Claims
- 1. A compound of the formula ##STR83## wherein R.sup.1 is
- (1) C.sub.1 to C.sub.10 alkanoyl,
- (2) C.sub.1 to C.sub.7 haloalkanoyl,
- (3) azidoacetyl, cyanoacetyl, trifluoromethylthioacetyl, cyanomethylthioacetyl, or (4-pyridon-1-yl)acetyl;
- (4) acyl group of the following formula
- Ar--CO--
- wherein Ar is an aryl selected from furyl, thienyl, pyrrolyl, oxazolyl, isoxazolyl, oxadiazolyl, oxatriazolyl, thiazolyl, isothiazolyl, thiadiazolyl, thiatriazolyl, pyrazolyl, imidazolyl, triazolyl, tetrazolyl, phenyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, triazinyl, dihydrophenyl, tetrahydrophenyl, tetrahydropyrimidyl, naphthyl, benzothiazolyl, indolyl, quinolyl, isoquinolyl, benzopyrimidyl, cinnolinyl, pyridopyrimidyl, or indanyl ring group;
- (5) group of the following formula:
- Ar--CQQ'--CO--
- wherein Ar is as defined above and Q and Q' each is hydrogen or methyl;
- (6) acyl group of the following formula:
- Ar--G--CQQ'--CO--
- wherein Ar, Q and Q' each is as defined above and G is oxygen, sulfur, or imino;
- (7) acyl group of the following formula ##STR84## wherein Ar is as defined above and T.sup.1 is hydrogen or C.sub.1 to C.sub.6 alkyl;
- (8) acyl group of the following formula: ##STR85## wherein Ar is as defined above and T.sup.2 is one of (i) hydroxy or C.sub.1 to C.sub.10 acyloxy, (ii) carboxy or protected carboxy, (iii) sulfo or C.sub.1 to C.sub.5 alkoxysulfonyl, or a group of the formula: ##STR86## in which W.sup.1 and W.sup.2 each is hydrogen or a C.sub.1 to C.sub.15 aminosubstituent;
- (9) 5-aminoadipoyl, 5-aminoadipoyl protected at the amino or 5-aminoadipoyl protected at the carboxy;
- (10) acyl group of the following formula:
- L--O--CO--
- wherein L is an easily removable and unsubstituted or substitured C.sub.1 to C.sub.10 hydrocarbyl group; or
- (11) C.sub.1 to C.sub.20 optionally substituted hydrocarbyl, C.sub.3 to C.sub.10 organic silyl, or C.sub.1 to C.sub.10 sulfenyl,
- COB is carboxy or protected carboxy, the carboxy protecting group B in said COB being C.sub.1 to C.sub.10 alkoxy, C.sub.1 to C.sub.6 haloalkoxy, C.sub.3 to C.sub.10 acylalkoxy, C.sub.3 to C.sub.10 alkoxyalkoxy, C.sub.2 to C.sub.10 aminoalkoxy, aryloxy, aralkoxy, C.sub.1 to C.sub.10 alkylsilyloxy, C.sub.1 to C.sub.10 alkylstannyloxy, C.sub.1 to C.sub.10 acyloxy, inorganic acyloxy, metal oxy of a group I, II or III metal in the periodical table, C.sub.1 to C.sub.15 hydrocarbylammoniooxy, C.sub.1 to C.sub.10 hydrocarbylthio or mercapto, C.sub.1 to C.sub.5 alkylamino, di-C.sub.1 to C.sub.5 alkylamino, hydrazinyl or azido;
- E is .beta.-hydrogen or .alpha.-methoxy;
- X is hydrogen, halogen, hydroxy, C.sub.1 to C.sub.4 alkanoyloxy, substituted C.sub.1 to C.sub.4 alkanoyloxy, aroyloxy, carbonic acyloxy, C.sub.1 to C.sub.6 alkoxy, aralkoxy of the formula Ar--CH.sub.2 O-- or aryloxy of the formula Ar--O-- in which Ar is as defined above, mercapto, C.sub.1 to C.sub.5 alkanoylthio, aroylthio, C.sub.1 to C.sub.6 -alkylthio, aralkylthio, arylthio of the formula Ar--S-- in which Ar is as defined above, amino, azido, hydrazinyl, acetylamino, methylamino, pyridinium, picolinium, 4-carboxypyridinium, carbamoylpyridinium, hydroxymethylpyridinium, carboxymethylpyridinium, or chloropyridinium, and
- Z is a group of the formula
- RS(O).sub.n -- or RSe(O).sub.n --
- in which R is C.sub.1 to C.sub.3 alkyl or monocyclic aryl and n is 0, 1 or 2.
- 2. A sulfide compound as claimed in claim 1 that is a compound of the following formula ##STR87## wherein R.sup.1, E, R, X and COB are as defined in claim 1.
- 3. A sulfoxide compound as claimed in claim 1 that is a compound of the following formula ##STR88## wherein R.sup.1, E, R, X and COB are as defined in claim 1.
- 4. A sulfone compound as claimed in claim 1 that is a compound of the following formula ##STR89## wherein R.sup.1, E, R, X and COB are as defined in claim 1.
- 5. A selenyl compound as claimed in claim 1 that is a compound of the following formula ##STR90## wherein R.sup.1, E, R, X and COB are as defined in claim 1.
- 6. A selenoxide compound as claimed in claim 1 that is a compound of the following formula ##STR91## wherein R.sup.1, E, R, X and COB are as defined in claim 1.
Priority Claims (3)
Number |
Date |
Country |
Kind |
52-15813 |
Feb 1977 |
JPX |
|
52-67025 |
Jun 1977 |
JPX |
|
55-138092 |
Oct 1980 |
JPX |
|
Parent Case Info
This application is a division of application Ser. No. 374,862, filed May 4, 1982 (now U.S. Pat. No. 4,443,598), which application is a continuation-in-part of application Ser. No. 322,662, filed Nov. 18, 1981 (now U.S. Pat. No. 4,366,316), which is a continuation of application Ser. No. 72,600, filed Sept. 5, 1979 (now abandoned), which is a continuation of application Ser. No. 877,811, filed Feb. 14, 1978 (now abandoned).
US Referenced Citations (10)
Divisions (1)
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374862 |
May 1982 |
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Continuations (2)
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72600 |
Sep 1979 |
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Parent |
877811 |
Feb 1978 |
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Continuation in Parts (1)
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322662 |
Nov 1981 |
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