Claims
- 1. A compound of the formula ##STR10## or a pharmaceutically acceptable acid addition salt thereof, wherein, R.sub.l and R.sub.2 are the same or different and each is hydrogen; C.sub.3-7 cycloalkyl; phenyl; phenyl mono- or disubstituted by halogen or methoxy; straight or branched chain, saturated, or unsaturated C.sub.1-5 alkyl which may be substituted by hydroxy, C.sub.1-4 alkoxy, halogen, amino, C.sub.1-2 alkylamino-, C.sub.1-2 dialkylamino, C.sub.2-4 acylamino, C.sub.3-7 or phenyl; furyl; or, thienyl;
- or, R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a 4-piperazinyl, 1-morpholino, 1-pyrrolidinyl or 1-piperidinyl ring which is unsubstituted or substituted by phenyl C.sub.1-4 alkyl, wherein the phenyl is unsubstituted or substituted by halogen or methoxy;
- with the proviso that, when R.sub.1 is hydrogen, R.sub.2 may additionally be amino, C.sub.1-2 dialkylamino, acetonylamino, C.sub.2-3 acylamino, C.sub.1-3 alkylsulphonyl or C.sub.1-3 alkoxycarbonyl;
- R.sub.3, R.sub.4 and R.sub.5 may be the same or different and each is hydrogen or C.sub.1-4 alkyl;
- R.sub.7 and R.sub.8 may be the same or different and each is hydroxy, C.sub.1-4 alkoxy or C.sub.1-4 alkylthio, and
- R.sub.6 and R.sub.9 may be the same or different and each is hydrogen, hydroxy, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, or a group ##STR11## wherein R.sub.10 is hydrogen or C.sub.1-4 alkyl and
- R.sub.11 is hydrogen or C.sub.1-4 alkyl wherein any such alkyl group may be unsubstituted or substituted by hydroxy, methoxy or furfuryl.
- 2. A compound of formula (I), as claimed in claim 1, wherein
- R.sub.1 and R.sub.2, which may be the same or different, are each hydrogen, or straight- or branched-chain C.sub.1-5 alkyl or
- R.sub.1 is hydrogen and R.sub.2 is amino, methylamino, dimethylamino, dimethylamino-C.sub.1-4 alkyl, methoxy-C.sub.1-4 alkyl, cyclopropyl, cyclopentyl, cyclohexyl, cyclohexylmethyl, phenyl which is unsubstituted or mono- or disubstituted by methoxy, or p-halophenyl the phenyl moiety of which is optionally additionally mono- or disubstituted by methoxy,
- or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a morpholino ring or a piperazine ring and
- R.sub.7 and R.sub.8 are each methoxy.
- 3. 3,4-Dihydro-6,7-dimethoxy-12-benzylamino-pyridazino[4',5':3,4]pyrrolo[2,1-a]isoquinoline, or a pharmaceutically acceptable salt thereof.
- 4. 3,4-Dihydro-6,7-dimethoxy-12-cyclohexylmethylamino-pyridazino[4',5':3,4]pyrrolo[2,1-a]isoquinoline, or a pharmaceutically acceptable salt thereof.
- 5. 3,4-Dihydro-6,7-dimethoxy-12-[4-(2-methoxyphenyl)piperazinyl]-pyridazino[4',5':3,4 ]pyrrolo[2,1-a]isoquinoline, or a pharmaceutically acceptable salt thereof.
- 6. 3,4-Dihydro-6,7-dimethoxy-12-[2-(3-thienyl)-ethyl]-aminopyridazino[4',5':3,4]pyrrolo[2,1-a]isoquinoline, or a pharmaceutically acceptable salt thereof.
- 7. A pharmaceutical composition which comprises a compound as claimed in claims 1, 2, 3, 4, 5 or 6 together with a pharmaceutically acceptable carrier or excipient.
- 8. A method of treating cardiac insufficiency which comprises administering to a subject suffering from the same a cardiotonic amount of a compound of formula (I), as claimed in claims 1, 2, 3, 4, 5 or 6 or a pharmaceutically acceptable acid addition salt thereof.
Priority Claims (2)
| Number |
Date |
Country |
Kind |
| 3500941 |
Jan 1985 |
DEX |
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| 3525048 |
Jul 1985 |
DEX |
|
Parent Case Info
This is a continuation of Ser. No. 294,460, filed Aug. 23, 1994, now abandoned, which is a continuation of application Ser. No. 151,081, filed Nov. 12, 1993, now abandoned, which is a continuation of application Ser. No. 026,675, filed Mar. 4, 1993, now abandoned, which is a continuation of application Ser. No. 912,049, filed Jul. 9, 1992, now abandoned, which is a continuation of application Ser. No. 779,208, filed Oct. 18, 1991, now abandoned, which is a continuation of application Ser. No. 668,347, filed Mar. 11, 1991, now abandoned, which is a continuation of application Ser. No. 549,657, filed Jul. 9, 1990, now abandoned, which is a continuation of application Ser. No. 432,932, filed Nov. 7, 1989, now abandoned, which is a continuation of application Ser. No. 322,325, filed Mar. 10, 1989, now abandoned, which is a continuation of application Ser. No. 196,905, filed May 20, 1988, now abandoned, which is a continuation of application Ser. No. 073,032, filed Jul. 14, 1987, now abandoned, which is a continuation of application Ser. No. 818,562, filed Jan. 13, 1986, now abandoned.
US Referenced Citations (3)
| Number |
Name |
Date |
Kind |
|
4508720 |
Kan et al. |
Apr 1985 |
|
|
4694085 |
Losel et al. |
Sep 1987 |
|
|
4721711 |
Chambon et al. |
Jan 1988 |
|
Foreign Referenced Citations (2)
| Number |
Date |
Country |
| 1288703 |
Jul 1954 |
EPX |
| 73161 |
Mar 1983 |
EPX |
Non-Patent Literature Citations (2)
| Entry |
| Ferrari et al, Chemical Abstracts, vol. 71, No. 81215 (1969). |
| Losel et al, Chemische Berichte, 118, p. 413 (1985). |
Continuations (12)
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Date |
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| Parent |
294460 |
Aug 1994 |
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| Parent |
151081 |
Nov 1993 |
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| Parent |
26675 |
Mar 1993 |
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| Parent |
912049 |
Jul 1992 |
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| Parent |
779208 |
Oct 1991 |
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| Parent |
668347 |
Mar 1991 |
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| Parent |
549657 |
Jul 1990 |
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| Parent |
432932 |
Nov 1989 |
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| Parent |
322325 |
Mar 1989 |
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| Parent |
196905 |
May 1988 |
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| Parent |
73032 |
Jul 1987 |
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| Parent |
818562 |
Jan 1986 |
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Patent Grant
5614516
