for interleukins [IL]

Industry

CPC
C07K14/7155

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Parent Industries

CCHEMISTRY METALLURGY C07Organic chemistry C07KPEPTIDES C07K14/00Peptides having more than 20 amino acids Gastrins Somatostatins Melanotropins Derivatives thereof

Current Industry

C07K14/7155for interleukins [IL]

Industries

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Patents Grantslast 30 patents

Information Patent Grant
Humanized IL-6 and IL-6 receptor
- Patent number 12,239,111
- Issue date Mar 4, 2025
- REGENERON PHARMACEUTICALS, INC.
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Decoy cytokine receptor
- Patent number 12,240,889
- Issue date Mar 4, 2025
- National University of Singapore
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
IL-15/IL-15RA heterodimeric Fc fusion proteins and uses thereof
- Patent number 12,239,688
- Issue date Mar 4, 2025
- Xencor, Inc.
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Treatment of kidney injury
- Patent number 12,234,284
- Issue date Feb 25, 2025
- National University of Singapore
- Stuart Alexander Cook
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Chimeric transmembrane protein comprising antibody dimerization dom...
- Patent number 12,234,295
- Issue date Feb 25, 2025
- AUTOLUS LIMITED
- Martin Pulé
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Collagen-localized immunomodulatory molecules and methods thereof
- Patent number 12,227,559
- Issue date Feb 18, 2025
- Massachusetts Institute of Technology
- Karl Dane Wittrup
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Switch receptors using IL-9 signaling domains
- Patent number 12,221,469
- Issue date Feb 11, 2025
- Parker Institute for Cancer Immunotherapy
- John Connolly
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
IgG Fc-IL2-Rα-IL2 fusions and methods of use thereof
- Patent number 12,215,131
- Issue date Feb 4, 2025
- REGENERON PHARMACEUTICALS, INC.
- Jiaxi Wu
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Compositions and methods for T cell delivery of therapeutic molecules
- Patent number 12,215,137
- Issue date Feb 4, 2025
- The Trustees of the University of Pennsylvania
- Yangbing Zhao
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Compositions and methods related to IL27 receptor binding
- Patent number 12,209,132
- Issue date Jan 28, 2025
- Synthekine, Inc.
- Robert Kastelein
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Tethered interleukin-2 to its receptor IL-2RBETA, a platform to enh...
- Patent number 12,202,856
- Issue date Jan 21, 2025
- The General Hospital Corporation
- Youssef Jounaidi
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Interleukin-2/interleukin-2 receptor alpha fusion proteins and meth...
- Patent number 12,202,872
- Issue date Jan 21, 2025
- Bristol-Myers Squibb Company
- Mary Struthers
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Nucleic acids encoding switch receptors using IL-9 receptor signali...
- Patent number 12,202,884
- Issue date Jan 21, 2025
- Parker Institute for Cancer Immunotherapy
- John Connolly
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Advanced avatar dendritic cells
- Patent number 12,195,520
- Issue date Jan 14, 2025
- ImmunityBio, Inc.
- Patrick Soon-Shiong
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Chromatography resin and uses thereof
- Patent number 12,187,763
- Issue date Jan 7, 2025
- ImmunityBio, Inc.
- Hing C. Wong
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Grant
IL-15-based molecules and methods of treating a neoplasia
- Patent number 12,186,372
- Issue date Jan 7, 2025
- ALTOR BIOSCIENCE, LLC
- Bai Liu
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
IL1-R1 derived inhibitor of IL-1β and use thereof
- Patent number 12,180,264
- Issue date Dec 31, 2024
- Yan Lavrovsky
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Methods and systems for producing a protein of interest in a plant
- Patent number 12,180,492
- Issue date Dec 31, 2024
- ImmunityBio, Inc.
- Patrick Soon-Shiong
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Grant
Anti-IL-31RA antibody-containing formulations
- Patent number 12,171,830
- Issue date Dec 24, 2024
- CHUGAI SEIYAKU KABUSHIKI KAISHA
- Daisuke Kameoka
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Fusion molecules and IL-15 variants
- Patent number 12,168,680
- Issue date Dec 17, 2024
- ALTOR BIOSCIENCE, LLC
- Hing C. Wong
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Oncolytic herpes simplex virus vectors expressing immune system-sti...
- Patent number 12,162,919
- Issue date Dec 10, 2024
- Virogin Biotech Canada Ltd
- William Jia
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Inducible chimeric cytokine receptors
- Patent number 12,163,169
- Issue date Dec 10, 2024
- Allogene Therapeutics, Inc.
- Andrew Ross Nager
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
IL27RAlpha binding molecules and methods of use
- Patent number 12,157,773
- Issue date Dec 3, 2024
- Synthekine, Inc.
- Robert Kastelein
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Targeted heterodimeric Fc fusion proteins containing IL-15 IL-15alp...
- Patent number 12,139,525
- Issue date Nov 12, 2024
- Xencor, Inc.
- Matthew J. Bernett
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
IL-15Rα sushi domain—IL-15 fusion proteins
- Patent number 12,134,639
- Issue date Nov 5, 2024
- INSERM (Institut National de la Sante et de la Recherche Medicale
- Yannick Jacques
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
IFNGR binding synthetic cytokines and methods of use
- Patent number 12,122,839
- Issue date Oct 22, 2024
- Synthekine, Inc.
- Robert Kastelein
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
IL-IR-I binding polypeptide
- Patent number 12,116,397
- Issue date Oct 15, 2024
- Swedish Orphan Biovitrum AB (publ)
- Joachim Feldwisch
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Constitutively active cytokine receptors for cell therapy
- Patent number 12,102,652
- Issue date Oct 1, 2024
- Baylor College of Medicine
- Thomas C. T. Shum
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
DHFR tunable protein regulation
- Patent number 12,104,178
- Issue date Oct 1, 2024
- Obsidian Therapeutics, Inc.
- Vipin Suri
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods of treating a neoplasia with IL-15-based molecules and CTLA...
- Patent number 12,097,244
- Issue date Sep 24, 2024
- ALTOR BIOSCIENCE, LLC
- Bai Liu
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE

Patents Applicationslast 30 patents

Information Patent Application
ANTI-IL-31RA ANTIBODY-CONTAINING FORMULATIONS
- Publication number 20250064930
- Publication date Feb 27, 2025
- Chugai SeiYaku Kabushiki Kaisha
- Daisuke Kameoka
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
FUSION MOLECULES AND IL-15 VARIANTS
- Publication number 20250066442
- Publication date Feb 27, 2025
- Altor BioScience LLC
- Hing C. Wong
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
IL-IR-I BINDING POLYPEPTIDE
- Publication number 20250066451
- Publication date Feb 27, 2025
- SWEDISH ORPHAN BIOVITRUM AB (publ)
- Joachim Feldwisch
- C07 - ORGANIC CHEMISTRY
Information Patent Application
CONTROLLABLE STIMULATION OF GENETICALLY ENGINEERED LYMPHOCYTES FOR...
- Publication number 20250057883
- Publication date Feb 20, 2025
- The Trustees of the University of Pennsylvania
- Saar GILL
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
IL-15/IL-15RA HETERODIMERIC FC FUSION PROTEINS AND USES THEREOF
- Publication number 20250057919
- Publication date Feb 20, 2025
- Xencor, Inc.
- Matthew Bernett
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
CELLS COMPRISING A SUPPRESSOR OF GENE EXPRESSION AND/OR A SYNTHETIC...
- Publication number 20250049854
- Publication date Feb 13, 2025
- Arsenal Biosciences, Inc.
- Aaron Cooper
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
NOVEL IL2 AGONISTS AND METHODS OF USE THEREOF
- Publication number 20250034224
- Publication date Jan 30, 2025
- Regeneron Pharmaceuticals, Inc.
- Jiaxi WU
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
EFFECTOR CELLS AND USE THEREOF FOR ALLOGENEIC ADOPTIVE CELL THERAPI...
- Publication number 20250032547
- Publication date Jan 30, 2025
- FATE THERAPEUTICS, INC.
- Emily CARRON
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
CELLS EXPRESSING AN ANTI-MESOTHELIN CAR
- Publication number 20250025555
- Publication date Jan 23, 2025
- GammaDelta Therapeutics Ltd
- Istvan KOVACS
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITIONS AND METHODS FOR CONTROLLING CELL SIGNALING WITH CHIMER...
- Publication number 20250025502
- Publication date Jan 23, 2025
- GentiBio, Inc.
- Tom Wickham
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Methods And Systems For Producing A Protein Of Interest In A Plant
- Publication number 20250019716
- Publication date Jan 16, 2025
- ImmunityBio, Inc.
- Patrick SOON-SHIONG
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Application
TRUNCATED DOMAIN IV EGFR AND USES THEREOF
- Publication number 20250009795
- Publication date Jan 9, 2025
- CITY OF HOPE
- Alfur HUNG
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
SERPIN FUSION POLYPEPTIDES AND METHODS OF USE THEREOF
- Publication number 20250011394
- Publication date Jan 9, 2025
- Sanofi AATD Inc.
- Brendan P. ECKELMAN
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ENGINEERED EFFECTOR CELLS FOR TRAFFICKING OF ALLOGENEIC CELL THERAP...
- Publication number 20250009882
- Publication date Jan 9, 2025
- FATE THERAPEUTICS, INC.
- Martin HOSKING
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CYTOKINE-IMMUNORECEPTOR FUSION PROTEINS AND USES THEREOF
- Publication number 20250011384
- Publication date Jan 9, 2025
- Senti Biosciences, Inc.
- Aldo Omar Sotelo
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
EFFECTOR CELLS AND USE THEREOF FOR ALLOGENEIC ADOPTIVE CELL THERAPI...
- Publication number 20250000904
- Publication date Jan 2, 2025
- FATE THERAPEUTICS, INC.
- Emily CARRON
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOUND CHIMERIC ANTIGEN RECEPTOR (CCAR) TARGETING MULTIPLE ANTIGE...
- Publication number 20250002550
- Publication date Jan 2, 2025
- iCell Gene Therapeutics Inc.
- Yupo MA
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CONSTITUTIVELY ACTIVE CYTOKINE RECEPTORS FOR CELL THERAPY
- Publication number 20250002558
- Publication date Jan 2, 2025
- Baylor College of Medicine
- Thomas C. T. Shum
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
IL5RA CELL SURFACE MARKERS
- Publication number 20240417443
- Publication date Dec 19, 2024
- Sonoma Biotherapeutics, Inc.
- James MATTHAEI
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
COMPOSITIONS AND METHODS FOR TREATING INTERLEUKIN 7 RECEPTOR DEFICI...
- Publication number 20240417444
- Publication date Dec 19, 2024
- The Children's Hospital of Philadelphia
- Stefano Rivella
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
Linker Polypeptides
- Publication number 20240417437
- Publication date Dec 19, 2024
- TRUTINO BIOSCIENCES INC.
- Phillip S. Kim
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ENGINEERED CYTOKINE RECEPTORS FOR TUNABLE ADOPTIVE CELL THERAPY
- Publication number 20240408139
- Publication date Dec 12, 2024
- Dana-Farber Cancer Institute, Inc.
- Carl NOVINA
- C07 - ORGANIC CHEMISTRY
Information Patent Application
CHIMERIC ANTIGEN RECEPTOR IMMUNE CELL, AND PREPARATION METHOD THERE...
- Publication number 20240408199
- Publication date Dec 12, 2024
- GRACELL BIOTECHNOLOGIES (SHANGHAI) CO., LTD.
- Qi DONG
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
NOVEL IL2 AGONISTS AND METHODS OF USE THEREOF
- Publication number 20240400632
- Publication date Dec 5, 2024
- Regeneron Pharmaceuticals, Inc.
- Jiaxi WU
- C07 - ORGANIC CHEMISTRY
Information Patent Application
DHFR TUNABLE PROTEIN REGULATION
- Publication number 20240401004
- Publication date Dec 5, 2024
- Obsidian Therapeutics, Inc.
- Vipin SURI
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
IL-12 AND IL-15 POLYPEPTIDES
- Publication number 20240391972
- Publication date Nov 28, 2024
- SAGITTARIUS BIO, INC
- Kayvan NIAZI
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ANTIBODY RESISTANT MODIFIED RECEPTORS TO ENHANCE CELL-BASED THERAPIES
- Publication number 20240390460
- Publication date Nov 28, 2024
- Regeneron Pharmaceuticals, Inc.
- Michael Moore
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ANTIGEN TARGETING, ANTI-CD16A, AND IMMUNE EFFECTOR CELL ACTIVATING...
- Publication number 20240383985
- Publication date Nov 21, 2024
- QURE BIOTECHNOLOGY (SHANGHAI) CO., LTD.
- Xiangdong QU
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
IL23R BINDING MOLECULES AND METHODS OF USE
- Publication number 20240376217
- Publication date Nov 14, 2024
- Synthekine, Inc.
- Robert Kastelein
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
SENESCENCE TREATMENT with IL-15-BASED FUSIONS to IL-7 and IL-21
- Publication number 20240368237
- Publication date Nov 7, 2024
- Altor BioScience, LLC.
- Hing C. Wong
- A21 - BAKING EDIBLE DOUGHS

for interleukins [IL]

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Humanized IL-6 and IL-6 receptor

Decoy cytokine receptor

IL-15/IL-15RA heterodimeric Fc fusion proteins and uses thereof

Treatment of kidney injury

Chimeric transmembrane protein comprising antibody dimerization dom...

Collagen-localized immunomodulatory molecules and methods thereof

Switch receptors using IL-9 signaling domains

IgG Fc-IL2-Rα-IL2 fusions and methods of use thereof

Compositions and methods for T cell delivery of therapeutic molecules

Compositions and methods related to IL27 receptor binding

Tethered interleukin-2 to its receptor IL-2RBETA, a platform to enh...

Interleukin-2/interleukin-2 receptor alpha fusion proteins and meth...

Nucleic acids encoding switch receptors using IL-9 receptor signali...

Advanced avatar dendritic cells

Chromatography resin and uses thereof

IL-15-based molecules and methods of treating a neoplasia

IL1-R1 derived inhibitor of IL-1β and use thereof

Methods and systems for producing a protein of interest in a plant

Anti-IL-31RA antibody-containing formulations

Fusion molecules and IL-15 variants

Oncolytic herpes simplex virus vectors expressing immune system-sti...

Inducible chimeric cytokine receptors

IL27RAlpha binding molecules and methods of use

Targeted heterodimeric Fc fusion proteins containing IL-15 IL-15alp...

IL-15Rα sushi domain—IL-15 fusion proteins

IFNGR binding synthetic cytokines and methods of use

IL-IR-I binding polypeptide

Constitutively active cytokine receptors for cell therapy

DHFR tunable protein regulation

Methods of treating a neoplasia with IL-15-based molecules and CTLA...

Patents Applicationslast 30 patents

ANTI-IL-31RA ANTIBODY-CONTAINING FORMULATIONS

FUSION MOLECULES AND IL-15 VARIANTS

IL-IR-I BINDING POLYPEPTIDE

CONTROLLABLE STIMULATION OF GENETICALLY ENGINEERED LYMPHOCYTES FOR...

IL-15/IL-15RA HETERODIMERIC FC FUSION PROTEINS AND USES THEREOF

CELLS COMPRISING A SUPPRESSOR OF GENE EXPRESSION AND/OR A SYNTHETIC...

NOVEL IL2 AGONISTS AND METHODS OF USE THEREOF

EFFECTOR CELLS AND USE THEREOF FOR ALLOGENEIC ADOPTIVE CELL THERAPI...

CELLS EXPRESSING AN ANTI-MESOTHELIN CAR

COMPOSITIONS AND METHODS FOR CONTROLLING CELL SIGNALING WITH CHIMER...

Methods And Systems For Producing A Protein Of Interest In A Plant

TRUNCATED DOMAIN IV EGFR AND USES THEREOF

SERPIN FUSION POLYPEPTIDES AND METHODS OF USE THEREOF

ENGINEERED EFFECTOR CELLS FOR TRAFFICKING OF ALLOGENEIC CELL THERAP...

CYTOKINE-IMMUNORECEPTOR FUSION PROTEINS AND USES THEREOF

EFFECTOR CELLS AND USE THEREOF FOR ALLOGENEIC ADOPTIVE CELL THERAPI...

COMPOUND CHIMERIC ANTIGEN RECEPTOR (CCAR) TARGETING MULTIPLE ANTIGE...

CONSTITUTIVELY ACTIVE CYTOKINE RECEPTORS FOR CELL THERAPY

IL5RA CELL SURFACE MARKERS

COMPOSITIONS AND METHODS FOR TREATING INTERLEUKIN 7 RECEPTOR DEFICI...

Linker Polypeptides

ENGINEERED CYTOKINE RECEPTORS FOR TUNABLE ADOPTIVE CELL THERAPY

CHIMERIC ANTIGEN RECEPTOR IMMUNE CELL, AND PREPARATION METHOD THERE...

NOVEL IL2 AGONISTS AND METHODS OF USE THEREOF

DHFR TUNABLE PROTEIN REGULATION

IL-12 AND IL-15 POLYPEPTIDES

ANTIBODY RESISTANT MODIFIED RECEPTORS TO ENHANCE CELL-BASED THERAPIES

ANTIGEN TARGETING, ANTI-CD16A, AND IMMUNE EFFECTOR CELL ACTIVATING...

IL23R BINDING MOLECULES AND METHODS OF USE

SENESCENCE TREATMENT with IL-15-BASED FUSIONS to IL-7 and IL-21