication number 20250041326
- Publication date Feb 6, 2025
- TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE
- Michinori KOHARA
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
HEMOGLOBIN-BASED NANOPARTICLES
- Publication number 20250041237
- Publication date Feb 6, 2025
- Wisconsin Alumni Research Foundation
- Shaoqin Gong
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
COMPOSITIONS FOR INTRODUCING RNA INTO CELLS
- Publication number 20250041443
- Publication date Feb 6, 2025
- Ethris GmbH
- Christian Dohmen
- C08 - ORGANIC MACROMOLECULAR COMPOUNDS THEIR PREPARATION OR CHEMICAL WORKING-...
Information Patent Application
THERAPEUTIC TARGETING OF GASTROINTESTINAL STROMAL TUMOR (GIST) BY D...
- Publication number 20250041299
- Publication date Feb 6, 2025
- Dana-Farber Cancer Institute, Inc.
- Scott A. ARMSTRONG
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
COMPOSITIONS AND METHODS FOR DELIVERY OF RNA
- Publication number 20250032639
- Publication date Jan 30, 2025
- HDT Bio Corp.
- Amit KHANDHAR
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
USE OF AURANOFIN AS AN INHIBITOR OF ATYPICAL PROTEIN KINASE C FOR T...
- Publication number 20250032530
- Publication date Jan 30, 2025
- Robert Vito FARESE
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE
- Publication number 20250034566
- Publication date Jan 30, 2025
- Alnylam Pharmaceuticals, Inc.
- Brian Bettencourt
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
STEROL REGULATORY ELEMENT BINDING PROTEIN (SREBP) CHAPERONE (SCAP)...
- Publication number 20250034570
- Publication date Jan 30, 2025
- Alnylam Pharmaceuticals, Inc.
- Kevin Fitzgerald
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
NON-LIPOSOMAL SYSTEMS FOR NUCLEIC ACID DELIVERY
- Publication number 20250034571
- Publication date Jan 30, 2025
- ARBUTUS BIOPHARMA CORPORATION
- Ed Yaworski
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CELL DEATH-INDUCING DFFA-LIKE EFFECTOR B (CIDEB) IRNA COMPOSITIONS...
- Publication number 20250034567
- Publication date Jan 30, 2025
- Alnylam Pharmaceuticals, Inc.
- JEFFREY ZUBER
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
PHYSIOLOGICALLY ACTIVE SUBSTANCE CARRIER
- Publication number 20250032414
- Publication date Jan 30, 2025
- LEMONEX INC.
- Cheolhee WON
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
NUCLEIC ACIDS FOR INHIBITING EXPRESSION OF TMPRSS6 AND IRON CHELATORS
- Publication number 20250025488
- Publication date Jan 23, 2025
- Silence Therapeutics GMBH
- Ute Schaeper
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS OF VACCINATION IN PREMALIGNANT SETTINGS
- Publication number 20250025489
- Publication date Jan 23, 2025
- University of Miami
- Eli GILBOA
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
Compositions and Methods for Dengue Virus Chimeric Constructions in...
- Publication number 20250018006
- Publication date Jan 16, 2025
- Takeda Vaccines, Inc.
- Dan STINCHCOMB
- Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMA...
Information Patent Application
HOMEOBOX TRANSCRIPTION FACTOR VENTX REGULATES DIFFERENTIATION AND M...
- Publication number 20250019763
- Publication date Jan 16, 2025
- Zhenglun Zhu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Methods Of Treating Skin Cancer With Carboxypeptidase Vitellogenic...
- Publication number 20250017929
- Publication date Jan 16, 2025
- Regeneron Pharmaceuticals, Inc.
- Xinyuan Zhang
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
NANOPARTICLE DRUG TARGETING JFK AND USE THEREOF
- Publication number 20250009662
- Publication date Jan 9, 2025
- Peking University
- Luyang SUN
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Methods and Compositions for Treating Cancers and Enhancing Therape...
- Publication number 20250009781
- Publication date Jan 9, 2025
- Thomas Jefferson University
- David W. Andrews
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Antibody Binding to Tie2 and Use Thereof
- Publication number 20250011438
- Publication date Jan 9, 2025
- Institute for Basic Science
- Gou Young Koh
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
AGENTS FOR IMPROVED DELIVERY OF NUCLEIC ACIDS TO EUKARYOTIC CELLS
- Publication number 20250011815
- Publication date Jan 9, 2025
- MOLECULAR TRANSFER, INC.
- Joel Jessee
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
TOLL-LIKE RECEPTOR THERAPY COMBINATIONS WITH CBL-B INHIBITOR COMPOUNDS
- Publication number 20250009731
- Publication date Jan 9, 2025
- Nurix Therapeutics, Inc.
- Marilena GALLOTTA
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
GENETIC MODIFICATION OF MAMMALIAN CELLS TO CONFER RESISTANCE TO CSF...
- Publication number 20250002920
- Publication date Jan 2, 2025
- The Regents of the University of California
- Mathew Blurton-Jones
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS FOR TREATING OR PREVENTING OPHTHALMOLOGICAL CONDITIONS
- Publication number 20250000889
- Publication date Jan 2, 2025
- IVERIC bio, Inc.
- Samir Patel
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
PROGRAMMABLE DELIVERY PLATFORMS FOR RNA STRUCTURES
- Publication number 20250000892
- Publication date Jan 2, 2025
- Arizona Board of Regents on behalf of Arizona State University
- Hao YAN
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
REGENERATION OR REJUVENATION OF TISSUES AND ORGANS
- Publication number 20250002919
- Publication date Jan 2, 2025
- The Board of Trustees of the Leland Stanford Junior University
- Helen M. Blau
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
BLOCK COPOLYMERS AND USES THEREOF
- Publication number 20250001005
- Publication date Jan 2, 2025
- ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
- Jeffrey A. HUBBELL
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMBINATION OF TLR LIGANDS, COMPOUNDS LABELLING TUMORS FOR IMMUNE A...
- Publication number 20240424004
- Publication date Dec 26, 2024
- BIOCANIM A.S.
- Jan ŽENKA
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS
- Publication number 20240424105
- Publication date Dec 26, 2024
- ARBUTUS BIOPHARMA CORPORATION
- Muthiah Manoharan
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
NUCLEIC ACID-BASED ASSEMBLY AND USES THEREOF
- Publication number 20240425867
- Publication date Dec 26, 2024
- Rheinische Friedrich-Wilhelms-Universitat Bonn
- Michael Famulok
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
COMPOSITIONS AND METHODS FOR TREATING HUNTINGTON'S DISEASE
- Publication number 20240415868
- Publication date Dec 19, 2024
- VOYAGER THERAPEUTICS, INC.
- Dinah Wen-Yee Sah
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Double-stranded nucleic acids or oligonucleotides

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Liver protective MARC variants and uses thereof

Anti-tissue factor antibodies, antibody-drug conjugates, and relate...

Immunoregulatory agent

Compositions and methods for transport across the blood brain barrier

Exosome-targeted DNA vaccine

Methods and products for nucleic acid production and delivery

Nanostructured lipid carriers and stable emulsions and uses thereof

NXTAR-derived oligonucleotides and uses thereof

Nucleic acid and other compositions and methods for the modulation...

Antibodies directed to Tie-2 and methods of use

SiRNA delivery system compound as well as preparation method and ap...

Cellular delivery of DNA intercalating agents

Composition for regulating cell division comprising FCHO1 modulator...

Compositions and methods for dengue virus chimeric constructions in...

Tolerogenic liposomes and methods of use thereof

Use of PIWI-interacting RNA piR-hsa-211106

Alpha-v beta-6 integrin ligands and uses thereof

Nano-plasmonic molecular probes and methods of use

Sequence specific antimicrobials

Compositions and methods for the delivery of nucleic acids

Combination cancer therapy with pentaaza macrocyclic ring complex a...

Methods for promoting entry of an agent into a cell

Direct and selective inhibition of MDM4 for treatment of cancer

Methods for treating hair loss disorders

Cell-penetrating peptides for antisense delivery

Physiologically active substance carrier

Control of replication and transcription of self-replicating RNA in...

MicroRNA-198 as a tumor suppressor in ovarian cancer

Increasing gene expression

Compositions and methods for delivery of RNA

Patents Applicationslast 30 patents

THERAPEUTIC AGENT FOR REFRACTORY VIRAL INFECTIONS

HEMOGLOBIN-BASED NANOPARTICLES

COMPOSITIONS FOR INTRODUCING RNA INTO CELLS

THERAPEUTIC TARGETING OF GASTROINTESTINAL STROMAL TUMOR (GIST) BY D...

COMPOSITIONS AND METHODS FOR DELIVERY OF RNA

USE OF AURANOFIN AS AN INHIBITOR OF ATYPICAL PROTEIN KINASE C FOR T...

COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE

STEROL REGULATORY ELEMENT BINDING PROTEIN (SREBP) CHAPERONE (SCAP)...

NON-LIPOSOMAL SYSTEMS FOR NUCLEIC ACID DELIVERY

CELL DEATH-INDUCING DFFA-LIKE EFFECTOR B (CIDEB) IRNA COMPOSITIONS...

PHYSIOLOGICALLY ACTIVE SUBSTANCE CARRIER

NUCLEIC ACIDS FOR INHIBITING EXPRESSION OF TMPRSS6 AND IRON CHELATORS

METHODS OF VACCINATION IN PREMALIGNANT SETTINGS

Compositions and Methods for Dengue Virus Chimeric Constructions in...

HOMEOBOX TRANSCRIPTION FACTOR VENTX REGULATES DIFFERENTIATION AND M...

Methods Of Treating Skin Cancer With Carboxypeptidase Vitellogenic...

NANOPARTICLE DRUG TARGETING JFK AND USE THEREOF

Methods and Compositions for Treating Cancers and Enhancing Therape...

Antibody Binding to Tie2 and Use Thereof

AGENTS FOR IMPROVED DELIVERY OF NUCLEIC ACIDS TO EUKARYOTIC CELLS

TOLL-LIKE RECEPTOR THERAPY COMBINATIONS WITH CBL-B INHIBITOR COMPOUNDS

GENETIC MODIFICATION OF MAMMALIAN CELLS TO CONFER RESISTANCE TO CSF...

METHODS FOR TREATING OR PREVENTING OPHTHALMOLOGICAL CONDITIONS

PROGRAMMABLE DELIVERY PLATFORMS FOR RNA STRUCTURES

REGENERATION OR REJUVENATION OF TISSUES AND ORGANS

BLOCK COPOLYMERS AND USES THEREOF

COMBINATION OF TLR LIGANDS, COMPOUNDS LABELLING TUMORS FOR IMMUNE A...

NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS

NUCLEIC ACID-BASED ASSEMBLY AND USES THEREOF

COMPOSITIONS AND METHODS FOR TREATING HUNTINGTON'S DISEASE