Claims
- 1. The method of tranquilizing a mammal comprising administering to a mammal a tranquilizing effective amount of a compound of the formula: ##STR17## wherein R.sup.o is hydrogen, halo of atomic weight of the 18 to 80, i.e. fluoro, chloro or bromo, or alkyl of 1 to 3 carbon atoms,
- R is hydrogen, halo of atomic weight of from 18 to 80, alkyl of 1 to 4 carbon atoms, nitro or trifluoromethyl,
- n is 0 or 1,
- R.sub.1,R.sub.2 and R.sub.3 are each independently hydrogen or alkyl of 1 or 2 carbon atoms, with the proviso that no more than 2 of R.sub.1, R.sub.2 and R.sub.3 are other than hydrogen,
- Z is ##STR18## R' is hydrogen or alkyl of 1 or 2 carbon atoms, Y.sup.o is hydrogen, halo of atomic weight of from 18 to 80 or alkyl of 1 to 3 carbon atoms,
- Y is hydrogen, halo of atomic weight of from 18 to 80, alkyl of 1 to 4 carbon atoms, trifluoromethyl or nitro,
- p is 1 or 2,
- q is 0, 1 or 2, and
- m is 0, 1, 2, 3 or 4.
- 2. The method of claim 1 in which R.sub.1, R.sub.2 and R.sub.3 are each H.
- 3. The method of claim 2 in which R.sup.o is H.
- 4. The method of claim 1 in which R is halo or trifluoromethyl in the b position of Ring A.
- 5. The method of claim 3 in which R is chloro or trifluoromethyl in the b position of Ring A.
- 6. The method of claim 1 in which the compound is 1-(o-chlorobenzyl)-7-chloro-2,3-dihydro-imidazo[2,1-b]quinazolin-5(1H)-one
- 7. The method of claim 1 in which the compound is 1-benzyl-7-chloro-2,3-dihydro-imidazo[2,1-b]quinazolin-5(1H)-one.
- 8. The method of claim 1 in which the compound is 1-benzyl-8-chloro-1,2,3,4-tetrahydro-6H-pyrimido[2,1-b]quinazolin-6-one.
- 9. The method of claim 1 in which the compound is 1-(p-chlorobenzyl)-7-chloro-2,3-dihydro-imidazo[2,1-b]quinazolin-5(1H)-one.
- 10. The method of claim 1 in which the compound is 1-(p-fluorobenzyl)-8-chloro-1,2,3,4-tetrahydro-6H-pyrimido[2,1-b]quinazolin-6-one.
- 11. A compound of the formula ##STR19## wherein R.sup.o is hydrogen, halo of atomic weight of from 18 to 80, i.e. fluoro, chloro or bromo, or alkyl of 1 to 3 carbon atoms,
- R is hydrogen, halo of atomic weight of from 18 to 80, alkyl of 1 to 4 carbon atoms, nitro or trifluoromethyl,
- n is 0 or 1,
- R.sub.1,R.sub.2 and R.sub.3 are each independently hydrogen or alkyl of 1 or 2 carbon atoms, with the proviso that no more than 2 of R.sub.1, R.sub.2 and R.sub.3 are other than hydrogen,
- Z is ##STR20## R' is hydrogen or alkyl of 1 or 2 carbon atoms, Y.sup.o is hydrogen, halo of atomic weight of from 18 to 80 or alkyl of 1 to 3 carbon atoms,
- Y is hydrogen, halo of atomic weight of from 18 to 80, alkyl of 1 to 4 carbon atoms, trifluoromethyl or nitro,
- p is 1 or 2,
- q is 0, 1 or 2, and
- m is 0, 1, 2, 3 or 4,
- with the proviso that R is other than hydrogen when n is 0 and Z is of type (a).
- 12. A compound of claim 11 in which R.sub.1, R.sub.2 and R.sub.3 are each H.
- 13. A compound of claim 12 in which R.sup.o is H.
- 14. A compound of claim 11 in which R is halo or trifluoromethyl in the b position of Ring A.
- 15. A compound of claim 13 in which R is chloro or trifluoromethyl in the b position of Ring A.
- 16. The compound of claim 11 which is 1-(o-chlorobenzyl)-7-chloro-2,3-dihydro-imidazo[2,1-b]quinazolin-5(1H)-one.
- 17. The compound of claim 11 which is 1-benzyl-7-chloro-2,3-dihydro-imidazo[2,1-b]quinazolin-5(1H)-one.
- 18. The compound of claim 11 which is 1-benzyl-8-chloro-1,2,3,4-tetrahydro-6H-pyrimido[2,1-b]quinazolin-6-one.
- 19. The compound of claim 11 which is 1-(p-chlorobenzyl)-7-chloro-2,3-dihydro-imidazo[2,1-p]quinazolin-5(1H)-one.
- 20. The compound of claim 11 which is 1-(p-fluorobenzyl)-8-chloro-1,2,3,4-tetrahydro-6H-pyrimido[2,1-b]quinazolin-6-one.
- 21. A compound of claim 1, 14 or 15 in which Z is ##STR21## in which m is 1, R' is hydrogen or methyl, Y.sup.o is hydrogen and Y is hydrogen, fluoro or chloro.
- 22. A pharmaceutical composition comprising an inert pharmaceutically acceptable carrier and a tranquilizing effective amount of a compound of claim 11.
Parent Case Info
This is a continuation-in-part of application Ser. No. 302,483 filed Sept. 16, 1981 now abandoned.
US Referenced Citations (6)
Foreign Referenced Citations (1)
Number |
Date |
Country |
2008998 |
Sep 1971 |
DEX |
Non-Patent Literature Citations (3)
Entry |
Hardtmann et al., J. Med. Chem., vol. 18(5), pp. 447-453 (1975). |
Vlasenko et al., Chemical Abstracts, vol. 85, 123861u (1976). |
Grout et al., J. Chem. Soc., (1960), pp. 3551-3557 (1960). |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
302483 |
Sep 1981 |
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