Claims
- 1. 1-aryloxy-3-alkylamino-2-propanol nitrate esters of general formula I ##STR9## and the enantiomers and diastereoisomers and therapeutically acceptable organic and inorganic acid salts thereof;
- where
- R.sub.1 is a chain of general formula II
- --(CH.sub.2).sub.m --Z--R.sub.2 (II)
- where m is 1 or 2; Z is an, --O--, ether or, --COO, ester function; and R.sub.2 is a C.sub.2-3 straight or branched chain alkyl having at least one ONO.sub.2 group as a substituent; and Ar is a benzene ring.
- 2. A pharmaceutical composition comprising a therapeutically effective amount of at least one of the compounds according to claim 1, produced in a form selected from the group consisting of tablets, retard tablets, capsules and injectables.
- 3. Nitrate esters of general formula I, according to claim 1, selected from the group consisting of 1-isopropylamino-3-[4-(2-nitroxy)propoxymethyl]phenoxy-2-propanol, 1-isopropylamino-3-[4-(3-nitroxy)propoxymethyl]phenoxy-2-propanol, 1-isopropylamino-3-[4-(2,3-dinitroxy)propoxymethyl]phenoxy-2-propanol and 2-nitroxyethyl 4-[(2-hydroxy-3-isopropylamino)propoxy]phenyl acetate.
Priority Claims (1)
Number |
Date |
Country |
Kind |
9301721 |
Jul 1993 |
ESX |
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Parent Case Info
This is a continuation of application Ser. No. 08/265,960 filed Jun. 27, 1994 now U.S. Pat. No. 5,502,237.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3873600 |
Brandstrom et al. |
Mar 1975 |
|
4374840 |
Shiratsuchi et al. |
Feb 1983 |
|
4448989 |
Shiratsuchi et al. |
May 1984 |
|
Continuations (1)
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Number |
Date |
Country |
Parent |
265960 |
Jun 1994 |
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