Information
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Patent Grant
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4128711
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Patent Number
4,128,711
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Date Filed
Thursday, October 6, 197746 years ago
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Date Issued
Tuesday, December 5, 197845 years ago
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Inventors
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Original Assignees
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Examiners
Agents
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CPC
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US Classifications
Field of Search
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International Classifications
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Abstract
A compound 1-[[1H-pyrrol-2-ylmethylene]amino]-2,4-imidazolidinedione possesses pharmacological activity as a muscle relaxant.
Description
This invention relates to chemical compounds. In particular, it is concerned with the compound 1-[[1H-pyrrol-2-ylmethylene]amino]-2,4-imidazolidinedione.
This compound elicits pharmacological activity. In particular, it is useful as a muscle relaxant. When administered perorally to mice in doses of 50-800 mg/kg, muscle relaxant effects are produced. Such administration is readily and conveniently achieved using a carrier such as methylcellulose.
In order that this invention be readily available to and understood by those skilled in the art, the following example is supplied:
1-[[1H-Pyrrol-2-ylmethylene]amino]-2,4-imidazolidinedione
To a solution containing 14.25 g (0.15 mole) of pyrrol-2-carboxaldehyde in 100 ml 95% ethanol was added a solution of 22.80 g (0.15 mole) of 1-amino-2,4-imidazolidinedione hydrochloride in 100 ml water. A pink solid separated immediately. The mixture was diluted with 100 ml water and stirred at ambient temperature for 45 minutes. The solid was filtered, washed with 3 .times. 30 ml water, air dried for 1 hr., and dried at 60.degree. for 4 hrs. to give 29.48 g (100%) of the product, m.p. 276.degree.-279.degree..
Recrystallization from dimethylformamide-water gave an analytical sample, m.p. 269.degree.-272.degree..
Anal. Calcd. for C.sub.8 H.sub.8 N.sub.4 O.sub.2 : C, 49.99; H, 4.20; N, 29.16. Found: C, 50.08; H, 4.31; N, 29.21.
Claims
- 1. The compound 1-[[1H-pyrrol-2-ylmethylene]amino]-2,4-imidazolidinedione.
US Referenced Citations (3)