with ribosyl as saccharide radical

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CPC
C07H21/02

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CCHEMISTRY METALLURGY C07Organic chemistry C07HSUGARS DERIVATIVES THEREOF NUCLEOSIDES NUCLEOTIDES NUCLEIC ACIDS C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups

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C07H21/02with ribosyl as saccharide radical

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Patents Grantslast 30 patents

Information Patent Grant
Vectors for protein manufacture
- Patent number 12,157,897
- Issue date Dec 3, 2024
- Catalent Pharma Solutions, LLC
- Gregory T. Bleck
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Selective antisense compounds and uses thereof
- Patent number 12,152,244
- Issue date Nov 26, 2024
- Ionis Pharmaceuticals, Inc.
- Michael Oestergaard
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Cyclic dinucleotide analogue, pharmaceutical composition thereof, a...
- Patent number 12,152,051
- Issue date Nov 26, 2024
- SHANGHAI DE NOVO PHARMATECH CO., LTD.
- Zhaolong Tong
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Construction and methods of use of a barcoded and gene edited DNA l...
- Patent number 12,145,962
- Issue date Nov 19, 2024
- The Regents of the University of Colorado, a Body Corporate
- Kenneth Felsenstein
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Synthesis of modified oligonucleotides with increased stability
- Patent number 12,146,136
- Issue date Nov 19, 2024
- University of Massachusetts
- Anastasia Khvorova
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Frameshift suppressor tRNA compositions and methods of use
- Patent number 12,139,708
- Issue date Nov 12, 2024
- Massachusetts Institute of Technology
- Ahmed Hussein Badran
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method of nonspecific target capture of nucleic acids
- Patent number 12,139,706
- Issue date Nov 12, 2024
- Gen-Probe Incorporated
- Michael M. Becker
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Segment for use in synthesis of oligonucleotide, method for produci...
- Patent number 12,139,507
- Issue date Nov 12, 2024
- NATiAS Inc.
- Masanori Kataoka
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Antisense oligomers and methods of using the same for treating dise...
- Patent number 12,139,709
- Issue date Nov 12, 2024
- Sarepta Therapeutics, Inc.
- Frederick Joseph Schnell
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Multiplexed genome editing
- Patent number 12,133,515
- Issue date Nov 5, 2024
- President and Fellows of Harvard College
- George M. Church
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Polynucleotides containing a stabilizing tail region
- Patent number 12,109,274
- Issue date Oct 8, 2024
- ModernaTX, Inc.
- Gabor Butora
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Compositions and methods for synthesizing 5′-capped RNAs
- Patent number 12,103,944
- Issue date Oct 1, 2024
- TriLink Biotechnologies, LLC
- Richard I. Hogrefe
- A23 - FOODS OR FOODSTUFFS THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
Information Patent Grant
Systems and methods for determining nucleic acids
- Patent number 12,104,151
- Issue date Oct 1, 2024
- President and Fellows of Harvard College
- Xiaowei Zhuang
- G06 - COMPUTING CALCULATING COUNTING
Information Patent Grant
Method for generating higher order genome editing libraries
- Patent number 12,091,656
- Issue date Sep 17, 2024
- Johann Wolfgang Goethe-Universität Frankfur
- Manuel Kaulich
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Organic compositions to treat HSF1-related diseases
- Patent number 12,091,661
- Issue date Sep 17, 2024
- Arrowhead Pharmaceuticals, Inc.
- Gregory Hinkle
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Compositions for modulating tau expression
- Patent number 12,091,662
- Issue date Sep 17, 2024
- Biogen MA Inc.
- Holly Kordasiewicz
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Compositions and methods for modulating PNPLA3 expression
- Patent number 12,084,662
- Issue date Sep 10, 2024
- Dicerna Pharmaceuticals, Inc.
- Utsav Saxena
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods for purification of messenger RNA
- Patent number 12,084,702
- Issue date Sep 10, 2024
- Translate Bio, Inc.
- Joseph Parella
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Grant
Compositions of toehold primer duplexes and methods of use
- Patent number 12,077,811
- Issue date Sep 3, 2024
- President and Fellows of Harvard College
- David Yu Zhang
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Modified oligonucleotides and methods of use
- Patent number 12,077,757
- Issue date Sep 3, 2024
- JANSSEN PHARMACEUTICA NV
- Sergei Gryaznov
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Carbohydrate conjugates as delivery agents for oligonucleotides
- Patent number 12,059,468
- Issue date Aug 13, 2024
- Alnylam Pharmaceuticals, Inc.
- Muthiah Manoharan
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Methods for purification of messenger RNA
- Patent number 12,060,381
- Issue date Aug 13, 2024
- Translate Bio, Inc.
- Frank DeRosa
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Compounds for RNA capping and uses thereof
- Patent number 12,060,385
- Issue date Aug 13, 2024
- GUANGZHOU HENOVCOM BIOSCIENCE CO., LTD.
- Jiancun Zhang
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Purification and purity assessment of RNA molecules synthesized wit...
- Patent number 12,054,734
- Issue date Aug 6, 2024
- The Trustees of the University of Pennsylvania
- Drew Weissman
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Helix 73-derived RNA molecules interacting with Erm protein and met...
- Patent number 12,037,642
- Issue date Jul 16, 2024
- INDUSTRY-UNIVERSITY COOPERATION OF USW
- Hyung Jong Jin
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
4′-phosphate analogs and oligonucleotides comprising the same
- Patent number 12,037,586
- Issue date Jul 16, 2024
- Dicerna Pharmaceuticals, Inc.
- Weimin Wang
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Cyclic dinucleotides as agonists of stimulator of interferon gene d...
- Patent number 12,036,231
- Issue date Jul 16, 2024
- Board of Regents, The University of Texas System
- Maria Emilia Di Francesco
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Freshness label with aggregation-induced phosphor
- Patent number 12,025,558
- Issue date Jul 2, 2024
- Toshiba Tec Kabushiki Kaisha
- Ryozo Akiyama
- B65 - CONVEYING PACKING STORING HANDLING THIN OR FILAMENTARY MATERIAL
Information Patent Grant
RNA purification methods
- Patent number 12,018,044
- Issue date Jun 25, 2024
- GlaxoSmithKline Biologicals SA
- Francesco Berlanda Scorza
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Grant
CNS delivery of mRNA and uses thereof
- Patent number 12,016,954
- Issue date Jun 25, 2024
- Translate Bio, Inc.
- Frank DeRosa
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Patents Applicationslast 30 patents

Information Patent Application
ARNATAR COMPOUNDS AND METHODS FOR ENHANCED CELLULAR UPTAKE
- Publication number 20240417422
- Publication date Dec 19, 2024
- Arnatar Therapeutics, Inc
- Derek Steiner
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ANTISENSE-INDUCED EXON EXCLUSION IN TYPE VII COLLAGEN
- Publication number 20240415857
- Publication date Dec 19, 2024
- Sarepta Therapeutics, Inc.
- Dan V. Mourich
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CNS DELIVERY OF MRNA AND USES THEREOF
- Publication number 20240408013
- Publication date Dec 12, 2024
- Translate Bio, Inc.
- Frank DeRosa
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITIONS AND METHODS FOR MODULATING PNPLA3 EXPRESSION
- Publication number 20240401059
- Publication date Dec 5, 2024
- Dicerna Pharmaceuticals, Inc.
- Utsav SAXENA
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
SYNTHESIS OF TRINUCLEOTIDE AND TETRANUCLEOTIDE CAPS FOR MRNA PRODUC...
- Publication number 20240383940
- Publication date Nov 21, 2024
- Moderna TX, Inc.
- Atsushi Endo
- C07 - ORGANIC CHEMISTRY
Information Patent Application
CYCLIC-DISULFIDE MODIFIED PHOSPHATE BASED OLIGONUCLEOTIDE PRODRUGS
- Publication number 20240343746
- Publication date Oct 17, 2024
- Alnylam Pharmaceuticals, Inc.
- Alexander V. KEL’IN
- C07 - ORGANIC CHEMISTRY
Information Patent Application
7-SUBSTITUTED 7-DEAZAADENINE-CONTAINING 2',3'-CYCLIC DINUCLEOTIDES
- Publication number 20240343754
- Publication date Oct 17, 2024
- USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, v.v.i.
- Michal HOCEK
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SYNTHESIS OF MODIFIED OLIGONUCLEOTIDES WITH INCREASED STABILITY
- Publication number 20240336916
- Publication date Oct 10, 2024
- University of Massachusetts
- Anastasia Khvorova
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
POLYNUCLEOTIDE AND PHARMACEUTICAL COMPOSITION
- Publication number 20240325426
- Publication date Oct 3, 2024
- KYOWA KIRIN CO., LTD.
- Hiroto Iwai
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
GALNAC-MONOMERS AND GALNAC-NUCLEIC ACID CONJUGATES
- Publication number 20240327842
- Publication date Oct 3, 2024
- LERNA BIOPHARMA PTE. LTD.
- Xi LIN
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MCM FOR GENE THERAPY TO ACTIVATE WNT PATHWAY
- Publication number 20240316091
- Publication date Sep 26, 2024
- STEADMAN PHILIPPON RESEARCH INSTITUTE
- Chelsea BAHNEY
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
COMPOSITION CONTAINING NUCLEIC ACID OLIGOMER
- Publication number 20240300993
- Publication date Sep 12, 2024
- Sumitomo Chemical Company, Limited
- Yuya MORIYAMA
- C07 - ORGANIC CHEMISTRY
Information Patent Application
RNA PURIFICATION METHODS
- Publication number 20240300994
- Publication date Sep 12, 2024
- GlaxoSmithKline Biologicals S.A.
- Francesco BERLANDA SCORZA
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Application
Selective Antisense Compounds and Uses Thereof
- Publication number 20240294923
- Publication date Sep 5, 2024
- Ionis Pharmaceuticals, Inc.
- Michael Oestergaard
- C07 - ORGANIC CHEMISTRY
Information Patent Application
RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT...
- Publication number 20240287515
- Publication date Aug 29, 2024
- Srina Therapeutics, Inc.
- Mark Cancilla
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
RNAi AGENTS, COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING T...
- Publication number 20240279652
- Publication date Aug 22, 2024
- Alnylam Pharmaceuticals, Inc.
- Kallanthottathil G. Rajeev
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
SCALABLE PRODUCTION OF POLYRIBONUCLEOTIDES OF CONTROLLED SIZE
- Publication number 20240262858
- Publication date Aug 8, 2024
- Oncovir, Inc.
- Peter C. Michels
- C07 - ORGANIC CHEMISTRY
Information Patent Application
METHODS AND COMPOSITIONS FOR LINKING RNA STEM LOOPS
- Publication number 20240254477
- Publication date Aug 1, 2024
- The Regents of the University of California
- Neal Devaraj
- C07 - ORGANIC CHEMISTRY
Information Patent Application
Chemical Phosphorylation Reagents, Preparation, and Their Uses
- Publication number 20240254149
- Publication date Aug 1, 2024
- OliX US, Inc.
- Dongwon Shin
- C07 - ORGANIC CHEMISTRY
Information Patent Application
POLYNUCLEOTIDE CONSTRUCTS
- Publication number 20240247025
- Publication date Jul 25, 2024
- Sirius Therapeutics, Inc.
- Sukumar SAKAMURI
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
NEUROPROTECTIVE MOLECULES AND METHODS OF TREATING NEUROLOGICAL DISO...
- Publication number 20240240181
- Publication date Jul 18, 2024
- The Brigham & Women's Hospital, Inc.
- Paul Anderson
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
RNA Containing Modified Nucleosides and Methods of Use Thereof
- Publication number 20240226335
- Publication date Jul 11, 2024
- The Trustees of the University of Pennsylvania
- Katalin Kariko
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF
- Publication number 20240189337
- Publication date Jun 13, 2024
- ASCLETIS BIOSCIENCE CO., LTD.
- Bin LIANG
- C07 - ORGANIC CHEMISTRY
Information Patent Application
N-(2-AMINOETHYL)MORPHOLINE-BASED RNA ANALOGS, METHOD FOR THE PREPAR...
- Publication number 20240182512
- Publication date Jun 6, 2024
- UNIWERSYTET WARSZAWSKI
- Adam MAMOT
- C07 - ORGANIC CHEMISTRY
Information Patent Application
Conjugated Antisense Compounds for Use in Therapy
- Publication number 20240165146
- Publication date May 23, 2024
- Ionis Pharmaceuticals, Inc.
- Nicholas J. Viney
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CHEMICAL TOOLS FOR RNA 3D STRUCTURE DETERMINATION IN VIVO
- Publication number 20240166683
- Publication date May 23, 2024
- University of Southern California
- Zhipeng LU
- C07 - ORGANIC CHEMISTRY
Information Patent Application
COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS
- Publication number 20240158433
- Publication date May 16, 2024
- TriLink Biotechnologies, LLC
- Richard I. HOGREFE
- A23 - FOODS OR FOODSTUFFS THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
Information Patent Application
PATATIN-LIKE PHOSPHOLIPASE DOMAIN CONTAINING 3 (PNPLA3) iRNA COMPOS...
- Publication number 20240148773
- Publication date May 9, 2024
- Alnylam Pharmaceuticals, Inc.
- Kevin Fitzgerald
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS
- Publication number 20240140982
- Publication date May 2, 2024
- TriLink Biotechnologies, LLC
- Richard I. HOGREFE
- A23 - FOODS OR FOODSTUFFS THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
Information Patent Application
RNA Containing Modified Nucleosides and Methods of Use Thereof
- Publication number 20240131194
- Publication date Apr 25, 2024
- The Trustees of the University of Pennsylvania
- Katalin Kariko
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

with ribosyl as saccharide radical

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Vectors for protein manufacture

Selective antisense compounds and uses thereof

Cyclic dinucleotide analogue, pharmaceutical composition thereof, a...

Construction and methods of use of a barcoded and gene edited DNA l...

Synthesis of modified oligonucleotides with increased stability

Frameshift suppressor tRNA compositions and methods of use

Method of nonspecific target capture of nucleic acids

Segment for use in synthesis of oligonucleotide, method for produci...

Antisense oligomers and methods of using the same for treating dise...

Multiplexed genome editing

Polynucleotides containing a stabilizing tail region

Compositions and methods for synthesizing 5′-capped RNAs

Systems and methods for determining nucleic acids

Method for generating higher order genome editing libraries

Organic compositions to treat HSF1-related diseases

Compositions for modulating tau expression

Compositions and methods for modulating PNPLA3 expression

Methods for purification of messenger RNA

Compositions of toehold primer duplexes and methods of use

Modified oligonucleotides and methods of use

Carbohydrate conjugates as delivery agents for oligonucleotides

Methods for purification of messenger RNA

Compounds for RNA capping and uses thereof

Purification and purity assessment of RNA molecules synthesized wit...

Helix 73-derived RNA molecules interacting with Erm protein and met...

4′-phosphate analogs and oligonucleotides comprising the same

Cyclic dinucleotides as agonists of stimulator of interferon gene d...

Freshness label with aggregation-induced phosphor

RNA purification methods

CNS delivery of mRNA and uses thereof

Patents Applicationslast 30 patents

ARNATAR COMPOUNDS AND METHODS FOR ENHANCED CELLULAR UPTAKE

ANTISENSE-INDUCED EXON EXCLUSION IN TYPE VII COLLAGEN

CNS DELIVERY OF MRNA AND USES THEREOF

COMPOSITIONS AND METHODS FOR MODULATING PNPLA3 EXPRESSION

SYNTHESIS OF TRINUCLEOTIDE AND TETRANUCLEOTIDE CAPS FOR MRNA PRODUC...

CYCLIC-DISULFIDE MODIFIED PHOSPHATE BASED OLIGONUCLEOTIDE PRODRUGS

7-SUBSTITUTED 7-DEAZAADENINE-CONTAINING 2',3'-CYCLIC DINUCLEOTIDES

SYNTHESIS OF MODIFIED OLIGONUCLEOTIDES WITH INCREASED STABILITY

POLYNUCLEOTIDE AND PHARMACEUTICAL COMPOSITION

GALNAC-MONOMERS AND GALNAC-NUCLEIC ACID CONJUGATES

MCM FOR GENE THERAPY TO ACTIVATE WNT PATHWAY

COMPOSITION CONTAINING NUCLEIC ACID OLIGOMER

RNA PURIFICATION METHODS

Selective Antisense Compounds and Uses Thereof

RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT...

RNAi AGENTS, COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING T...

SCALABLE PRODUCTION OF POLYRIBONUCLEOTIDES OF CONTROLLED SIZE

METHODS AND COMPOSITIONS FOR LINKING RNA STEM LOOPS

Chemical Phosphorylation Reagents, Preparation, and Their Uses

POLYNUCLEOTIDE CONSTRUCTS

NEUROPROTECTIVE MOLECULES AND METHODS OF TREATING NEUROLOGICAL DISO...

RNA Containing Modified Nucleosides and Methods of Use Thereof

NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF

N-(2-AMINOETHYL)MORPHOLINE-BASED RNA ANALOGS, METHOD FOR THE PREPAR...

Conjugated Antisense Compounds for Use in Therapy

CHEMICAL TOOLS FOR RNA 3D STRUCTURE DETERMINATION IN VIVO

COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS

PATATIN-LIKE PHOSPHOLIPASE DOMAIN CONTAINING 3 (PNPLA3) iRNA COMPOS...

COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS

RNA Containing Modified Nucleosides and Methods of Use Thereof