Claims
- 1. A compound selected from those of formula (I): wherein:n represents 1, R1 represents hydrogen, aryl-(C1-C6)alkyl in which the alkyl moiety is linear or branched, linear or branched (C1-C6)alkyl, linear or branched (C1-C6)acyl, linear or branched (C1-C6)alkoxycarbonyl, aryl-(C1-C6)alkoxycarbonyl in which the alkoxy moiety is linear or branched, or trifluoroacetyl, R2 represents linear or branched (C1-C6)alkyl, X represents oxygen, chlorine, OR3, SR4 or NOR5, wherein R3 represents hydrogen, linear or branched (C1-C6)alkyl, linear or branched (C1-C6)acyl, linear or branched (C1-C6)alkoxycarbonyl, or aryl-(C1-C6)alkoxycarbonyl in which the alkoxy moiety is linear or branched, R4 represents hydrogen, linear or branched (C1-C6)alkyl, or aryl, R5 represents hydrogen or linear or branched C1-C6)alkyl optionally substituted by one or more identical or different groups selected from hydroxy, amino (optionally substituted by one or two linear or branched C1-C6)alkyl groups), and linear or branched C1-C6)alkoxy, represents a single or double bond, it being understood that the valency of the atoms is respected, Ar represents aryl or heteroaryl, its isomers and addition salts thereof with a pharmaceutically-acceptable acid, on the understanding that the term “aryl” means phenyl, biphenylyl, naphthyl, or tetrahydronaphthyl, each of those groups being optionally substituted by one or more identical or different groups selected from halogen, linear or branched C1-C6)alkyl, hydroxy, linear or branched C1-C6)alkoxy, trihalomethyl, and amino (optionally substituted by one or more linear or branched C1-C6)alkyl groups),and that the term “heteroaryl” denotes an aromatic, mono- or bi-cyclic, 5- to 12-membered group containing one, two or three hetero atoms selected from oxygen, nitrogen and sulphur, it being understood that the heteroaryl group may be optionally substituted by one or more identical or different groups selected from halogen, linear or branched C1-C6)alkyl, hydroxy, linear or branched C1-C6)alkoxy, trihalomethyl, and amino (optionally substituted by one or more linear or branched C1-C6)alkyl groups).
- 2. A compound of claim 1 wherein X represents oxygen or OR3 wherein R3 is as defined in claim 1.
- 3. A compound of claim 1, wherein X represents NOR5 wherein R5 is as defined in claim 1.
- 4. A compound of claim 1, wherein X represents SR4 wherein R4 is as defined in claim 1.
- 5. A compound of claim 1, wherein X represents chlorine.
- 6. A compound of claim 2, wherein X represents oxygen or OR3 wherein R3 represents hydrogen.
- 7. A compound of claim 1 wherein R1 represents hydrogen.
- 8. A compound of claim 1, wherein Ar represents optionally substituted phenyl.
- 9. A compound of claim 1, wherein Ar represents optionally substituted thienyl.
- 10. A compound of claim 1, wherein Ar represents optionally substituted pyridyl.
- 11. A compound of claim 1 which is (±)-6-(4-chlorophenyl)-2-methyl-1,5,6,7-tetrahydro-4H-azepin-4-one.
- 12. A Method for treating a mammal afflicted with a condition requiring an antalgic agent or a facilitator of memory and cognition, comprising the step of administering to the mammal an amount of a compound of claim 1 which is effective for alleviation of said condition.
- 13. A pharmaceutical composition comprising as active principle an effective amount of a compound as claimed in claim 1, together with one or more pharmaceutically acceptable excipients or vehicles.
Priority Claims (1)
Number |
Date |
Country |
Kind |
99 05600 |
May 1999 |
FR |
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Parent Case Info
This application is a division of No. 09/561,646 filed May 2, 2000, now U.S. Pat. No. 6,323,222.
Foreign Referenced Citations (3)
Number |
Date |
Country |
2013761 |
Oct 1971 |
DE |
0 159 640 |
Apr 1985 |
EP |
1050530 |
Nov 2000 |
EP |