A compound 1-benzyl-1,2-dihydro-3-methyl-2-oxopyrimidinium iodide possesses pharmacological activity as an antihypertensive agent.
Description
This invention relates to a chemical compound. In particular, it is concerned with a compound of the formula: ##STR1## When administered intravenously to animals this compound exhibits antihypertensive activity. Administration of 50 mg/kg of this compound to anesthetized dogs caused marked inhibition of the response to epinephrine. In order that this invention be readily available to and understood by those skilled in the art the following illustrative example is supplied: A solution of 1-benzyl-2(1H)pyrimidone, (28.1 g., 0.15 mole) in 290 ml of methanol was stirred at room temperature with 290 ml of iodomethane for 90 hours. The solution was concentrated to dryness in vacuo leaving a semi-solid which was crystallized by trituration with ethanol to give 46 g. (94%) of 1-benzyl-1,2-dihydro-3-methyl-2-oxopyrimidinium iodide. An analytical sample, m.p. 170.degree.-172.degree., was prepared from ethanol. Anal. Calcd. for C.sub.12 H.sub.13 IN.sub.2 O: C, 43.92; H, 3.99; H, 8.54; Found: C, 44.06; H, 4.02; N, 8.46.
Patent Grant
4041035
