Claims
- 1. A compound of the formula: ##STR9## wherein R.sup.o is hydrogen, halo of atomic weight of from 18 to 80, or alkyl of 1 to 3 carbon atoms,
- R is halo of atomic weight of from 18 to 80, alkyl of 1 to 4 carbon atoms or trifluoromethyl,
- R' is alkenyl of 3 to 6 carbon atoms, alkynyl of 3 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, norbornyl, alkyl of 1 to 3 carbon atoms substituted by cycloalkyl of 3 to 7 carbon atoms or --CH.sub.2 (F.sub.x ALK) wherein
- X is 1 to 3 and ALK is alkyl of 1 to 4 carbon atoms,
- R.sub.1, R.sub.2 and R.sub.3 are each independently hydrogen or alkyl of 1 or 2 carbon atoms, and n is 0 or 1,
- or a pharmaceutically acceptable acid addition salt thereof.
- 2. A compound of claim 1 in which R.sub.1, R.sub.2 and R.sub.3 are each H.
- 3. A compound of claim 2 in which R.sup.o is H.
- 4. A compound of claim 1 in which R is halo or trifluoromethyl.
- 5. A compound of claim 3 in which R is chloro or trifluoromethyl.
- 6. A compound of claim 1, 2, 3, 4 or 5 in which R' is alkenyl, cycloalkyl of 4 to 7 carbon atoms, methyl substituted by cycloalkyl of 4 to 6 carbon atoms or norbornyl.
- 7. A compound of claim 1, 2, 3, 4 or 5 in which R is allyl.
- 8. A compound of claim 6 in which n is 0.
- 9. A compound of claim 6 in which n is 1.
- 10. A compound of claim 1 in which n is 0.
- 11. A compound of claim 1 in which n is 1.
- 12. The compound of claim 1 which is 1-cyclohexyl-7-chloro-2,3-dihydro-imidazo[2,1-b]quinazolin-5(1H)-one.
- 13. The compound of claim 1 which is 1-cyclohexylmethyl-7-chloro-2,3-dihydro-imidazo[2,1-b]quinazolin-5(1H)-one
- 14. The compound of claim 1 which is 1-allyl-8-chloro-1,2,3,4-tetrahydro-6H-pyrimido[2,1-b]quinazolin-6-one.
- 15. The method of tranquilizing a mammal comprising administering to a mammal a tranquilizing effective amount of a compound of claim 1.
- 16. The method of claim 15 in which R.sub.1, R.sub.2 and R.sub.3 are each H.
- 17. The method of claim 16 in which R.sup.o is H.
- 18. The method of claim 15 in which R is halo or trifluoromethyl.
- 19. The method of claim 17 in which R is chloro or trifluoromethyl.
- 20. The method of claim 15, 16, 17, 18 or 19 in which R' is alkenyl, cycloalkyl of 4 to 7 carbon atoms, methyl substituted by cycloalkyl of 4 to 6 carbon atoms or norbornyl.
- 21. The method of claim 15, 16, 17, 18 or 19 in which R' is allyl.
- 22. The method of claim 20 in which n is 0.
- 23. The method of claim 20 in which n is 1.
- 24. The method of claim 15 in which n is 0.
- 25. The method of claim 15 in which n is 1.
- 26. The method of claim 15 in which the compound is 1-cyclohexyl-7-chloro-2,3-dihydro-imidazo[2,1-b]quinazolin-5(1H)-one.
- 27. The method of claim 15 in which the compound is 1-cyclohexylmethyl-7-chloro-2,3-dihydro-imidazo[2,1-b]quinazolin-5(1H)-one.
- 28. The method of claim 15 which the compound is 1-allyl-8-chloro-1,2,3,4-tetrahydro-6H-pyrimido[2,1-b]quinazolin-6-one.
- 29. A pharmaceutical composition comprising an inert pharmaceutically acceptable carrier and a tranquilizing effective amount of a compound of claim 1.
Parent Case Info
This is a continuation in part of application Ser. No. 401,647, filed July 26, 1982 which is a continuation-in-part of application Ser. No. 302,484 filed Sept. 16, 1981, now both abandoned.
US Referenced Citations (4)
Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
401647 |
Jul 1982 |
|
Parent |
302484 |
Sep 1981 |
|