Claims
- 1. A compound of the formula ##STR117## wherein R.sub.4 is hydrogen, alkyl of 1 to 5 carbon atoms, or aralkyl of 7 to 14 carbon atoms;
- R.sub.5 is ##STR118## where R.sub.10 and R.sub.11 are each hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, trifluoromethyl, carboxamido or, together with each other, --O--(CH.sub.2).sub.y --O--, where y is 1 or 2, attached to carbon atoms of the phenyl ring in o-position with respect to each other; and
- D is alkylene of 1 to 12 carbon atoms,
- or a non-toxic, pharmacologically acceptable acid addition salt thereof.
- 2. A compound of claim 1, wherein
- R.sub.4 is hydrogen or methyl;
- R.sub.5 is ##STR119## D is alkylene of 2 to 8 carbon atoms, or a non-toxic, pharmacologically acceptable acid addition salt thereof.
- 3. A compound of the formula ##STR120## wherein R.sub.4 is hydrogen or methyl; and
- D' is alkylene of 2 to 8 carbon atoms,
- or a non-toxic, pharmacologically acceptable acid addition salt thereof.
- 4. The compound of claim 3, which is 1-(2-cyanophenoxy)-3-[1,1-dimethyl-4-(N-benzimidazolon(2)yl)-butylamino-1]-propanol-(2) or a non-toxic, pharmacologically acceptable acid addition salt thereof.
- 5. An .alpha.- and .beta.-adrenolytic pharmaceutical dosage composition consisting essentially of an inert pharmaceutical carrier and an effective amount of a compound of claims 1 or 3.
- 6. The method of blocking the .alpha.- and .beta.-adrenergic receptors in a warm-blooded animal in need thereof, which comprises perorally, parenterally or rectally administering to said animal an effective amount of a compound of claims 1 or 3.
Priority Claims (1)
Number |
Date |
Country |
Kind |
2644833 |
Oct 1976 |
DEX |
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Parent Case Info
This is a continuation-in-part of
(i) copending application Ser. No. 103,724, filed Dec. 14, 1979, now U.S. Pat. No. 4,255,430, which in turn is a continuation-in-part of application Ser. No. 004,280, filed Jan. 17, 1979, now U.S. Pat. No. 4,212,877, which in turn is a continuation-in-part of application Ser. No. 838,450, filed Oct. 3, 1977, now abandoned, and
(ii) copending application Ser. No. 112,640, filed Jan. 16, 1980, now U.S. Pat. No. 4,296,177, which in turn is a divisional of copending application Ser. No. 004,279, filed Jan. 17, 1979, now U.S. Pat. No. 4,256,756, which in turn is a continuation-in-part of application Ser. No. 838,450, filed Oct. 3, 1977, now abandoned.
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
3818017 |
Janssen et al. |
Jun 1974 |
|
3852291 |
Augstein et al. |
Dec 1974 |
|
3894030 |
Janssen et al. |
Jul 1975 |
|
4154829 |
Mentrup et al. |
May 1979 |
|
Foreign Referenced Citations (2)
Number |
Date |
Country |
2109651 |
Sep 1971 |
DEX |
2234332 |
Feb 1973 |
DEX |
Non-Patent Literature Citations (2)
Entry |
Maruyama et al., Chem. Abst. 1974, vol. 81, No. 105507w. |
Bond et al., Chem. Abst. 1967, vol. 67, No. 81991g. |
Divisions (1)
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Number |
Date |
Country |
Parent |
4279 |
Jan 1979 |
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Continuation in Parts (4)
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Number |
Date |
Country |
Parent |
103724 |
Dec 1979 |
|
Parent |
4280 |
Jan 1979 |
|
Parent |
838450 |
Oct 1977 |
|
Parent |
838450 |
Oct 1977 |
|