Claims
- 1. A compound selected from those of formula (I): ##STR78## wherein: R.sub.1 is selected from hydrogen, alkyl, alkenyl, cyanoalkyl, and arylalkyl,
- W is selected from --A--R.sub.2 and ##STR79## R.sub.2 is selected from alkyl, cycloalkyl, cycloalkylalkyl, phenyl, phenylalkyl, naphthyl, and naphthylalkyl,
- R.sub.3 and R.sub.4 are selected, each independently of the other, from hydrogen, alkyl, phenyl, phenylalkyl, cycloalkyl, and cycloalkylalkyl,
- n is 1 to 4 inclusive,
- m is 0 or 1,
- A is selected from ##STR80## and ##STR81## Y represents ##STR82## wherein R.sub.5 and R.sub.6 are each selected, independently of the other, from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, phenyl, and benzyl,
- it being understood that:
- the terms "alkenyl", and "alkoxy" denote straight-chain or branched groups having 1 to 6 carbon atoms inclusive which may be unsubstituted or substituted by one or more alkoxy,
- the term "aryl" denotes phenyl, naphthyl, or pyridyl,
- the radicals phenyl, benzyl, phenylalkyl, naphthyl, pyrimidyl, pyrimidyl, and benzhydryl may be unsubstituted or substituted by one or more halogen, hydroxy, alkyl, alkoxy, trifluoromethyl, or nitro,
- the term "cycloalkyl" denotes a ring system having 3 to 8 carbon atoms inclusive,
- the terms "cycloalkylalkyl", "arylalkyl", "phenylalkyl", and "naphthylalkyl" denote cycloalkyl, aryl, phenyl, or naphthyl bonded by way of a linear or branched carbon chain containing 1 to 6 carbon atoms inclusive,
- its possible geometric and/or optical isomers, in pure form or in the form of a mixture, and its pharmaceutically-acceptable addition salts with an acid or a base.
- 2. A compound according to claim 1, which is 5-benzoyl-1-methyl-1,3-dihydro-2H-pyrrolo�2,3-b!pyridin-2-one.
- 3. A method for treating a mammal afflicted with a condition requiring an analgesic comprising the step of administering to said mammal an analgesically effective amount of a compound of claim 1 which is effective for alleviation of said condition.
- 4. A pharmaceutical composition useful as an analgesic comprising an analgesically effective amount of a compound as claimed in claim 1, together with a pharmaceutically-acceptable excipient.
- 5. A pharmaceutical composition according to claim 4 wherein said composition additionally comprises caffeine.
- 6. A compound according to claim 1, which is 1,3-dihydro-1,3,3-trimethyl-5-acetyl-2H-Pyrrolo�2,3-b!pyridin-2-one.
- 7. A compound according to claim 1, which is 1,3-dihydro-1-methyl-5-acetyl-2H-pyrrolo�2,3-b!pyridin-2-one.
Priority Claims (2)
Number |
Date |
Country |
Kind |
94 08418 |
Jul 1994 |
FRX |
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94 08419 |
Jul 1994 |
FRX |
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Parent Case Info
The present application is a division of our prior-filed application Ser. No. 08/497,524, filed Jul. 3, 1995, now U.S. Pat. No. 5,618,819, issued Apr. 8, 1997.
US Referenced Citations (5)
Number |
Name |
Date |
Kind |
4038396 |
Shen et al. |
Jul 1977 |
|
4866074 |
Spada et al. |
Sep 1989 |
|
5077408 |
Guillaumet et al. |
Dec 1991 |
|
5130311 |
Guillaumet et al. |
Jul 1992 |
|
5618819 |
Guillaumet et al. |
Apr 1997 |
|
Divisions (1)
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Number |
Date |
Country |
Parent |
497524 |
Jul 1995 |
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