Claims
- 1. A compound of formula I:
- 2. A compound according to claim 1, wherein the compound is of Formula II;
- 3. A compound according to claim 2, wherein: ring M is substituted with 0-2 R1a and is selected from the group:
- 4. A compound according to claim 3, wherein:
ring M is substituted with 0-2 R1a and is selected from the group: 508509510511512ring P, including P1, P2, P3, and P4 is selected from group: 513514G is selected from the group:
phenyl; 2-amido-4-methoxy-phenyl; 2-amido-phenyl; 2-aminomethyl-3-fluoro-phenyl; 2-aminomethyl-4-fluoro-phenyl; 2-aminomethyl-4-methoxy-phenyl; 2-aminomethyl-5-fluoro-phenyl; 2-aminomethyl-5-methoxy-phenyl; 2-aminomethyl-6-fluoro-phenyl; 2-aminomethyl-phenyl; 2-amino-pyrid-4-yl; 2-aminosulfonyl-4-methoxy-phenyl; 2-aminosulfonyl-phenyl; 2-methylsulfonyl-phenyl; 2-aminomethyl-4-ethyl-phenyl; 2-aminosulfonyl-4-ethyl-phenyl; 2-amido-4-ethyl-phenyl; 3-(N,N-dimethylamino)-4-chloro-phenyl; 3-(N,N-dimethylamino)-phenyl; 3-(N-methylamino)-4-chloro-phenyl; 3-(N-methylamino)-phenyl; 3-amido-phenyl; 3-amino-4-chloro-phenyl; 3-aminomethyl-phenyl; 3-amino-phenyl; 3-chloro-phenyl; 4-(N,N-dimethylamino)-5-chloro-thien-2-yl; 4-(N-methylamino)-5-chloro-thien-2-yl; 4-amino-5-chloro-thien-2-yl; 4-chloro-phenyl; 4-ethyl-phenyl; 4-ethyl-2-methylsulfonyl-phenyl; 4-ethyl-2-methoxy-phenyl; 4-methoxy-2-methylsulfonyl-phenyl; 4-methoxy-phenyl; 5-(N,N-dimethylamino)-4-chloro-thien-2-yl; 5-(N-methylamino)-4-chloro-thien-2-yl; 5-amino-4-chloro-thien-2-yl; 5-chloro-pyrid-2-yl; 5-chloro-thien-2-yl; 5-methoxy-thien-2-yl; 5-methyl-thien-2-yl; 5-fluoro-thien-2-yl; 6-amino-5-chloro-pyrid-2-yl; 6-amino-pyrid-2-yl; 515516517518519520521G1 is absent or is selected from CH2, CH2CH2, CH═CH, CH2O, OCH2, NH, CH2NH, NHCH2, CH2C(O), C(O)CH2, C(O)NH, NHC(O), CH2S(O)2, S(O)2(CH2), SO2NH, and NHSO2, provided that G1 does not form a N—S, NCH2N, NCH2O, or NCH2S bond with either group to which it is attached; A is selected from cyclohexyl, piperidinyl, phenyl, pyridyl, and pyrimidyl, and is substituted with 0-2 R4; X is selected from CH2, C(O), —S(O)2—, —NHC(O)—, —C(O)NH—, —CH2NH—, O, and —CH2O—; Y is selected from C(CH3)2, C(CH2CH3)2, cyclopropyl, cyclobutyl, cyclopentyl, cyclopentanonyl, cyclohexyl, cyclohexanonyl, pyrrolidinyl, pyrrolidinonyl, piperidinyl, piperidinonyl, tetrahydrofuranyl, and tetrahydropyranyl, and, when Y is a ring, Y is substituted with 0-1 R4; R1a, at each occurrence, is selected from H, R1b, CH(CH3)R1b, C(CH3)2R1b, and CH2R1b, provided that R1a forms other than an N-halo, N—S, or N—CN bond; R1b is selected from CH3, CH2CH3, F, Cl, Br, —CN, CF3, OR2, NR2R2a, C(O )R2b, CO2R2b, CO2R2a, S(O)pR2, C(O)NR2R2a, SO2NR2R2a, NR2SO2R2, and 5-6 membered aromatic heterocycle consisting of carbon atoms and from 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p and substituted with 0-2 R4b, provided that R1b forms other than an O—O, N-halo, N—S, or N—CN bond; R2, at each occurrence, is selected from H, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, phenyl substituted with 0-1 R4b, benzyl substituted with 0-1 R4b, and 5-6 membered aromatic heterocycle substituted with 0-1 R4b and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p; R2a, at each occurrence, is selected from H, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, benzyl, phenyl substituted with 0-1 R4b, and 5-6 membered aromatic heterocycle substituted with 0-1 R4b and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p; alternatively, R2 and R2a, together with the nitrogen atom to which they are attached, combine to form a 5 or 6 membered saturated, partially saturated or unsaturated ring substituted with 0-1 R4b and consisting of: 0-1 additional heteroatoms selected from the group consisting of N, O, and S(O)p; R2b, at each occurrence, is selected from OH, OCH3, OCH2CH3, OCH2CH2CH3, OCH(CH3)2, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, benzyl, phenyl substituted with 0-1 R4b, and 5-6 membered aromatic heterocycle substituted with 0-1 R4b and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p; R2c, at each occurrence, is selected from OH, OCH3, OCH2CH3, OCH2CH2CH3, OCH(CH3)2, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, benzyl, phenyl substituted with 0-1 R4b, and 5-6 membered aromatic heterocycle substituted with 0-1 R4b and consisting of carbon atoms and from 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p; R2d, at each occurrence, is selected from H, R4c, C1-4 alkyl substituted with 0-2 R4c, C3-6 carbocycle substituted with 0-2 R4c, —(CH2)-C3-6 carbocycle substituted with 0-2 R4c, 5-6 membered heterocycle substituted with 0-2 R4c and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, and —(CH2)-5-6 membered heterocycle substituted with 0-2 R4c and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, provided that R2d forms other than a N-halo, N—C-halo, S(O)p-halo, O-halo, N—S, S—N, S(O)p—S(O)p, S—O, O—N, O—S, or O—O moiety; R2e, at each occurrence, is selected from H, R4c, C1-4 alkyl substituted with 0-2 R4c, C3-6 carbocycle substituted with 0-2 R4c, —(CH2)-C3-6 carbocycle substituted with 0-2 R4c, 5-6 membered heterocycle substituted with 0-2 R4c and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, and —(CH2)-5-6 membered heterocycle and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, provided that R2e forms other than a C(O)-halo or C(O)—S(O)p moiety; R4, at each occurrence, is selected from OH, OR2, CH2OR2, (CH2)2OR2, F, Br, Cl, I, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, CH2CH2CH2CH3, CH2CH(CH3)2, CH(CH3)CH2CH3, C(CH3)3, NR2R2a, CH2NR2R2a, (CH2)2NR2R2a, CF3, and CF2CF3; R4a is selected from —(CR3R3g)r-5-6 membered carbocycle substituted with 0-3 R4c, —(CR3R3g)r-5-6 membered heterocycle substituted with 0-3 R4c and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, (CR3R3g)rNR2dR2d, (CR3R3g)rN(→O)R2dR2d, (CR3R3g)rOR2d, (CR3R3g)r—C(O)NR2dR2d, (CR3R3g)r—NR2dC(O)R2e, (CR3R3g)r—C(O)R2e, (CR3R3g)r—NR2dC(O)NR2dR2d, (CR3R3g)r—NR2dC(O)OR2d, (CR3R3g)r—NR2dSO2R2d, and (CR3R3g)r—S(O)pR2d, provided that S(O)pR2d forms other than S(O)2H or S(O)H; R4b, at each occurrence, is selected from H, ═O, OR3, CH2OR3, F, Cl, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, —CN, NO2, NR3R3a, CH2NR3R3a, C(O)R3, C(O)OR3c, NR3C(O)R3a, C(O)NR3R3a, SO2NR3R3a, NR3SO2-C1-4 alkyl, NR3SO2-phenyl, S(O)p-C1-4 alkyl, S(O)p-phenyl, and CF3; R4c, at each occurrence, is selected from ═O, OR2, CH2OR2, F, Br, Cl, CF3, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, C2-3 alkenyl, C2-3 alkynyl, —CN, NO2, NR2R2a, CH2NR2R2a, N(→O)R2R2a, CH2N(→O)R2R2a, C(O)R2c, CH2C(O)R2c, NR2C(O)R2b, CH2NR2C(O)R2b, C(O)NR2R2a, CH2C(O)NR2R2a, SO2NR2R2a, CH2SO2NR2R2a, NR2SO2R5a, CH2NR2SO2R5a, S(O)pR5a, CH2S(O)pR5a, CF3, CF2CF3, C3-6 carbocycle substituted with 0-2 R4b, (CH2)-C3-6 carbocycle substituted with 0-2 R4b, 5-6 membered heterocycle substituted with 0-2 R4b and consisting of carbon atoms and from 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, and (CH2)-5-6 membered heterocycle substituted with 0-2 R4b and consisting of carbon atoms and from 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p; R5, at each occurrence, is selected from H, ═O, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, OR3, CH2OR3, F, Cl, —CN, NO2, NR3R3a, CH2NR3R3a, C(O)R3, C(O)OR3c, NR3C(O)R3a, C(O)NR3R3a, SO2NR3R3a, NR3SO2-C1-4 alkyl, NR3SO2-phenyl, S(O)p-C1-4 alkyl, S(O)p-phenyl, CF3, phenyl substituted with 0-2 R6, naphthyl substituted with 0-2 R6, and benzyl substituted with 0-2 R6; R6, at each occurrence, is selected from H, OH, OR2, F, Cl, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, —CN, NO2, NR2R2a, CH2NR2R2a, C(O)R2b, CH2C(O)R2b, NR2C(O)R2b, and SO2NR2R2a; and, r, at each occurrence, is selected from 0, 1, and 2.
- 5. A compound according to claim 4, wherein:
ring M is substituted with 0-1 R1a and is selected from the group: 522523524525ring P, including P1, P2, P3, and P4 is selected from group: 526-G is selected from:
2-amido-4-methoxy-phenyl; 2-amido-phenyl; 2-aminomethyl-3-fluoro-phenyl; 2-aminomethyl-4-fluoro-phenyl; 2-aminomethyl-5-fluoro-phenyl; 2-aminomethyl-6-fluoro-phenyl; 2-aminomethyl-phenyl; 2-amino-pyrid-4-yl; 2-aminosulfonyl-4-methoxy-phenyl; 2-aminosulfonyl-phenyl; 3-amido-phenyl; 3-amino-4-chloro-phenyl; 3-aminomethyl-phenyl; 3-chloro-phenyl; 4-chloro-phenyl; 4-ethyl-phenyl; 4-methoxy-phenyl; 5-chloro-pyrid-2-yl; 5-chloro-thien-2-yl; 6-amino-5-chloro-pyrid-2-yl; 6-amino-pyrid-2-yl; 527528529530A is selected from the group: cyclohexyl, piperidinyl, phenyl, 2-pyridyl, 3-pyridyl, 2-pyrimidyl, 2-Cl-phenyl, 3-Cl-phenyl, 2-F-phenyl, 3-F-phenyl, 2-methylphenyl, 2-aminophenyl, and 2-methoxyphenyl; Y is selected from C(CH3)2, C(CH2CH3)21 cyclopropyl, cyclobutyl, cyclopentyl, 2-cyclopentanonyl, cyclohexyl, 2-cyclohexanonyl, pyrrolidinyl (attached to A and R4a at the 2-position), pyrrolidinyl (attached to A and R4a at the 3-position), 2-pyrrolidinonyl (attached to A and R4a at the 3-position), piperidinyl (attached to A and R4a at the 4-position), 4-piperdinonyl (attached to A and R4a at the 3-position), tetrahydrofuranyl, and tetrahydropyranyl (attached to A and R4a at the 4-position); R1a, at each occurrence, is selected from H, CH3, CH2CH3, CH2CH2CH3, CH2F, CH2Cl, Br, CH2Br, —CN, CH2CN, CF3, CH2CF3, OCH3, CH2OH, C(CH3)20H, CH2OCH3, NH2, CH2NH2, NHCH3, CH2NHCH3, N(CH3)2, CH2N(CH3)2, CO2H, COCH3, CO2CH3, CH2CO2CH3, SCH3, CH2SCH3, S(O)CH3, CH2S(O)CH3, S(O)2CH3, CH2S(O)2CH3, C(O)NH2, CH2C(O)NH2, SO2NH2, CH2SO2NH2, NHSO2CH3, CH2NHSO2CH3, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyridin-2-yl-N-oxide, pyridin-3-yl-N-oxide, pyridin-4-yl-N-oxide, imidazol-1-yl, CH2-imidazol-1-yl, 4-methyl-oxazol-2-yl, 4-N,N-dimethylaminomethyl-oxazol-2-yl, 1,2,3,4-tetrazol-1-yl, 1,2,3,4-tetrazol-5-yl, CH2-1,2,3,4-tetrazol-1-yl, and CH2-1,2,3,4-tetrazol-5-yl, provided that R1a forms other than an N-halo, N—S, or N—CN bond; R2, at each occurrence, is selected from H, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, phenyl substituted with 0-1 R4b, benzyl substituted with 0-1 R4b, and 5 membered aromatic heterocycle substituted with 0-1 R4b and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p; R2a, at each occurrence, is selected from H, CH3, and CH2CH3; alternatively, R2 and R2a, together with the nitrogen atom to which they are attached, combine to form a 5 or 6 membered saturated, partially saturated or unsaturated ring substituted with 0-1 R4b and consisting of: 0-1 additional heteroatoms selected from the group consisting of N, O, and S(O)p; R2b, at each occurrence, is selected from OH, OCH3, OCH2CH3, CH3, and CH2CH3; R2c, at each occurrence, is selected from OH, OCH3, OCH2CH3, CH3, and CH2CH3; R2d, at each occurrence, is selected from H, R4c, C1-4 alkyl substituted with 0-2 R4c, C3-6 cycloalkyl substituted with 0-2 R4c, phenyl substituted with 0-2 R4c, and 5-6 membered aromatic heterocycle substituted with 0-2 R4c and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, provided that R2d forms other than a N-halo, N—C-halo, S(O)p-halo, O-halo, N—S, S—N, S(O)p—S(O)p, S—O, O—N, O—S, or O—O moiety; R2e, at each occurrence, is selected from H, R4c, C1-4 alkyl substituted with 0-2 R4c, C3-6 cycloalkyl substituted with 0-2 R4c, phenyl substituted with 0-2 R4c, and 5-6 membered aromatic heterocycle substituted with 0-2 R4c and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, provided that R2e forms other than a C(O)-halo or C(O)—S(O)p moiety; R4a is selected from —(CH2)r-5-6 membered carbocycle substituted with 0-3 R4c, —(CH2)r-5-6 membered heterocycle substituted with 0-3 R4c and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, (CH2)rNR2dR2d, (CH2)rN(O)R2dR2d, (CH2)rOR2d, (CH2)r—C(O)NR2dR2d, (CH2)r—NR2dC(O)R2e, (CH2)r—C(O)R2e, (CH2)r—NR2dC(O)NR2dR2d, (CH2)r—NR2dC(O)OR2d, (CH2)r—NR2dSO2R2d, and (CH2)r—S(O)pR2d, provided that S(O)pR2d forms other than S(O)2H or S(O)H; R4b, at each occurrence, is selected from H, ═O, OR3, CH2OR3, F, Cl, CH3, CH2CH3, NR3R3a, CH2NR3R3a, C(O)R3, C(O)OR3c, NR3C(O)R3a, C(O)NR3R3a, SO2NR3R3a, NR3SO2-phenyl, S(O)2CH3, S(O)2-phenyl, and CF3; R4c, at each occurrence, is selected from ═O, OH, OCH3, OCH2CH3, OCH2CH2CH3, OCH(CH3)2, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, C2-3 alkenyl, C2-3 alkynyl, CH2OH, CH2OCH3, CH2OCH2CH3, CH2OCH2CH2CH3, CH2OCH(CH3)2, F, Br, Cl, CF3, NR2R2a, CH2NR2R2a, N(→O)R2R2a, CH2N(→O)R2R2a, C(O)R2c, CH2C(O)R2c, NR2C(O)R2b, CH2NR2C(O)R2b, C(O)NR2R2a, CH2C(O)NR2R2a, SO2NR2R2a, CH2SO2NR2R2a, NR2SO2R5a, CH2NR2SO2R5a, S(O)pR5a, CH2S(O)pR5a, CF3, cyclopropyl substituted with 0-1 R4b, cyclobutyl substituted with 0-1 R4b, cyclopentyl substituted with 0-1 R4b, phenyl substituted with 0-1 R4b, —CH2-cyclopropyl substituted with 0-1 R4b, —CH2-cyclobutyl substituted with 0-1 R4b, —CH2-cyclopentyl substituted with 0-1 R4b, benzyl substituted with 0-2 R4b, 5-6 membered aromatic heterocycle substituted with 0-2 R4b and consisting of carbon atoms and from 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, and (CH2)5-6 membered aromatic heterocycle substituted with 0-2 R4b and consisting of carbon atoms and from 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p; R5, at each occurrence, is selected from H, ═O, CH3, CH2CH3, OR3, CH2OR3, F, Cl, NR3R3a, CH2NR3R3a, C(O)R3, C(O)OR3c, NR3C(O)R3a, C(O)NR3R3a, SO2NR3R3a, NR3SO2-C1-4 alkyl, NR3SO2-phenyl, S(O)2—CH3, S(O)2-phenyl, CF3, phenyl substituted with 0-2 R6, naphthyl substituted with 0-2 R6, and benzyl substituted with 0-2 R6; and, R6, at each occurrence, is selected from H, OH, OR2, F, Cl, CH3, CH2CH3, NR2R2a, CH2NR2R2a, C(O)R2b, CH2C(O)R2b, NR2C(O)R2b, and SO2NR2R2a.
- 6. A compound according to claim 5, wherein the compound is selected from:
- 8. A compound according to claim 1, wherein the compound is the compound is selected from the group:
1-(4-methoxyphenyl)-6-(4-{1-[(methylamino)methyl]cyclopropyl}phenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(dimethylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(diethylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(isopropylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(cyclopentylamino)methyl]cyclopropyl}phenyl)1-1(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-{4-[1-(1-pyrrolidinylmethyl)cyclopropyl]phenyl}-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-[4-(1-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}cyclopropyl)phenyl]-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(4-hydroxy-1-piperidinyl)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-{4-[1-(4-morpholinylmethyl)cyclopropyl]phenyl}-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-{4-[1-(1-pyrrolidinylcarbonyl)cyclopropyl]phenyl}-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}-N,N-dimethylcyclopropanecarboxamide; 1-(4-methoxyphenyl)-6-(4-{1-[(4-methyl-1-piperazinyl)carbonyl]cyclopropyl}phenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(4-hydroxypiperidine-1-carbonyl)cyclopropyl]phenyl}-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropanecarboxamide; 1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropanecarboxylic acid cyclopentylamide; 1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}-N-(1,3,4-thiadiazol-2-yl)cyclopropanecarboxamide; 1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}-N-(1H-tetraazol-5-yl)cyclopropanecarboxamide; methyl 1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropanecarboxylate; 1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropanecarbonitrile; 6-{4-[1-(aminomethyl)cyclopropyl]phenyl}-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; N-[(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)methyl]-N-methylacetamide; N′-ethyl-N-[(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)methyl]-N-methylurea; N-[(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)methyl]-N-methylmethanesulfonamide; 1-(4-methoxyphenyl)-6-{4-[1-(2-methylimidazol-1-ylmethyl)cyclopropyl]phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-{4-[1-(thiazol-2-ylaminomethyl)-cyclopropyl]phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; methyl 1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopentanecarboxylate; 1-(4-methoxyphenyl)-6-(4-{1-[(methylamino)methyl]cyclopentyl}phenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(dimethylamino)methyl]cyclopentyl}phenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-{4-[1-(1-pyrrolidinylmethyl)cyclopentyl]phenyl}-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-[4-(1-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}cyclopentyl)phenyl]-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-{4-[1-(4-morpholinylmethyl)cyclopentyl]phenyl}-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; N-[(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopentyl)methyl]-N-methylacetamide; N-[(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopentyl)methyl]-N-methylmethanesulfonamide; methyl 1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclobutanecarboxylate; 1-(4-methoxyphenyl)-6-(4-{1-[(methylamino)methyl]cyclobutyl}phenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(dimethylamino)methyl]cyclobutyl}phenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(diethylamino)methyl]cyclobutyl}phenyl)1-1(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-{4-[1-(1-pyrrolidinylmethyl)cyclobutyl]phenyl}-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-[4-(1-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}cyclobutyl)phenyl]-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-{4-[1-(4-morpholinylmethyl)cyclobutyl]phenyl}-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; N-[(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclobutyl)methyl]-N-methylacetamide; N-[(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclobutyl)methyl]-N-methylmethanesulfonamide; 1-{4-[l-(4-Methoxyphenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}cyclohexanecarboxylic acid methyl ester; 1-(4-methoxyphenyl)-6-(4-{1-[(methylamino)methyl]cyclohexyl}phenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(dimethylamino)methyl]cyclohexyl}phenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; N-[(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclohexyl)methyl]-N-methylacetamide; N-[(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclohexyl)methyl]-N-methylmethanesulfonamide; 1-(4-methoxyphenyl)-6-(4-{1-[(methylamino)methyl]cyclopropyl}phenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro 7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(dimethylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(isopropylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(cyclopentylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-3-(methylsulfonyl)-6-{4-[1-(1-pyrrolidinylmethyl)cyclopropyl]phenyl}-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-[4-(1-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}cyclopropyl)phenyl]-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(diethylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-3-(methylsulfonyl)-6-{4-[1-(4-morpholinylmethyl)cyclopropyl]phenyl}-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; N-[(1-{4-[1-(4-methoxyphenyl)-3-(methylsulfonyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)methyl]-N-methylacetamide; 3-methanesulfonyl-1-(4-methoxyphenyl)-6-{4-[1-(2-methylimidazol-1-ylmethyl)cyclopropyl]phenyl}-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 3-methanesulfonyl-1-(4-methoxyphenyl)-6-{4-[1-(thiazol-2-ylaminomethyl)cyclopropyl]phenyl}-1,4,5,6-tetrahydro-pyrazolo [3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-(4-{1-[(methylamino)methyl]cyclobutyl)phenyl)-3-(methylsulfonyl)-1,4,5, 6-tetrahydro 7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(dimethylamino)methyl]cyclobutyl}phenyl)-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(isopropylamino)methyl]cyclobutyl}phenyl)-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-3-(methylsulfonyl)-6-{4-[1-(1-pyrrolidinylmethyl)cyclobutyl]phenyl}-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-[4-(1-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}cyclobutyl)phenyl]-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(diethylamino)methyl]cyclobutyl}phenyl)-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-3-(methylsulfonyl)-6-{4-[1-(4-morpholinylmethyl)cyclobutyl]phenyl}-1,4,5,6-tetrahydro-7H-pyrazolo [3,4-c] pyridin-7-one; N-[(1-{4-[l-(4-methoxyphenyl)-3-(methylsulfonyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)methyl]-N-methylacetamide; 1-(4-methoxyphenyl)-6-(4-{1-[(methylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-(4-{1-[(dimethylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-(4-{1-[(diethylamino)methyl]cyclopropyl}phenyl)-1(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(4-methoxyphenyl)-7-oxo-6-{4-[1-(1-pyrrolidinylmethyl)cyclopropyl]phenyl}-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(4-methoxyphenyl)-6-{4-[1-(4-morpholinylmethyl)cyclopropyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1 H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-(4-{1-[(isopropylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-[4-(1-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}cyclopropyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(4-methoxyphenyl)-6-(4-{1-[(methylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-(4-{1-[(dimethylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-(4-{1-[(diethylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-7-oxo-6-{4-[1-(1-pyrrolidinylmethyl)cyclopropyl]phenyl}-4,5,6,7-tetrahydro-1 H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-(4-{1-[(isopropylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-[4-(1-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}cyclopropyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-6-{4-[1-(4-morpholinylmethyl)cyclopropyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(3-chlorophenyl)-6-{4-[1-(isopropylamino)methyl)cyclopropyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-chlorophenyl)-6-{4-[1-(4-morpholinylmethyl)cyclopropyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-(4-{1-[(isopropylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-6-{4-[1-(4-morpholinylmethyl)cyclopropyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1 H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(3-chlorophenyl)-6-(4-{1-[(methylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-chlorophenyl)-6-(4-{1-[(dimethylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-chlorophenyl)-6-(4-{1-[(diethylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-chlorophenyl)-6-(4-{1-[(diisopropylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-chlorophenyl)-6-(4-{1-[(cyclopropylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-chlorophenyl)-6-(4-{1-[(cyclobutylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-chlorophenyl)-7-oxo-6-(4-{1-[(2-oxo-1-pyrrolidinyl)methyl]cyclopropyl}phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-chlorophenyl)-6-[4-(1-{[(2-hydroxyethyl)(methyl)amino]methyl}cyclopropyl)phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-chlorophenyl)-6-(4-{1-[2-(dimethylamino)-2-oxoethyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-chlorophenyl)-6-{4-[1-(methoxymethyl)cyclopropyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-chlorophenyl)-6-{4-[1-(methoxymethyl)cyclopropyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(3-chlorophenyl)-6-(4-{1-[(methylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(3-chlorophenyl)-6-(4-{1-[(dimethylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(3-chlorophenyl)-6-[4-(1-{[(2-hydroxyethyl)(methyl)amino]methyl}cyclopropyl)phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-7-oxo-6-(4-{1-[(2-oxo-1-pyrrolidinyl)methyl]cyclopropyl}phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; N-[(1-{4-[3-cyano-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)methyl]-N-methylacetamide; 6-(4-{1-[(cyclopropylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-(4-{1-[(cyclobutylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-[4-(1-{[(2-hydroxyethyl)amino]methyl}cyclopropyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-[4-(1-{[(2-hydroxyethyl)(methyl)amino]methyl}cyclopropyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-(4-{1-[(diisopropylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 5-(4-{1-[(diisopropylamino)methyl]cyclopropyl}phenyl)-3-(4-methoxyphenyl)-3,5,6,7-tetrahydro-4H-[1,2,3]triazolo[4,5-c]pyridin-4-one; 5-(4-{1-[(isopropylamino)methyl]cyclopropyl}phenyl)-3-(4-methoxyphenyl)-3,5,6,7-tetrahydro-4H-[1,2,3]triazolo[4,5-c]pyridin-4-one; 3-(4-methoxyphenyl)-5-(4-{1-[(methylamino)methyl]cyclopropyl}phenyl)-3,5,6,7-tetrahydro-4H-[1,2,3]triazolo[4,5-c]pyridin-4-one; 3-(4-methoxyphenyl)-5-{4-[1-(1-pyrrolidinylmethyl)cyclopropyl]phenyl}-3,5,6,7-tetrahydro-4H-[1,2,3]triazolo[4,5-c]pyridin-4-one; 3-(4-methoxyphenyl)-5-(4-{l-[(2-oxo-1-pyrrolidinyl)methyl]cyclopropyl}phenyl)-3,5,6,7-tetrahydro-4H-[1,2,3]triazolo[4,5-c]pyridin-4-one; 5-[4-(1-{[(2-hydroxyethyl)amino]methyl}cyclopropyl)phenyl]-3-(4-methoxyphenyl)-3,5,6,7-tetrahydro-4H-[1,2,3]triazolo[4,5-c]pyridin-4-one; 3-(3-chlorophenyl)-5-[4-(1-{[(2-hydroxyethyl)amino]methyl}cyclopropyl)phenyl]-3,5,6,7-tetrahydro-4H-[1,2,3]triazolo[4,5-c]pyridin-4-one; 3-(3-chlorophenyl)-5-[4-(1-{[(2-hydroxyethyl)(methyl)amino]methyl]cyclopropyl)phenyl]-3,5,6,7-tetrahydro-4H-[1,2,3]triazolo[4,5-c]pyridin-4-one; 3-(3-chlorophenyl)-5-{4-[1-(1-pyrrolidinylmethyl)cyclopropyl]phenyl}-3,5,6,7-tetrahydro-4H-[1,2,3]triazolo[4,5-c]pyridin-4-one; 3-(3-chlorophenyl)-5-(4-{1-[(3-hydroxy-1-pyrrolidinyl)methyl]cyclopropyl}phenyl)-3,5,6,7-tetrahydro-4H-[1,2,3]triazolo[4,5-c]pyridin-4-one; 6-[4-(1-{[(2-hydroxyethyl)(methyl)amino]methyl}cyclopropyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-{4-[1-(dimethylamino)cyclopropyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-(4-{1-[(2-hydroxyethyl)(methyl)amino]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 2-(1-{4-[1-(4-methoxyphenyl)-3-(methylsulfonyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)-N,N-dimethylacetamide; 6-(4-{1-[2-(dimethylamino)-2-oxoethyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 2-(1-{4-[3-cyano-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)-N,N-dimethylacetamide; 2-(1-{4-[3-cyano-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)acetamide; 2-(1-{4-[1-(3-chlorophenyl)-3-cyano-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)acetamide; 1-(3-chlorophenyl)-6-(4-{1-[2-(dimethylamino)-2-oxoethyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 2-(1-{4-[1-(3-chlorophenyl)-3-(methylsulfonyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)-N, N-dimethylacetamide; 2-(1-{4-[3-(3-chlorophenyl)-4-oxo-3,4,6,7-tetrahydro-5H-[1,2,3]triazolo[4,5-c]pyridin-5-yl]phenyl}cyclopropyl)-N, N-dimethylacetamide; 2-(1-{4-[3-(4-methoxyphenyl)-4-oxo-3,4,6,7-tetrahydro-5H-[1,2,3]triazolo[4,5-c]pyridin-5-yl]phenyl}cyclopropyl)-N, N-dimethylacetamide; 2-(1-{4-[3-(4-methoxyphenyl)-4-oxo-3,4,6,7-tetrahydro-5H-[1,2,3]triazolo[4,5-c]pyridin-5-yl]phenyl}cyclopropyl)acetamide; 1-(4-methoxyphenyl)-7-oxo-6-(4-{1-[(2-oxo-1-imidazolidinyl)methyl]cyclopropyl}phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-7-oxo-6-(4-{1-[(2-oxo-1-piperazinyl)methyl]cyclopropyl}phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-7-oxo-6-(4-{1-[(3-oxo-4-morpholinyl)methyl]cyclopropyl}phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-7-oxo-6-(4-{1-[(2-oxo-1-piperidinyl)methyl]cyclopropyl}phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 2-[(1-{4-[3-cyano-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)oxy]acetamide; 1-[4-{3-cyano-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl carbamate; 2-(1-{4-[3-cyano-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)acetamide; 2-(1-{4-[3-cyano-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)-N,N-dimethylacetamide; 1-(4-methoxyphenyl)-6-{4-[1-(methylamino)cyclopropyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-{4-[1-(dimethylamino)cyclopropyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-7-oxo-6-{4-[1-(1,3-thiazol-2-ylamino)cyclopropyl]phenyl}-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; N-(1-{4-[3-cyano-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)urea; N-(1-{4-[3-cyano-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)-N′-methylurea; N-(1-{4-[3-cyano-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)-2-methylpropanamide; 6-(4-{1-[(4-hydroxy-1-piperidinyl)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-6-(4-{1-[(2-methyl-5,6-dihydro-1(4H)-pyrimidinyl)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-6-(4-{1-[(2-methyl-4,5-dihydro-1H-imidazol-1-yl)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-{4-[1-(4,5-dihydro-1,3-oxazol-2-ylmethyl)cyclopropyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-{4-[1-(4,5-dihydro-1H-imidazol-2-ylmethyl)cyclopropyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-6-(4-{1-[(1-methyl-4,5-dihydro-1H-imidazol-2-yl)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-7-oxo-6-(4-{1-[(1,3-thiazol-2-ylamino)methyl]cyclopropyl}phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-6-(4-{1-[(2-methyl-1H-imidazol-1-yl)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-6-{4-[1-methyl-1-(2-oxo-1-pyrrolidinyl)ethyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(4-methoxyphenyl)-6-{4-[1-methyl-1-(2-oxo-1-piperidinyl)ethyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-{4-[1,1-dimethyl-2-(2-oxo-1-piperidinyl)ethyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-{4-[1,1-dimethyl-2-(2-oxo-1-pyrrolidinyl)ethyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-{4-[1,1-dimethyl-2-(3-oxo-4-morpholinyl)ethyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-{4-[1,1-dimethyl-2-(2-oxo-1-piperazinyl)ethyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-{4-[1,1-dimethyl-2-(2-oxotetrahydro-1(2H)-pyrimidinyl)ethyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-{4-[1,1-dimethyl-2-(2-oxodihydro-2H-1,3-oxazin-3(4H)-yl)ethyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-{4-[3-(aminocarbonyl)-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3, 4-c]pyridin-6-yl]phenyl}-1-methylethyl methylcarbamate; 1-{4-[3-(aminocarbonyl)-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}-1-methylethyl 3-pyrrolidinylcarbamate; 6-{4-[1-ethyl-1-(1-pyrrolidinylmethyl)propyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-(4-{1-[(dimethylamino)methyl]-1-ethylpropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-[3-(aminomethyl)phenyl]-6-{4-[1,1-dimethyl-2-(1-pyrrolidinyl)ethyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-[3-(aminomethyl)phenyl]-6-{4-[2-(dimethylamino)-1,1-dimethylethyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-[3-(aminocarbonyl)phenyl]-6-{4-[2-(dimethylamino)-1,1-dimethylethyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-[3-(aminocarbonyl)phenyl]-6-{4-[1,1-dimethyl-2-(1-pyrrolidinyl)ethyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-amino-1,2-benzisoxazol-5-yl)-6-{4-[1,1-dimethyl-2-(1-pyrrolidinyl)ethyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-amino-1,2-benzisoxazol-5-yl)-6-{4-[1,1-dimethyl-2-(1-pyrrolidinyl)ethyl]phenyl}-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(1-amino-7-isoquinolinyl)-6-{4-[1,1-dimethyl-2-(1-pyrrolidinyl)ethyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(1-amino-7-isoquinolinyl)-6-{4-[2-(dimethylamino)-1,1-dimethylethyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(1-amino-7-isoquinolinyl)-6-(4-{1-[(dimethylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(1-amino-7-isoquinolinyl)-7-oxo-6-{4-[1-(1-pyrrolidinylmethyl)cyclopropyl]phenyl}-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-amino-1,2-benzisoxazol-5-yl)-7-oxo-6-{4-[1-(1-pyrrolidinylmethyl)cyclopropyl]phenyl}-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-amino-1,2-benzisoxazol-5-yl)-6-{4-[1-(1-pyrrolidinylmethyl)cyclopropyl]phenyl}-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(3-amino-1,2-benzisoxazol-5-yl)-7-oxo-6-{4-[1-(1-pyrrolidinylmethyl)cyclopropyl]phenyl}-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-[3-(aminomethyl)phenyl]-7-oxo-6-(4-{1-[(2-oxo-1-pyrrolidinyl)methyl]cyclopropyl}phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-[4-(1-{[acetyl(methyl)amino]methyl}cyclopropyl)phenyl]-1-[3-(aminomethyl)phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-[3-(aminocarbonyl)phenyl]-6-(4-{1-[(dimethylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 3-[3-cyano-6-(4-{1-[(dimethylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-1-yl]benzamide; 1-(2,3-dihydro-1H-indol-6-yl)-6-(4-{1-[(dimethylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(2,3-dihydro-1H-indol-6-yl)-7-oxo-6-{4-[1-(1-pyrrolidinylmethyl)cyclopropyl]phenyl}-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(2,3-dihydro-1H-indol-6-yl)-7-oxo-6-(4-{1-[(2-oxo-1-pyrrolidinyl)methyl]cyclopropyl}phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-(4-{1-[(dimethylamino)methyl]cyclobutyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(4-methoxyphenyl)-6-{4-[1-(4-morpholinylmethyl)cyclobutyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(4-methoxyphenyl)-6-{4-[1-(4-morpholinylmethyl)cyclopentyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-(4-{1-[(dimethylamino)methyl]cyclopentyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(4-methoxyphenyl)-6-{4-[1-(2-oxo-pyrrolidin-1-yl)-cyclopropyl]phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-{4-[1-(2-oxo-piperidin-1-yl)-cyclopropyl]phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-[4-(1-methylaminocyclopropyl)-phenyl]-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-[4-(1-dimethylaminocyclopropyl)phenyl]-1-(4-methoxyphenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; N-(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]phenyl}-cyclopropyl)-N-methyl-acetamide; N-(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]phenyl}-cyclopropyl)-N-methyl-methanesulfonamide; N-(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]phenyl}-cyclopropyl)-N-methyl-2-methylaminoacetamide; 2-dimethylamino-N-(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)-N-methylacetamide; N-(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]phenyl}-cyclopropyl)-N-methyl-2-morpholin-4-yl-acetamide; 6-{4-[1-(1-hydroxyethyl)cyclopropyl]phenyl}-1-(4-methoxyphenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-[4-(1-acetylcyclopropyl)phenyl]-1-(4-methoxyphenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(1-hydroxy-1-methyl-ethyl)cyclopropyl]phenyl}-1-(4-methoxyphenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-[4-(1-methoxymethylcyclopropyl)phenyl]-1-(4-methoxyphenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(4,5-dihydro-oxazol-2-yl)cyclopropyl]phenyl}-1-(4-methoxyphenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-{4-[1-(4-methoxy-phenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropanecarboxylic acid 2-amino-ethyl ester; 6-{4-[1-(4,5-dihydro-oxazol-2-yl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-{4-[1-(4,5-dihydro-1H-imidazol-2-yl)cyclopropyl]phenyl}-1-(4-methoxyphenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-{4-[1-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)cyclopropyl]phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(1-methanesulfonyl-4,5-dihydro-1H-imidazol-2-yl)-cyclopropyl]phenyl}-1-(4-methoxyphenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(1H-imidazol-2-yl)cyclopropyl]phenyl}-1-(4-methoxy-phenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-{4-[1-(1-methyl-1H-imidazol-2-yl)-cyclopropyl]phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 2-[(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]phenyl}-cyclopropyl)-methyl-amino]-acetamide; 6-(4-{1-[(2-hydroxyethyl)-methylamino]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-[4-(1-(4-methoxy-phenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropanecarboxylic acid methoxy-methyl-amide; 6-[4-(1-hydroxymethylcyclopropyl)phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-[4-(1-acetyl-cyclopropyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-[4-(1-aminocyclopropyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxyphenyl)-6-[4-(1-methylaminocyclopropyl)-phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amid; 6-[4-(1-dimethylaminocyclopropyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-[4-(1-methylaminomethylcyclopentyl)phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4c]pyridine-3-carboxylic acid amide; 6-[4-(1-dimethylaminomethylcyclopentyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-[4-(1-dimethylaminomethylcyclopentyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3, 4-c]pyridine-3-carbonitrile; 6-[4-(1-[(2-hydroxyethyl)methylaminomethyl]-cyclopentyl)phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-[4-(1-hydroxymethyl-cyclopentyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-(4-{1-[(2-hydroxyethyl)methylamino]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxyphenyl)-6-{4-[1-(methyl-prop-2-ynylamino)-cyclopropyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 3-(1-hydroxyethyl)-1-(4-methoxyphenyl)-6-[4-(1-methylamino-cyclopropyl)phenyl]-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 3-acetyl-1-(4-methoxyphenyl)-6-[4-(1-methylamino-cyclopropyl)phenyl]-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-[4-(1-methylaminocyclopropyl)phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid methylamide; 1-(4-methoxyphenyl)-6-[4-(1-methylaminocyclopropyl)phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid dimethylamide; 6-[4-(1-aminocyclopropyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-6-[4-(1-methylaminocyclopropyl)phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-[4-(1-dimethylaminocyclopropyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 2-[(1-{4-[3-cyano-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)-methylamino]acetamide; 6-(4-{1-[(2-hydroxyethyl)methylamino]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-7-oxo-6-[4-(1-pyrrolidin-1-yl-cyclopropyl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester; 1-(4-methoxyphenyl)-7-oxo-6-[4-(1-pyrrolidin-1-yl-cyclopropyl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxyphenyl)-7-oxo-6-[4-(1-pyrrolidin-1-yl-cyclopropyl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-6-[4-(1-morpholin-4-yl-cyclopropyl)phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxyphenyl)-6-[4-(1-morpholin-4-yl-cyclopropyl)phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-[4-(1-dimethylaminocyclopropyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid methylamide; 6-[4-(1-dimethylaminocyclopropyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid dimethylamide; 6-{4-[1-(1,1-dioxo-1λ6-thiomorpholin-4-yl)cyclopropyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-[4-(1-aminocyclopropylmethyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-[4-(1-dimethylaminocyclopropylmethyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(3-chloro-phenyl)-6-{4-[1,1-dimethyl-2-(2-oxo-pyrrolidin-1-yl)-ethyl]-phenyl}-7-oxo-4,5,6,7-tetrahydro-1H pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-{4-[1,1-dimethyl-2-(2-oxo-pyrrolidin-1-yl)-ethyl]-phenyl}-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxy-phenyl)-6-[4-(1-methyl-1-pyrrolidin-1-ylethyl)-phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-[4-(1-dimethylamino-1-methyl-ethyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-{4-[1-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-[4-(1-methanesulfonyl-1-methyl-ethyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxy-phenyl)-6-(4-{1-[2-(2-oxo-2H-pyridin-1-yl)-ethyl]-cyclopropyl}-phenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 2-(1-{4-[1-(4-methoxy-phenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-acetamide; 2-(1-{4-[1-(4-methoxy-phenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-N-methyl-acetamide; 2-(1-{4-[1-(4-methoxy-phenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-N,N-dimethyl-acetamide; 1-(4-methoxy-phenyl)-6-{4-[1-(2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopropyl]-phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-hydroxy-ethyl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxy-phenyl)-6-{4-[1-(2-methylamino-ethyl)-cyclopropyl]-phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxy-phenyl)-6-{4-[1-(2-pyrrolidin-1-yl-ethyl)-cyclopropyl]-phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxy-phenyl)-6-{4-[1-(2-morpholin-4-yl-ethyl)-cyclopropyl]-phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxy-phenyl)-6-{4-[1-(2-pyrrolidin-1-yl-acetyl)-cyclopropyl]-phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-[4-(1-carbamoylmethyl-cyclopropyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester; 6-[4-(1-carbamoylmethyl-cyclopropyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxy-phenyl)-6-[4-(1-methylcarbamoylmethyl-cyclopropyl)-phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester; 1-(4-methoxy-phenyl)-6-[4-(1-methylcarbamoylmethyl-cyclopropyl)-phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-[4-(1-dimethylcarbamoylmethyl-cyclopropyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester; 6-[4-(1-dimethylcarbamoylmethyl-cyclopropyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-{4-[1-(2-hydroxy-ethyl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxy-phenyl)-6-{4-[1-(2-morpholin-4-yl-ethyl)-cyclopropyl]-phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxy-phenyl)-7-oxo-6-(4-{1-[2-(2-oxo-pyrrolidin-1-yl)-ethyl]-cyclopropyl}-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxy-phenyl)-6-{4-[1-(2-methylamino-ethyl)-cyclopropyl]-phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-{4-[1-(2-diethylamino-ethyl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxy-phenyl)-7-oxo-6-{4-[l-(2-pyrrolidin-1-yl-ethyl)-cyclopropyl]-phenyl}-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-(4-{1-[2-(2,5-dimethyl-pyrrolidin-1-yl)-ethyl]-cyclopropyl}-phenyl)-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-(4-{l-[2-(3-hydroxy-pyrrolidin-1-yl)-ethyl]-cyclopropyl}-phenyl)-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-(4-{l-[2-(2,5-dimethyl-pyrrolidin-1-yl)-ethyl]-cyclopropyl}-phenyl)-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxy-phenyl)-7-oxo-6-(4-{1-[2-(2-oxo-piperidin-1-yl)-ethyl]-cyclopropyl}-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxy-phenyl)-7-oxo-6-(4-{l-[2-(2-oxo-2H-pyridin-1-yl)-ethyl]-cyclopropyl}-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxy-phenyl)-6-(4-{1-[2-(methyl-thiazol-2-yl-amino)-ethyl]-cyclopropyl}-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-[4-(1-{2-[(2-hydroxy-ethyl)-methyl-amino]-ethyl}-cyclopropyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxy-phenyl)-6-(4-{1-[2-(2-methyl-imidazol-1-yl)-ethyl]-cyclopropyl}-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-(4-{1-[2-(2,6-dimethyl-piperidin-1-yl)-ethyl]-cyclopropyl}-phenyl)-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 2-(1-{4-[3-methanesulfonyl-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-N,N-dimethyl-acetamide; 2-(1-{4-[3-methanesulfonyl-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-acetamide; 2-(1-{4-[3-methanesulfonyl-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-N-methyl-acetamide; 2-(1-{4-[3-methanesulfonyl-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-N,N-dimethyl-acetamide; 6-{4-[1-(2-hydroxy-ethyl)-cyclopropyl]-phenyl}-3-methanesulfonyl-1-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 3-methanesulfonyl-6-{4-[1-(2-methoxy-ethyl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 3-methanesulfonyl-1-(4-methoxy-phenyl)-6-{4-[1-(2-methylamino-ethyl)-cyclopropyl]-phenyl}-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-3-methanesulfonyl-1-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-diethylamino-ethyl)-cyclopropyl]-phenyl}-3-methanesulfonyl-1-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-isopropylamino-ethyl)-cyclopropyl]-phenyl}-3-methanesulfonyl-1-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 3-methanesulfonyl-1-(4-methoxy-phenyl)-6-{4-[1-(2-pyrrolidin-1-yl-ethyl)-cyclopropyl]-phenyl}-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 3-methanesulfonyl-1-(4-methoxy-phenyl)-6-(4-{1-[2-(2-oxo-pyrrolidin-1-yl)-ethyl]-cyclopropyl}-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[2-(2,5-dimethyl-pyrrolidin-1-yl)-ethyl]-cyclopropyl}-phenyl)-3-methanesulfonyl-1-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[2-(3-hydroxy-pyrrolidin-1-yl)-ethyl]-cyclopropyl}-phenyl)-3-methanesulfonyl-1-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 3-methanesulfonyl-1-(4-methoxy-phenyl)-6-(4-{l-[2-(2-oxo-piperidin-1-yl)-ethyl]-cyclopropyl}-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 3-methanesulfonyl-1-(4-methoxy-phenyl)-6-{4-[1-(2-morpholin-4-yl-ethyl)-cyclopropyl]-phenyl}-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-[4-(1-{2-[(2-hydroxy-ethyl)-methyl-amino]-ethyl}-cyclopropyl)-phenyl]-3-methanesulfonyl-1-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 2-{[2-(1-{4-[3-methanesulfonyl-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-ethyl]-methyl-amino}-acetamide; 2-[2-(1-{4-[3-methanesulfonyl-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-ethylamino]-acetamide; 6-(4-{1-[2-(2-hydroxy-ethylamino)-ethyl]-cyclopropyl}-phenyl)-3-methanesulfonyl-1-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 3-methanesulfonyl-1-(4-methoxy-phenyl)-6-(4-{1-[2-(2-methyl-imidazol-1-yl)-ethyl]-cyclopropyl}-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 3-methanesulfonyl-1-(4-methoxy-phenyl)-6-(4-{1-[2-(thiazol-2-ylamino)-ethyl]-cyclopropyl}-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 3-methanesulfonyl-1-(4-methoxy-phenyl)-6-(4-{1-[2-(2-oxo-2H-pyridin-1-yl)-ethyl]-cyclopropyl}-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 2-(1-{4-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-acetamide; 2-(1-{4-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-N-methyl-acetamide; 2-(1-{4-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-N,N-dimethyl-acetamide; 6-{4-[1-(2-hydroxy-ethyl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxy-phenyl)-6-{4-[1-(2-methylamino-ethyl)-cyclopropyl]-phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxy-phenyl)-7-oxo-6-{4-[1-(2-pyrrolidin-1-yl-ethyl)-cyclopropyl]-phenyl}-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxy-phenyl)-6-{4-[1-(2-morpholin-4-yl-ethyl)-cyclopropyl]-phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-(4-{1-[2-(1,1-dioxo-116-thiomorpholin-4-yl)-ethyl]-cyclopropyl}-phenyl)-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-(4-{1-[2-(2-hydroxy-ethylamino)-ethyl]-cyclopropyl}-phenyl)-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 2-[2-(1-{4-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-ethylamino]-acetamide; 2-{[2-(1-{4-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-ethyl]-methyl-amino}-acetamide; 6-[4-(1-{2-[(2-hydroxy-ethyl)-methyl-amino]-ethyl}-cyclopropyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; N-[2-(l-{4-[3-cyano-l-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-ethyl]-N-methyl-methanesulfonamide; N-[2-(1-{4-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-ethyl]-N-methyl-acetamide; 1-(4-methoxy-phenyl)-7-oxo-6-(4-{l-[2-(2-oxo-pyrrolidin-1-yl)-ethyl]-cyclopropyl}-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxy-phenyl)-7-oxo-6-(4-{1-[2-(2-oxo-2H-pyridin-1-yl)-ethyl]-cyclopropyl}-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-3-methyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 5-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-3-(4-methoxy-phenyl)-3,5,6,7-tetrahydro-[1,2,3]triazolo[4,5-c]pyridin-4-one; 5-{4-[1-(2-dimethylamino-ethyl)-cyclobutyl]-phenyl}-3-(4-methoxy-phenyl)-3,5,6,7-tetrahydro-[1,2,3]triazolo[4,5-c]pyridin-4-one; 6-{4-[1-(2-dimethylamino-ethyl)-cyclobutyl]-phenyl}-1-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-dimethylamino-ethyl)-cyclobutyl]-phenyl}-1-(4-methoxy-phenyl)-3-methyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-dimethylamino-ethyl)-cyclobutyl]-phenyl}-1-(4-methoxy-phenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-dimethylamino-ethyl)-cyclobutyl]-phenyl}-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-{4-[1-(2-dimethylamino-ethyl)-cyclobutyl]-phenyl}-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-{4-[1-(2-dimethylamino-ethyl)-cyclobutyl]-phenyl}-3-methanesulfonyl-1-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-dimethylamino-ethyl)-cyclopentyl]-phenyl}-3-methanesulfonyl-1-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-dimethylamino-ethyl)-cyclopentyl]-phenyl}-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-{4-[1-(2-dimethylamino-ethyl)-cyclopentyl]-phenyl}-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-{4-[1-(2-dimethylamino-ethyl)-cyclopentyl]-phenyl}-1-(4-methoxy-phenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-dimethylamino-ethyl)-cyclopentyl]-phenyl}-1-(4-methoxy-phenyl)-3-methyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 5-{4-[1-(2-dimethylamino-ethyl)-cyclopentyl]-phenyl}-3-(4-methoxy-phenyl)-3,5,6,7-tetrahydro-[1,2,3]triazolo[4,5-c]pyridin-4-one; 2-(1-{4-[3-(4-methoxy-phenyl)-4-oxo-3,4,6,7-tetrahydro-[1,2,3]triazolo[4,5-c]pyridin-5-yl]-phenyl}-cyclopentyl)-N-methyl-acetamide; 2-(1-{4-[3-(4-methoxy-phenyl)-4-oxo-3,4,6,7-tetrahydro-[1,2,3]triazolo[4,5-c]pyridin-5-yl]-phenyl}-cyclopentyl)-N,N-dimethyl-acetamide; 2-(1-{4-[3-(4-methoxy-phenyl)-4-oxo-3,4,6,7-tetrahydro-[1,2,3]triazolo[4,5-c]pyridin-5-yl]-phenyl}-cyclopentyl)-acetamide; 2-(1-{4-[3-methanesulfonyl-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopentyl)-acetamide; 6-[4-(1-carbamoylmethyl-cyclopentyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxy-phenyl)-6-[4-(1-methylcarbamoylmethyl-cyclopentyl)-phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-[4-(1-dimethylcarbamoylmethyl-cyclopentyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 2-(1-{4-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopentyl)-N,N-dimethyl-acetamide; 2-(1-{4-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopentyl)-N-methyl-acetamide; 2-(1-{4-[3-methanesulfonyl-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopentyl)-N-methyl-acetamide; 2-(1-{4-[3-methanesulfonyl-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopentyl)-N,N-dimethyl-acetamide; 2-(1-{4-[3-methanesulfonyl-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopentyl)-acetamide; 2-(1-{4-[3-methanesulfonyl-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclobutyl)-acetamide; 2-(1-{4-[3-methanesulfonyl-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclobutyl)-N-methyl-acetamide; 2-(1-{4-[3-methanesulfonyl-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclobutyl)-N,N-dimethyl-acetamide; 2-(1-{4-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclobutyl)-N,N-dimethyl-acetamide; 2-(1-{4-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclobutyl)-N-methyl-acetamide; 2-(1-{4-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclobutyl)-acetamide; 2-(1-{4-[1-(4-methoxy-phenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclobutyl)-acetamide; 2-(1-{4-[l-(4-methoxy-phenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclobutyl)-N-methyl-acetamide; 2-(1-{4-[l-(4-methoxy-phenyl)-3-methyl-7-oxo-l,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclobutyl)-N-methyl-acetamide; 2-(1-{4-[1-(4-methoxy-phenyl)-3-methyl-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclobutyl)-acetamide; 2-(1-{4-[1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclobutyl)-acetamide; 2-(1-{4-[1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclobutyl)-N-methyl-acetamide; 2-(1-{4-[1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclobutyl)-N,N-dimethyl-acetamide; 2-(1-{4-[3-(4-methoxy-phenyl)-4-oxo-3,4,6,7-tetrahydro-[1,2,3]triazolo[4,5-c]pyridin-5-yl]-phenyl}-cyclobutyl)-N,N-dimethyl-acetamide; 2-(1-{4-[3-(4-methoxy-phenyl)-4-oxo-3,4,6,7-tetrahydro-[1,2,3]triazolo[4,5-c]pyridin-5-yl]-phenyl}-cyclobutyl)-N-methyl-acetamide; 2-(1-{4-[3-(4-methoxy-phenyl)-4-oxo-3,4,6,7-tetrahydro-[1,2,3]triazolo[4,5-c]pyridin-5-yl]-phenyl}-cyclobutyl)-acetamide; 5-chloro-thiophene-2-carboxylic acid {2-[4-(1-dimethylaminomethyl-cyclopropyl)-benzyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}-amide; 5-chloro-thiophene-2-carboxylic acid {2-[4-(1-dimethylaminomethyl-cyclopropyl)-benzyl]-1-oxo-2,3-dihydro-1H-isoindol-4-yl}-amide; 5-chloro-thiophene-2-carboxylic acid {2-[4-(1-dimethylaminomethyl-cyclopropyl)-benzyl]-3-oxo-2,3-dihydro-1H-isoindol-4-yl}-amide; 5-chloro-thiophene-2-carboxylic acid [2-(2-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-ethyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-amide; 5-chloro-thiophene-2-carboxylic acid [2-(2-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-ethyl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]-amide; 5-chloro-thiophene-2-carboxylic acid [2-(2-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-ethyl)-3-oxo-2,3-dihydro-1H-isoindol-4-yl]-amide; 5-chloro-thiophene-2-carboxylic acid [2-(2-{3-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-ethyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-amide; 5-chloro-thiophene-2-carboxylic acid [2-(2-{3-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-ethyl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]-amide; 5-chloro-thiophene-2-carboxylic acid [2-(2-{3-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-ethyl)-3-oxo-2,3-dihydro-1H-isoindol-4-yl]-amide; 5-chloro-thiophene-2-carboxylic acid (2-{2-[4-(1-dimethylaminomethyl-cyclopropyl)-phenyl]-ethyl}-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)-amide; 5-chloro-thiophene-2-carboxylic acid (2-{2-[4-(1-dimethylaminomethyl-cyclopropyl)-phenyl]-ethyl}-1-oxo-2,3-dihydro-1H-isoindol-4-yl)-amide; 5-chloro-thiophene-2-carboxylic acid (2-{2-[4-(1-dimethylaminomethyl-cyclopropyl)-phenyl]-ethyl}-3-oxo-2,3-dihydro-1H-isoindol-4-yl)-amide; 5-chloro-thiophene-2-carboxylic acid (2-{2-[3-(1-dimethylaminomethyl-cyclopropyl)-phenyl]-ethyl}-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)-amide; 5-chloro-thiophene-2-carboxylic acid (2-{2-[3-(1-dimethylaminomethyl-cyclopropyl)-phenyl]-ethyl}-1-oxo-2,3-dihydro-1H-isoindol-4-yl)-amide; 5-chloro-thiophene-2-carboxylic acid (2-{2-[3-(1-dimethylaminomethyl-cyclopropyl)-phenyl]-ethyl}-3-oxo-2,3-dihydro-1H-isoindol-4-yl)-amide; 5-chloro-thiophene-2-carboxylic acid {2-[3-(1-dimethylaminomethyl-cyclopropyl)-benzyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}-amide; 5-chloro-thiophene-2-carboxylic acid {2-[3-(1-dimethylaminomethyl-cyclopropyl)-benzyl]-1-oxo-2,3-dihydro-1H-isoindol-4-yl}-amide; 5-chloro-thiophene-2-carboxylic acid {2-[3-(1-dimethylaminomethyl-cyclopropyl)-benzyl]-3-oxo-2,3-dihydro-1H-isoindol-4-yl}-amide; 5-chloro-thiophene-2-carboxylic acid (2-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-benzyl}-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)-amide; 5-chloro-thiophene-2-carboxylic acid (2-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-benzyl}-1-oxo-2,3-dihydro-1H-isoindol-4-yl)-amide; 5-chloro-thiophene-2-carboxylic acid (2-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-benzyl}-3-oxo-2,3-dihydro-1H-isoindol-4-yl)-amide; 5-chloro-thiophene-2-carboxylic acid (2-{3-[1-(2-dimethylamino-ethyl)-cyclopropyl]-benzyl}-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)-amide; 5-chloro-thiophene-2-carboxylic acid (2-{3-[1-(2-dimethylamino-ethyl)-cyclopropyl]-benzyl}-1-oxo-2,3-dihydro-1H-isoindol-4-yl)-amide; 5-chloro-thiophene-2-carboxylic acid (2-{3-[1-(2-dimethylamino-ethyl)-cyclopropyl]-benzyl}-3-oxo-2,3-dihydro-1H-isoindol-4-yl)-amide; 5-chloro-thiophene-2-carboxylic acid {6-chloro-2-[4-(1-dimethylaminomethyl-cyclopropyl)-benzyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}-amide; 5-chloro-thiophene-2-carboxylic acid {6-chloro-2-[4-(1-dimethylaminomethyl-cyclopropyl)-benzyl]-1-oxo-2,3-dihydro-1H-isoindol-4-yl}-amide; 5-chloro-thiophene-2-carboxylic acid {6-chloro-2-[4-(1-dimethylaminomethyl-cyclopropyl)-benzyl]-3-oxo-2,3-dihydro-1H-isoindol-4-yl}-amide; 5-chloro-thiophene-2-carboxylic acid [6-chloro-2-(2-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-ethyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-amide; 5-chloro-thiophene-2-carboxylic acid [6-chloro-2-(2-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-ethyl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]-amide; 5-chloro-thiophene-2-carboxylic acid [6-chloro-2-(2-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-ethyl)-3-oxo-2,3-dihydro-1H-isoindol-4-yl]-amide; 5-chloro-thiophene-2-carboxylic acid [6-chloro-2-(2-{3-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-ethyl)-1,3-dioxo-2,3-dihydro-1 H-isoindol-4-yl]-amide; 5-chloro-thiophene-2-carboxylic acid [6-chloro-2-(2-{3-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-ethyl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]-amide; 5-chloro-thiophene-2-carboxylic acid [6-chloro-2-(2-{3-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-ethyl)-3-oxo-2,3-dihydro-1H-isoindol-4-yl]-amide; 5-chloro-thiophene-2-carboxylic acid (6-chloro-2-{2-[4-(1-dimethylaminomethyl-cyclopropyl)-phenyl]-ethyl}-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)-amide; 5-chloro-thiophene-2-carboxylic acid (6-chloro-2-{2-[4-(1-dimethylaminomethyl-cyclopropyl)-phenyl]-ethyl}-1-oxo-2,3-dihydro-1H-isoindol-4-yl)-amide; 5-chloro-thiophene-2-carboxylic acid (6-chloro-2-{2-[4-(1-dimethylaminomethyl-cyclopropyl)-phenyl]-ethyl}-3-oxo-2,3-dihydro-1H-isoindol-4-yl)-amide; 5-chloro-thiophene-2-carboxylic acid (6-chloro-2-{2-[3-(1-dimethylaminomethyl-cyclopropyl)-phenyl]-ethyl}-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)-amide; 5-chloro-thiophene-2-carboxylic acid (6-chloro-2-{2-[3-(1-dimethylaminomethyl-cyclopropyl)-phenyl]-ethyl}-1-oxo-2,3-dihydro-1H-isoindol-4-yl)-amide; 5-chloro-thiophene-2-carboxylic acid (6-chloro-2-{2-[3-(1-dimethylaminomethyl-cyclopropyl)-phenyl]-ethyl}-3-oxo-2,3-dihydro-1H-isoindol-4-yl)-amide; 5-chloro-thiophene-2-carboxylic acid {6-chloro-2-[3-(1-dimethylaminomethyl-cyclopropyl)-benzyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}-amide; 5-chloro-thiophene-2-carboxylic acid {6-chloro-2-[3-(1-dimethylaminomethyl-cyclopropyl)-benzyl]-1-oxo-2,3-dihydro-1H-isoindol-4-yl}-amide; 5-chloro-thiophene-2-carboxylic acid {6-chloro-2-[3-(1-dimethylaminomethyl-cyclopropyl)-benzyl]-3-oxo-2,3-dihydro-1H-isoindol-4-yl}-amide; 5-chloro-thiophene-2-carboxylic acid (6-chloro-2-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-benzyl}-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)-amide; 5-chloro-thiophene-2-carboxylic acid (6-chloro-2-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-benzyl}-1-oxo-2,3-dihydro-1H-isoindol-4-yl)-amide; 5-chloro-thiophene-2-carboxylic acid (6-chloro-2-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-benzyl}-3-oxo-2,3-dihydro-1H-isoindol-4-yl)-amide; 5-chloro-thiophene-2-carboxylic acid (6-chloro-2-{3-[1-(2-dimethylamino-ethyl)-cyclopropyl]-benzyl}-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)-amide; 5-chloro-thiophene-2-carboxylic acid (6-chloro-2-{3-[1-(2-dimethylamino-ethyl)-cyclopropyl]-benzyl}-1-oxo-2,3-dihydro-1H-isoindol-4-yl)-amide; 5-chloro-thiophene-2-carboxylic acid (6-chloro-2-{3-[1-(2-dimethylamino-ethyl)-cyclopropyl]-benzyl}-3-oxo-2,3-dihydro-1H-isoindol-4-yl)-amide; (1-{4-[1-(4-methoxy-phenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-acetic acid; 2-(1-{4-[1-(4-methoxy-phenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-acetamide; 2-(1-{4-[1-(4-methoxy-phenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-N-methyl-acetamide; 2-(1-{4-[1-(4-methoxy-phenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-N,N-dimethyl-acetamide; 1-(4-methoxy-phenyl)-6-{4-[1-(2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopropyl]-phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-hydroxy-ethyl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxy-phenyl)-6-{4-[1-(2-methylamino-ethyl)cyclopropyl]-phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxy-phenyl)-6-{4-[1-(2-pyrrolidin-1-yl-ethyl)-cyclopropyl]-phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxy-phenyl)-6-{4-[1-(2-morpholin-4-yl-ethyl)-cyclopropyl]-phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one 1-(4-methoxy-phenyl)-6-{4-[1-(2-pyrrolidin-1-yl-acetyl)-cyclopropyl]-phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-[4-(1-carbamoylmethyl-cyclopropyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester; 6-[4-(1-carbamoylmethyl-cyclopropyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxy-phenyl)-6-[4-(1-methylcarbamoylmethyl-cyclopropyl)-phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester; 1-(4-Methoxy-phenyl)-6-[4-(1-methylcarbamoylmethyl-cyclopropyl)-phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-[4-(l-dimethylcarbamoylmethyl-cyclopropyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester; 6-[4-(1-dimethylcarbamoylmethyl-cyclopropyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-{4-[l-(2-hydroxy-ethyl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxy-phenyl)-6-{4-[1-(2-morpholin-4-yl-ethyl)-cyclopropyl]-phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; and, 1-(4-methoxy-phenyl)-6-{4-[1-(2-morpholin-4-yl-ethyl)-cyclopropyl]-phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; or a pharmaceutically acceptable salt form thereof.
- 9. A compound according to claim 1, wherein the compound is of Formula IIIa, IIIb, or IIIc:
- 10. A compound according to claim 9, wherein:
ring M, including M1, M2, and, if present, M3, is selected from phenyl, pyrrole, furan, thiophene, pyrazole, imidazole, isoxazole, oxazole, isothiazole, thiazole, 1,2,3-triazole, 1,2,4-triazole, 1,3,4-triazole, 1,2,3-oxadiazole, 1,2,4-oxadiazole, 1,3,4-oxadiazole, 1,2,3-thiadiazole, 1,2,4-thiadiazole, 1,3,4-thiadiazole, 1,2,3,4-tetrazole, 1,2,3,5-tetrazole, pyran, thiopyran, thiopyran-1,1-dioxide, pyridine, pyrimidine, pyridazine, pyrazine, 1,2,3-triazine, 1,2,4-triazine, 1,2,3,4-tetrazine, dihydro-pyrrole, dihydro-furan, dihydro-thiophene, dihydro-pyrazole, dihydro-imidazole, dihydro-isoxazole, dihydro-oxazole, dihydro-isothiazole, dihydro-thiazole, dihydro-1,2,3-triazole, dihydro-1,2,4-triazole, dihydro-1,3,4-triazole, dihydro-1,2,3-oxadiazole, dihydro-1,2,4-oxadiazole, dihydro-1,3,4-oxadiazole, dihydro-1,2,3-thiadiazole, dihydro-1,2,4-thiadiazole, dihydro-1,3,4-thiadiazole, dihydro-1,2,3,4-tetrazole, dihydro-1,2,3,5-tetrazole, dihydro-pyran, dihydro-thiopyran, dihydro-thiopyran-1,1-dioxide, dihydro-pyridine, dihydro-pyrimidine, dihydro-pyridazine, dihydro-pyrazine, dihydro-1,2,3-triazine, dihydro-1,2,4-triazine, dihydro-1,2,3,4-tetrazine, cyclopropane, cyclobutane, cyclopentene, cyclopentane, cyclohexene, cyclohexane, cycloheptane, tetrahydro-pyrrole, tetrahydro-furan, tetrahydro-thiophene, tetrahydro-thiophene-1,1-dioxide, tetrahydro-pyrazole, tetrahydro-imidazole, tetrahydro-isoxazole, tetrahydro-oxazole, tetrahydro-isothiazole, tetrahydro-thiazole, tetrahydro-1,2,3-triazole, tetrahydro-1,2,4-triazole, tetrahydro-1,3,4-triazole, tetrahydro-1,2,3-oxadiazole, tetrahydro-1,2,4-oxadiazole, tetrahydro-1,3,4-oxadiazole, tetrahydro-1,2,3-thiadiazole, tetrahydro-1,2,4-thiadiazole, tetrahydro-1,3,4-thiadiazole, tetrahydro-1,2,3,4-tetrazole, tetrahydro-1,2,3,5-tetrazole, tetrahydro-pyran, tetrahydro-thiopyran, tetrahydro-thiopyran-1,1-dioxide, tetrahydro-pyridine, tetrahydro-pyrimidine, tetrahydro-pyridazine, tetrahydro-pyrazine, tetrahydro-1,2,3-triazine, tetrahydro-1,2,4-triazine, tetrahydro-1,2,3,4-tetrazine, piperidine, indan, isothiazolidine 1,1-dioxide, [1,2]thiazinane 1,1-dioxide, 1,2,3,4-tetrahydro-naphthalene, 7,8-dimethyl-1-oxa-spiro[4.4]nonane, 6,7-dihydro-5H-[l]pyrindine, 6,7-dihydro-5H-[2]pyrindine, 5,6,7,8-tetrahydro-quinoline, 5,6,7,8-tetrahydro-isoquinoline, 5,6,7,8-tetrahydro-quinoxaline, 6,7-dihydro-5H-cyclopentapyrazine, 4,5,6,7-tetrahydro-1H-benzoimidazole, 4,5,6,7-tetrahydro-benzothiazole, 4,5,6,7-tetrahydro-benzooxazole, 4,5,6,7-tetrahydro-benzo[c]isothiazole, 4,5,6,7-tetrahydro-benzo[c]isoxazole, 4,5,6,7-tetrahydro-2H-indazole, 4,5,6,7-tetrahydro-2H-isoindole, 4,5,6,7-tetrahydro-1H-indole, 5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyridine, 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridine, 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyridine, 5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine, 6,7-dihydro-5H-pyrrolo[1,2-c]imidazole, 6,7-dihydro-5H-pyrrolo[1,2-a]imidazole, 6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazole, 6,7-dihydro-5H-pyrrolotetrazole, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole, 5,6-dihydro-4H-cyclopenta[d]isoxazole, 5,6-dihydro-4H-cyclopentaoxazole, 5,6-dihydro-4H-cyclopenta[c]isoxazole, 5,6-dihydro-4H-cyclopenta[d]isothiazole, 5,6-dihydro-4H-cyclopentathiazole, 5,6-dihydro-4H-cyclopenta[c]isothiazole, 1,4,5,6-tetrahydro-cyclopentapyrazole, 1,4,5,6-tetrahydro-cyclopentaimidazole, 2,4,5,6-tetrahydro-cyclopentapyrazole, 5,6-dihydro-4H-cyclopenta[1,2,5]thiadiazole, 5,6-dihydro-4H-cyclopenta[1,2,5]oxadiazole, 5,6-dihydro-4H-cyclopenta[c]furan, 2,4,5,6-tetrahydro-cyclopenta[c]pyrrole, 5,6-dihydro-4H-cyclopenta[b]furan, 5,6-dihydro-4H-cyclopenta[c]thiophene, 5,6-dihydro-4H-cyclopenta[b]furan, 5,6-dihydro-4H-cyclopenta[b]thiophene, 1,4,5,6-tetrahydro-cyclopenta[b]pyrrole, 2,3-dihydro-1H-indolizin-5-one, 6,7,8,9-tetrahydro-quinolizin-4-one, 1-oxa-spiro[4.4]nonane, 1-aza-spiro[4.4]nonane, 2-oxa-spiro[4.4]nonane, 2-aza-spiro[4.4]nonane, 1-aza-spiro[4.5]decane, 1-oxa-spiro[4.5]decane, 2-oxa-spiro[4.5]decane, 2-aza-spiro[4.5]decane, 1-thia-spiro[4.4]nonane, 1-thia-spiro[4.5]decane, 2-thia-spiro[4.4]nonane, 2-thia-spiro[4.5]decane, 7-oxa-5 bicyclo[2.2.1]heptane, 2-oxa-bicyclo[2.2.1]heptane, 7-thia-bicyclo[2.2.1]heptane, 2-thia-bicyclo[2.2.1]heptane, 2-aza-bicyclo[2.2.1]heptane, 7-aza-bicyclo[2.2.1]heptane, 4,5,6,7-tetrahydro-benzo[d]isoxazole, 4,5,6,7-tetrahydro-benzooxazole, 4,5,6,7-tetrahydro-benzo[d]isothiazole, 4,5,6,7-tetrahydro-benzothiazole, 4,5,6,7-tetrahydro-1H-indazole, 4,5,6,7-tetrahydro-benzo[c]thiophene, 4,5,6,7-tetrahydro-benzo[b]thiophene, 4,5,6,7-tetrahydro-isobenzofuran, 4,5,6,7-tetrahydro-benzofuran, 5,6,7,8-tetrahydro-quinoxaline, 6,7-dihydro-5H-cyclopentapyrazine, 5,6,7,8-tetrahydro-imidazo[1,5-a]pyridine, 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridine, 5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine, 5,6,7,8-tetrahydro-20 tetrazolo[1,5-a]pyridine, 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyridine, 6,7-dihydro-5H-pyrrolo[1,2-a]imidazole, 6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazole, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole, and 6,7-dihydro-5H-pyrrolotetrazole; ring M is substituted with 0-3 R1a and 0-1 carbonyl group; G is selected from the group:
phenyl; 4-ethyl-phenyl; 2,5-bis-aminomethyl-phenyl; 2-amido-4-methoxy-phenyl; 2-amido-5-chloro-phenyl; 2-amido-phenyl; 2-aminomethyl-3-fluoro-phenyl; 2-aminomethyl-3-methoxy-phenyl; 2-aminomethyl-4-fluoro-phenyl; 2-aminomethyl-4-methoxy-phenyl; 2-aminomethyl-5-fluoro-phenyl; 2-aminomethyl-5-methoxy-phenyl; 2-aminomethyl-6-fluoro-phenyl; 2-aminomethyl-phenyl; 2-amino-pyrid-4-yl; 2-aminosulfonyl-4-methoxy-phenyl; 2-aminosulfonyl-phenyl; 2-hydroxy-4-methoxy-phenyl; 2-methylsulfonyl-phenyl; 3-(N,N-dimethylamino)-4-chloro-phenyl; 3-(N,N-dimethylamino)-phenyl; 3-(N-hydroxy-amidino)-phenyl; 3-(N-methoxy-amidino)-phenyl; 3-(N-methylamino)-4-chloro-phenyl; 3-(N-metliylamino)-phenyl; 3-amidino-phenyl; 3-amido-6-hydroxy-phenyl; 3-amido-phenyl; 3-amino-4-chloro-phenyl; 3-aminomethyl-phenyl; 3-aimino-phenyl; 3-chloro-4-fluoro-phenyl; 3-chloro-phenyl; 3-hydroxy-4-methoxy-phenyl; 3,5-dichloro-thien-2-yl; 4-(N,N-dimethylamino)-5-chloro-thien-2-yl; 4-(N-methylamino)-5-chloro-thien-2-yl; 4-amino-5-chloro-thien-2-yl; 4-amino-pyrid-2-yl; 4-chloro-3-fluoro-phenyl; 4-chloro-phenyl; 4-chloro-pyrid-2-yI; 4-methoxy-2-methylsulfonyl-phenyl; 4-methoxy-phenyl; 2-methoxy-pyrid-5-yl; 5-(N,N-dimethylamino)-4-cliloro-thien-2-yI; 5-(N-methylamino)-4-chloro-thien-2-yl; 5-amino-4-chloro-thien-2-yl; 5-chloro-2-aminosulfonyl-phenyl; 5-chloro-2-methylsulfonyl-phenyl; 5-chloro-pyrid-2-yl; 5-chloro-thien-2-yl; 5-methoxy-thien-2-yl; 6-amino-5-chloro-pyrid-2-yl; 6-aniino-pyrid-2-yl; 5-chloro-pyrimidin-3-yl; 6-chloro-pyridazin-3-yl; 2-aminomethyl-4-chloro-phenyl; 2-aminosulfonyl-4-chloro-phenyl; 2-amido-4-chloro-phenyl; 4-chloro-2-methylsulfonyl-phenyl; 2-aminosulfonyl-4-fluoro-phenyl; 2-amido-4-fluoro-plienyl; 4-fluoro-2-methylsulfonyl-phenyl; 2-aninomethyl-4-bromo-phenyl; 2-aminosuilfonyl-4-bromo-phenyl; 2-amido-4-bromo-phenyl; 4-bromo-2-methylsulfonyl-phenyl; 2-aminomethyl-4-methyl-phenyl; 2-aminosulfonyl-4-methyl-phenyl; 2-anido-4-methyl-phenyl; 2-methylsulfonyl-4-methyl-phenyl; 4-fluoro-pyrid-2-yl; 4-bromo-pyrid-2-yl; 4-niethyl-pyrid-2-yl; 5-fluoro-thien-2-yl; 5-bromo-thien-2-yl; 5-methyl-thien-2-yl; 2-amido-4-methoxy-phenyl; 585586587588589590591592593594595G1 is absent or is selected from (CR3R3a)1-3, CR3═CR3, (CR3R3a)uC(O)(CR3R3a)w, (CR3R3a)u(CR3R3a)w, (CR3R3a)uNR3b(CR3R3a)w, (CR3R3a)uC(O)NR3b(CR3R3a)w, (CR3R3a)uNR3bC(O)(CR3R3a)w, (CR3R3a)uNR3bC(O)(CR3R3a)uC(O)NR3b(CR3R3a)w, (CR3R3a)uS(CR3R3a)w, (CR3R3a)uS(O)(CR3R3a)w, (CR3R3a)uS(O)2(CR3R3a)w, (CR3R3a)uS(O)NR3b(CR3R3a)w, (CR3R3a)uNR3bS(O)2(CR3R3a)w, (CR3R3a)uS(O)2NR3b(CR3R3a)w, (CR3R3a)uC(O)NR3bS(O)2(CR3R3a)w, (CR3R3a)uNR3bC(S)(CR3R3a)uC(O)NR3b(CR3R3a)w, and (CR3R3a)uNR3bC(O)(CR3R3a)uC(S)NR3b(CR3R3a)w, wherein u+w total 0, 1, or 2, provided that G1 does not form a N—S, NCH2N, NCH2O, or NCH2S bond with either group to which it is attached; A is selected from one of the following carbocycles and heterocycles which are substituted with 0-2 R4; cyclohexyl, phenyl, piperidinyl, piperazinyl, pyridyl, pyrimidyl, furanyl, morpholinyl, thienyl, pyrrolyl, pyrrolidinyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, imidazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,5-thiadiazolyl, 1,3,4-thiadiazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,5-triazolyl, 1,3,4-triazolyl, benzofuranyl, benzothiofuranyl, indolinyl, indolyl, benzimidazolyl, benzoxazolyl, benzthiazolyl, indazolyl, benzisoxazolyl, benzisothiazolyl, and isoindazolyl; X is selected from —(CR2R2a)1-2—, —C(O)—, —S(O)2—, —NR2S (O)2—, —NR2S(O)2NR2—, —NR2C(O)—, —C(O)NR2—, NR2, —NR2CR2R2a—, —CR2R2aNR2—, O, —OCR2R2a—, and —CR2R2aO—; Y is a C3-6 monocyclic carbocycle or 5-6 membered monocyclic heterocycle, wherein the carobocycle or heterocycle consists of carbon atoms and 0-2 heteroatoms selected from N, O, and S(O)p, the carbocycle or heterocycle further comprises 0-1 double bonds and 0-1 carbonyl groups, and the carbocycle or heterocycle is substituted with 0-2 R4; alternatively, Y is CY1Y2, and Y1 and Y2 are independently C1-2 alkyl substituted with 0-1 R4; R1a, at each occurrence, is selected from H, R1b, CH(CH3)R1b, C(CH3)2R1b, CH2R1b, and CH2CH2R1b, provided that R1a forms other than an N-halo, N—S, or N—CN bond; alternatively, when two Ria groups are attached to adjacent atoms or to the same carbon atom, together with the atoms to which they are attached, they form a 5-6 membered ring consisting of: carbon atoms and 0-2 heteroatoms selected from the group consisting of N, O, and S(O)p, this ring being substituted with 0-2 R4b and comprising: 0-3 double bonds; R1b is selected from H, CH3, CH2CH3, F, Cl, Br, —CN, —CHO, CF3, OR2, NR2R2a, C(O)R2b, CO2R2b, OC(O)R2, CO2R2a, S(O)pR2, NR2(CH2)rOR2, NR2C(O)R2b, C(O)NR2R2a, SO2NR2R2a, NR2SO2R2, C3-6 carbocycle substituted with 0-2 R4b, and 5-6 membered aromatic heterocycle consisting of carbon atoms and from 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p and substituted with 0-2 R4b, provided that R1b forms other than an O—O, N-halo, N—S, or N—CN bond; R2, at each occurrence, is selected from H, CF3, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, phenyl substituted with 0-2 R4b, benzyl substituted with 0-2 R4b, and 5-6 membered aromatic heterocycle substituted with 0-2 R4b and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p; R2a, at each occurrence, is selected from H, CF3, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, benzyl, C3-6 carbocycle substituted with 0-2 R4b, and 5-6 membered aromatic heterocycle substituted with 0-2 R4b and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p; R2b, at each occurrence, is selected from CF3, C1-4 alkoxy, C1-5 alkyl substituted with 0-3 R4b, benzyl, C3-6 carbocycle substituted with 0-2 R4b, and 4-6 membered substituted with 0-2 R4b and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p; R2c, at each occurrence, is selected from CF3, OH, OCH3, OCH2CH3, OCH2CH2CH3, OCH(CH3)2, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, benzyl, phenyl substituted with 0-2 R4b, and 5-6 membered aromatic heterocycle substituted with 0-2 R4b and consisting of carbon atoms and from 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p; alternatively, R2 and R2a, together with the nitrogen atom to which they are attached, combine to form a 3-6 membered saturated, partially saturated or unsaturated ring substituted with 0-2 R4b and consisting of: 0-1 additional heteroatoms selected from the group consisting of N, O, and S(O)p; R2d, at each occurrence, is selected from H, R4c, C1-4 alkyl substituted with 0-2 R4c, C3-6 carbocycle substituted with 0-2 R4c, —(CR3R3a)-C3-6 carbocycle substituted with 0-2 R4c, 5-6 membered heterocycle substituted with 0-2 R4c and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, and —(CR3R3a)-5-6 membered heterocycle substituted with 0-2 R4c and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, provided that R2d forms other than a N-halo, N—C-halo, S(O)p-halo, O-halo, N—S, S—N, S(O)p—S(O)p, S—O, O—N, O—S, or O—O moiety; R2e, at each occurrence, is selected from H, R4c, C1-4 alkyl substituted with 0-2 R4c, C3-6 carbocycle substituted with 0-2 R4c, —(CR3R3a)-C3-6 carbocycle substituted with 0-2 R4c, 5-6 membered heterocycle substituted with 0-2 R4c consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, and —(CR3R3a)-5-6 membered heterocycle substituted with 0-2 R4c and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, provided that R2e forms other than a C(O)-halo or C(O)—S(O)p moiety; R4, at each occurrence, is selected from H, (CH2)2OR2, CH2OR2, OR2, F, Cl, Br, I, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, CH2CH2CH2CH3, CH2CH(CH3)2, CH(CH3)CH2CH3, C(CH3)3, —CN, NO2, NR2R2a, CH2NR2R2a, (CH2)2NR2R2a, C(O)R2c, NR2C(O)R2b, C(O)NR2R2a, SO2NR2R2a, CF3, and CF2CF3; R4a is selected from —(CR3R3g)r-5-6 membered carbocycle substituted with 0-3 R4c, —(CR3R3g)r-5-6 membered heterocycle substituted with 0-3 R4c and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, (CR3R3g)rNR2dR2d, (CR3R3g)rN(→O)R2dR2d, (CR3R3g)rOR2d, (CR3R3g)r—NR2dC(O)R2e, (CR3R3g)r—C(O)R2e, (CR3R3g)r—OC(O)R2e, (CR3R3g)r—C(O)NR2dR2d, (CR3R3g)r—C(O)OR2d, (CR3R3g)r—NR2dC(O)NR2dR2d, (CR3R3g)r—NR2dC(O)OR2d, (CR3R3g)r—SO2NR2dR2d, (CR3R3g)r—NR2dSO2R2d, and (CR3R3g)r—S(O)pR2d, provided that S(O)pR2d forms other than S(O)2H or S(O)H; R4b, at each occurrence, is selected from H, ═O, OR3, CH2OR3, F, Cl, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, —CN, NO2, NR3R3a, CH2NR3R3a, C(O)R3, CH2—C(O)R3, C(O)OR3c, CH2—C(O)OR3c, NR3C(O)R3a, CH2NR3C(O)R3a, C(O)NR3R3a, CH2—C(O)NR3R3a, SO2NR3R3a, CH2SO2NR3R3a, NR3SO2-C1-4 alkyl, CH2NR3SO2-C1-4 alkyl, NR3SO2-phenyl, CH2NR3SO2-phenyl, S(O)pCF3, CH2S(O)pCF3, S(O)p-C1-4 alkyl, CH2S(O)p-C1-4 alkyl, S(O)p-phenyl, CH2S(O)p-phenyl, and CF3; R4c, at each occurrence, is selected from ═O, OR2, (CR3R3a)OR2, F, (CR3R3a)F, Br, (CR3R3a)Br, Cl, (CR3R3a)Cl, CF3, (CR3R3a)CF3, C1-4 alkyl, C2-3 alkenyl, C2-3 alkynyl, —CN, (CR3R3a)CN, NO2, (CR3R3a)NO2, NR2R2a, (CR3R3a)NR2R2a, N(→O)R2R2a, (CR3R3a)N(→O)R2R2a, C(O)R2c, (CR3R3a)C(O)R2c, NR2C(O)R2b, (CR3R3a)NR2C(O)R2b, C(O)NR2R2a, (CR3R3a)C(O)NR2R2a, NR2C(O)NR2R2a, (CR3R3a)NR2C(O)NR2R2a, SO2NR2R2a, (CR3R3a)SO2NR2R2a, NR2SO2NR2R2a, (CR3R3a)NR2SO2NR2R2a, NR2SO2R5a, (CR3R3a)NR2SO2R5a, S(O)pR5a, (CR3R3a)S(O)pR5a, CF3, CF2CF3, C3-10 carbocycle substituted with 0-2 R4b, (CR3R3a)C3-10 carbocycle substituted with 0-2 R4b, 5-10 membered heterocycle substituted with 0-2 R4b and consisting of carbon atoms and from 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, and (CR3R3a)5-10 membered heterocycle substituted with 0-2 R4b and consisting of carbon atoms and from 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p; R5, at each occurrence, is selected from H, ═O, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, OR3, CH2OR3, F, Cl, —CN, NO2, NR3R3a, CH2NR3R3a, C(O)R3, CH2C(O)R3, C(O)OR3c, CH2C(O)OR3c, NR3C(O)R3a, C(O)NR3R3a, SO2NR3R3a, NR3SO2-C1-4 alkyl, NR3SO2CF3, NR3SO2-phenyl, S(O)pCF3, S(O)p-C1-4 alkyl, S(O)p-phenyl, CF3, phenyl substituted with 0-2 R6, naphthyl substituted with 0-2 R6, and benzyl substituted with 0-2 R6; R6, at each occurrence, is selected from H, OH, OR2, F, Cl, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, —CN, NO2, NR2R2a, CH2NR2R2a, C (O) R2b, CH2C(O)R2b, NR2C(O)R2b, SO2NR2R2a, and NR2SO2C1-4 alkyl; and, r, at each occurrence, is selected from 0, 1, and 2.
- 11. A compound according to claim 10, wherein: the compound is selected from:
- 12. A compound according to claim 11, wherein the compound is selected from:
- 13. A compound according to claim 12, wherein the compound is selected from:
- 14. A compound according to claim 13, wherein the compound is selected from:
- 15. A compound according to claim 1, wherein the compound is selected from the group:
1-[(6-chloro-2-naphthyl)sulfonyl]-4-{4-[1-(1-pyrrolidinylmethyl)cyclopropyl]benzoyl}piperazine; 5-chloro-N- (5-chloro-2-pyridinyl)-2-({4-[1-(1-pyrrolidinylmethyl)cyclopropyl]benzoyl}amino)benzamide; N-{4-[1,1-dimethyl-2-(1-pyrrolidinyl)ethyl]phenyl}-1-(4-methoxyphenyl)-1H-1,2,3-triazole-5-carboxamide; N-{4-[2-(dimethylamino)-1,1-dimethylethyl]phenyl}-1-(4-methoxyphenyl)-1H-1,2,3-triazole-5-carboxamide; N5-{4-[2-(dimethylamino)-1,1-dimethylethyl]phenyl}-1-(4-methoxyphenyl)-1H-pyrazole-3,5-dicarboxamide; 3-cyano-N-{4-[2-(dimethylamino)-1,1-dimethylethyl]phenyl}-1-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide; N-{4-[2-(dimethylamino)-1,1-dimethylethyl]phenyl}-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide; N-{4-[2-(dimethylamino)-1,1-dimethylethyl]phenyl}-1-(4-methoxyphenyl)-1H-1,2,3-triazole-5-carboxamide; N-(4-{1-[(dimethylamino)methyl]cyclopentyl}phenyl)-1-(4-methoxyphenyl)-1H-1,2,3-triazole-5-carboxamide; N-(4-{1-[(dimethylamino)methyl]cyclobutyl}phenyl)-1-(4-methoxyphenyl)-1H-1,2,3-triazole-5-carboxamide; N-(4-{1-[(dimethylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-1H-1,2,3-triazole-5-carboxamide; 1-(2,3-dihydro-1H-indol-6-yl)-N5-(4-{1-[(2-oxo-1-pyrrolidinyl)methyl]cyclopropyl}phenyl)-1H-pyrazole-3,5-dicarboxamide; 1-(2,3-dihydro-1H-indol-6-yl)-N5-(4-{1-[(dimethylamino)methyl]cyclopropyl}phenyl)-1H-pyrazole-3,5-dicarboxamide; 5-chloro-N-(5-chloro-2-pyridinyl)-2-({4-[2-(dimethylamino)-1,1-dimethylethyl]benzoyl}amino)benzamide; 5-chloro-N-(5-chloro-2-pyridinyl)-2-[(4-{1-[(methylamino)methyl]cyclopropyl}benzoyl)amino]benzami de; 5-chloro-N-(5-chloro-2-pyridinyl)-2-({4-[1-(methoxymethyl)cyclopropyl]benzoyl}amino)benzamide; 5-chloro-N-(5-chloro-2-pyridinyl)-2-[(4-{1-[(dimethylamino)methyl]cyclopropyl}benzoyl)amino]benza mide; 5-chloro-N-(5-chloro-2-pyridinyl)-2-[(4-{1-[(2-methyl-1-pyrrolidinyl)methyl]cyclopropyl}benzoyl)amino]benzamid e; 5-chloro-N-(5-chloro-2-pyridinyl)-2-[(4-{1-[(2-oxo-1-pyrrolidinyl)methyl]cyclopropyl}benzoyl)amino]benzamid e; 5-chloro-N-(5-chloro-2-pyridinyl)-2-[(4-{1-[(isopropylamino)methyl]cyclopropyl}benzoyl)amino]benz amide; 5-chloro-N-(5-chloro-2-pyridinyl)-2-[(4-{1-[(cyclopropylamino)methyl]cyclopropyl}benzoyl)amino]be nzamide; 5-chloro-N-(5-chloro-2-pyridinyl)-2-[(4-{1-[(cyclobutylamino)methyl]cyclopropyl}benzoyl)amino]ben zamide; 5-chloro-N-(5-chloro-2-pyridinyl)-2-{[4-(1-{[(2-hydroxyethyl)amino]methyl}cyclopropyl)benzoyl]amino}be nzamide; 5-chloro-N-(5-chloro-2-pyridinyl)-2-{[4-(1-{[(2-hydroxyethyl)(methyl)amino]methyl}cyclopropyl)benzoyl]amino}benzamide; 5-chloro-N-(5-chloro-2-pyridinyl)-2-[(4-{l-[(3-hydroxy-1-pyrrolidinyl)methyl]cyclopropyl}benzoyl)amino]benzamid e; 5-chloro-N-(5-chloro-2-pyridinyl)-2-[(4-{l-[(4-hydroxy-1-piperidinyl)methyl]cyclopropyl}benzoyl)amino]benzamide; 5-chloro-N-(5-chloro-2-pyridinyl)-2-({4-[1-(1-piperidinylmethyl)cyclopropyl]benzoyl}amino)benzamide; 5-chloro-N-(5-chloro-2-pyridinyl)-2-[(4-{l-[(2-oxo-1-piperidinyl)methyl]cyclopropyl}benzoyl)amino]benzamide; 5-chloro-N-(5-chloro-2-pyridinyl)-2-[(4-{1-[(2-oxo-1-imidazolidinyl)methyl]cyclopropyl}benzoyl)amino]benzam ide; 5-chloro-N-(5-chloro-2-pyridinyl)-2-[(4-{1-[(2-oxo-1-pyrrolidinyl)methyl]cyclopropyl}benzyl)amino]benzamide; 2-{[4-(1-{[acetyl(methyl)amino]methyl}cyclopropyl)benzyl]amino}-5-chloro-N-(5-chloro-2-pyridinyl)benzamide; 5-chloro-N-(5-chloro-2-pyridinyl)-2-({4-[1-({methyl[(methylamino)carbonyl]amino}methyl)cyclopropy l]benzyl}amino)benzamide; 5-chloro-N-(5-chloro-2-pyridinyl)-2-{[4-(1-{[methyl(methylsulfonyl)amino]methyl}cyclopropyl)benzy l]amino}benzamide; 5-chloro-N-(5-chloro-2-pyridinyl)-2-[(4-{1-[(methylsulfonyl)amino]cyclopropyl}benzyl)amino]benzam ide; 2-({4-[1-(acetylamino)cyclopropyl]benzyl}amino)-5-chloro-N-(5-chloro-2-pyridinyl)benzamide; 5-chloro-N-(5-chloro-2-pyridinyl)-2-{[4-(1-{[(2-hydroxyethyl)amino]methyl}cyclopropyl)benzyl]amino}ben zamide; 5-chloro-N-(5-chloro-2-pyridinyl)-2-{[4-(1-{[(2-hydroxyethyl)(methyl)amino]methyl}cyclopropyl)benzyl]a mino}benzamide; 5-chloro-N-(5-chloro-2-pyridinyl)-2-[(4-{1-[(1,3-thiazol-2-ylamino)methyl]cyclopropyl}benzoyl)amino]benzamide; 5-chloro-N-(5-chloro-2-pyridinyl)-2-{(4-[1-[(2-methyl-1H-imidazol-1-yl)methyl]cyclopropyl}benzoyl)amino]benzamide; 5-chloro-N-(5-chloro-2-pyridinyl)-2-({4-[1-({[(methylamino)carbonyl]amino}methyl)cyclopropyl]benz oyl}amino)benzamide; methyl [1-(4-{[(4-chloro-2-{[(5-chloro-2-pyridinyl)amino]carbonyl}phenyl)amino]carbonyl}phenyl) cyclopropyl]methylcarbamate; 5-chloro-N-(5-chloro-2-pyridinyl)-2-{[4-(1-{[(methylsulfonyl)amino]methyl}cyclopropyl)benzoyl]ami no}benzamide; 2-({4-[1-(2-amino-2-oxoethyl)cyclopropyl]benzoyl}amino)-5-chloro-N-(5-chloro-2-pyridinyl)benzamide; 5-chloro-N-(5-chloro-2-pyridinyl)-2-[(4-{1-[2-(dimethylamino)-2-oxoethyl]cyclopropyl}benzyl)amino]benzamide; 2-({4-[l-(2-amino-2-oxoethyl)cyclopropyl]benzyl}amino)-5-chloro-N-(5-chloro-2-pyridinyl)benzamide; N-{4-[1-(2-amino-2-oxoethyl)cyclopropyl]phenyl}-1-(4-methoxyphenyl)-1H-1,2,3-triazole-5-carboxamide; N-{4-[1-(aminomethyl)cyclopropyl]phenyl}-1-(4-methoxyphenyl)-1H-1,2,3-triazole-5-carboxamide; 1-(4-methoxyphenyl)-N-(4-{1-[(methylamino)methyl]cyclopropyl}phenyl)-1H-1,2,3-triazole-5-carboxamide; 1-(4-methoxyphenyl)-N-{4-[1-(1-pyrrolidinylmethyl)cyclopropyl]phenyl}-1H-1,2,3-triazole-5-carboxamide; 1-(4-methoxyphenyl)-N5-{4-[1-(1-pyrrolidinylmethyl)cyclopropyl]phenyl}-1H-pyrazole-3,5-dicarboxamide; 1-(4-methoxyphenyl)-N5-(4-{1-[(2-oxo-1-pyrrolidinyl)methyl]cyclopropyl}phenyl)-1H-pyrazole-3,5-dicarboxamide; 1-(4-methoxyphenyl)-N5-(4-{1-[(methylamino)methyl]cyclopropyl}phenyl)-1H-pyrazole-3,5-dicarboxamide; 3-cyano-1-(4-methoxyphenyl)-N-(4-{1-[(methylamino)methyl]cyclopropyl}phenyl)-1H-pyrazole-5-carboxamide; 3-cyano-1-(4-methoxyphenyl)-N-{4-[1-(1-pyrrolidinylmethyl)cyclopropyl]phenyl}-1H-pyrazole-5-carboxamide; 3-cyano-1-(4-methoxyphenyl)-N-(4-{1-[(2-oxo-1-pyrrolidinyl)methyl]cyclopropyl}phenyl)-1H-pyrazole-5-carboxamide; 1-(4-methoxyphenyl)-3-(methylsulfonyl)-N-(4-{1-[(2-oxo-1-pyrrolidinyl)methyl]cyclopropyl}phenyl)-1H-pyrazole-5-carboxamide; N-(4-{1-[(3-hydroxy-1-pyrrolidinyl)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1H-pyrazole-5-carboxamide; 5-chloro-thiophene-2-carboxylic acid {1-[4-(1-pyrrolidin-1-ylmethyl-cyclopropyl)-benzoyl]-pyrrolidin-3-yl}-amide 5-chloro-thiophene-2-carboxylic acid {1-[4-(1-dimethylaminomethyl-cyclopropyl)-benzoyl]-pyrrolidin-3-yl}-amide; 3-chloro-1H-indole-6-carboxylic acid {1-[4-(1-pyrrolidin-1-ylmethyl-cyclopropyl)-benzoyl]-pyrrolidin-3-yl}-amide; 3-chloro-1H-indole-6-carboxylic acid {1,1-[4-(1-dimethylaminomethyl-cyclopropyl)-benzoyl]-pyrrolidin-3-yl}-amide; 3-chloro-1H-indole-6-carboxylic acid {2-[4-(1-pyrrolidin-1-ylmethyl-cyclopropyl)-benzoylamino]-cyclohexyl}-amide; 5-chloro-thiophene-2-carboxylic acid {2-[4-(1-pyrrolidin-1-ylmethyl-cyclopropyl)-benzoylamino]-cyclohexyl}-amide; 2-{4-[4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-phenylcarbamoyl]-phenyl}-2-methyl-propionic acid methyl ester; 2-{4-[4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-phenylcarbamoyl]-phenyl}-2-methyl-propyl alcohol; 5-chloro-N-(5-chloropyridin-2-yl)-2-({4-[2-(ethylamino)-1,1-dimethylethyl]benzoyl}amino)benzamide; 5-chloro-N-(5-chloropyridin-2-yl)-2-{[4-(1,1-dimethyl-2-pyrrolidin-l-ylethyl)benzoyl]amino}benzamide; 5-chloro-N-(5-chloropyridin-2-yl)-2-{[4-(1,1-dimethyl-2-morpholin-4-ylethyl)benzoyl]amino}benzamide; 2-{4-[2-(5-chloro-pyridin-2-ylcarbamoyl)-phenylcarbamoyl]-phenyl}-2-methyl-propionic acid methyl ester; 2-{4-[2-(5-chloro-pyridin-2-ylcarbamoyl)-4-methoxy-phenylcarbamoyl]-phenyl}-2-methyl-propionic acid methyl ester; N-(5-chloropyridin-2-yl)-2-{[4-(2-hydroxy-1,1-dimethylethyl)benzoyl]amino}benzamide; N-(5-chloropyridin-2-yl)-2-{[4-(2-hydroxy-1,1-dimethylethyl)benzoyl]amino}-5-methoxybenzamide; N-(5-chloropyridin-2-yl)-2-{[4-(1,1-dimethyl-2-pyrrolidin-1-ylethyl)benzoyl]amino}benzamide; N-(5-chloropyridin-2-yl)-2-{[4-(1,1-dimethyl-2-morpholin-4-ylethyl)benzoyl]amino}benzamide; N-(5-chloropyridin-2-yl)-2-{[4-(1,1-dimethyl-2-pyrrolidin-1-ylethyl)benzoyl]amino}-5-methoxybenzamide; 2-[(4-{2-[acetyl(methyl)amino]-1,1-dimethylethyl}benzoyl)amino]-N-(5-chloropyridin-2-yl)benzamide; 2-(4-{[2-(5-chloro-pyridin-2-ylcarbamoyl)-phenylamino]methyl}-phenyl)-2-methyl-propionic acid methyl ester; 5-chloro-N-(5-chloropyridin-2-yl)-2-{[4-(2-hydroxy-1,1-dimethylethyl)benzyl]amino}benzamide; 5-chloro-N-(5-chloro-pyridin-2-yl)-2-[4-(2-dimethylamino-1,1-dimethyl-ethyl)-benzylamino]-benzamide; N-(5-chloropyridin-2-yl)-2-({4-[1-(hydroxymethyl)cyclopropyl]benzoyl}amino)-5-methoxybenzamide; N-(5-chloropyridin-2-yl)-5-methoxy-2-({4-[1-(pyrrolidin-1-ylmethyl)cyclopropyl]benzoyl}amino)benzamide; N-(5-chloropyridin-2-yl)-2-({4-[1-(pyrrolidin-1-ylmethyl)cyclopropyl]benzoyl}amino)benzamide; 1-{4-[2-(5-chloro-pyridin-2-ylcarbamoyl)-phenylcarbamoyl]-phenyl}-cyclopropanecarboxylic acid methyl ester; N-(5-chloropyridin-2-yl)-2-({4-[1-(hydroxymethyl)cyclopropyl]benzoyl}amino)benzamide; 6-chloro-3-(5-chloropyridin-2-yl)-2-[4-(1,1-dimethyl-2-morpholin-4-ylethyl)phenyl]quinazolin-4(3H)-one; 3-(5-chloropyridin-2-yl)-2-{4-[1-(pyrrolidin-1-ylmethyl)cyclopropyl]phenyl}quinazolin-4(3H)-one; 2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid {4-[1-(2-methylamino-ethyl)-cyclopropyl]-phenyl}-amide; 2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid {4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-amide; 2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid {4-[l-(2-pyrrolidin-1-yl-ethyl)-cyclopropyl]-phenyl}-amide; 2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [4-(1-{2-[(2-hydroxy-ethyl)-methyl-amino]-ethyl}-cyclopropyl)-phenyl]-amide; 2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (4-{1-[2-(carbamoylmethyl-methyl-amino)-ethyl]-cyclopropyl}-phenyl)-amide; 2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid {4-[1-(2-morpholin-4-yl-ethyl)-cyclopropyl]-phenyl}-amide; 2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [4-(1-carbamoylmethyl-cyclopropyl)-phenyl]-amide; 2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [4-(l-methylcarbamoylmethyl-cyclopropyl)-phenyl]-amide; 2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [4-(1-methylcarbamoylmethyl-cyclobutyl)-phenyl]-amide; 2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [4-(1-carbamoylmethyl-cyclobutyl)-phenyl]-amide; 2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid {4-[1-(2-methylamino-ethyl)-cyclobutyl]-phenyl}-amide; 2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid {-[1-(2-dimethylamino-ethyl)-cyclobutyl]-phenyl}-amide; 2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid {4-[1-(2-pyrrolidin-1-yl-ethyl)-cyclobutyl]-phenyl}-amide; 2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid {4-[1-(2-morpholin-4-yl-ethyl)-cyclobutyl]-phenyl}-amide; 2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid {4-[1-(2-dimethylamino-ethyl)-cyclopentyl]-phenyl}-amide; 5-cyano-2-(4-methoxy-phenyl)-2H-pyrazole-3-carboxylic acid {4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-amide; 2-(4-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid {4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-amide; 1-(4-methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-amide 5-({4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-amide); 5-methanesulfonyl-2-(4-methoxy-phenyl)-2H-pyrazole-3-carboxylic acid {4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-amide; 3-(4-methoxy-phenyl)-3H-[1,2,3]triazole-4-carboxylic acid {4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-amide; 3-(4-methoxy-phenyl)-3H-[1,2,3]triazole-4-carboxylic acid [4-(1-carbamoylmethyl-cyclopropyl)-phenyl]-amide; 3-(4-methoxy-phenyl)-3H-[1,2,3]triazole-4-carboxylic acid [4-(1-methylcarbamoylmethyl-cyclopropyl)-phenyl]-amide; 2-[1-(4-{2-[3-(4-methoxy-phenyl)-3H-[1,2,3]triazol-4-yl]-2-oxo-ethyl}-phenyl)-cyclopropyl]-N-methyl-acetamide; 2-[1-(4-{2-[3-(4-methoxy-phenyl)-3H-[1,2,3]triazol-4-yl]-2-oxo-ethyl}-phenyl)-cyclopropyl]-acetamide; 2-[1-(4-{2-[2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-2-oxo-ethyl}-phenyl)-cyclopropyl]-acetamide; 2-[1-(4-{2-[5-cyano-2-(4-methoxy-phenyl)-2H-pyrazol-3-yl]-2-oxo-ethyl}-phenyl)-cyclopropyl]-acetamide; 2-[1-(4-{2-[5-methanesulfonyl-2-(4-methoxy-phenyl)-2H-pyrazol-3-yl]-2-oxo-ethyl}-phenyl)-cyclopropyl]-acetamide; 2-[1-(4-{2-[5-methanesulfonyl-2-(4-methoxy-phenyl)-2H-pyrazol-3-yl]-2-oxo-ethyl}-phenyl)-cyclopropyl]-N-methyl-acetamide; 5-chloro-N-(5-chloro-2-pyridinyl)-2-({4-[1-(2-dimethylamino-ethyl)cyclopropyl]benzoyl}amino)benzamide; N-(5-chloro-2-pyridinyl)-5-methoxy-2-({4-[1-(2-dimethylamino-ethyl)cyclopropyl]benzoyl}amino)benzamide; N-(5-chloro-2-pyridinyl)-5-fluoro-2-({4-[1-(2-dimethylamino-ethyl)cyclopropyl]benzoyl}amino)benzamide; N-(5-chloro-2-pyridinyl)-5-methyl-2-({4-[1-(2-dimethylamino-ethyl)cyclopropyl]benzoyl}amino)benzamide; N-(5-chloro-2-pyridinyl)-5-methylsulfonyl-2-({4-[1-(2-dimethylamino-ethyl)cyclopropyl]benzoyl}amino)benzamide; N-(5-chloro-2-pyridinyl)-5-cyano-2-({4-[1-(2-dimethylamino-ethyl)cyclopropyl]benzoyl}amino)benzamide; N-(5-chloro-2-pyridinyl)-2-({4-[1-(2-dimethylamino-ethyl)cyclopropyl]benzoyl}amino)benzamide; 3-{4-[l-(2-dimethylamino-ethyl)-cyclopropyl]-benzoylamino}-pyridine-2-carboxylic acid (5-chloro-pyridin-2-yl)-amide; N-(5-chloro-pyridin-2-yl)-4-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-benzoylamino}-nicotinamide; N-(5-chloro-pyridin-2-yl)-3-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-benzoylamino}-isonicotinamide; N-(5-chloro-pyridin-2-yl)-2-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-benzoylamino}-nicotinamide; 5-chloro-N-(5-chloro-2-pyridinyl)-2-(4-{1-[2-(2-oxo-pyrrolidin-1-yl)-ethyl]-cyclopropyl}-benzoylamino)benzamide; N-(5-chloro-2-pyridinyl)-5-methoxy-2-(4-{1-[2-(2-oxo-pyrrolidin-1-yl)-ethyl]-cyclopropyl}-benzoylamino)benzamide; N-(5-chloro-2-pyridinyl)-5-fluoro-2-(4-{1-[2-(2-oxo-pyrrolidin-1-yl)-ethyl]-cyclopropyl}-benzoylamino)benzamide; N- (5-chloro-2-pyridinyl) -5-methyl-2- (4-{1- [2- (2-oxo-pyrrolidin-1-yl)-ethyl]-cyclopropyl}-benzoylamino)benzamide; N-(5-chloro-2-pyridinyl)-5-methylsulfonyl-2-(4-{1-[2-(2-oxo-pyrrolidin-1-yl)-ethyl]-cyclopropyl}benzoylamino)benzamide; N-(5-chloro-2-pyridinyl)-5-cyano-2-(4-{1-[2-(2-oxo-pyrrolidin-l-yl)-ethyl]-cyclopropyl}-benzoylamino)benzamide; N-(5-chloro-2-pyridinyl)-2-(4-{1-[2-(2-oxo-pyrrolidin-1-yl)-ethyl]-cyclopropyl}-benzoylamino)benzamide; 3-(4-{1-[2-(2-oxo-pyrrolidin-1-yl)-ethyl]-cyclopropyl}-benzoylamino)-pyridine-2-carboxylic acid (5-chloro-pyridin-2-yl)-amide; N-(5-chloro-pyridin-2-yl)-4-(4-{1-[2-(2-oxo-pyrrolidin-1-yl)-ethyl]-cyclopropyl}-benzoylamino)-nicotinamide; N-(5-chloro-pyridin-2-yl)-3-(4-{1-[2-(2-oxo-pyrrolidin-1-yl)-ethyl]-cyclopropyl}-benzoylamino)-isonicotinamide; N-(5-chloro-pyridin-2-yl)-2-(4-{1-[2-(2-oxo-pyrrolidin-1-yl)-ethyl]-cyclopropyl}-benzoylamino)-nicotinamide; 3-chloro-1H-indole-6-carboxylic acid {4-dimethylcarbamoyl-2-[4-(l-pyrrolidin-1-ylmethyl-cyclopropyl)-benzoylamino]-cyclohexyl}-amide; 3-chloro-1H-indole-6-carboxylic acid {5-dimethylcarbamoyl-2-[4-(1-pyrrolidin-1-ylmethyl-cyclopropyl)-benzoylamino]-cyclohexyl}-amide; 3-chloro-1H-indole-6-carboxylic acid {4-[4-(1-pyrrolidin-1-ylmethyl-cyclopropyl)-benzoylamino]-tetrahydro-pyran-3-yl}-amide; 3-chloro-1H-indole-6-carboxylic acid {3-[4-(1-pyrrolidin-1-ylmethyl-cyclopropyl)-benzoylamino]-tetrahydro-pyran-4-yl}-amide; 3-chloro-1H-indole-6-carboxylic acid {1,1-dioxo-3-[4-(1-pyrrolidin-1-ylmethyl-cyclopropyl)-benzoylamino]-hexahydro-1λ6-thiopyran-4 -yl }-amide; 3-chloro-1H-indole-6-carboxylic acid {1,1-dioxo-4-[4-(1-pyrrolidin-1-ylmethyl-cyclopropyl)-benzoylamino]-hexahydro-1λ6-thiopyran-3-yl}-amide; 3-chloro-1H-indole-6-carboxylic acid {1-acetyl-3-[4-(1-pyrrolidin-1-ylmethyl-cyclopropyl)-benzoylamino]-piperidin-4-yl}-amide; 3-chloro-1H-indole-6-carboxylic acid {1-acetyl-3-[4-(1-pyrrolidin-1-ylmethyl-cyclopropyl)-benzoylamino]-piperidin-4-yl}-amide; 4-[(3-chloro-1H-indole-6-carbonyl)-amino]-3-[4-(1-pyrrolidin-1-ylmethyl-cyclopropyl)-benzoylamino]-piperidine-1-carboxylic acid methyl ester; 3-chloro-1H-indole-6-carboxylic acid {1-(2-methoxy-acetyl)-3-[4-(1-pyrrolidin-1-ylmethyl-cyclopropyl)-benzoylamino]-piperidin-4-yl}-amide; 5-chloro-thiophene-2-carboxylic acid {2-[4-(1-dimethylaminomethyl-cyclopropyl)-benzoylamino]-cyclopentyl}-amide; 5-chloro-thiophene-2-carboxylic acid {4-[4-(1-dimethylaminomethyl-cyclopropyl)-benzoylamino]-tetrahydro-furan-3-yl}-amide; 5-chloro-thiophene-2-carboxylic acid {1-acetyl-4-[4-(1-dimethylaminomethyl-cyclopropyl)-benzoylamino]-pyrrolidin-3-yl}-amide; 5-chloro-thiophene-2-carboxylic acid {1-cyclopropanecarbonyl-4-[4-(1-dimethylaminomethyl-cyclopropyl)-benzoylamino]-pyrrolidin-3-yl}-amide; 3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-[4-(1-dimethylaminomethyl-cyclopropyl)-benzoylamino]-pyrrolidine-1-carboxylic acid methyl ester; 5-chloro-thiophene-2-carboxylic acid [4-[4-(1-dimethylaminomethyl-cyclopropyl)-benzoylamino]-1-(2-methoxy-acetyl)-pyrrolidin-3-yl]-amide; 5-chloro-thiophene-2-carboxylic acid {2-[4-(1-dimethylaminomethyl-cyclopropyl)-benzoylamino]-4-dimethylcarbamoyl-cyclopentyl}-amide; 5-chloro-thiophene-2-carboxylic acid {l-[4-(1-dimethylaminomethyl-cyclopropyl)-benzoylamino]-indan-2-yl}-amide; 3-chloro-1H-indole-6-carboxylic acid {3-[4-(1-dimethylaminomethyl-cyclopropyl)-benzoylamino]-1,2,3,4-tetrahydro-naphthalen-2-yl}-amide; 3-chloro-1H-indole-6-carboxylic acid {3-[4-(1-dimethylaminomethyl-cyclopropyl)-benzoylamino]-7-oxa-bicyclo[2.2.1]hept-2-yl}-amide; 5-chloro-thiophene-2-carboxylic acid {2-[4-(1-dimethylaminomethyl-cyclopropyl)-benzoylamino]-4-dimethylcarbamoyl-cyclopentyl}-amide; 5-chloro-thiophene-2-carboxylic acid {8-[4-(1-dimethylaminomethyl-cyclopropyl)-benzoylamino]-1-oxa-spiro[4.4]non-7-yl}-amide; 5-chloro-thiophene-2-carboxylic acid (8-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-benzoylamino}-1-oxa-spiro[4.4]non-7-yl)-amide; 5-chloro-thiophene-2-carboxylic acid (2-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-benzoylamino}-cyclopentyl)-amide; 5-chloro-thiophene-2-carboxylic acid (2-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-benzoylamino}-4-dimethylcarbamoyl-cyclopentyl)-amide; 3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-benzoylamino}-pyrrolidine-1-carboxylic acid methyl ester; 5-chloro-thiophene-2-carboxylic acid (4-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-benzoylamino}-tetrahydro-furan-3-yl)-amide; 3-chloro-1H-indole-6-carboxylic acid (2-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-benzoylamino}-cyclohexyl)-amide; 3-chloro-1H-indole-6-carboxylic acid (2-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-benzoylamino}-4-dimethylcarbamoyl-cyclohexyl)-amide; 4-[(3-Chloro-1H-indole-6-carbonyl)-amino]-3-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-benzoylamino}-piperidine-1-carboxylic acid methyl ester; 3-chloro-1H-indole-6-carboxylic acid (3-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-benzoylamino}-1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl) -amide; 3-chloro-1H-indole-6-carboxylic acid (4-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-benzoylamino}-1,1-dioxo-hexahydro-1λ6-thiopyran-3-yl)-amide; 3-chloro-1H-indole-6-carboxylic acid (4-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-benzoylamino}-tetrahydro-pyran-3-yl)-amide; 3-chloro-1H-indole-6-carboxylic acid (3-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-benzoylamino}-tetrahydro-pyran-4-yl)-amide; (1R, 2S)-5-chloro-thiophene-2-carboxylic acid {2-[4-(1-pyrrolidin-1-ylmethyl-cyclopropyl)-benzoylamino]-cyclopentyl}-amide; (1R, 2S)-3-chloro-1H-indole-6-carboxylic acid {2-[4-(1-pyrrolidin-1-ylmethyl-cyclopropyl)-benzoylamino]-cyclopentyl}-amide; (1R, 2S)-5-chloro-thiophene-2-carboxylic acid {2-[4-(1-pyrrolidin-1-ylmethyl-cyclopropyl)-benzoylamino]-cyclohexyl}-amide; and, Cis-3-chloro-1H-indole-6-carboxylic acid {2-[4-(1-pyrrolidin-1-ylmethyl-cyclopropyl)-phenylcarbamoyl]-cyclohexyl}-amide; or a pharmaceutically acceptable salt form thereof.
- 16. A pharmaceutical composition, comprising: a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof.
- 17. A method for treating a thromboembolic disorder, comprising: administering to a patient in need thereof a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt form thereof.
- 18. A method according to claim 17 wherein the thromboembolic disorder is selected from the group consisting of arterial cardiovascular thromboembolic disorders, venous cardiovascular thromboembolic disorders, and thromboembolic disorders in the chambers of the heart.
- 19. A method according to claim 17, wherein the thromboembolic disorder is selected from unstable angina, an acute coronary syndrome, first myocardial infarction, recurrent myocardial infarction, ischemic sudden death, transient ischemic attack, stroke, atherosclerosis, peripheral occlusive arterial disease, venous thrombosis, deep vein thrombosis, thrombophlebitis, arterial embolism, coronary arterial thrombosis, cerebral arterial thrombosis, cerebral embolism, kidney embolism, pulmonary embolism, and thrombosis resulting from (a) prosthetic valves or other implants, (b) indwelling catheters, (c) stents, (d) cardiopulmonary bypass, (e) hemodialysis, or (f) other procedures in which blood is exposed to an artificial surface that promotes thrombosis.
- 20. A method of treating a patient in need of thromboembolic disorder treatment, comprising: administering a compound of claim 1 or a pharmaceutically acceptable salt form thereof in an amount effective to treat a thromboembolic disorder
- 21. A method, comprising: administering a compound of claim 1 or a pharmaceutically acceptable salt form thereof in an amount effective to treat a thromboembolic disorder.
- 22. A method for treating a thromboembolic disorder, comprising: administering to a patient in need thereof a therapeutically effective amount of a first and second therapeutic agent, wherein the first therapeutic agent is compound of claim 1 or a pharmaceutically acceptable salt thereof and the second therapeutic agent is at least one agent selected from a second factor Xa inhibitor, an anti-coagulant agent, an anti-platelet agent, a thrombin inhibiting agent, a thrombolytic agent, and a fibrinolytic agent.
- 23. A method according to claim 22, wherein the second therapeutic agent is at least one agent selected from warfarin, unfractionated heparin, low molecular weight heparin, synthetic pentasaccharide, hirudin, argatrobanas, aspirin, ibuprofen, naproxen, sulindac, indomethacin, mefenamate, droxicam, diclofenac, sulfinpyrazone, piroxicam, ticlopidine, clopidogrel, tirofiban, eptifibatide, abciximab, melagatran, disulfatohirudin, tissue plasminogen activator, modified tissue plasminogen activator, anistreplase, urokinase, and streptokinase.
- 24. The method according to claim 22, wherein the second therapeutic agent is at least one anti-platelet agent.
- 25. The method according to claim 24, wherein the anti-platelet agent is aspirin and clopidogrel.
- 26. The method according to claim 24, wherein the anti-platelet agent is clopidogrel.
- 27. An article of manufacture, comprising:
(a) a first container; (b) a pharmaceutical composition located within the first container, wherein the composition, comprises: a first therapeutic agent, comprising: a compound according to claim 1 or a pharmaceutically acceptable salt form thereof; and, (c) a package insert stating that the pharmaceutical composition can be used for the treatment of a thromboembolic disorder.
- 28. An article of manufacture according to claim 27, further comprising:
(d) a second container; wherein components (a) and (b) are located within the second container and component (c) is located within or outside of the second container.
- 29. An article of manufacture, comprising:
(a) a first container; (b) a pharmaceutical composition located within the first container, wherein the composition, comprises: a first therapeutic agent, comprising: a compound according to claim 1 or a pharmaceutically acceptable salt form thereof; and, (c) a package insert stating that the pharmaceutical composition can be used in combination with a second therapeutic agent to treat a thromboembolic disorder.
- 30. An article of manufacture according to claim 29, further comprising:
(d) a second container; wherein components (a) and (b) are located within the second container and component (c) is located within or outside of the second container.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] The present application claims the priority benefits of U.S. Provisional Application No. 60/379,357, filed May 10, 2002 and U.S. Provisional Application No. 60/415,367, filed Oct. 2, 2002, all of which are fully incorporated herein by reference.
Provisional Applications (2)
|
Number |
Date |
Country |
|
60379357 |
May 2002 |
US |
|
60415367 |
Oct 2002 |
US |
Patent Application
20040254158
