Claims
- 1. A compound of formula (X) in which:R is (1) hydrogen; or (2) (C1-C6)-alkyl; R(1) is (1) halogen; (2) hydroxyl; (3) (C1-C4)-alkoxy; (4) (C1-C8)-alkoxy, wherein 1 to 6 carbon atoms are replaced by the heteroatoms O, S, or NH; (5) (C1-C4)-alkoxy, substituted by a saturated cyclic ether; (6) O—(C1-C4)-alkenyl; (7) O—(C1-C4)-alkylaryl; or (8) phenoxy, unsubstituted or substituted by a substituent selected from halogen, (C1-C3)-alkyl, (C1-C3)-alkoxy, and trifluoromethyl; R(2) is (1) CHO; R(3) is (1) (C1-C4)-alkyl; or (2) aryl; R(4) is (1) hydrogen; (2) halogen; or (3) (C1-C4)-alkyl; and R(6) is (1) (C1-C5)-alkyl; in any stereoisomeric form or mixture thereof in any ratio, or a physiologically tolerable salt thereof.
- 2. A pharmaceutical composition, comprising at least one compound of claim 1, and at least one pharmaceutically tolerable carrier or excipient.
- 3. A pharmaceutical composition of claim 2, further comprising at least one other pharmaceutically active compound.
- 4. A method for treating or preventing illnesses which are primarily or secondarily caused or at least partly caused by reduced production and/or release of the vasorelaxant, antithrombotic, and cardioprotective messengers cyclic 3′, 5′-guanosine monophosphate and nitrogen monoxide, comprising administering to a patient in need thereof an effective amount of at least one compound of claim 1.
- 5. A method for treating or preventing high blood pressure, cardiac hypertrophy, cardiac insufficiency, coronary heart diseases such as angina pectoris, cardiac infarct, vascular restenosis after angioplasty, cardiomyopathies, endothelial dysfunction or endothelial damage, and also of arterial and venous thromboses, comprising administering to a patient in need thereof an effective amount of at least one compound of claim 1.
Priority Claims (2)
Number |
Date |
Country |
Kind |
199 20 815 |
May 1999 |
DE |
|
199 61 686 |
Dec 1999 |
DE |
|
Parent Case Info
This application is a divisional of U.S. Ser. No. 09/564,544, filed May 4, 2000, U.S. Pat. No. 6,235,706 filed May 22, 2001.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5198438 |
Allen et al. |
Mar 1993 |
A |