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CCHEMISTRY METALLURGY C07Organic chemistry C07KPEPTIDES C07K14/00Peptides having more than 20 amino acids Gastrins Somatostatins Melanotropins Derivatives thereof

Current Industry

C07K14/24from Enterobacteriaceae (F)

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Patents Grantslast 30 patents

Information Patent Grant
Methods and compositions for display of macrocyclic peptides
- Patent number 12,359,192
- Issue date Jul 15, 2025
- University of Rochester
- Rudi Fasan
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Virulence attenuated bacteria based protein delivery
- Patent number 12,358,955
- Issue date Jul 15, 2025
- Universitaet Basel
- Simon Ittig
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
E. coli FimH mutants and uses thereof
- Patent number 12,357,681
- Issue date Jul 15, 2025
- Pfizer Inc.
- Ye Che
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Method of making recombinant silk and silk-amyloid hybrid proteins...
- Patent number 12,351,805
- Issue date Jul 8, 2025
- Northeastern University
- Neel Satish Joshi
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Artificial organelles for enzymatic cofactor reduction
- Patent number 12,344,878
- Issue date Jul 1, 2025
- ENSOVI, INC.
- Kyle A. Minor
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Mutated e. coli enterotoxins as anti-inflammatory agents
- Patent number 12,337,025
- Issue date Jun 24, 2025
- The Administrators of the Tulane Educational Fund
- Elizabeth Bray Norton
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Methods and compositions related to the next generation vaccine
- Patent number 12,331,085
- Issue date Jun 17, 2025
- University of Kansas
- Wendy L. Picking
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Method of producing sulfur-containing amino acid or derivative thereof
- Patent number 12,331,339
- Issue date Jun 17, 2025
- CJ Cheiljedang Corporation
- Sol Choi
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Immunogenic composition against severe acute respiratory syndrome c...
- Patent number 12,296,002
- Issue date May 13, 2025
- MEDIGEN VACCINE BIOLOGICS CORPORATION
- Tsun-Yung Kuo
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
FimH mutants, compositions therewith and use thereof
- Patent number 12,297,238
- Issue date May 13, 2025
- Janssen Pharmaceuticals, Inc.
- Jan Grijpstra
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Mutant CsgG pores
- Patent number 12,275,761
- Issue date Apr 15, 2025
- VIB VZW
- Stefan Howorka
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Bioactive polypeptides for improvements in plant protection, growth...
- Patent number 12,268,727
- Issue date Apr 8, 2025
- Spogen Biotech Inc.
- Brian Thompson
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Klebsiella vaccine and methods of use
- Patent number 12,263,211
- Issue date Apr 1, 2025
- Cornell University
- Rodrigo Bicalho
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Compositions and methods for the production of cysteine
- Patent number 12,246,056
- Issue date Mar 11, 2025
- The Regents of the University of Michigan
- Lydia Petra Freddolino
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Mutant pores
- Patent number 12,227,800
- Issue date Feb 18, 2025
- Oxford Nanopore Technologies PLC
- Lakmal Nishantha Jayasinghe
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Organic solvent method for preparing membrane protein based nanoshe...
- Patent number 12,220,667
- Issue date Feb 11, 2025
- The Penn State Research Foundation
- Manish Kumar
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Grant
Modified bacterial protein expression system
- Patent number 12,221,642
- Issue date Feb 11, 2025
- University in the City of New York
- Maxwell Gottesman
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Polysaccharide and uses thereof
- Patent number 12,214,029
- Issue date Feb 4, 2025
- GlaxoSmithKline Biologicals SA
- Michael T. Kowarik
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Immunogenic formulation that induces protection against shiga toxin...
- Patent number 12,214,028
- Issue date Feb 4, 2025
- Universidad de Chile
- Roberto Mauricio Vidal Alvarez
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Engineered bacteria secreting therapeutic proteins and methods of u...
- Patent number 12,201,654
- Issue date Jan 21, 2025
- President and Fellows of Harvard College
- Peter Q. Nguyen
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method of producing sulfur-containing amino acid or derivative thereof
- Patent number 12,203,117
- Issue date Jan 21, 2025
- CJ Cheiljedang Corporation
- Sol Choi
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Genetically encoded biosensors
- Patent number 12,203,932
- Issue date Jan 21, 2025
- Howard Hughes Medical Institute
- Jonathan S. Marvin
- G01 - MEASURING TESTING
Information Patent Grant
Sialyltransferases for in vivo synthesis of 3′SL
- Patent number 12,188,056
- Issue date Jan 7, 2025
- DSM IP Assets B.V.
- Manos Papadakis
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Modified bacteria for enhanced bioproduction and methods of using t...
- Patent number 12,168,679
- Issue date Dec 17, 2024
- Northwestern University
- William H. Bothfeld
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Heme sequesting peptides and uses therefor
- Patent number 12,168,678
- Issue date Dec 17, 2024
- Board of Regents, The University of Texas System
- Li Zhang
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Recombinant microorganism having increased ability to produce hydro...
- Patent number 12,134,793
- Issue date Nov 5, 2024
- Korea Advanced Institute of Science and Technology
- Sang Yup Lee
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
PepCon proteomics standards and methods of use
- Patent number 12,110,314
- Issue date Oct 8, 2024
- Lawrence Livermore National Security, LLC
- Mathew Gerald Lyman
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Cofactor self-sufficient Escherichia coli and construction method a...
- Patent number 12,104,191
- Issue date Oct 1, 2024
- Zhejiang University of Technology
- Yaping Xue
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
XylR mutant for improved xylose utilization or improved co-utilizat...
- Patent number 12,098,168
- Issue date Sep 24, 2024
- Genomatica, Inc.
- Stephen Thomas Payne
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Bacteria-based protein delivery
- Patent number 12,091,670
- Issue date Sep 17, 2024
- Universitaet Basel
- Cécile Arrieumerlou
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Patents Applicationslast 30 patents

Information Patent Application
CONSTITUTIVE PRODUCTION OF MICROCINS TO TARGET ENTERIC BACTERIA
- Publication number 20250236648
- Publication date Jul 24, 2025
- University of Massachusetts
- Vanni BUCCI
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITIONS AND METHODS FOR MAKING AND USING PROTEIN NANOWIRES WIT...
- Publication number 20250230198
- Publication date Jul 17, 2025
- Yale University
- Farren Isaacs
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MODIFIED CASCADE RIBONUCLEOPROTEINS AND USES THEREOF
- Publication number 20250230424
- Publication date Jul 17, 2025
- Caribou Biosciences, Inc.
- Stan Johan Josef Brouns
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
IMPROVED CHIMERIC POLYPEPTIDES AND USES THEREOF
- Publication number 20250223319
- Publication date Jul 10, 2025
- The University of Queensland
- Keith CHAPPELL
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MODIFIED CASCADE RIBONUCLEOPROTEINS AND USES THEREOF
- Publication number 20250223578
- Publication date Jul 10, 2025
- Caribou Biosciences, Inc.
- Stan Johan Josef Brouns
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
KLEBSIELLA VACCINE AND METHODS OF USE
- Publication number 20250222089
- Publication date Jul 10, 2025
- Cornell University
- Rodrigo BICALHO
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
GENETICALLY MODIFIED MICROORGANISM FOR PRODUCING 3-HYDROXYADIPIC AC...
- Publication number 20250215461
- Publication date Jul 3, 2025
- TORAY INDUSTRIES, INC.
- Kyohei ISOBE
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MECHANICALLY TUNABLE, SCALABLE AND COMPOSTABLE AQUAPLASTIC
- Publication number 20250197459
- Publication date Jun 19, 2025
- Northeastern University
- Avinash Manjula Basavanna
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MUTANT L-THREONINE-RELEASING PROTEIN AND METHOD FOR PRODUCING L-THR...
- Publication number 20250197900
- Publication date Jun 19, 2025
- CJ CHEILJEDANG CORPORATION
- Woosung CHOI
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
VARIANT L-THREONINE EXPORT PROTEIN AND METHOD OF PRODUCING L-THREON...
- Publication number 20250179127
- Publication date Jun 5, 2025
- CJ CHEILJEDANG CORPORATION
- Woosung CHOI
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS AND COMPOSITIONS FOR MULTIVALENT VACCINES
- Publication number 20250152694
- Publication date May 15, 2025
- Board of Regents, The University of Texas System
- Zackary Armstrong
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
PEPTIDES FOR DISSOLVING PROTEIN AGGREGATES AND METHODS THEREOF
- Publication number 20250154207
- Publication date May 15, 2025
- REJUKON BIOPHARM INC.
- Chenchen WANG
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITIONS COMPRISING RECOMBINANT STRAINS OF MYCOBACTERIUM, USES...
- Publication number 20250144196
- Publication date May 8, 2025
- INSTITUTO BUTANTAN
- Luciana Cezar De Cerqueira Leite
- C07 - ORGANIC CHEMISTRY
Information Patent Application
NEW SIALYLTRANSFERASES FOR IN VIVO SYNTHESIS OF 3'SL
- Publication number 20250136955
- Publication date May 1, 2025
- DSM IP Assets B.V.
- Manos PAPADAKIS
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Immunogenic Fusion Peptides Including FC Fragment and a Non Toxic B...
- Publication number 20250127888
- Publication date Apr 24, 2025
- St. George's Hospital Medical School
- Rajko Reljic
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITIONS AND METHODS FOR CONTROLLING COLEOPTERAN INSECTS
- Publication number 20250101452
- Publication date Mar 27, 2025
- Syngenta Crop Protection AG
- Clarence Michael Reynolds
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Method for Regulating and Controlling Heterologous Synthetic Flavon...
- Publication number 20250092431
- Publication date Mar 20, 2025
- CAS Center for Exellence in Molecular Plant Sciences
- Yong Wang
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Methods And Compositions For Improved Production Of Fatty Acids And...
- Publication number 20250092355
- Publication date Mar 20, 2025
- Genomatica, Inc.
- Derek L. GREENFIELD
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MULTI-COMPONENTED STRUCTURE FOR CAPTURING COMPOUND
- Publication number 20250074952
- Publication date Mar 6, 2025
- Rigaku Corporation
- Takashi MATSUMOTO
- G01 - MEASURING TESTING
Information Patent Application
METHOD FOR PRODUCING SUGAR INCLUDING LACTO-N-TRIOSE II AS CORE TRIS...
- Publication number 20250051814
- Publication date Feb 13, 2025
- KYOWA HAKKO BIO CO., LTD.
- Tomotoshi SUGITA
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
TRANSMEMBRANE PORE CONSISTING OF TWO CSGG PORES
- Publication number 20250042952
- Publication date Feb 6, 2025
- Oxford Nanopore Technologies PLC
- Lakmal Nishantha Jayasinghe
- G01 - MEASURING TESTING
Information Patent Application
MICROORGANISM AND METHOD FOR THE IMPROVED PRODUCTION OF VALINE
- Publication number 20250027124
- Publication date Jan 23, 2025
- Metabolic Explorer
- Perrine VASSEUR
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITIONS AND METHODS FOR THE PRODUCTION OF CYSTEINE
- Publication number 20250025529
- Publication date Jan 23, 2025
- The Regents of the University of Michigan
- Lydia Petra Freddolino
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
IN PHA PRODUCTION
- Publication number 20250019729
- Publication date Jan 16, 2025
- ExxonMobil Technology and Engineering Company
- Leticia R. CARRILLO-MAX
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHOD FOR CONSTRUCTING STRAIN FOR PRODUCING RECOMBINANT PROTEIN CO...
- Publication number 20250019711
- Publication date Jan 16, 2025
- Novocodex Biopharmaceuticals Co., Ltd.
- Longfei Chen
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS AND COMPOSITIONS FOR PREVENTING INFECTION
- Publication number 20250011375
- Publication date Jan 9, 2025
- Vaxxinova US, Inc.
- Graham J.M. Cox
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
POLYNUCLEOTIDE COMPOSITIONS AND USES THEREOF
- Publication number 20250000960
- Publication date Jan 2, 2025
- Pfizer Inc.
- Eric Matthew Bennett
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
RNAYLATION
- Publication number 20250002962
- Publication date Jan 2, 2025
- Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.
- Katharina HÖFER
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
BACTERIA PRODUCING GAMMA-AMINOBUTYRIC ACID (GABA) AND USES OF THE B...
- Publication number 20240424035
- Publication date Dec 26, 2024
- Washington State University
- Jean-Baptiste O. Roullet
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
BACTERIAL COLICIN-IMMUNITY PROTEIN PROTEIN PURIFICATION SYSTEM
- Publication number 20240417426
- Publication date Dec 19, 2024
- The UAB Research Foundation
- Dmitry Vassylyev
- C07 - ORGANIC CHEMISTRY

from Enterobacteriaceae (F)

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Methods and compositions for display of macrocyclic peptides

Virulence attenuated bacteria based protein delivery

E. coli FimH mutants and uses thereof

Method of making recombinant silk and silk-amyloid hybrid proteins...

Artificial organelles for enzymatic cofactor reduction

Mutated e. coli enterotoxins as anti-inflammatory agents

Methods and compositions related to the next generation vaccine

Method of producing sulfur-containing amino acid or derivative thereof

Immunogenic composition against severe acute respiratory syndrome c...

FimH mutants, compositions therewith and use thereof

Mutant CsgG pores

Bioactive polypeptides for improvements in plant protection, growth...

Klebsiella vaccine and methods of use

Compositions and methods for the production of cysteine

Mutant pores

Organic solvent method for preparing membrane protein based nanoshe...

Modified bacterial protein expression system

Polysaccharide and uses thereof

Immunogenic formulation that induces protection against shiga toxin...

Engineered bacteria secreting therapeutic proteins and methods of u...

Method of producing sulfur-containing amino acid or derivative thereof

Genetically encoded biosensors

Sialyltransferases for in vivo synthesis of 3′SL

Modified bacteria for enhanced bioproduction and methods of using t...

Heme sequesting peptides and uses therefor

Recombinant microorganism having increased ability to produce hydro...

PepCon proteomics standards and methods of use

Cofactor self-sufficient Escherichia coli and construction method a...

XylR mutant for improved xylose utilization or improved co-utilizat...

Bacteria-based protein delivery

Patents Applicationslast 30 patents

CONSTITUTIVE PRODUCTION OF MICROCINS TO TARGET ENTERIC BACTERIA

COMPOSITIONS AND METHODS FOR MAKING AND USING PROTEIN NANOWIRES WIT...

MODIFIED CASCADE RIBONUCLEOPROTEINS AND USES THEREOF

IMPROVED CHIMERIC POLYPEPTIDES AND USES THEREOF

MODIFIED CASCADE RIBONUCLEOPROTEINS AND USES THEREOF

KLEBSIELLA VACCINE AND METHODS OF USE

GENETICALLY MODIFIED MICROORGANISM FOR PRODUCING 3-HYDROXYADIPIC AC...

MECHANICALLY TUNABLE, SCALABLE AND COMPOSTABLE AQUAPLASTIC

MUTANT L-THREONINE-RELEASING PROTEIN AND METHOD FOR PRODUCING L-THR...

VARIANT L-THREONINE EXPORT PROTEIN AND METHOD OF PRODUCING L-THREON...

METHODS AND COMPOSITIONS FOR MULTIVALENT VACCINES

PEPTIDES FOR DISSOLVING PROTEIN AGGREGATES AND METHODS THEREOF

COMPOSITIONS COMPRISING RECOMBINANT STRAINS OF MYCOBACTERIUM, USES...

NEW SIALYLTRANSFERASES FOR IN VIVO SYNTHESIS OF 3'SL

Immunogenic Fusion Peptides Including FC Fragment and a Non Toxic B...

COMPOSITIONS AND METHODS FOR CONTROLLING COLEOPTERAN INSECTS

Method for Regulating and Controlling Heterologous Synthetic Flavon...

Methods And Compositions For Improved Production Of Fatty Acids And...

MULTI-COMPONENTED STRUCTURE FOR CAPTURING COMPOUND

METHOD FOR PRODUCING SUGAR INCLUDING LACTO-N-TRIOSE II AS CORE TRIS...

TRANSMEMBRANE PORE CONSISTING OF TWO CSGG PORES

MICROORGANISM AND METHOD FOR THE IMPROVED PRODUCTION OF VALINE

COMPOSITIONS AND METHODS FOR THE PRODUCTION OF CYSTEINE

IN PHA PRODUCTION

METHOD FOR CONSTRUCTING STRAIN FOR PRODUCING RECOMBINANT PROTEIN CO...

METHODS AND COMPOSITIONS FOR PREVENTING INFECTION

POLYNUCLEOTIDE COMPOSITIONS AND USES THEREOF

RNAYLATION

BACTERIA PRODUCING GAMMA-AMINOBUTYRIC ACID (GABA) AND USES OF THE B...

BACTERIAL COLICIN-IMMUNITY PROTEIN PROTEIN PURIFICATION SYSTEM