Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof

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C08B37/0072

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CCHEMISTRY METALLURGY C08Organic compounds C08BPOLYSACCHARIDES DERIVATIVES THEREOF C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00 Derivatives thereof

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C08B37/0072Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof

Industries

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Patents Grantslast 30 patents

Information Patent Grant
Cross-linkable polymer, hydrogel, and method of preparation thereof
- Patent number 12,138,363
- Issue date Nov 12, 2024
- ÉCOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE
- Peyman Karami
- C08 - ORGANIC MACROMOLECULAR COMPOUNDS THEIR PREPARATION OR CHEMICAL WORKING-...
Information Patent Grant
Crosslinked hyaluronic acid, hyaluronic acid hydrogel, and method f...
- Patent number 12,090,248
- Issue date Sep 17, 2024
- Hanmi Pharm. Co., Ltd
- Soo Jin Kim
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Bioconjugates of polysaccharides and elastin-like polypeptides and...
- Patent number 12,084,488
- Issue date Sep 10, 2024
- INSTITUT POLYTECHNIQUE DE BORDEAUX
- Sébastien Lecommandoux
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Dendritic macroporous hydrogels prepared by crystal templating
- Patent number 12,031,008
- Issue date Jul 9, 2024
- Board of Regents, The University of Texas System
- Scott Zawko
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Grant
Matrices comprising a modified polysaccharide
- Patent number 12,030,963
- Issue date Jul 9, 2024
- MAPTech Holdings UG
- V. Prasad Shastri
- C10 - PETROLEUM, GAS OR COKE INDUSTRIES TECHNICAL GASES CONTAINING CARBON MON...
Information Patent Grant
Sulfated glycosaminoglycan biomaterials as proteoglycan mimics
- Patent number 11,975,019
- Issue date May 7, 2024
- Glycologix, Inc.
- Thomas H. Jozefiak
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Sodium hyaluronate with full molecular weight distribution (MWD), a...
- Patent number 11,976,139
- Issue date May 7, 2024
- MEYER BIO-MEDICINE CO., LTD.
- Peixue Ling
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Grant
Method for preparing acylated crosslinked glycosaminoglycans
- Patent number 11,939,433
- Issue date Mar 26, 2024
- Galderma Holding SA
- Johan Olsson
- C08 - ORGANIC MACROMOLECULAR COMPOUNDS THEIR PREPARATION OR CHEMICAL WORKING-...
Information Patent Grant
Hyaluronic acid derivatives
- Patent number 11,939,408
- Issue date Mar 26, 2024
- Massachusetts Institute of Technology
- Bradley David Olsen
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Cross-linked polycarboxylated polysaccharides and methods of use th...
- Patent number 11,939,409
- Issue date Mar 26, 2024
- HALLURA LTD.
- Stephane Meunier
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Polymer, preparation method therefor, nanofiber synthesized therefr...
- Patent number 11,920,026
- Issue date Mar 5, 2024
- I-Corebio Inc.
- Jae Ho Shin
- B82 - NANO-TECHNOLOGY
Information Patent Grant
Preparation and purification method for cationic quaternary ammoniu...
- Patent number 11,919,976
- Issue date Mar 5, 2024
- SHANDONG FOCUSFREDA BIOTECH CO., LTD
- Jinmao You
- C08 - ORGANIC MACROMOLECULAR COMPOUNDS THEIR PREPARATION OR CHEMICAL WORKING-...
Information Patent Grant
Process for efficient cross-linking of hyaluronic acid
- Patent number 11,866,556
- Issue date Jan 9, 2024
- Galderma Holding SA
- Morgan Karlsson
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Crosslinked polymeric network and use thereof
- Patent number 11,845,813
- Issue date Dec 19, 2023
- Bausch & Lomb Incorporated
- George L. Grobe
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Method of crosslinking glycosaminoglycans
- Patent number 11,807,726
- Issue date Nov 7, 2023
- Centre National de la Recherche Scientifique
- Rachel Auzely-Velty
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Carbohydrate crosslinker
- Patent number 11,780,970
- Issue date Oct 10, 2023
- Galderma Holding SA
- Hotan Mojarradi
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Skin care composition comprising acetylated hyaluronic acid with de...
- Patent number 11,766,393
- Issue date Sep 26, 2023
- Givaudan S.A.
- Martin Lovchik
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Dendritic macroporous hydrogels prepared by crystal templating
- Patent number 11,760,858
- Issue date Sep 19, 2023
- Board of Regents, The University of Texas System
- Scott Zawko
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Crosslinked polymeric network and use thereof
- Patent number 11,732,060
- Issue date Aug 22, 2023
- Bausch & Lomb Incorporated
- George L. Grobe
- A45 - HAND OR TRAVELLING ARTICLES
Information Patent Grant
Method for preparing acylated crosslinked glycosaminoglycans
- Patent number 11,708,461
- Issue date Jul 25, 2023
- Galderma Holding SA
- Johan Olsson
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Method for manufacturing a shaped cross-linked hyaluronic acid product
- Patent number 11,702,484
- Issue date Jul 18, 2023
- Galderma Holding SA
- Morgan Karlsson
- D01 - NATURAL OR ARTIFICIAL THREADS OR FIBRES SPINNING
Information Patent Grant
Glycophospholipid polymeric network and use thereof
- Patent number 11,673,974
- Issue date Jun 13, 2023
- Bausch & Lomb Incorporated
- Alok Kumar Awasthi
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Carbohydrate crosslinker
- Patent number 11,643,509
- Issue date May 9, 2023
- Galderma Holding SA
- Hotan Mojarradi
- C08 - ORGANIC MACROMOLECULAR COMPOUNDS THEIR PREPARATION OR CHEMICAL WORKING-...
Information Patent Grant
Hemostatic composition comprising cross-linked hyaluronic acid deri...
- Patent number 11,602,539
- Issue date Mar 14, 2023
- BMI KOREA CO., LTD
- Min-Kyoung Kim
- C08 - ORGANIC MACROMOLECULAR COMPOUNDS THEIR PREPARATION OR CHEMICAL WORKING-...
Information Patent Grant
Process for the purification of hyaluronic acid salt, conducted in...
- Patent number 11,566,085
- Issue date Jan 31, 2023
- BMG PHARMA S.P.A.
- Luca Stucchi
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Hyaluronic acid derivative having amino acid and steryl group intro...
- Patent number 11,564,971
- Issue date Jan 31, 2023
- CHUGAI SEIYAKU KABUSHIKI KAISHA
- Takashi Nakai
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Compliant hydrophilic coatings for medical devices
- Patent number 11,555,131
- Issue date Jan 17, 2023
- Covidien LP
- Edwin Wang
- C09 - DYES PAINTS POLISHES NATURAL RESINS ADHESIVES MISCELLANEOUS COMPOSITION...
Information Patent Grant
Carbohydrate crosslinker
- Patent number 11,530,301
- Issue date Dec 20, 2022
- Galderma Holding SA
- Hotan Mojarradi
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Method to prepare a filler with a hyaluronic acid base using specif...
- Patent number 11,530,302
- Issue date Dec 20, 2022
- MATEX LAB S.P.A.
- Nicola Zerbinati
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Compositions of hyaluronan with high elasticity and uses thereof
- Patent number 11,524,027
- Issue date Dec 13, 2022
- Matrix Biology Institute
- Endre A. Balazs
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE

Patents Applicationslast 30 patents

Information Patent Application
METHOD FOR CROSSLINKING HYALURONIC ACID USING RESONANT ACOUSTIC MIXING
- Publication number 20240417522
- Publication date Dec 19, 2024
- STUDIO BIOSCIENCE INC.
- Felix POLYAK
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Application
CROSS LINKED SILK-HYALURONIC ACID COMPOSITION
- Publication number 20240366490
- Publication date Nov 7, 2024
- Allergan, Inc.
- Elizabeta Pavlovic
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
Dendritic Macroporous Hydrogels Prepared By Crystal Templating
- Publication number 20240360290
- Publication date Oct 31, 2024
- Board of Regents, The University of Texas System
- Scott Zawko
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Application
CROSSLINKED HYALURONIC ACID PRECIPITATES
- Publication number 20240352158
- Publication date Oct 24, 2024
- Prohibix LLC
- Brendan Purcell
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
DERMAL FILLER COMPOSITIONS
- Publication number 20240342072
- Publication date Oct 17, 2024
- Allergan, Inc.
- Gabriel N. Njikang
- C08 - ORGANIC MACROMOLECULAR COMPOUNDS THEIR PREPARATION OR CHEMICAL WORKING-...
Information Patent Application
MATRICES COMPRISING A MODIFIED POLYSACCHARIDE
- Publication number 20240336707
- Publication date Oct 10, 2024
- MAPTECH Holdings UG
- V. Prasad Shastri
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
A METHOD FOR PREPARING HYALURONIC ACID GRAFTED POLY(N-ISOPROPYLACRY...
- Publication number 20240336748
- Publication date Oct 10, 2024
- NABSOLUTE COMPANY LIMITED
- Jittima Amie LUCKANAGUL
- C08 - ORGANIC MACROMOLECULAR COMPOUNDS THEIR PREPARATION OR CHEMICAL WORKING-...
Information Patent Application
COACERVATE HYALURONAN HYDROGELS FOR DERMAL FILLER APPLICATIONS
- Publication number 20240316246
- Publication date Sep 26, 2024
- Allergan, Inc.
- Futian Liu
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
CROSS-LINKING POLYSACCHARIDE WITH FIBROIN AND USES OF THE OBTAINED...
- Publication number 20240317900
- Publication date Sep 26, 2024
- MERZ PHARMA GMBH & CO. KGAA
- Radovan VUKICEVIC
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
MIXTURES OF POLYSACCHARIDES AND POLYAMINOSACCHARIDES WITH IMPROVED...
- Publication number 20240254323
- Publication date Aug 1, 2024
- JOINTHERAPEUTICS S.R.L.
- Lanfranco Callegaro
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
POLYMERIC COMPOUND OF GLUCURONIC ACID WITH PHENOLIC GROUPS, GEL-FOR...
- Publication number 20240245604
- Publication date Jul 25, 2024
- Université Clermont Auvergne
- Cédric DELATTRE
- C08 - ORGANIC MACROMOLECULAR COMPOUNDS THEIR PREPARATION OR CHEMICAL WORKING-...
Information Patent Application
A BIO-INK FOR 3D PRINTING, RELATED CONJUGATE AND PREPARATION PROCES...
- Publication number 20240217166
- Publication date Jul 4, 2024
- FIDIA FARMACEUTICI S.P.A.
- Devis GALESSO
- B33 - ADDITIVE MANUFACTURING TECHNOLOGY
Information Patent Application
METHOD FOR PREPARING ACYLATED CROSSLINKED GLYCOSAMINOGLYCANS
- Publication number 20240199822
- Publication date Jun 20, 2024
- Galderma Holding SA
- Johan Olsson
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
IMPLANTABLE OR INJECTABLE PRODUCTS BASED ON POLYMERS AND METHOD FOR...
- Publication number 20240189428
- Publication date Jun 13, 2024
- SYMATESE
- Fabien FUCHEZ
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
CROSS-LINKED POLYCARBOXYLATED POLYSACCHARIDES AND METHODS OF USE TH...
- Publication number 20240191002
- Publication date Jun 13, 2024
- HALLURA LTD.
- Stephane MEUNIER
- C07 - ORGANIC CHEMISTRY
Information Patent Application
HYDROGEL COMPOSITION, MANUFACTURING METHOD THEREOF AND HYDROGEL MAT...
- Publication number 20240182651
- Publication date Jun 6, 2024
- Win Coat Corporation
- Ta-Jo LIU
- C08 - ORGANIC MACROMOLECULAR COMPOUNDS THEIR PREPARATION OR CHEMICAL WORKING-...
Information Patent Application
DYNAMIC RECOMBINANT HYDROGELS WITH DEGRADATION-INDEPENDENT RELAXATI...
- Publication number 20240150499
- Publication date May 9, 2024
- The Board of Trustees of the Leland Stanford Junior University
- Renato Navarro
- C07 - ORGANIC CHEMISTRY
Information Patent Application
AMIDE LINKAGES OF SUGAR MOIETIES TO AMINE TERMINATED LEASHES ATTACH...
- Publication number 20240132630
- Publication date Apr 25, 2024
- NAVIDEA BIOPHARMACEUTICALS, INC.
- Jeffrey Scott Arnold
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
CONDUCTIVE HYDROGEL COMPRISING MUSSEL ADHESIVE PROTEIN AND PREPARAT...
- Publication number 20240124656
- Publication date Apr 18, 2024
- POSTECH Research and Business Development Foundation
- Hyung Joon Cha
- C08 - ORGANIC MACROMOLECULAR COMPOUNDS THEIR PREPARATION OR CHEMICAL WORKING-...
Information Patent Application
COMPOSITIONS AND METHODS FOR TREATING A DISORDER OR DEFECT IN SOFT...
- Publication number 20240117158
- Publication date Apr 11, 2024
- Drexel University
- Michele Marcolongo
- C08 - ORGANIC MACROMOLECULAR COMPOUNDS THEIR PREPARATION OR CHEMICAL WORKING-...
Information Patent Application
PREPARATION AND/OR FORMULATION OF PROTEINS CROSS-LINKED WITH POLYSA...
- Publication number 20240100221
- Publication date Mar 28, 2024
- Allergan Pharmaceuticals International Limited
- Jens Sommer-Knudsen
- C08 - ORGANIC MACROMOLECULAR COMPOUNDS THEIR PREPARATION OR CHEMICAL WORKING-...
Information Patent Application
PROCESS FOR EFFICIENT CROSS-LINKING OF HYALURONIC ACID
- Publication number 20240092982
- Publication date Mar 21, 2024
- Galderma Holding SA
- Morgan KARLSSON
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
CROSSLINKED HYALURONIC ACID HYDROGEL CROSSLINKED USING CROSSLINKER...
- Publication number 20240084045
- Publication date Mar 14, 2024
- LG CHEM, LTD.
- Hyun Tae JUNG
- C08 - ORGANIC MACROMOLECULAR COMPOUNDS THEIR PREPARATION OR CHEMICAL WORKING-...
Information Patent Application
METHOD OF MANUFACTURING AUTO-CROSSLINKED HYALURONIC ACID GEL AND PR...
- Publication number 20240076417
- Publication date Mar 7, 2024
- SCIVISION BIOTECH INC.
- TAI-SHIEN HAN
- C08 - ORGANIC MACROMOLECULAR COMPOUNDS THEIR PREPARATION OR CHEMICAL WORKING-...
Information Patent Application
INJECTABLE PHOTOCROSSLINKED HYALURONIC ACID HYDROGELS, PRODUCTION M...
- Publication number 20240050628
- Publication date Feb 15, 2024
- VSY BIYOTEKNOLOJI VE ILAC SANAYI ANONIM SIRKETI
- Faruk OYTUN
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
MODIFIED HYALURONIC ACID AS DOPANT FOR PEDOT AND/OR PPRODOT POLYMERS
- Publication number 20240043574
- Publication date Feb 8, 2024
- Commissariat A L'Energie Atomique et Aux Energies Alternatives
- Maxime LEPRINCE
- C08 - ORGANIC MACROMOLECULAR COMPOUNDS THEIR PREPARATION OR CHEMICAL WORKING-...
Information Patent Application
FUNCTIONALIZED AND CROSSLINKED POLYMERS
- Publication number 20240033283
- Publication date Feb 1, 2024
- PMIDG, LLC
- David M. GRAVETT
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SELF-REPAIRING BIOMIMETIC LUBRICANTS AND METHODS OF MAKING AND USIN...
- Publication number 20240024487
- Publication date Jan 25, 2024
- DUKE UNIVERSITY
- Shyni Varghese
- C08 - ORGANIC MACROMOLECULAR COMPOUNDS THEIR PREPARATION OR CHEMICAL WORKING-...
Information Patent Application
SODIUM HYALURONATE WITH FULL MOLECULAR WEIGHT DISTRIBUTION (MWD), A...
- Publication number 20240002551
- Publication date Jan 4, 2024
- MEYER BIO-MEDICINE CO., LTD.
- Peixue LING
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
CARBOHYDRATE CROSSLINKER
- Publication number 20230416469
- Publication date Dec 28, 2023
- Galderma Holding SA
- Hotan MOJARRADI
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE

Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Cross-linkable polymer, hydrogel, and method of preparation thereof

Crosslinked hyaluronic acid, hyaluronic acid hydrogel, and method f...

Bioconjugates of polysaccharides and elastin-like polypeptides and...

Dendritic macroporous hydrogels prepared by crystal templating

Matrices comprising a modified polysaccharide

Sulfated glycosaminoglycan biomaterials as proteoglycan mimics

Sodium hyaluronate with full molecular weight distribution (MWD), a...

Method for preparing acylated crosslinked glycosaminoglycans

Hyaluronic acid derivatives

Cross-linked polycarboxylated polysaccharides and methods of use th...

Polymer, preparation method therefor, nanofiber synthesized therefr...

Preparation and purification method for cationic quaternary ammoniu...

Process for efficient cross-linking of hyaluronic acid

Crosslinked polymeric network and use thereof

Method of crosslinking glycosaminoglycans

Carbohydrate crosslinker

Skin care composition comprising acetylated hyaluronic acid with de...

Dendritic macroporous hydrogels prepared by crystal templating

Crosslinked polymeric network and use thereof

Method for preparing acylated crosslinked glycosaminoglycans

Method for manufacturing a shaped cross-linked hyaluronic acid product

Glycophospholipid polymeric network and use thereof

Carbohydrate crosslinker

Hemostatic composition comprising cross-linked hyaluronic acid deri...

Process for the purification of hyaluronic acid salt, conducted in...

Hyaluronic acid derivative having amino acid and steryl group intro...

Compliant hydrophilic coatings for medical devices

Carbohydrate crosslinker

Method to prepare a filler with a hyaluronic acid base using specif...

Compositions of hyaluronan with high elasticity and uses thereof

Patents Applicationslast 30 patents

METHOD FOR CROSSLINKING HYALURONIC ACID USING RESONANT ACOUSTIC MIXING

CROSS LINKED SILK-HYALURONIC ACID COMPOSITION

Dendritic Macroporous Hydrogels Prepared By Crystal Templating

CROSSLINKED HYALURONIC ACID PRECIPITATES

DERMAL FILLER COMPOSITIONS

MATRICES COMPRISING A MODIFIED POLYSACCHARIDE

A METHOD FOR PREPARING HYALURONIC ACID GRAFTED POLY(N-ISOPROPYLACRY...

COACERVATE HYALURONAN HYDROGELS FOR DERMAL FILLER APPLICATIONS

CROSS-LINKING POLYSACCHARIDE WITH FIBROIN AND USES OF THE OBTAINED...

MIXTURES OF POLYSACCHARIDES AND POLYAMINOSACCHARIDES WITH IMPROVED...

POLYMERIC COMPOUND OF GLUCURONIC ACID WITH PHENOLIC GROUPS, GEL-FOR...

A BIO-INK FOR 3D PRINTING, RELATED CONJUGATE AND PREPARATION PROCES...

METHOD FOR PREPARING ACYLATED CROSSLINKED GLYCOSAMINOGLYCANS

IMPLANTABLE OR INJECTABLE PRODUCTS BASED ON POLYMERS AND METHOD FOR...

CROSS-LINKED POLYCARBOXYLATED POLYSACCHARIDES AND METHODS OF USE TH...

HYDROGEL COMPOSITION, MANUFACTURING METHOD THEREOF AND HYDROGEL MAT...

DYNAMIC RECOMBINANT HYDROGELS WITH DEGRADATION-INDEPENDENT RELAXATI...

AMIDE LINKAGES OF SUGAR MOIETIES TO AMINE TERMINATED LEASHES ATTACH...

CONDUCTIVE HYDROGEL COMPRISING MUSSEL ADHESIVE PROTEIN AND PREPARAT...

COMPOSITIONS AND METHODS FOR TREATING A DISORDER OR DEFECT IN SOFT...

PREPARATION AND/OR FORMULATION OF PROTEINS CROSS-LINKED WITH POLYSA...

PROCESS FOR EFFICIENT CROSS-LINKING OF HYALURONIC ACID

CROSSLINKED HYALURONIC ACID HYDROGEL CROSSLINKED USING CROSSLINKER...

METHOD OF MANUFACTURING AUTO-CROSSLINKED HYALURONIC ACID GEL AND PR...

INJECTABLE PHOTOCROSSLINKED HYALURONIC ACID HYDROGELS, PRODUCTION M...

MODIFIED HYALURONIC ACID AS DOPANT FOR PEDOT AND/OR PPRODOT POLYMERS

FUNCTIONALIZED AND CROSSLINKED POLYMERS

SELF-REPAIRING BIOMIMETIC LUBRICANTS AND METHODS OF MAKING AND USIN...

SODIUM HYALURONATE WITH FULL MOLECULAR WEIGHT DISTRIBUTION (MWD), A...

CARBOHYDRATE CROSSLINKER