Claims
- 1. A pharmaceutical composition for tranquilizing or inducing sleep comprising in unit dosage form an inert pharmaceutically acceptable carrier and from 40 to 1600 milligrams of a compound of the formula: ##STR5## wherein R.sub.0, R and R.sub.1 are independently hydrogen, fluoro, chloro or lower alkyl of 1 to 4 carbon atoms, and
- R.sub.2 and R.sub.3 are independently hydrogen or alkyl of 1 to 4 carbon atoms,
- with the proviso that at least one of R.sub.0, R and R.sub.1 is hydrogen.
- 2. A pharmaceutical composition in accordance with claim 1 in which the compound is of the formula: ##STR6## wherein R is fluoro or chloro.
- 3. A pharmaceutical composition in accordance with claim 1 in which the compound is of the formula: ##STR7##
- 4. A pharmaceutical composition in accordance with claim 1 in which the compound is of the formula: ##STR8##
- 5. A pharmaceutical composition in accordance with claim 1 in solid unit dosage form and comprising from 40 to 800 milligrams of the compound.
- 6. The method for effecting tranquilization comprising administering to a mammal in need of such treatment a tranquilizing effective amount of a compound of the formula: ##STR9## wherein R.sub.0, R and R.sub.1 are independently hydrogen, fluoro, chloro or lower alkyl of 1 to 4 carbon atoms, and
- R.sub.2 and R.sub.3 are independently hydrogen or alkyl of 1 to 4 carbon atoms,
- with the proviso that at least one of R.sub.0, R and R.sub.1 is hydrogen.
- 7. The method of claim 6 comprising administering a tranquilizing effective amount of a compound of the formula: ##STR10## wherein R is fluoro or chloro.
- 8. The method of claim 6 comprising administering a tranquilizing effective amount of the compound of the formula: ##STR11##
- 9. The method of claim 6 comprising administering a tranquilizing effective amount of the compound of the formula: ##STR12##
- 10. The method of claim 6 wherein the compound is administered at a daily dosage of from 160 to 1600 milligrams of the compound.
- 11. The method of claim 6 wherein the compound is administered in unit dosages from 40 to 800 milligrams of the compound.
- 12. The method of inducing sleep comprising administering to a mammal in need of such treatment a sleep inducing effective amount of a compound of the formula: ##STR13## wherein R.sub.0, R and R.sub.1 are independently hydrogen, fluoro, chloro, or lower alkyl of 1 to 4 carbon atoms, and
- R.sub.2 and R.sub.3 are independently hydrogen or alkyl of 1 to 4 carbon atoms,
- with the proviso that at least one of R.sub.0, R and R.sub.1 is hydrogen.
- 13. The method of claim 12 comprising administering a sleep-inducing effective amount of a compound of the formula: ##STR14## wherein R is fluoro or chloro.
- 14. The method of claim 12 comprising administering a sleep-inducing effective amount of the compound of the formula: ##STR15##
- 15. The method of claim 12 comprising administering a sleep-inducing effective amount of the compound of the formula: ##STR16##
- 16. The method of claim 12 wherein the compound is administered in an amount of from 160 to 1600 milligrams at bedtime.
Parent Case Info
This application is a continuation-in-part of copending application Ser. No. 473,778, filed May 28, 1974, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3917838 |
Bass et al. |
Nov 1975 |
|
Non-Patent Literature Citations (3)
Entry |
Nagarajan et al.; Tetrahedron, vol. 23, (1967) pp. 1683-1690. |
Rapaport; Chem. Abst. vol. 53 (1958) 8139g. |
Kato et al.; Chem. Pharm. Bull., vol. 19, pp. 832-836 (1971). |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
473778 |
May 1974 |
|