Claims
- 1. A compound of the formula ##STR3## wherein A is oxygen or sulfur, and R is hydrogen, loweralkyl, arylloweralkyl, heteroarylloweralkyl.
- 2. A compound as defined in claim 1 wherein A is oxygen.
- 3. A compound as defined in claim 2 wherein R is hydrogen, loweralkyl, or arylloweralkyl.
- 4. The compound of claim 3 which is 1-formyl-4-(2,3,4,5,6-pentafluorophenoxy)piperidine.
- 5. The compound of claim 3 which is 1-acetyl-4-(2,3,4,5,6-pentafluorophenoxy)piperidine.
- 6. A compound as defined in claim 2 wherein R is heteroarylloweralkyl.
- 7. The compound of claim 6 which is 1-[(2-imidazol-1-yl)acetyl]-4-(2,3,4,5,6-pentafluorophenoxy)piperidine.
- 8. A compound as defined in claim 1 wherein A is sulfur.
- 9. A compound as defined in claim 8 wherein R is hydrogen, loweralkyl, or arylloweralkyl.
- 10. A compound as defined in claim 8 wherein R is heteroarylloweralkyl.
- 11. A method of treatment which comprises administering to a mammal in need of relief from convulsions a pharmaceutically effective amount of a compound as defined in claim 1.
- 12. A method of treatment which comprises administering to a mammal in need of relief from depression a pharmaceutically effective amount of a compound as defined in claim 1.
- 13. An antihypertensive composition comprising an effective blood pressure lowering amount of the compound as defined in claim 1 and a pharmaceutically acceptable carrier therefor.
- 14. A method of treating a patient in need of relief from high blood pressure which comprises administering to the patient an effective amount of the compound as defined in claim 1.
- 15. A pharmaceutical composition for treating convulsions or treating depression which comprises a compound as defined in claim 1 present in an amount effective for treating convulsions or depression and a pharmaceutically acceptable carrier therefor.
Parent Case Info
This is a division of application Ser. No. 764,280 filed Sep. 23, 1991, which is a continuation of Ser. No. 167,935 filed Mar. 14, 1988, now abandoned.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
4518713 |
Kasley et al. |
May 1985 |
|
4529730 |
Schneider et al. |
Jul 1985 |
|
4547514 |
Mathur et al. |
Oct 1985 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
1280699 |
Jul 1972 |
GBX |
Non-Patent Literature Citations (1)
Entry |
Boswell, et al., J. Med. Chem, "Synthesis of some N-Carboxylic Acid Derivatives of 3-Phenoxypiperidines . . . " 17 (9) pp. 1000-1008 (1974). |
Divisions (1)
|
Number |
Date |
Country |
Parent |
764280 |
Sep 1991 |
|
Continuations (1)
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Number |
Date |
Country |
Parent |
167935 |
Mar 1988 |
|