Claims
- 1. A compound selected from the group consisting of ##STR45## wherein R.sup.1 is a member selected from the group consisting of alkyl of 1 to 6 carbon atoms and hydrocarbyl aralkyl of 7 to 16 carbon atoms;
- R.sup.2 is a member selected from the group consisting of dialkylaminoalkyl of 3 to 18 carbon atoms, and hydrocarbyl diaralkylaminoalkyl of 14 to 32 carbon atoms;
- R.sup.1 and R.sup.2, when taken together form a member selected from the group consisting of ##STR46## wherein R.sup.4 is a member selected from the group consisting of alkyl of 1 to 6 carbon atoms, hydrocarbyl aryl of 6 to 10 carbon atoms, hydroxyalkyl of 1 to 6 carbon atoms, hydrocarbyl aralkyl of 7 to 16 carbon atoms and alkoxyalkyl of 2 to 12 carbon atoms;
- R.sup.5 is a member selected from the group consisting of alkylamino of 1 to 6 carbon atoms and piperidino; n is one of the integers 3, 4 or 5; m is one of the integers 1 or 2; r is one of the integers 2 or 3; s is an integer from 0 to 6; t is an integer from 0 to 6; with the proviso that the sum of s and t must be at least 3 and not more than 6;
- R.sup.3 is a member selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, hydrocarbyl aralkyl of 7 to 12 carbon atoms and alkoxy alkyl of 2 to 12 carbon atoms;
- X is a member selected from the group consisting of halogen, cyano, trifluoromethyl, nitro and alkylthio of 1 to 6 carbon atoms;
- Y is a member selected from the group consisting of hydrogen, halogen, trifluoromethyl, nitro and alkylthio of 1 to 6 carbon atoms; and the pharmaceutically acceptable salts thereof.
- 2. A compound as defined in claim 1 which is a hydrochloride salt of 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one, 4-methyl-1-piperazineacetate.
- 3. A compound as defined in claim 1 which is a hydrochloride salt of 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one, 4-methyl-1-piperazineacetate.
- 4. A compound as defined in claim 1 which is a hydrochloride salt of 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one, N-(2-dimethylaminoethyl)-N-methylglycinate.
- 5. A compound as defined in claim 1 which is a hydrochloride salt of 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one, 4-(hydroxyethyl)-1-piperazineacetate.
- 6. A compound as defined in claim 1 which is a methanesulfonate salt of 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one, 4-methyl-1-piperazineacetate.
- 7. A compound as defined in claim 1 which is a methanesulfonate salt of 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one, 4-methyl-1-piperazineacetate.
- 8. A compound as defined in claim 1 which is a maleic acid salt of 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one, 4-methyl-1-piperazineacetate.
- 9. A compound as defined in claim 1 which is a hydrochloride salt of 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one, 4-methyl-1-piperazineacetate.
- 10. A compound as defined in claim 1 which is a methanesulfonate salt of 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one, 4-methyl-1-piperazineacetate.
- 11. A compound as defined in claim 1 which is a hydrochloride salt of 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2H- 1,4-benzodiazepin-2-one, 4-methyl-1-piperazineacetate.
- 12. A compound as defined in claim 1 which is a methanesulfonate salt of 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one, 4-methyl-1-piperazineacetate.
RELATED APPLICATIONS
This application is a continuation-in-part of Ser. No. 129,638 filed Mar. 30, 1971, now abandoned, by Ronald J. McCaully, Abraham Nudelman and Stanley C. Bell.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3296249 |
Bell |
Jan 1967 |
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3391138 |
Archer et al. |
Jul 1968 |
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Non-Patent Literature Citations (1)
Entry |
Bell et al., "J. Med. Chem.", vol. 11, pp. 457-461, (1968). |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
129638 |
Mar 1971 |
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