Claims
- 1. A 1'-substituted-spiro(pyrrolidine-3,3'-indoline)-2,2',5-trione of the formula: ##STR15## wherein Ra is benzyl bearing two independently selected halogeno substituents located at positions 2 and 4, or 3 and 4, or is benzyl bearing a bromo or trifluoromethyl substituent located at position 3 or 4; and benzene ring A is unsubstituted or bears one or two substituents independently selected from halogeno, (1-4C)alkyl, trifluoromethyl and nitro; or a salt thereof with a base affording a pharmaceutically acceptable cation; or the non-toxic, biodegradable 1-pivaloyloxymethyl precursor thereof.
- 2. A compound as claimed in claim 1 wherein the halogeno substituents present as part of Ra are independently selected from fluoro, chloro, bromo or iodo and the substituents which may be present on the benzene ring A are independently selected from fluoro, chloro, bromo, iodo, methyl, ethyl, trifluoromethyl and nitro substituents located at the 5', 6' or 7'-position.
- 3. A compound as claimed in claim 1 wherein Ra is 4-bromobenzyl, 3-trifluoromethylbenzyl, 4-trifluoromethylbenzyl, 2,4-dichlorobenzyl, 4-chloro-2-fluorobenzyl, 4-bromo-2-fluorobenzyl, 2-fluoro-4-iodobenzyl, 3,4-dichlorobenzyl, 3-bromo-4-chlorobenzyl or 4-bromo-3-chlorobenzyl; and benzene ring A is unsubstituted or bears a fluoro, chloro, bromo, methyl or trifluoromethyl substituent located in the 5', 6' or 7' position.
- 4. A compound of formula I set out in claim 1 wherein Ra is 3,4-dichlorobenzyl, 2-fluoro-4-iodobenzyl or 4-bromo-2-fluorobenzyl; and benzene ring A is unsubstituted or bears a 5'-fluoro, 5'-chloro, 7'-fluoro or 7'-methyl substituent; or a salt thereof with a base affording a pharmaceutically acceptable cation; or a non-toxic biodegradable precursor thereof.
- 5. A salt of a compound of formula I as claimed in claim 1, with a base affording a pharmaceutically acceptable cation, in which the cation is an alkali metal, alkaline earth metal, aluminium, ammonium or triethanolammonium cation.
Priority Claims (1)
Number |
Date |
Country |
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8114397 |
May 1981 |
GBX |
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Parent Case Info
This is a division of application Ser. No. 377,135, filed May 11, 1982 now U.S. Pat. No. 4,478,847.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4177230 |
Sarges |
Sep 1978 |
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4307108 |
Belletire |
Dec 1981 |
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Non-Patent Literature Citations (1)
Entry |
H. Schaefer, Archiv. der Pharmazie (Weinheim), 1970, 303, 183-191; Chem. Abstracts, 1970, 73:3739. |
Divisions (1)
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Number |
Date |
Country |
Parent |
377135 |
May 1982 |
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