Claims
- 1. A compound selected from the group consisting of 10-(bis-pyrrolinyl)phenoxazines represented by ##STR4## and non-toxic pharmaceutically acceptable acid addition salts thereof wherein
- X is oxygen;
- Y represents hydrogen, trifluoromethyl, halogen, lower alkyl of from 1 to 4 carbon atoms inclusive or lower alkoxy of 1 to 4 carbon atoms inclusive; and
- R represents hydrogen or straight chain lower alkyl of 1 to 4 carbon atoms inclusive.
- 2. A compound according to claim 1 being a member selected from the group consisting of 10-[1-(1-pyrrolin-2-yl)-2-pyrrolin-2-yl]phenoxazine or a pharmaceutically acceptable non-toxic acid addition salt thereof.
- 3. A compound according to claim 1 being a member selected from the group consisting of 2-chloro-10-[1-(1-pyrrolin-2-yl)-2-pyrrolin-2-yl]phenoxazine or a pharmaceutically acceptable non-toxic acid addition salt thereof.
- 4. A compound according to claim 1 being a member selected from the group consisting of 3-chloro-10-[1-(1-pyrrolin-2-yl)-2-pyrrolin-2-yl]phenoxazine or a pharmaceutically acceptable non-toxic acid addition salt thereof.
- 5. A compound according to claim 1 being a member selected from the group consisting of 4-chloro-10-[1-pyrrolin-2-yl)-2-pyrrolin-2yl]phenoxazine or a pharmaceutically acceptable non-toxic acid addition salt thereof.
- 6. A compound according to claim 1 being a member selected from the group consisting of 2-trifluoromethyl-10-[1-(1-pyrrolin-2-yl)-2-pyrrolin-2-yl]phenoxazine or a pharmaceutically acceptable non-toxic acid addition salt thereof.
- 7. A compound according to claim 1 being a member selected from the group consisting of 2-methoxy-10-[1-(1-pyrrolin-2-yl)-2-pyrrolin-2-yl]phenoxazine or a pharmaceutically acceptable non-toxic acid addition salt thereof.
- 8. A process for producing a diuretic, smooth muscle relaxant or antithrombogenic effect in a mammal which comprises administering thereto a dose of from about 0.01 to 30 mg./kg. of body weight of said mammal of a compound selected from the group consisting of 10-(bis-pyrrolinyl)phenothiazines, 10-(bis-pyrrolinyl)acridans and 10-(bis-pyrriolinyl)phenoxazines represented by Formula I ##STR5## and non-toxic pharmaceutically acceptable acid addition salts thereto wherein
- X is selected from the group consisting of sulfur, oxygen, or a divalent methylene radical represented by the formula --C(Z.sub.1 Z.sub.2)--, wherein Z.sub.1 and Z.sub.2 are independently selected from hydrogen or straight chain lower alkyl of from 1 to 4 carbon atoms inclusive;
- Y represents hydrogen, trifluoromethyl, halogen, lower alkyl of from 1 to 4 carbon atoms inclusive or lower alkoxy of 1 to 4 carbon atoms inclusive; and
- R represents hydrogen or straight chain lower alkyl of 1 to 4 carbon atoms inclusive.
- 9. A pharmaceutical composition in dosage unit form suitable for administration to a mammalian host comprising a pharmaceutical carrier and sufficient of an active ingredient to provide a dose of from about 0.01 to 30 mg./kg. of body weight of said host, said active ingredient being selected from the group consisting of 10 -(bis-pyrrolinyl)phenothiazines, 10-(bis-pyrrolinyl)acridans, and 10-(bis-pyrrolinyl)phenoxazines represented by Formula I ##STR6## and non-toxic pharmaceutically acceptable acid addition salts thereof wherein
- X is selected from the group consisting of sulfur, oxygen, or a divalent methylene radical represented by the formula --C(Z.sub.1 Z.sub.2)--, wherein Z.sub.1 and Z.sub.2 are independently selected from hydrogen or straight chain lower alkyl of from 1 to 4 carbon atoms inclusive;
- Y represents hydrogen, trifluoromethyl, halogen, lower alkyl of from 1 to 4 carbon atoms inclusive or lower alkoxy of 1 to 4 carbon atoms inclusive; and
- R represents hydrogen or straight chain lower alkyl of 1 to 4 carbon atoms inclusive.
REFERENCE TO RELATED APPLICATIONS
This application is a division of co-pending application Ser. No. 641,007 filed Dec. 15, 1975, now U.S. Pat. No. 4,077,959 granted Mar. 7, 1978 which is a division of then co-pending application Ser. No. 521,618 filed Nov. 6, 1974, and now U.S. Pat. No. 3,946,004, which is a continuation-in-part of then co-pending applicatin Ser. No. 336,845 filed Feb. 28, 1973, and now abandoned, which is a continuation-in-part of then co-pending application Ser. No. 147,667 filed May 17, 1971, now U.S. Pat. No. 3,719,671.
US Referenced Citations (8)
Non-Patent Literature Citations (1)
Entry |
Moskovkina et al., Chem. Abstracts, abst. No. 14649n (1970). |
Divisions (2)
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Number |
Date |
Country |
Parent |
641007 |
Dec 1975 |
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Parent |
521618 |
Nov 1974 |
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Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
336845 |
Feb 1973 |
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Parent |
147667 |
May 1971 |
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