Number | Date | Country | Kind |
---|---|---|---|
9009604 | Apr 1990 | GBX | |
9027100 | Dec 1990 | GBX |
Filing Document | Filing Date | Country | Kind | 102e Date | 371c Date |
---|---|---|---|---|---|
PCT/EP91/00717 | 4/12/1991 | 12/23/1992 | 12/23/1992 |
Publishing Document | Publishing Date | Country | Kind |
---|---|---|---|
WO91/17116 | 11/14/1991 |
Number | Name | Date | Kind |
---|---|---|---|
4753952 | Vecchietti | Jun 1988 | |
4806547 | Giardina | Feb 1989 | |
4826819 | Vecchietti | May 1989 | |
4999359 | Vecchietti | Mar 1991 | |
5030649 | Vecchietti | Jul 1991 | |
5041451 | Colle | Aug 1991 | |
5087630 | Colle | Feb 1992 | |
5089507 | Vecchietti | Feb 1992 | |
5254564 | Vecchietti | Oct 1993 |
Number | Date | Country |
---|---|---|
0232612 | Aug 1987 | EPX |
0333315 | Sep 1987 | EPX |
0275696 | Jul 1988 | EPX |
0330461 | Aug 1989 | EPX |
0330467 | Aug 1989 | EPX |
0330469 | Aug 1989 | EPX |
0356247 | Feb 1990 | EPX |
0366327 | May 1990 | EPX |
0374756 | Jun 1990 | EPX |
3409237 | Sep 1985 | DEX |
3523002 | Jan 1987 | DEX |
3643667 | Jun 1988 | DEX |
WO9108205 | Jun 1991 | WOX |
WO9108206 | Jun 1991 | WOX |
WO9117116 | Nov 1991 | WOX |
WO9215304 | Sep 1992 | WOX |
WO9215592 | Sep 1993 | WOX |
Entry |
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Engel et al., J. Med. Chem., 32(8), 1718-1724 1989. |
Brooks et al., Opiate Receptors within the Blood-Brain Barrier Mediate Kappa Agonist-Induced Water Diuresis, J. Pharmacol. Exp. Ther., 266, 164 (1993). |
Silvia et al., Protection from ischemia-induced cerebral edema in the rat by U-50488H, a kappa opioid receptor agonist, Brain Res., 403, 52 (1987). |
Hall et al., Stroke, Quantitative Analysis of Effects of .kappa.-Opioid Agonists on Postischemic Hippocampal CA1 Neuronal Necrosis in Gerbils, 19, 8 1008 (1988). |
Journal of Medicinal Chemistry, vol. 32, No. 8, Aug. 1989, American Chemical Society, (Washington, D.C., US) W. W. Engel et al: "Tricyclic compounds as selective muscarinic receptor antagonists. 3. Structure-selectivity relationships in a series of cardioselective (M.sub.2) anti-muscarinics", pp. 1718-1724. |