Claims
- 1. A compound of the formula ##STR17## wherein R.sup.1 and R.sup.2 are independently alkyl having 1 to 12 carbon atoms or the group ##STR18## in which n is 0 to 3; X and Y are independently oxygen or sulfur; and the antimicrobial acid addition salts thereof.
- 2. A compound of claim 1 wherein X and Y are oxygen.
- 3. A compound of claim 1 wherein X is sulfur and Y is oxygen.
- 4. A compound of claim 1 wherein X is oxygen and Y is sulfur.
- 5. A compound of claim 1 wherein X and Y are sulfur.
- 6. A compound of claim 1 wherein R.sup.1 and R.sup.2 are alkyl.
- 7. The compound of claim 6 which is 1-[2',3'-bis(n-octyloxy)propyl]imidazole and the antimicrobial acid addition salts thereof.
- 8. The compound of claim 6 which is 1-[3'-(n-decyloxy)-2'-(n-hexyloxy)propyl]imidazole and the antimicrobial acid addition salts thereof.
- 9. The compound of claim 6 which is 1-[3'-(n-decyloxy)-2'-(n-heptyloxy)propyl]imidazole and the antimicrobial acid addition salts thereof.
- 10. The compound of claim 6 which is 1-[3'-(n-decyloxy)-2'-(n-octyloxy)propyl]imidazole and the antimicrobial acid addition salts thereof.
- 11. The compound of claim 6 which is 1-[2'-(n-heptyloxy)-3'-(n-heptylthio)propyl]imidazole and the antimicrobial acid addition salts thereof.
- 12. The compound of claim 6 which is 1-[3'-(n-heptylthio)-2'-(n-octyloxy)propyl]imidazole and the antimicrobial acid addition salts thereof.
- 13. The compound of claim 6 which is 1-[2'-(n-octyloxy)-3'-(n-octylthio)propyl]imidazole and the antimicrobial acid addition salts thereof.
- 14. The compound of claim 6 which is 1-[2'-(n-dodecylthio)-3'-(isopropoxy)propyl]imidazole and the antimicrobial acid addition salts thereof.
- 15. The compound of claim 6 which is 1-[3'-(n-octyloxy)-2'-(n-octylthio)propyl]imidazole and the antimicrobial acid addition salts thereof.
- 16. The compound of claim 6 which is 1-[2'-(n-heptylthio)-3'-(n-octyloxy)propyl]imidazole and the antimicrobial acid addition salts thereof.
- 17. The compound of claim 6 which is 1-[2'-(butylthio)-3'-(n-dodecyloxy)propyl]imidazole and the antimicrobial acid addition salts thereof.
- 18. The compound of claim 6 which is 1-[2'-(n-dodecylthio)-3'-(methylthio)propyl]imidazole and the antimicrobial acid addition salts thereof.
- 19. The compound of claim 6 which is 1-[3'-(t-butylthio)-2'-(n-nonylthio)propyl]imidazole and the antimicrobial acid addition salts thereof.
- 20. The compound of claim 6 which is 1-[2',3'-bis(n-hexylthio)propyl]imidazole and the antimicrobial acid addition salts thereof.
- 21. The compound of claim 6 which is 1-[2',3'-bis-(n-heptylthio)propyl]imidazole and the antimicrobial acid addition salts thereof.
- 22. The compound of claim 6 which is 1-[2',3'-bis-(n-pentylthio)propyl]imidazole and the antimicrobial acid addition salts thereof.
- 23. A composition useful for inhibiting the growth of fungi, bacteria or protozoa which comprises an effective amount of a compound of the formula ##STR19## wherein R.sup.1 and R.sup.2 are independently alkyl having 1 to 12 carbon atoms or the group ##STR20## in which n is 0 to 3 and X and Y are independently oxygen or sulfur; or an antimicrobial acid addition salt thereof in admixture with a suitable carrier.
- 24. A composition of claim 23 for pharmaceutical use wherein the carrier is a pharmaceutically acceptable, nontoxic carrier.
- 25. A composition of claim 24 for topical administration wherein the compound of Formula (I) is present in an amount ranging between 0.1 and 10.0 weight percent of the composition.
- 26. A method of inhibiting the growth of fungi, bacteria or protozoa which comprises applying to a host object containing or subject to attack by fungi, bacteria or protozoa an effective amount of a compound of the formula ##STR21## wherein R.sup.1 and R.sup.2 are independently alkyl having 1 to 12 carbon atoms or the group ##STR22## in which n is 0 to 3 and X and Y are independently oxygen or sulfur; or an antimicrobial acid addition salt thereof or a composition containing same as an active ingredient.
- 27. The method of claim 26 wherein the compound of Formula (I) is administered topically.
- 28. The method of claim 26 wherein the compound of Formula (I) is administered orally or parenterally.
RELATED APPLICATIONS
This case is a continuation-in-part of U.S. Ser. No. 599,611, filed July 28, 1975, now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3531494 |
Adolphi et al. |
Sep 1970 |
|
3940415 |
Buchel et al. |
Feb 1976 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
599611 |
Jul 1975 |
|