Retroviridae

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AHUMAN NECESSITIES A61Medical science A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES A61K39/00Medicinal preparations containing antigens or antibodies

Current Industry

A61K39/21Retroviridae

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Patents Grantslast 30 patents

Information Patent Grant
Adenoviral vector
- Patent number 12,365,920
- Issue date Jul 22, 2025
- Oxford University Innovation Limited
- Sarah C. Gilbert
- Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMA...
Information Patent Grant
Conserved region T cell vaccines for coronavirus and methods of use
- Patent number 12,364,750
- Issue date Jul 22, 2025
- Triad National Security, LLC
- Bette T. M. Korber
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Compositions and vaccines for treating and/or preventing viral infe...
- Patent number 12,357,687
- Issue date Jul 15, 2025
- Engeneic Molecular Delivery Pty Ltd
- Himanshu Brahmbhatt
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Porcine epidemic diarrhea (PED) virus vaccine composition and prepa...
- Patent number 12,357,686
- Issue date Jul 15, 2025
- BIOAPPLICATIONS INC.
- Eun-Ju Sohn
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Fusion protein and use thereof
- Patent number 12,351,604
- Issue date Jul 8, 2025
- Shanxi Jinbo Bio-Pharmaceutical Co., Ltd.
- Lu Lu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
RNA separation and related techniques for determining viruses such...
- Patent number 12,351,882
- Issue date Jul 8, 2025
- Analiza, Inc.
- Arnon Chait
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
COVID-19 vaccine
- Patent number 12,344,635
- Issue date Jul 1, 2025
- The Medical College of Wisconsin, Inc.
- Joseph T. Barbieri
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Antigen specific immunotherapy for COVID-19 fusion proteins and met...
- Patent number 12,343,393
- Issue date Jul 1, 2025
- Vakston, Inc.
- Todd C. Zion
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Compositions including Sbi adjuvants and methods of use thereof
- Patent number 12,343,392
- Issue date Jul 1, 2025
- Helix Nanotechnologies Inc
- Kyle Backman
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Porcine epidemic diarrhea virus strains and immunogenic composition...
- Patent number 12,329,813
- Issue date Jun 17, 2025
- Zoetis Services LLC
- Jianqiang Zhang
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Nucleic acid vaccine against the SARS-CoV-2 coronavirus
- Patent number 12,324,834
- Issue date Jun 10, 2025
- Institut Pasteur
- Etienne Simon-Loriere
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
mRNA vaccine encoding fusion antigen against Mpox and severe acute...
- Patent number 12,324,835
- Issue date Jun 10, 2025
- ACADEMY OF MILITARY MEDICAL SCIENCES, AMS, PLA
- Yilong Yang
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Cationic lipid compound and composition for delivery of nucleic aci...
- Patent number 12,325,676
- Issue date Jun 10, 2025
- ShenZhen Rhegen Biotechnology Co., Ltd.
- Yong Hu
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Recombinant severe respiratory syndrome coronavirus 2 Rbd trimer pr...
- Patent number 12,324,833
- Issue date Jun 10, 2025
- Qiming Li
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Hyperimmunized egg product for treatment or prevention of coronavir...
- Patent number 12,324,441
- Issue date Jun 10, 2025
- LAY SCIENCES, INC.
- Subramanian V. Iyer
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Methods of fabricating carriers for targeted delivery to a host
- Patent number 12,311,061
- Issue date May 27, 2025
- FinnCure Oy
- Erik Johan Niemelä
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Replication-competent attenuated chimeric VSV vectors encoding immu...
- Patent number 12,311,021
- Issue date May 27, 2025
- INTERNATIONAL AIDS VACCINE INITIATIVE INC.
- Christopher Lee Parks
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Monoclonal antibodies directed against trimeric forms of the HIV-1...
- Patent number 12,312,396
- Issue date May 27, 2025
- Theraclone Sciences, Inc.
- Po-Ying Chan-Hui
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Immunostimulatory compositions and methods of use thereof
- Patent number 12,303,566
- Issue date May 20, 2025
- Massachusetts Institute of Technology
- Darrell Irvine
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Recombinant bovine immunodeficiency virus-like particles comprising...
- Patent number 12,303,560
- Issue date May 20, 2025
- Medigen, Inc.
- Peter Pushko
- G01 - MEASURING TESTING
Information Patent Grant
Viral preparations and methods for treating and modulating mitochon...
- Patent number 12,297,460
- Issue date May 13, 2025
- Julian Daich
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Immunogenic composition against severe acute respiratory syndrome c...
- Patent number 12,296,002
- Issue date May 13, 2025
- MEDIGEN VACCINE BIOLOGICS CORPORATION
- Tsun-Yung Kuo
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
SARS-CoV-2 vaccines comprising human adenovirus vectors encoding sp...
- Patent number 12,290,558
- Issue date May 6, 2025
- ImmunityBio, Inc.
- Patrick Soon-Shiong
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Vaccine compositions for porcine epidemic diarrhea virus and porcin...
- Patent number 12,290,557
- Issue date May 6, 2025
- Zoetis Services LLC
- Jacqueline Gayle Marx
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Recombinant multivalent influenza viruses
- Patent number 12,290,562
- Issue date May 6, 2025
- Wisconsin Alumni Research Foundation (WARF)
- Yoshihiro Kawaoka
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method of inducing immunity against SARS-CoV-2 using spike and nucl...
- Patent number 12,285,480
- Issue date Apr 29, 2025
- NantCell, Inc.
- Adrian Rice
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods for the treatment of COVID-19 comprising administering repl...
- Patent number 12,285,481
- Issue date Apr 29, 2025
- NantCell, Inc.
- Kayvan Niazi
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Anti-coronavirus vaccines
- Patent number 12,285,479
- Issue date Apr 29, 2025
- Zoetis Services LLC
- Eric Todd Baima
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Vaccines having an antigen and interleukin-21 as an adjuvant
- Patent number 12,280,108
- Issue date Apr 22, 2025
- The Trustees of the University of Pennsylvania
- David B. Weiner
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Alphavirus replicon encoding chimeric SARS-CoV-2 receptor binding d...
- Patent number 12,280,102
- Issue date Apr 22, 2025
- VLP Therapeutics, Inc.
- Wataru Akahata
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Patents Applicationslast 30 patents

Information Patent Application
VACCINE COMPOSITION COMPRISING AN ANTIGEN AND A TLR3 AGONIST
- Publication number 20250235528
- Publication date Jul 24, 2025
- ISR IMMUNE SYSTEM REGULATION HOLDING AB (PUBL)
- Ola WINQVIST
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
Anti COVID-19 Therapies targeting nucleocapsid and spike proteins
- Publication number 20250235530
- Publication date Jul 24, 2025
- ImmunityBio, Inc.
- Patrick Soon-Shiong
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SYNTHETIC MODIFIED VACCINIA ANKARA (SMVA) BASED CORONAVIRUS VACCINES
- Publication number 20250235527
- Publication date Jul 24, 2025
- CITY OF HOPE
- Don J. DIAMOND
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SARS-CoV-2 VACCINE COMPOSITIONS
- Publication number 20250235529
- Publication date Jul 24, 2025
- MERCIA PHARMA, INC.
- Peter BLACKBURN
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
COMPOSITIONS AND METHODS FOR OPTIMIZED HIV PEPTIDE VACCINES
- Publication number 20250235526
- Publication date Jul 24, 2025
- Think Therapeutics, Inc.
- David GIFFORD
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
POLYMER-LIPID HYBRID NANOPARTICLES COMPRISING A LIPID AND A BLOCK C...
- Publication number 20250235532
- Publication date Jul 24, 2025
- ACM BIOLABS PTE LTD
- Madhavan NALLANI
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
RECOMBINANT NEWCASTLE DISEASE VIRUSES AND IMMUNOGENIC COMPOSITIONS...
- Publication number 20250228929
- Publication date Jul 17, 2025
- Peter PALESE
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MODIFIED SELF-REPLICATING MRNA
- Publication number 20250230196
- Publication date Jul 17, 2025
- IMMORNA (HANGZHOU) BIOTECHNOLOGY CO., LTD.
- Zihao WANG
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
RNA VACCINE LIPID NANOPARTICLES
- Publication number 20250228926
- Publication date Jul 17, 2025
- GLOBAL LIFE SCIENCES SOLUTIONS CANADA ULC
- Andy John Geall
- B82 - NANO-TECHNOLOGY
Information Patent Application
IMMUNE ENHANCEMENT AND INFECTIOUS DISEASE TREATMENT
- Publication number 20250228928
- Publication date Jul 17, 2025
- Spark Therapeutics, Inc.
- Xavier ANGUELA
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SARS-COV-2 RNA VACCINE COMPOSITIONS AND METHODS OF USE
- Publication number 20250228930
- Publication date Jul 17, 2025
- HDT Bio Corp.
- Steven Gregory Reed
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ALPHAVIRUS REPLICON ENCODING CHIMERIC SARS-COV-2 RECEPTOR BINDING D...
- Publication number 20250228931
- Publication date Jul 17, 2025
- VLP Therapeutics, Inc.
- Wataru AKAHATA
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
RECOMBINANT FUSION PROTEIN DERIVED FROM HR REGION OF S2 PROTEIN OF...
- Publication number 20250228927
- Publication date Jul 17, 2025
- Eternivax Biomedical, Inc
- Wei PANG
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
IMPROVED CHIMERIC POLYPEPTIDES AND USES THEREOF
- Publication number 20250223319
- Publication date Jul 10, 2025
- The University of Queensland
- Keith CHAPPELL
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CORONAVIRUS VACCINE
- Publication number 20250222096
- Publication date Jul 10, 2025
- BIONTECH SE
- Ugur Sahin
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
LIPID-BASED FORMULATIONS FOR ADMINISTRATION OF RNA
- Publication number 20250222097
- Publication date Jul 10, 2025
- BIONTECH SE
- Sara MENINA
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
Novel Peptides and Vaccines Capable of Eliciting Protective Immunit...
- Publication number 20250222098
- Publication date Jul 10, 2025
- VELJKO VELJKOVIC
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
IMMUNOGENS AND VACCINE COMPOSITIONS AGAINST HIV
- Publication number 20250213675
- Publication date Jul 3, 2025
- The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
- Morgane Marie ROLLAND
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
POXVIRUS-BASED VECTORS PRODUCED BY NATURAL OR SYNTHETIC DNA AND USE...
- Publication number 20250215456
- Publication date Jul 3, 2025
- CITY OF HOPE
- Don J. DIAMOND
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
LIPID NANOPARTICLES AND PREPARATION METHODS AND USE THEREOF
- Publication number 20250213496
- Publication date Jul 3, 2025
- INSTITUTE OF CHEMISTRY, CHINESE ACADEMY OF SCIENCES
- Xueguang LV
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
METHODS OF TARGETED DELIVERY TO A HOST USING A CARRIER
- Publication number 20250213498
- Publication date Jul 3, 2025
- Finncure Oy
- Erik Johan Niemelä
- C07 - ORGANIC CHEMISTRY
Information Patent Application
MODIFIED SPIKE PROTEINS AND USES THEREOF
- Publication number 20250206784
- Publication date Jun 26, 2025
- CILOA
- Zaïne El Abiddine Robert MAMOUN
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
NOVEL PLANT VIRUS AND BACTERIOPHAGE VACCINES
- Publication number 20250205331
- Publication date Jun 26, 2025
- The Regents of the University of California
- Nicole F. Steinmetz
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
IMMUNOSTIMULATORY COMPOSITIONS AND METHODS OF USE THEREOF
- Publication number 20250195674
- Publication date Jun 19, 2025
- Massachusetts Institute of Technology
- Darrell Irvine
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
TREATMENT AND PREVENTION OF CONDITIONS ASSOCIATED WITH RESPIRATORY...
- Publication number 20250195638
- Publication date Jun 19, 2025
- UNIVERSITY OF HOUSTON SYSTEM
- Navin Varadarajan
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MULTI-EPITOPE MRNA SARS-COV-2 VACCINE FOR BOOSTING IMMUNITY THROUGH...
- Publication number 20250195639
- Publication date Jun 19, 2025
- The Regents of the University of California
- Andre E. NEL
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
LIPID NANOPARTICLES FOR TARGETED DELIVERY OF MRNA
- Publication number 20250195431
- Publication date Jun 19, 2025
- Trustees of Tufts College
- Qiaobing Xu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
VACCINE COMPOSITION COMPRISING AN ANTIGEN AND A TLR3 AGONIST
- Publication number 20250186577
- Publication date Jun 12, 2025
- ISR IMMUNE SYSTEM REGULATION HOLDING AB (PUBL)
- Ola WINQVIST
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
VACCINE FOR USE IN THE PROPHYLAXIS AND/OR TREATMENT OF A DISEASE
- Publication number 20250186579
- Publication date Jun 12, 2025
- INPROTHER APS
- Peter HOLST
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
VACCINE CONSTRUCT AND USES THEREOF
- Publication number 20250186575
- Publication date Jun 12, 2025
- The University of Melbourne
- Joseph Torresi
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Retroviridae

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Adenoviral vector

Conserved region T cell vaccines for coronavirus and methods of use

Compositions and vaccines for treating and/or preventing viral infe...

Porcine epidemic diarrhea (PED) virus vaccine composition and prepa...

Fusion protein and use thereof

RNA separation and related techniques for determining viruses such...

COVID-19 vaccine

Antigen specific immunotherapy for COVID-19 fusion proteins and met...

Compositions including Sbi adjuvants and methods of use thereof

Porcine epidemic diarrhea virus strains and immunogenic composition...

Nucleic acid vaccine against the SARS-CoV-2 coronavirus

mRNA vaccine encoding fusion antigen against Mpox and severe acute...

Cationic lipid compound and composition for delivery of nucleic aci...

Recombinant severe respiratory syndrome coronavirus 2 Rbd trimer pr...

Hyperimmunized egg product for treatment or prevention of coronavir...

Methods of fabricating carriers for targeted delivery to a host

Replication-competent attenuated chimeric VSV vectors encoding immu...

Monoclonal antibodies directed against trimeric forms of the HIV-1...

Immunostimulatory compositions and methods of use thereof

Recombinant bovine immunodeficiency virus-like particles comprising...

Viral preparations and methods for treating and modulating mitochon...

Immunogenic composition against severe acute respiratory syndrome c...

SARS-CoV-2 vaccines comprising human adenovirus vectors encoding sp...

Vaccine compositions for porcine epidemic diarrhea virus and porcin...

Recombinant multivalent influenza viruses

Method of inducing immunity against SARS-CoV-2 using spike and nucl...

Methods for the treatment of COVID-19 comprising administering repl...

Anti-coronavirus vaccines

Vaccines having an antigen and interleukin-21 as an adjuvant

Alphavirus replicon encoding chimeric SARS-CoV-2 receptor binding d...

Patents Applicationslast 30 patents

VACCINE COMPOSITION COMPRISING AN ANTIGEN AND A TLR3 AGONIST

Anti COVID-19 Therapies targeting nucleocapsid and spike proteins

SYNTHETIC MODIFIED VACCINIA ANKARA (SMVA) BASED CORONAVIRUS VACCINES

SARS-CoV-2 VACCINE COMPOSITIONS

COMPOSITIONS AND METHODS FOR OPTIMIZED HIV PEPTIDE VACCINES

POLYMER-LIPID HYBRID NANOPARTICLES COMPRISING A LIPID AND A BLOCK C...

RECOMBINANT NEWCASTLE DISEASE VIRUSES AND IMMUNOGENIC COMPOSITIONS...

MODIFIED SELF-REPLICATING MRNA

RNA VACCINE LIPID NANOPARTICLES

IMMUNE ENHANCEMENT AND INFECTIOUS DISEASE TREATMENT

SARS-COV-2 RNA VACCINE COMPOSITIONS AND METHODS OF USE

ALPHAVIRUS REPLICON ENCODING CHIMERIC SARS-COV-2 RECEPTOR BINDING D...

RECOMBINANT FUSION PROTEIN DERIVED FROM HR REGION OF S2 PROTEIN OF...

IMPROVED CHIMERIC POLYPEPTIDES AND USES THEREOF

CORONAVIRUS VACCINE

LIPID-BASED FORMULATIONS FOR ADMINISTRATION OF RNA

Novel Peptides and Vaccines Capable of Eliciting Protective Immunit...

IMMUNOGENS AND VACCINE COMPOSITIONS AGAINST HIV

POXVIRUS-BASED VECTORS PRODUCED BY NATURAL OR SYNTHETIC DNA AND USE...

LIPID NANOPARTICLES AND PREPARATION METHODS AND USE THEREOF

METHODS OF TARGETED DELIVERY TO A HOST USING A CARRIER

MODIFIED SPIKE PROTEINS AND USES THEREOF

NOVEL PLANT VIRUS AND BACTERIOPHAGE VACCINES

IMMUNOSTIMULATORY COMPOSITIONS AND METHODS OF USE THEREOF

TREATMENT AND PREVENTION OF CONDITIONS ASSOCIATED WITH RESPIRATORY...

MULTI-EPITOPE MRNA SARS-COV-2 VACCINE FOR BOOSTING IMMUNITY THROUGH...

LIPID NANOPARTICLES FOR TARGETED DELIVERY OF MRNA

VACCINE COMPOSITION COMPRISING AN ANTIGEN AND A TLR3 AGONIST

VACCINE FOR USE IN THE PROPHYLAXIS AND/OR TREATMENT OF A DISEASE

VACCINE CONSTRUCT AND USES THEREOF