1,3-oxazin-4-one derivatives, herbicides containing the same, and novel intermediates for preparing the same

Abstract

1,3-Oxazin-4-one derivatives represented by general formula (I) ##STR1## wherein R.sup.1 is a lower alkyl group, a lower alkenyl group, an aryl group which may be substituted, or an aralkyl group which may be substituted;R.sup.2 is a hydrogen atom or a lower alkyl group;R.sup.3 is a lower alkyl group, an aryl group which may be substituted, or an aralkyl group which may be substituted; andR.sup.4 and R.sup.5, independently, each is a lower alkyl group, or R.sup.4 and R.sup.5, taken together with the carbon atom to which they are bonded, combine to form a 3- to 8-membered carbocyclic group which may have a branch of a lower alkyl group. These compounds have broad herbicidal spectra and potent herbicidal activities and in addition high safety to useful crops, so that they are useful as herbicides.

Description

This is a national stage application (37 CFR 1.371) of PCT/JP93/00105, filed Jan. 28, 1993.

TECHNICAL FIELD

This invention relates to novel 1,3-oxazin-4-one derivatives having a tertiary alkyl substituent at the 3-position thereof, method for preparing the same, use thereof as a herbicide, and novel intermediates for preparing the same.

BACKGROUND ART

Certain types of 4H-2,3-dihydro-1,3-oxazin-4-one derivatives are described in, for example, Tetrahedron Lett., (33), 2905 (1976), Heterocycles, 17, 298 (1982), Chem. Pharm. Bull., 35(5), 1871 (1987), etc. and thus they are known.

However, the compounds described in the abovementioned publications differ from the compounds of this invention since none of them has a tertiary alkyl substituent on the 3-position of a 1,3-oxazine ring and no mention is made of their herbicidal activity and plant growth control activity.

U.S. Pat. Nos. 5,006,157 and 5,076,834 disclose 1-(1-methyl-1-phenylethyl)-3-phenyl-1,2,5,6-tetrahydropyridin-2-one derivatives and their use as a herbicide.

DISCLOSURE OF INVENTION

According to this invention, there are provided 1,3-oxazin-4-one derivatives represented by general formula (I) which follows ##STR2## wherein R.sup.1 is a lower alkyl group, a lower alkenyl group, an aryl group which may be substituted, or an aralkyl group which may be substituted;

R.sup.2 is a hydrogen atom or a lower alkyl group;

R.sup.3 is a lower alkyl group, an aryl group which may be substituted, or an aralkyl group which may be substituted; and

R.sup.4 and R.sup.5, independently each is a lower alkyl group , or R.sup.4 and R.sup.5, taken together with the carbon atom to which they are bonded, combine to form a 3- to 8-membered carbocyclic group which may have, as a substituent, a lower alkyl group.

The compounds of general formula (I) above provided by this invention have remarkable selective herbicidal activity, give no phytotoxicity to useful crops, and exhibit excellent herbicidal activity to various weeds at a very low dose, and therefore they are useful as herbicides.

BEST MODE FOR CARRYING OUT THE INVENTION

In the description and claims, the term "lower" means that groups or compounds to which this term is attached have 6 or less carbon atoms, preferably 4 or less carbon atoms.

"Lower alkyl group" may be either straight chained or branched chained, and includes, for example, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, isopentyl, neopentyl, tert-pentyl, n-hexyl, etc. groups.

"Lower alkenyl group" may be either straight chained or branched chained, and includes, for example, allyl, 2-methyl-2-propenyl, 2-butenyl, 3-butenyl, 3-methyl-2-butenyl, etc., groups.

"Lower alkynyl group" may be either straight chained or branched chained, and includes, for example, 2-propynyl, 1-methyl-2-propynyl, 2-butynyl, 3-butynyl, etc., groups.

"Halogen atom" includes four species, i.e., fluorine atom, chlorine atom, bromine and iodine atom.

"Lower alkoxy group" means lower alkyl-O-group of which the lower alkyl moiety has the above-described meaning, and includes, for example, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, n-pentoxy, etc., groups.

"Lower haloalkyl group" means one of which at least one hydrogen atom is substituted by a halogen atom, and includes, for example, trifluoromethoxy, difluoromethoxy, chlorodifluoromethoxy, 2-chloroethoxy, 1,1,2,2-tetrafluoroethoxy, 3-chloropropoxy, 2,2,3,3,3-pentafluoropropoxy, etc., groups.

"Aryl group" may be either monocyclic or polycyclic, and specific examples thereof include phenyl, naphthyl, etc., groups. Substituent group(s) on the ring of the "aryl group which may be substituted" may include halogen atoms, lower alkyl groups, lower alkoxy groups, lower haloalkyl groups, lower haloalkoxy groups, a nitro group, etc. The aryl group may be substituted with at least one, preferably 1 to 4, and more preferably 1 to 3, of the substituent groups. Specific examples of such a substituted group include 2-fluorophenyl, 4-chloro-2-naphthyl, 2-tolyl, 3-tolyl, 3,5-dichloro-4-methylphenyl, 3,5-diisopropylphenyl, 3,5-dichlorophenyl, 3,5-dimethoxyphenyl, 3,5-bis(difluoromethoxy)phenyl, 3-nitrophenyl, 3-(trifluoromethyl)phenyl, 3-(2chloroethyl)phenyl, 3,5-bis(3-bromopropyl)phenyl, 3,5-bis(1,1-dimethylethyl)phenyl, 3,5-diethylphenyl, 3,5dibromophenyl, 3,5-diiodophenyl, 3,4,5-tribromophenyl, 3-chloro-2-fluorophenyl, 3,5-dichloro-2-fluorophenyl, 2,6-difluorophenyl-3-chlorophenyl, 2,6-difluoro-3,5-dichlorophenyl, 2,3,5-trifluorophenyl, 3-fluoro-4-methylphenyl, 3,5-difluoro-4-methylphenyl, 3,5-difluoro-4-methoxyphenyl, 4-methyl- 3,5-bis(trifluoromethyl)phenyl, 4-methoxy-3-(trifluoromethyl)phenyl, etc., groups.

"Aralkyl group" means a lower alkyl group substituted with an aryl group of whose aryl and lower alkyl moieties have the same meanings as defined above, respectively, and include, for example, benzyl, phenethyl, 3-phenylpropyl, 4-phenylbutyl, etc. , groups. "Aralkyl group which may be substituted" means an aryl-substituted lower alkyl group whose aryl moiety is an "aryl group which may be substituted" as described above, and includes, for example, (2-chlorophenyl)methyl, 1-(3-chlorophenyl)ethyl, 1-methyl-1-phenylethyl, 1-methyl-2-phenylethyl, 1-ethyl-2-(3-trifluoromethylphenyl)ethyl, (2-difluoromethoxyphenyl)methyl, etc., groups.

"3- to 8-Membered carbocyclic group which may have, as a substituent a lower alkyl group" includes cycloalkyl groups which may be substituted with one or more lower alkyl groups, for example, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, 2,2-dimethylcyclopropyl, 3,5-diethylcyclohexyl, etc., groups.

Among the compounds represented by formula (I) described above, preferred groups of compounds include those compounds of formula (I) in which

R.sup.1 is a branched chain lower alkyl group (for example, isopropyl, isobutyl, etc., groups) , or a phenyl group which may be substituted with one substituent selected from the group consisting of a halogen atom and a lower alkyl group;

R.sup.2 is a methyl group or an ethyl group;

R.sup.3 is an aryl group which may be substituted with 1 to 3 substituents selected from the group consisting of a halogen atom, a lower alkyl group, a lower haloalkyl group and a lower haloalkoxy group; and

R.sup.4 and R.sup.5 each is a methyl group.

More preferred compounds of formula (I) are compounds of formula (I-1) below ##STR3## wherein R.sup.21 is a methyl group or an ethyl group;

X is a halogen atom or a lower alkyl group;

Y is a halogen atom, a lower haloalkyl group or a lower haloalkoxy group;

m is 0, 1, 2 or 3; and

n is 0or 1.

Specific examples of the compounds of formula (I) above provided by this invention are shown in Tables 1 to 5 hereinbelow. In the tables, abbreviations used have the following meanings.

Me: methyl group; Et: ethyl group; Pr: propyl group iPr: isopropyl group; Bu: n-butyl group; iBu: isobutyl group; sBu: s ec-butyl group; tBu: tert-butyl group; Hex: n-hexyl group; Ph: phenyl group; and -: no substituent. TABLE 1__________________________________________________________________________ ##STR4## MeltingCompound PointNo. (X) n (Y) m R.sup.2 [.degree.C.]__________________________________________________________________________ 1 -- -- Me 94.0-96.0 2 2-F -- Me 91.5-94.0 3 3-F -- Me 45.0-47.0 4 4-F -- Me Oily 5 2-Cl -- Me 114.5-118.0 6 3-Cl -- Me Oily 7 4-Cl -- Me 107.5-112.0 8 2-Br -- Me 9 4-I -- Me 10 2-F, 3-F -- Me 11 2-F, 4-F -- Me 12 2-F, 5-F -- Me 13 2-F, 6-F -- Me 14 3-F, 4-F -- Me 15 3-F, 5-F -- Me 16 2-F, 4-F, 6-F -- Me 17 2-F, 3-F, 4-F, 5-F, 6-F -- Me 18 2-Cl, 4-Cl -- Me 19 3-Cl, 5-Cl -- Me 20 2-Cl, 4-Cl, 6-Cl -- Me 21 2-Cl, 3-Cl, 4-Cl, 5-Cl, 6-Cl -- Me 22 2-Cl, 6-F -- Me 23 2-Me -- Me 95.5-97.0 24 3-Me -- Me 25 4-Me -- Me 26 2-Me, 4-Me -- Me 27 3-Me, 5-Me -- Me 28 2-Me, 4-Me, 6-Me -- Me 29 2-Et -- Me 30 3-Et -- Me 31 4-Et -- Me 32 4-Pr -- Me 33 2-iPr -- Me 34 3-iPr -- Me 35 4-iPr -- Me 36 2-Bu -- Me 37 3-Bu -- Me 38 4-Bu -- Me 39 2-iBu -- Me 40 3-sBu -- Me 41 4-tBu -- Me 42 2-Hex -- Me 43 4-Hex -- Me 44 2-Cl, 3-Me, 4-Cl -- Me 45 2-OMe -- Me Oily 46 3-OMe -- Me 47 4-OMe -- Me 48 2-OMe, 4-OMe -- Me 49 2-OMe, 6-OMe -- Me 50 3-OMe, 5-OMe -- Me 51 3-OMe, 4-OMe, 5-OMe -- Me 52 2-OEt -- Me 53 4-OEt -- Me 54 3-OPr -- Me 55 3-OiPr -- Me 56 2-OBu -- Me 57 4-OBu -- Me 58 2-OiBu -- Me 59 2-OsBu -- Me 60 4-OtBu -- Me 61 4-OHex -- Me 62 2-CF.sub.3 -- Me 106.0-109.0 63 3-CF.sub.3 -- Me Oily 64 4-CF.sub.3 -- Me 65 3-CF.sub.3, 5-CF.sub.3 -- Me 66 2-CH.sub.2 CF.sub.3 -- Me 67 2-CF.sub.2CF.sub.3 -- Me 68 2-NO.sub.2 -- Me 69 3-NO.sub.2 -- Me 70 4-NO.sub.2 -- Me 71 2-NO.sub.2, 4-NO.sub.2 -- Me 72 2-CF.sub.3, 4-NO.sub.2 -- Me 73 -- 3-Cl Me 66.5-68.5 74 2-F 3-Cl Me 68.0-72.0 75 3-F 3-Cl Me 58.5-62.0 76 4-F 3-Cl Me Oily 77 2-Cl 3-Cl Me 123.5-126.0 78 3-Cl 3-Cl Me Oily 79 4-Cl 3-Cl Me Oily 80 2-Br 3-Cl Me 81 3-Br 3-Cl Me 82 4-Br 3-Cl Me 83 2-I 3-Cl Me 84 3-I 3-Cl Me 85 4-I 3-Cl Me 86 2-F, 3-F 3-Cl Me 87 2-F, 4-F 3-Cl Me 88 2-F, 5-F 3-Cl Me 89 2-F, 6-F 3-Cl Me 90 3-F, 4-F 3-Cl Me 91 3-F, 5-F 3-Cl Me 92 2-F, 4-F, 6-F 3-Cl Me 93 2-F, 3-F, 4-F, 5-F, 6-F 3-Cl Me 94 2-Cl, 3-Cl 3-Cl Me 95 2-Cl, 4-Cl 3-Cl Me 96 2-Cl, 5-Cl 3-Cl Me 97 2-Cl, 6-Cl 3-Cl Me 98 3-Cl, 4-Cl 3-Cl Me 99 3-Cl, 5-Cl 3-Cl Me100 2-Cl, 4-Cl, 6-Cl 3-Cl Me101 2-Cl, 3-Cl, 4-Cl, 5-Cl, 6-Cl 3-Cl Me102 2-F, 3-Cl 3-Cl Me103 2-Cl, 6-F 3-Cl Me104 2-Me 3-Cl Me 92.0-96.0105 3-Me 3-Cl Me106 4-Me 3-Cl Me107 2-Me, 3-Me 3-Cl Me108 2-Me, 4-Me 3-Cl Me109 2-Me, 5-Me 3-Cl Me110 2-Me, 6-Me 3-Cl Me111 3-Me, 4-Me 3-Cl Me112 3-Me, 5-Me 3-Cl Me113 2-Me, 4-Me, 6-Me 3-Cl Me114 2-Me, 3-Me, 4-Me, 5-Me, 6-Me 3-Cl Me115 2-Et 3-Cl Me116 3-Et 3-Cl Me117 4-Et 3-Cl Me118 2-Pr 3-Cl Me119 3-Pr 3-Cl Me120 4-Pr 3-Cl Me121 2-iPr 3-Cl Me122 3-iPr 3-Cl Me123 4-iPr 3-Cl Me124 2-Bu 3-Cl Me125 3-Bu 3-Cl Me126 4-Bu 3-Cl Me127 2-iBu 3-Cl Me128 3-sBu 3-Cl Me129 4-tBu 3-Cl Me130 2-Hex 3-Cl Me131 3-Hex 3-Cl Me132 4-Hex 3-Cl Me133 2-F, 3-Me 3-Cl Me134 2-Cl, 3-Me, 4-Cl 3-Cl Me135 2-OMe 3-Cl Me 83.5-88.0136 3-OMe 3-Cl Me137 4-OMe 3-Cl Me138 2-OMe, 4-OMe 3-Cl Me139 2-OMe, 5-OMe 3-Cl Me140 2-OMe, 6-OMe 3-Cl Me141 3-OMe, 5-OMe 3-Cl Me142 3-OMe, 4-OMe, 5-OMe 3-Cl Me143 2-OEt 3-Cl Me144 3-OEt 3-Cl Me145 4-OEt 3-Cl Me146 2-OPr 3-Cl Me147 3-OPr 3-Cl Me148 4-OPr 3-Cl Me149 2-OiPr 3-Cl Me150 3-OiPr 3-Cl Me151 4-OiPr 3-Cl Me152 2-OBu 3-Cl Me153 3-OBu 3-Cl Me154 4-OBu 3-Cl Me155 2-OiBu 3-Cl Me156 3-OsBu 3-Cl Me157 4-OtBu 3-Cl Me158 2-OHex 3-Cl Me159 3-OHex 3-Cl Me160 4-OHex 3-Cl Me161 2-CF.sub.3 3-Cl Me 110.0-113.5162 3-CF.sub.3 3-Cl Me 94.5-98.5163 4-CF.sub.3 3-Cl Me164 3-CF.sub.3, 5-CF.sub.3 3-Cl Me165 2-CH.sub.2 CF.sub.3 3-Cl Me166 2-CF.sub.2 CF.sub.3 3-Cl Me167 2-NO.sub.2 3-Cl Me168 3-NO.sub.2 3-Cl Me169 4-NO.sub.2 3-Cl Me170 2-NO.sub.2, 4-NO.sub.2 3-Cl Me171 2-CF.sub.3, 4-NO.sub.2 3-Cl Me172 -- 2-F Me173 2-F 2-F Me174 2-Cl 2-F Me175 2-Me 2-F Me176 -- 3-F Me 103.5-106.0177 2-F 3-F Me 92.0-94.5178 3-F 3-F Me179 4-F 3-F Me180 2-Cl 3-F Me 138.0-139.5181 3-Cl 3-F Me182 4-Cl 3-F Me183 3-F, 5-F 3-F Me184 2-F, 4-F, 6-F 3-F Me185 2-Cl, 4-Cl 3-F Me186 3-Cl, 5-Cl 3-F Me187 2-Me 3-F Me 119.0-120.5188 3-Me 3-F Me189 4-Me 3-F Me190 2-Me, 4-Me 3-F Me191 3-Me, 5-Me 3-F Me192 2-Me, 4-Me, 6-Me 3-F Me193 4-iPr 3-F Me194 3-Bu 3-F Me195 2-iBu 3-F Me196 3-sBu 3-F Me197 4-tBu 3-F Me198 4-Hex 3-F Me199 2-F, 3-Me 3-F Me200 2-Cl, 3-Me, 4-Cl 3-F Me201 2-OMe 3-F Me202 3-OMe 3-F Me203 4-OMe 3-F Me204 3-OMe, 5-OMe 3-F Me205 3-OMe, 4-OMe, 5-OMe 3-F Me206 2-OEt 3-F Me207 3-OiPr 3-F Me208 2-CF.sub.3 3-F Me 128.0-131.0209 3-CF.sub.3 3-F Me210 4-CF.sub.3 3-F Me211 3-CF.sub.3, 5-CF.sub.3 3-F Me212 2-NO.sub.2 3-F Me213 3-NO.sub.2 3-F Me214 4-NO.sub.2 3-F Me215 2-NO.sub.2, 4-NO.sub.2 3-F Me216 2-CF.sub.3, 4-NO.sub.2 3-F Me217 -- 4-F Me 89.0-93.0218 2-F 4-F Me219 2-Cl 4-F Me220 2-Me 4-F Me221 -- 2-Cl Me 128.0-130.5222 2-F 2-Cl Me223 2-Cl 2-Cl Me224 2-Me 2-Cl Me225 -- 4-Cl Me 73.0-77.0226 2-F 4-Cl Me227 2-Cl 4-Cl Me228 2-Me 4-Cl Me229 -- 2-Br Me230 -- 3-Br Me Oily231 -- 4-Br Me232 2-F 3-Br Me 59.0-66.0233 -- 3-I Me Oily234 -- 4-I Me235 -- 3-Br, 4-OMe, 5-Br Me 163.0-163.5236 2-F 3-Br, 4-OMe, 5-Br Me 167.5-169.5237 -- 2-F, 5-F Me238 -- 2-F, 6-F Me239 -- 3-F, 4-F Me240 -- 3-F, 5-F Me241 -- 2-F, 4-F, 6-F Me242 -- 2-F, 3-F, 4-F, 5-F, 6-F Me243 -- 2-Cl, 3-Cl Me 113.0-116.0244 -- 2-Cl, 4-Cl Me245 -- 2-Cl, 5-Cl Me246 -- 2-Cl, 6-Cl Me247 -- 3-Cl, 4-Cl Me 106.5-109.0248 -- 3-Cl, 5-Cl Me 148.0-150.5249 2-Cl 3-Cl, 5-Cl Me 120.5-122.5250 3-Cl 3-Cl, 5-Cl Me251 4-Cl 3-Cl, 5-Cl Me252 2-Me 3-Cl, 5-Cl Me 109.5-112.5253 2-F 3-Cl, 5-Cl Me 140.0-142.0254 3-F 3-Cl, 5-Cl Me255 -- 2-Cl, 4-Cl, 6-Cl Me256 -- 3-Cl, 4-Cl, 5-Cl Me 162.0-162.5257 2-F 3-Cl, 4-Cl, 5-Cl Me 163.0-163.5258 -- 2-Cl, 3-Cl, 4-Cl, 5-Cl, 6-Cl Me259 -- 2-Me Me260 2-F 2-Me Me261 2-Cl 2-Me Me262 2-Me 2-Me Me263 -- 3-Me Me Oily264 2-F 3-Me Me265 3-F 3-Me Me266 4-F 3-Me Me267 2-Cl 3-Me Me 96.0-98.0268 3-Cl 3-Me Me269 4-Cl 3-Me Me270 3-F, 5-F 3-Me Me271 2-F, 4-F, 6-F 3-Me Me272 2-Cl, 4-Cl 3-Me Me273 3-Cl, 5-Cl 3-Me Me274 2-Me 3-Me Me 74.0-76.5275 3-Me 3-Me Me276 4-Me 3-Me Me277 2-Me, 4-Me 3-Me Me278 3-Me, 5-Me 3-Me Me279 2-OMe 3-Me Me280 3-OMe 3-Me Me281 4-OMe 3-Me Me282 2-CF.sub.3 3-Me Me283 3-CF.sub.3 3-Me Me Oily284 4-CF.sub.3 3-Me Me285 3-CF.sub.3, 5-CF.sub.3 3-Me Me286 4-NO.sub.2 3-Me Me287 -- 4-Me Me288 2-F 4-Me Me289 2-Cl 4-Me Me290 -- 3-Cl, 4-Me Me 86.0-87.5291 -- 2-Me, 3-Me Me292 -- 2-Me, 4-Me Me293 -- 2-Me, 5-Me Me294 -- 2-Me, 6-Me Me295 -- 3-Me, 4-Me Me296 -- 3-Me, 5-Me Me 123.5- 127.0297 -- 2-Me, 4-Me, 6-Me Me298 -- 2-Me, 3-Me, 4-Me, Me 5-Me, 6-Me,299 -- 2-Et Me300 -- 3-Et Me301 -- 4-Et Me302 -- 2-Pr Me303 -- 3-Pr Me304 -- 4-Pr Me305 -- 2-iPr Me306 -- 3-iPr Me307 -- 4-iPr Me308 -- 2-Bu Me309 -- 3-Bu Me310 -- 4-Bu Me311 -- 2-iBu Me312 -- 3-sBu Me313 -- 4-tBu Me314 -- 2-Hex Me315 -- 3-Hex Me316 -- 4-Hex Me317 -- 2-F, 3-Me Me318 -- 2-Cl, 3-Me, 4-Cl Me319 -- 2-OMe Me320 2-F 2-OMe Me321 -- 3-Cl, 4-OMe, 5-Cl Me 149.5-151.5322 2-F 3-Cl, 4-OMe, 5-Cl Me 149.0-152.5323 -- 3-OMe Me Oily324 2-F 3-OMe Me Oily325 2-Cl 3-OMe Me Oily326 2-Me 3-OMe Me327 -- 4-OMe Me328 2-F 4-OMe Me329 2-Cl 4-OMe Me330 -- 3-Cl, 4-OMe Me Oily331 -- 2-OMe, 4-OMe Me332 -- 2-OMe, 5-OMe Me333 -- 2-OMe, 6-OMe Me334 -- 3-OMe, 5-OMe Me335 -- 3-OMe, 4-OMe, 5-OMe Me336 -- 2-OEt Me337 -- 3-OEt Me338 -- 4-OEt Me339 -- 2-OPr Me340 -- 3-OPr Me341 -- 4-OPr Me342 -- 2-OiPr Me343 -- 3-OiPr Me244 -- 4-OiPr Me345 -- 2-OBu Me346 -- 3-OBu Me347 -- 4-OBu Me348 -- 2-OiBu Me349 -- 3-OsBu Me350 -- 4-OtBu Me351 -- 2-OHex Me352 -- 3-OHex Me353 -- 4-OHex Me354 -- 2-CF.sub.3 Me355 2-F 2-CF.sub.3 Me356 2-Cl 2-CF.sub.3 Me357 2-Me 2-CF.sub.3 Me358 -- 3-CF.sub.3 Me 67.5-72.0359 2-F 3-CF.sub.3 Me 71.5-76.0360 2-Cl 3-CF.sub.3 Me Oily361 3-Cl 3-CF.sub.3 Me362 4-Cl 3-CF.sub.3 Me363 2-Me 3-CF.sub.3 Me 75.0-78.0364 3-Me 3-CF.sub.3 Me365 3-CF.sub.3 3-CF.sub.3 Me Oily366 -- 4-CF.sub.3 Me367 2-F 4-CF.sub.3 Me368 2-Cl 4-CF.sub.3 Me369 2-Me 4-CF.sub.3 Me370 -- 3-CF.sub.3, 5-CF.sub.3 Me 122.0-123.0371 -- 2-CH.sub.2 CF.sub.3 Me372 -- 2-CF.sub.2 CF.sub.3 Me373 -- 2-OCHF.sub.2 Me374 -- 3-OCHF.sub.2 Me Oily375 2-F 3-OCHF.sub.2 Me 69.0-73.5376 2-Cl 3-OCHF.sub.2 Me Oily377 3-Cl 3-OCHF.sub.2 Me378 4-Cl 3-OCHF.sub.2 Me379 2-Me 3-OCHF.sub.2 Me380 3-Me 3-OCHF.sub.2 Me381 4-Me 3-OCHF.sub.2 Me382 -- 4-OCHF.sub.2 Me383 -- 3-OCH.sub.2 CF.sub.2 CF.sub.3 Me384 -- 3-OCH.sub.2 CH.sub.2 Cl Me385 -- 3-OCF.sub.2 CHCl.sub.2 Me386 -- 3-OCF.sub.2 CHF.sub.2 Me387 -- 3-OCF.sub.2 CH.sub.2 Cl Me388 -- -- H Oily389 2-F -- H390 2-Cl -- H391 2-Me -- H392 -- 3-Cl H Oily393 2-F 3-Cl H394 2-Cl 3-Cl H395 2-Me 3-Cl H396 -- 3-Me H397 2-F 3-Me H398 -- 3-CF.sub.3 H399 2-F 3-CF.sub.3 H400 -- 3-OCHF.sub.2 H401 -- 3-Cl, 5-Cl H402 -- -- Et 49.0-51.0403 -- 3-Cl Et Oily404 2-F 3-Cl Et405 2-Cl 3-Cl Et406 2-Me 3-Cl Et407 -- 3-Me Et408 2-F 3-Me Et409 2-Cl 3-Me Et410 2-Me 3-Me Et411 -- 3-CF.sub.3 Et412 2-F 3-CF.sub.3 Et413 2-Cl 3-CF.sub.3 Et414 2-Me 3-CF.sub.3 Et415 -- 3-OCHF.sub.2 Et416 2-F 3-OCHF.sub.2 Et417 2-Cl 3-OCHF.sub.2 Et418 -- 3-Br, 4-OMe, 5-Br Et 154.5-155.5419 -- 3-Cl, 5-Cl Et420 2-F 3-Cl, 5-Cl Et421 -- -- Pr Oily422 -- 3-Cl Pr Oily423 2-F 3-Cl Pr424 2-Cl 3-Cl Pr425 2-Me 3-Cl Pr426 -- 3-Me Pr427 2-F 3-Me Pr428 2-Cl 3-Me Pr429 2-Me 3-Me Pr430 -- 3-CF.sub.3 Pr431 2-F 3-CF.sub.3 Pr432 2-Cl 3-CF.sub.3 Pr433 2-Me 3-CF.sub.3 Pr434 -- 3-OCHF.sub.2 Pr435 2-F 3-OCHF.sub.2 Pr436 2-Cl 3-OCHF.sub.2 Pr437 2-Me 3-OCHF.sub.2 Pr438 -- 3-Cl, 5-Cl Pr439 2-F 3-Cl, 5-Cl Pr440 -- -- iPr Oily441 -- 3-Cl ipr442 2-F 3-Cl iPr443 2-Cl 3-Cl iPr444 2-Me 3-Cl iPr445 -- 3-Me iPr446 2-F 3-Me iPr447 2-Cl 3-Me iPr448 2-Me 3-Me iPr449 -- 3-CF.sub.3 iPr450 2-F 3-CF.sub.3 iPr451 2-Cl 3-CF.sub.3 iPr452 2-Me 3-CF.sub.3 iPr453 -- 3-OCHF.sub.2 iPr454 2-F 3-OCHF.sub.2 iPr455 2-Cl 3-OCHF.sub.2 iPr456 2-Me 3-OCHF.sub.2 iPr457 -- 3-Cl, 5-Cl iPr458 2-F 3-Cl, 5-Cl iPr459 -- -- Bu460 -- 3-Cl Bu461 2-F 3-Cl Bu462 2-Cl 3-Cl Bu463 2-Me 3-Cl Bu464 -- 3-Me Bu465 2-F 3-Me Bu466 2-Cl 3-Me Bu467 2-Me 3-Me Bu468 -- 3-CF.sub.3 Bu469 2-F 3-CF.sub.3 Bu470 2-Cl 3-CF.sub.3 Bu471 2-Me 3-CF.sub.3 Bu472 -- 3-OCHF.sub.2 Bu473 2-F 3-OCHF.sub.2 Bu474 2-Cl 3-OCHF.sub.2 Bu475 2-Me 3-OCHF.sub.2 Bu476 -- 3-Cl, 5-Cl Bu477 2-F 3-Cl, 5-Cl Bu478 -- -- .sup.n C.sub.5 H.sub.11479 -- 3-Cl .sup.n C.sub.5 H.sub.11480 2-F 3-Cl .sup.n C.sub.5 H.sub.11481 -- 3-CF.sub.3 .sup.n C.sub.5 H.sub.11482 2-F 3-CF.sub.3 .sup.n C.sub.5 H.sub.11483 -- 3-Me .sup.n C.sub.5 H.sub.11484 2-F 3-Me .sup.n C.sub.5 H.sub.11485 -- 3-OCHF.sub.2 .sup.n C.sub.5 H.sub.11486 2-F 3-OCHF.sub.2 .sup.n C.sub.5 H.sub.11487 -- 3-Cl, 5-Cl .sup.n C.sub.5 H.sub.11488 -- 3-Cl iBu489 -- 3-CF.sub.3 iBu490 -- 3-OCHF.sub.2 iBu491 -- 3-Cl, 5-Cl iBu492 -- 3-Cl sBu493 -- 3-CF.sub.3 sBu494 -- 3-OCHF.sub.2 sBu495 -- 3-Cl tBu496 -- 3-Cl Hex497 -- 3-CF.sub.3 Hex498 -- 3-OCHF.sub.2 Hex499 -- 3-Cl, 5-Cl Hex__________________________________________________________________________ TABLE 2__________________________________________________________________________ ##STR5##Compound MeltingNo. R.sup.1 Y R.sup.2 Point [.degree.C.]__________________________________________________________________________500 Me -- Me501 Et -- Me502 Pr -- Me503 iPr -- Me504 Bu -- Me505 iBu -- Me 63.0-67.0506 sBu -- Me507 tBu -- Me508 Hex -- Me509 Me 3-Cl Me510 Et 3-Cl Me511 Pr 3-Cl Me512 iPr 3-Cl Me513 Bu 3-Cl Me514 iBu 3-Cl Me 70.5-74.0515 sBu 3-Cl Me516 tBu 3-Cl Me517 Hex 3-Cl Me518 iPr 3-F Me519 iBu 3-F Me520 sBu 3-F Me521 tBu 3-F Me522 iPr 3-OCHF.sub.2 Me523 iBu 3-OCHF.sub.2 Me524 sBu 3-OCHF.sub.2 Me525 tBu 3-OCHF.sub.2 Me526 iPr 3-Cl H527 iBu 3-Cl H528 sBu 3-Cl H529 tBu 3-Cl H530 iPr 3-Cl Et531 iBu 3-Cl Et532 sBu 3-Cl Et533 tBu 3-Cl Et534 iBu 3-Cl iPr535 iBu 3-Cl iPr536 iBu 3-Cl Bu537 iBu 3-Cl iBu538 iBu 3-Cl sBu539 iBu 3-Cl tBu540 iBu 3-Cl Hex541 CH.sub.2CH -- Me542 CH.sub.2 CH 3-Cl Me543 CH.sub.2CH 3-Cl, 5-Cl Me544 CH.sub.3CHCH -- Me545 CH.sub.3CHCH 3-Cl Me546 CH.sub.3CHCH 3-Cl, 5-Cl Me547 CH.sub.2C(CH.sub.3) -- Me548 CH.sub.2C(CH.sub.3) 3-Cl Me549 CH.sub.2C(CH.sub.3) 3-Cl, 5-Cl Me550 CH.sub.2 CHCHCH -- Me551 CH.sub.2CHCHCH 3-Cl Me552 CH.sub.2 CHCHCH 3-Cl, 5-Cl Me553 CH.sub.3CHCHCHCH -- Me554 CH.sub.3CHCHCHCH 3-Cl Me555 CH.sub.3CHCHCHCH 3-Cl, 5-Cl Me556 (CH.sub.3).sub.2 CCH -- Me557 (CH.sub.3).sub.2 CCH 3-Cl Me558 (CH.sub.3).sub.2 CCH 3-Cl, 5-Cl Me559 CH.sub.2CHCH.sub.2 -- Me560 CH.sub.2CHCH.sub.2 3-Cl Me561 CH.sub.2CHCH.sub.2 3-Cl, 5-Cl Me562 CH.sub.2C(CH.sub.3)CH.sub.2 -- Me563 CH.sub.2C(CH.sub.3)CH.sub.2 3-Cl Me564 CH.sub.2C(CH.sub.3)CH.sub.2 3-Cl, 5-Cl Me565 HC C -- Me566 HCC 3-Cl Me567 HCC 3-Cl, 5-Cl Me 122.0-127.0568 CH.sub.3CC -- Me569 CH.sub.3CC 3-Cl Me570 CH.sub.3CC 3-Cl, 5-Cl Me571 HCCCH.sub.2 -- Me572 HCCCH.sub.2 3-Cl Me573 HCCCH.sub.2 3-Cl, 5-Cl Me574 HCCCH(CH.sub.3) -- Me575 HCCCH(CH.sub.3) 3-Cl Me576 HC CCH(CH.sub.3) 3-Cl, 5-Cl Me__________________________________________________________________________ TABLE 3______________________________________ ##STR6##Com-pound MeltingNo. R.sup.1 R.sup.3 R.sup.2 Point [.degree.C.]______________________________________600 ##STR7## Ph Me601 ##STR8## ##STR9## Me602 ##STR10## Ph Me603 ##STR11## ##STR12## Me604 ##STR13## ##STR14## Me605 ##STR15## ##STR16## Me606 Ph ##STR17## Me 77.0-81.0607 ##STR18## ##STR19## Me608 Ph ##STR20## Me609 ##STR21## ##STR22## Me610 Ph ##STR23## Me611 ##STR24## ##STR25## Me612 Ph ##STR26## H613 ##STR27## Ph Me614 ##STR28## ##STR29## Me615 ##STR30## ##STR31## Me616 ##STR32## ##STR33## Me617 ##STR34## ##STR35## Me618 ##STR36## ##STR37## Me619 ##STR38## ##STR39## Me620 ##STR40## ##STR41## Me621 ##STR42## Ph Me622 ##STR43## ##STR44## Me623 ##STR45## ##STR46## Me624 ##STR47## ##STR48## Me625 ##STR49## ##STR50## Me626 ##STR51## ##STR52## Me627 ##STR53## ##STR54## Me628 ##STR55## ##STR56## Me629 ##STR57## ##STR58## Me630 ##STR59## ##STR60## Me650 Ph Me H651 Ph Et H652 Ph Pr H653 Ph iPr H654 Ph Bu H655 Ph iBu H656 Ph sBu H657 Ph tBu H658 Ph Hex H659 Ph Me Me660 Ph Et Me661 Ph Pr Me662 Ph iPr Me663 Ph Bu Me664 Ph iBu Me665 Ph sBu Me666 Ph tBu Me 68.0-73.0667 Ph Hex Me668 Ph Me Et669 Ph Et Et670 Ph Pr Et671 Ph iPr Et672 Ph Bu Et673 Ph iBu Et674 Ph sBu Et675 Ph tBu Et676 Ph Hex Et700 Ph CH.sub.2 Ph Me Oily701 Ph ##STR61## Me702 Ph ##STR62## Me703 Ph ##STR63## Me704 Ph ##STR64## Me705 Ph ##STR65## Me706 Ph ##STR66## Me707 Ph ##STR67## Me708 Ph ##STR68## Me709 Ph ##STR69## Me710 Ph ##STR70## Me711 Ph ##STR71## Me712 Ph ##STR72## Me713 Ph ##STR73## Me714 Ph ##STR74## Me715 Ph ##STR75## Me716 Ph ##STR76## Me717 Ph ##STR77## Me718 Ph ##STR78## Me______________________________________ TABLE 6______________________________________ ##STR79##Compound MeltingNo. R.sup.4 R.sup.5 Y R.sup.2 Point [.degree.C.]______________________________________800 Et Me -- Me801 Et Me 3-Cl Me 71.0-74.0802 Et Me 3-Cl, 5-Cl Me803 Et Me 3-CF.sub.3 Me804 Et Me 3-OCHF.sub.2 Me805 Et Me 3-Cl, 5-Cl H806 Et Me -- Et807 Et Me 3-Cl Et808 Et Me 3-Cl, 5-Cl Et809 Pr Me -- Me810 Pr Me 3-Cl Me811 Pr Me 3-Cl, 5-Cl Me812 iPr Me -- Me813 iPr Me 3-Cl Me814 iPr Me 3-Cl, 5-Cl Me815 Bu Me -- Me816 iBu Me 3-Cl Me817 sBu Me 3-Cl, 5-Cl Me818 tBu Me -- Me 68.0-72.0819 tBu Me 3-Cl Me820 tBu Me 3-Cl, 5-Cl Me821 Hex Me -- Me822 Hex Me 3-Cl Me823 Hex Me 3-Cl, 5-Cl Me824 Et Et -- Me825 Et Et 3-Cl Me826 Et Et 3-Cl, 5-Cl Me827 Pr Et -- Me828 Pr Et 3-Cl Me829 Pr Et 3-Cl, 5-Cl Me830 iPr Et -- Me831 iBu Et 3-Cl Me832 sBu Et 3-Cl, 5-Cl Me833 tBu Et 3-Cl Me834 Pr Pr 3-Cl Me835 iPr Pr 3-Cl Me836 iBu Pr 3-Cl Me837 iBu Bu 3-Cl Me838 sBu Bu 3-Cl Me839 tBu Bu 3-Cl Me840 iBu iBu 3-Cl Me841 tBu iBu -- Me842 sBu Hex 3-Cl Me843 tBu Hex 3-Cl, 5-Cl Me844 Hex Hex -- Me______________________________________ TABLE 5______________________________________ ##STR80##Compound MeltingNo. n Y Point [.degree.C.]______________________________________850 0 --851 0 3-Cl852 0 3-Cl, 5-Cl853 1 --854 1 3-Cl855 1 3-Cl, 5-Cl856 2 --857 2 3-Cl 70.5-73.5858 2 3-Cl, 5-Cl859 3 --860 3 3-Cl 123.0-129.0861 3 3-Cl, 5-Cl862 4 --863 4 3-Cl864 4 3-Cl, 5-Cl865 5 --866 5 3-Cl867 5 3-Cl, 5-Cl______________________________________

According to this invention, the compounds of formula (I) above can be produced, for example, by reacting compounds of general formula (II) below ##STR81## wherein R.sup.1 and R.sup.2 are as defined above, with compounds of general formula (III) below ##STR82## wherein R.sup.3, R.sup.4 and R.sup.5 are as defined above.

The reaction between the compounds of formula (II) above and the compounds of formula (III) above can be carried out in a suitable solvent or without solvent at a reaction temperature which is usually between about 90.degree. C. and about 160.degree. C., or the boiling point of the solvent used. As the solvent, there is no limitation thereon and any one may be used so far as it is substantially inert. However, it is preferred from the viewpoint of reaction temperature to use organic solvents having high boiling points not lower than 90.degree. C., such as toluene, xylene and mesitylene. Reaction time may vary depending on other reaction conditions used but generally the reaction may be completed in 1 to 120 minutes.

Further, there is no strict limitation for the proportions of the compounds of formula (III) to the compounds of formula (II), and it is convenient to use the compounds of formula (III) in an amount within the range of usually 0.5 to 2 moles, and particularly 0.9 to 1.1 moles, per mole of the compounds of formula (II).

Separation and purification of the compounds of formula (I) produced may be carried out by methods known per se, such as recrystallization, extraction and chromatography.

Among the compounds of formula (II) above used as starting materials in the above-described reaction, 1,3-dioxin-4-one derivatives represented by general formula (II-1) below ##STR83## wherein R.sup.2 is as defined above; and

R.sup.6 is a substituted aryl group are not described in prior art references and are novel compounds.

As the substituted aryl group (R.sup.6) in formula (II-1) above, preferred is a phenyl group substituted with one or two substituent groups selected from the group consisting of a halogen atom, a lower alkyl group, a lower alkoxy group, a lower haloalkyl group and a nitro group.

The compounds of formula (II-1) can be produced by a method known per se, for example, the method described in Chem. Pharm. Bull., 31(6), 1895-1901 (1983).

More specifically, the compounds of formula (II-1) can be produced, for example, by reacting compounds of formula (IV) with acetone in acetic anhydride in the presence of a small amount of sulfuric acid as a catalyst in accordance with Reaction Scheme A below: ##STR84## wherein R.sup.2 and R.sup.6 are as defined above, and

A is a hydrogen atom or a group releasable under acidic conditions, for example, a tert-butyl group. Reaction temperature is desirably within the range of from -25.degree. C. to around room temperature. The reaction temperature may vary depending on other reaction conditions, and the reaction may be completed usually in about 1 to 100 hours. Proportion of acetone used to the compounds of formula (IV) may be within the range of 1 to moles, and particularly 1.5 to 3 moles, per mole of the compounds of formula (IV). The compounds of formula (II-1) can be separated from the reaction mixture by conventional methods and readily purified by recrystallization, column chromatography and the like.

The compounds of formula (IV) used as starting materials in the above-described reaction can be produced by methods known per se or methods similar thereto.

Among the compounds of formula (III) used as starting materials for the production of the compounds of formula (I) above, N-methylene-1-methyl-1-phenylethylamine derivatives represented by general formula (III-1) ##STR85## wherein R.sup.7 is a substituted aryl group are not described in prior art literature and novel compounds.

As the substituted aryl group (R.sup.7) in formula (III-1) above, preferred is a phenyl group substituted with 1 to 3 substituent groups selected from the group consisting of a halogen atom, a lower alkyl group, a lower alkoxy group, a lower haloalkyl group and a lower haloalkoxy group, particularly a phenyl group substituted with a halogen atom or a lower haloalkoxy group.

The compounds of formula (III-1) can be produced by methods known per se, for example, the method described in U.S. Pat. No. 2,582,128.

More specifically, the compounds of formula (III-1) can be produced by dropwise adding the compounds of formula (IV) in formalin according to Reaction Scheme B below: ##STR86## wherein R.sup.7 is as defined above. Reaction temperature is desirably room temperature. Reaction time may vary depending on other reaction conditions and the reaction is completed usually in about 0.1 to 10 hours. The products of formula (III-1) can be separated from the reaction mixtures by conventional methods and readily purified by recrystallization, distillation, column chromatography, etc.

It has revealed that the compounds of formula (V) used as starting materials in the production of the compounds of formula (I) mostly are in equilibrium states with trimers represented by formula below at around room temperature and sometimes exist as mixtures therewith, or can exist in some cases as trimers alone. ##STR87##

Therefore, although the compounds of formula (III) and the compounds of formula (III-1) include not only monomers but also mixtures of the above-described trimers and the monomers, they are represented herein by the structures and names of the monomers for simplification.

Specific examples of the compounds of formula (II-1) and of the novel intermediate compounds of formula (III-1) are as shown in Tables 6 and 7 below. In the tables, abbreviations have the same meanings as above.

TABLE 4______________________________________ ##STR88##Compound MeltingNo. X R.sup.2 Point [.degree.C.]______________________________________ 2-1 2-F Me 65.5-69.5 2-2 3-F Me Oily 2-3 4-F Me 78.0-81.5 2-4 2-Cl Me 58.0-61.5 2-5 3-Cl Me Oily 2-6 4-Cl Me 69.0-73.0 2-7 2-Br Me 2-8 4-I Me 2-9 2-F, 3-F Me 2-10 2-F, 4-F Me 2-11 2-F, 5-F Me 2-12 2-F, 6-F Me 2-13 3-F, 4-F Me 2-14 3-F, 5-F Me 2-15 2-F, 4-F, 6-F Me 2-16 2-F, 3-F, 4-F, 5-F, 6-F Me 2-17 2-Cl, 4-Cl Me 2-18 3-Cl, 5-Cl Me 2-19 2-Cl, 4-Cl, 6-Cl Me 2-20 2-Cl, 3-Cl, 4-Cl, 5-Cl, 6-Cl Me 2-21 2-Cl, 6-F Me 2-22 2-Me Me 73.0-78.0 2-23 3-Me Me 2-24 4-Me Me 2-25 2-Me, 4-Me Me 2-26 3-Me, 5-Me Me 2-27 2-Me, 4-Me, 6-Me Me 2-28 2-Et Me 2-29 3-Et Me 2-30 4-Et Me 2-31 4-Pr Me 2-32 2-iPr Me 2-33 3-iPr Me 2-34 4-iPr Me 2-35 2-Bu Me 2-36 3-Bu Me 2-37 4-Bu Me 2-38 2-iBu Me 2-39 3-sBu Me 2-40 4-tBu Me 2-41 2-Hex Me 2-42 4-Hex Me 2-43 2-Cl, 3-Me, 4-Cl Me 2-44 2-OMe Me 58.0-62.5 2-45 3-OMe Me 2-46 4-OMe Me 2-47 2-OMe, 4-OMe Me 2-48 2-OMe, 6-OMe Me 2-49 3-OMe, 5-OMe Me 2-50 3-OMe, 4-OMe, 5-OMe Me 2-51 2-OEt Me 2-52 4-OEt Me 2-53 3-OPr Me 2-54 3-OiPr Me 2-55 2-OBu Me 2-56 4-OBu Me 2-57 2-OiBu Me 2-58 3-OsBu Me 2-59 4-OtBu Me 2-60 4-OHex Me 2-61 2-CF.sub.3 Me 104.0-108.0 2-62 3-CF.sub.3 Me Oily 2-63 4-CF.sub.3 Me 2-64 3-CF.sub.3, 5-CF.sub.3 Me 2-65 2-CH.sub.2 CF.sub.3 Me 2-66 2-CF.sub.2 CF.sub.3 Me 2-67 2-NO.sub.2 Me 2-68 3-NO.sub.2 Me 2-69 4-NO.sub.2 Me 2-70 2-NO.sub.2, 4-NO.sub.2 Me 2-71 2-CF.sub.3, 4-NO.sub.2 Me 2-72 2-F H 2-73 3-F H 2-74 4-F H 2-75 2-Cl H 2-76 3-Cl H 2-77 4-Cl H 2-78 3-F, 5-F H 2-79 2-F, 4-F, 6-F H 2-80 2-Cl, 4-Cl H 2-81 3-Cl, 5-Cl H 2-82 2-Me H 2-83 3-Me H 2-84 4-Me H 2-85 2-Me, 4-Me H 2-86 3-Me, 5-Me H 2-87 2-Me, 4-Me, 6-Me H 2-88 4-iPr H 2-89 3-Bu H 2-90 2-iBu H 2-91 3-sBu H 2-92 4-tBu H 2-93 4-Hex H 2-94 2-F, 3-Me H 2-95 2-Cl, 3-Me, 4-Cl H 2-96 2-OMe H 2-97 3-OMe H 2-98 4-OMe H 2-99 3-OMe, 5-OMe H2-100 3-OMe, 4-OMe, 5-OMe H2-101 2-OEt H2-102 3-OiPr H2-103 2-CF.sub.3 H2-104 3-CF.sub.3 H2-105 4-CF.sub.3 H2-106 3-CF.sub.3, 5-CF.sub.3 H2-107 2-NO.sub.2 H2-108 3-NO.sub.2 H2-109 4-NO.sub.2 H2-110 2-NO.sub.2, 4-NO.sub.2 H2-111 2-CF.sub.3, 4-NO.sub.2 H2-112 2-F Et2-113 3-F Et2-114 4-F Et2-115 2-Cl Et2-116 3-Cl Et2-117 4-Cl Et2-118 3-F, 5-F Et2-119 2-F, 4-F, 6-F Et2-120 2-Cl, 4-Cl Et2-121 3-Cl, 5-Cl Et2-122 2-Me Et2-123 3-Me Et2-124 4-Me Et2-125 2-Me, 4-Me Et2-126 3-Me, 5-Me Et2-127 2-OMe Et2-128 3-OMe Et2-129 4-OMe Et2-130 2-CF.sub.3 Et2-131 3-CF.sub.3 Et2-132 4-CF.sub.3 Et2-133 3-CF.sub.3, 5-CF.sub.3 Et2-134 4-NO.sub.2 Et2-135 2-F Pr2-136 3-F Pr2-137 2-Cl Pr2-138 2-F iPr2-139 3-F iPr2-140 2-Cl iPr2-141 2-F Bu2-142 3-F Bu2-143 2-Cl Bu2-144 2-F iBu2-145 3-F sBu2-146 2-Cl tBu2-147 2-F Hex2-148 3-F Hex2-149 2-Cl Hex______________________________________ TABLE 7______________________________________ ##STR89##Compound MeltingNo. X Point [.degree.C.]______________________________________3-1 2-F3-2 3-F 69.0-74.03-3 4-F 155.5-160.53-4 2-Cl Oily3-5 3-Cl Oily3-6 4-Cl 90.0-102.03-7 2-Br3-8 3-Br Oily3-9 4-Br3-10 2-I3-11 3-I Oily3-12 4-I3-13 2-F, 3-F3-14 2-F, 4-F3-15 2-F, 5-F3-16 2-F, 6-F3-17 3-F, 4-F3-18 3-F, 5-F3-19 2-F, 4-F, 6-F3-20 2-F, 3-F, 4-F, 5-F, 6-F3-21 2-Cl, 3-Cl 89.5-94.03-22 2-Cl, 4-Cl3-23 2-Cl, 5-Cl3-24 2-Cl, 6-Cl3-25 3-Cl, 4-Cl 150.0-152.53-26 3-Cl, 5-Cl 44.0-47.53-27 2-Cl, 4-Cl, 6-Cl3-28 3-Cl, 4-Cl, 5-Cl 159.5-161.53-29 2-Cl, 3-Cl, 4-Cl, 5-Cl, 6-Cl3-30 2-Cl, 6-F3-31 2-Me3-32 3-Me Oily3-33 4-Me3-34 2-Me, 3-Me3-35 3-Me, 4-Me3-36 3-Me, 5-Me 128.5-134.03-37 2-Me, 4-Me, 6-Me3-38 3-Me, 4-Me, 5-Me3-39 2-Me, 3-Me, 4-Me, 5-Me, 6-Me3-40 3-Cl, 4-Me Oily3-41 3-Cl, 4-Me, 5-Cl3-42 2-Et3-43 3-Et3-44 4-Et3-45 2-Pr3-46 3-Pr3-47 4-Pr3-48 2-iPr3-49 3-iPr3-50 4-iPr3-51 2-Bu3-52 3-Bu3-53 4-Bu3-54 2-iBu3-55 3-sBu3-56 4-tBu3-57 3-Hex3-58 2-OMe3-59 3-OMe Oily3-60 4-OMe3-61 3-OMe, 4-OMe3-62 3-OMe, 5-OMe3-63 3-OMe, 4-OMe, 5-OMe3-64 3-OMe, 4-Me3-65 3-Cl, 4-OMe Oily3-66 3-Br, 4-OMe3-67 3-I, 4-OMe3-68 3-Cl, 4-OMe, 5-Cl 132.0-136.53-69 3-Br, 4-OMe, 4-Br 102.5-108.03-70 2-OEt3-71 3-OEt3-72 4-OEt3-73 2-OPr3-74 3-OPr3-75 4-OPr3-76 2-OiPr3-77 3-OiPr3-78 4-OiPr3-79 2-OBu3-80 3-OBu3-81 4-OBu3-82 2-OiBu3-83 3-OsBu3-84 4-OtBu3-85 2-OHex3-86 3-OHex3-87 4-OHex3-88 2-CF.sub.33-89 3-CF.sub.3 Oily3-90 4-CF.sub.33-91 3-CF.sub.3, 5-CF.sub.3 Oily3-92 2-CH.sub.2 CF.sub.33-93 2-CF.sub.2 CF.sub.33-94 2-OCHF.sub.23-95 3-OCHF.sub.2 Oily3-96 4-OCHF.sub.23-97 3-OCH.sub.2 CF.sub.2 CF.sub.33-98 3-OCH.sub.2 CH.sub.2 Cl3-99 3-OCF.sub.2 CHCl.sub.2 3-100 3-OCF.sub.2 CHF.sub.2 3-101 3-OCF.sub.2 CH.sub.2 Cl______________________________________

Next, production of the compounds of formula (I) and the intermediate compounds of formulae (II-1) and (III-1) will be described in more detail by examples.

EXAMPLE 1

Production of 5-(2-fluorophenyl)-2,2,6-trimethyl-2H,4H-1,3-dioxin-4-one (Compound No. 2-1)

A mixture of 2-(2-fluorophenyl)acetoacetic acid (5.1 g), acetone (4.2 ml), and acetic anhydride (5.4 ml) was kept at -20.degree. C. and concentrated sulfuric acid (0.3 ml) was added thereto. This was kept at -15.degree. C. and the reaction was carried out for 48 hours. The reaction mixture was added to an aqueous 10 % sodium carbonate solution (150 ml) which was ice-cooled, and the mixture was stirred for a short time at room temperature. White crystals which formed were collected by filtration, and washed well with water and then with hexane. The crystals obtained were dried well under reduced pressure to obtain the captioned compound (5.2 g).

EXAMPLE 2

Production of 5-(2-Chlorophenyl)2,2,6-trimethyl-2H,4H-1,3-dioxin-4-one (Compound No. 2-4)

A mixture of 2-(2-chlorophenyl)acetoacetic acid (9.6 g), acetone (6.8 ml), and acetic anhydride (8.8 ml) was kept at -15.degree. and concentrated sulfuric acid (0.53 ml) was added thereto. This was kept at -15.degree. C. and the reaction was carried out for 24 hours. The reaction mixture was added to an aqueous 10 % sodium carbonate solution (250 ml) which was ice-cooled, and the mixture was stirred for a short time at room temperature. White crystals which formed were collected by filtration, and washed well with water and then with hexane. The crystals obtained were dried well under reduced pressure to obtain the captioned compound (9.0 g).

Melting points of the substances produced according to Examples 1 and 2 and of substances produced by similar methods are shown in Table 6 above, and .sup.1 H-NMR peak values are shown in Table 8 below.

TABLE 8__________________________________________________________________________CompoundNo. NMR .delta. [ppm.] (300 MHz) Solvent CDCl.sub.3, TMS = 0__________________________________________________________________________ ppm2-1 1.79(s, 6H), 1.91(s, 3H), 7.06-7.21(m, 2H), 7.28-7.38(m, 2H)2-2 1.77(s, 6H), 1.96(s, 3H), 6.89-7.07(m, 3H), 7.28-7.39(m, 1H)2-3 1.77(s, 6H), 1.94(s, 3H), 7.04-7.12(m, 2H), 7.21-7.29(m, 2H)2-4 1.78(s, 3H), 1.86(s, 3H), 1.87(s, 3H), 7.22-7.48(m, 4H)2-5 1.77(s, 6H), 1.96(s, 3H), 7.14-7.35(m, 4H)2-6 1.77(s, 6H), 1.95(s, 3H), 7.21(d, 2H), 7.35(d, 2H) 2-22 1.79(s, 3H), 1.81(s, 3H), 1.81(s, 3H), 2.24(s, 3H), 7.08-7.29(m, 4H) 2-44 1.76(s, 3H), 1.83(s, 3H), 1.84(s, 3H), 3.80(s, 3H), 6.88-7.36(m, 4H) 2-61 1.76(s, 3H), 1.77(s, 3H), 1.83(s, 3H), 7.28-7.34(m, 1H), 7.45-7.65(m, 2H), 7.71-7.78(m, 1H) 2-62 1.79(s, 6H), 1.96(s, 3H), 7.36-7.62(m, 4H)__________________________________________________________________________

EXAMPLE 3

Production of N-methylene-1-methyl-1-(3chlorophenyl)ethylamine (Compound No. 3-5)

1-Methyl-1-(3-chlorophenyl)ethylamine (5.0 g) was added slowly to formalin (aqueous 37% HCHO solution) (3.5 g) at room temperature. This was allowed to react as it was for 1 hour. A saturated aqueous sodium hydrogen carbonate solution was added to the reaction mixture, which was then extracted with ether. After it was washed with saturated saline, the organic layer was dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain the captioned compound (5.6 g) as syrup.

EXAMPLE 4

Production of N-methylene-1-methyl-1-(3,5-dichlorophenyl)ethylamine (Compound No. 3-26)

1-Methyl-1-(3,5-dichlorophenyl)ethylamine (7.5 g) was added slowly to formalin (aqueous 37% HCHO solution) (4.6 g) at room temperature. This was allowed to react as it was for 7 hours. A saturated aqueous sodium hydrogen carbonate solution was added to the reaction mixture, which was then extracted with ether. After it was washed with saturated saline, the organic layer was dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain the captioned compound (8.6 g) as white crystals.

Melting points of the substances produced according to Examples 3 and 4 and of substances produced by similar methods are shown in Table 7 above, and .sup.1 H-NMR peak values are shown in Table 9 below.

TABLE 9__________________________________________________________________________ ##STR90## CompoundNo. NMR .delta.[ppm.] (300 MHz) Solvent CDCl.sub.3, TMS = 0__________________________________________________________________________ ppm3-2 1.36(s, A), 3.49(brs, B), 6.67-6.86(m, 1H), 7.10-7.32(m, 3H)3-3 1.33(s, A), 1.54(s, C), 3.46(brs, B), 6.86-7.46(m, 4H+D)3-4 1.68(s, C), 7.0-7.7(m, 4H+D)3-5 1.35(s, A), 1.51(s, C), 3.48(brs, B), 7.08-7.52(m, 4H+D)3-6 1.33(s, A), 1.53(s, C), 3.46(brs, B), 7.2-7.5(m, 4H+D)3-11 1.65(s, C), 6.98-7.83(m, 4H+D)3-21 1.69(s, C), 7.0-7.7(m, 4H+D)3-25 1.34(s, A), 1.52(s, C), 3.46(brs, B), 7.18-7.52(m, 3H+D)3-26 1.33(s, A), 1.51(s, C), 3.46(brs, B), 7.18-7.38(m, 3H), 7.42 and 7.47(ABq, D)3-32 1.33(s, A), 1.67(s, C), 2.33 and 2.34(a pair of s, 3H), 3.48(brs, B), 6.93-7.40(m, 4H+D)3-36 1.31(s, A), 1.54(s, C), 2.31(s, 6H), 3.47(brs, B), 6.78-7.18(m, 3H), 7.35 and 7.41(ABq, D)3-59 1.35(s, A), 1.55(s, C), 3.50(brs, B), 3.81(S, 3H), 6.64-7.46(m, 4H), 7.34 and 7.46(ABq, D)3-68 1.32(s, A), 1.51(s, C), 3.48(brs, B), 3.87 and 3.89(a pair of s, 2H), 7.29 and 7.38(a pair of s, 2H), 7.40 and 7.47 (ABq, D)3-69 1.31(s, A), 1.50(s, C), 3.49(brs, B), 3.86 and 3.87(a pair of s, 2H), 7.34 and 7.46(ABq, D), 7.50 and 7.62 (a pair s, 2H)3-89 1.36(s, A), 1.57(s, C), 3.49(brs, B), 7.29-7.75(m, 4H+D)3-91 1.35(s, A), 1.57(s, C), 3.54(brs, B), 7.10-8.03(m, 3H+D)3-95 1.35(s, A), 1.55(s, C), 3.48(brs, B), 6.49 and 6.51(a pair of t, 2H), 6.85-7.35(m, 4H), 7.41(Abq, D)__________________________________________________________________________

EXAMPLE 5

Production of 6-methyl-3-[1-methyl-1-(3,5-dichlorophenyl)ethyl]-5-phenyl-2,3-dihydro-4H-1,3-oxazin-4-one (Compound No. 248)

A mixture of 5-phenyl-2,2,6-trimethyl-2H,4H-1,3-dioxin-4-one (0.65 g) and N-methylene-1-methyl-1-(3,5-dichlorophenyl)ethyl amine (compound of Example 4) (0.65 g) was heated at 150.degree. C. for 30 minutes for reaction. The reaction mixture was recrystallized from a mixed solvent composed of hexane and ethyl acetate to obtain the captioned compound (0.90 g).

EXAMPLE 6

Production of 6-methyl-3-[1-methyl-1-(3-chlorophenyl)ethyl]-5-phenyl-2,3-dihydro-4H-1,3-oxazin-4-one (Compound No. 73)

A mixture of 5-phenyl-2,2,6-trimethyl-2H,4H-1,3-dioxin-4-one (1.0 g) and N-methylene-1-methyl-1-(3-chlorophenyl)ethylamine (Compound of Example 3) (0.76 g) was heated at 15 0.degree. C. for 30 minutes for reaction. The reaction mixture was purified by silica gel chromatography to obtain the captioned compound (1.0 g).

EXAMPLE 7

Production of 5-(2-fluorophenyl)-6-methyl-3-[1-methyl-1-(3-chlorophenyl)ethyl]-2,3-dihydro-4H-1,3-oxazin-4-one (Compound No. 74)

Xylene (2 ml ) was added to a mixture of 5-(2-fluorophenyl)-2,2 ,6-trimethyl-2H,4H-1,3-dioxin-4-one (compound of Example 1 ) (0.71 g) and N-methylene-1-methyl1-(3-chlorophenyl)ethylamine (compound of Example 3) (0.6 g), and the resulting mixture was heated at reflux for 20 minutes for reaction. The reaction mixture was purified by silica gel chromatography to obtain the captioned compound (0.9 g).

EXAMPLE 8

Production of 6-methyl-3-(1-methyl-1-phenylethyl) -5-phenyl-2,3-dihydro-4H-1,3-oxazin-4-one (Compound No. 1)

5-Phenyl-2,2,6-trimethyl-2H,4H-1,3-dioxin-4-one (2.2 g) and N-methylene-1-methyl-1-phenylethylamine (1.7 g) were reacted at 155.degree. C. for 20 minutes. The reaction mixture was recrystallized from hexane and ether solvent to obtain the captioned compound (1.6 g). Example 9 Production of 3-(1-methyl-1-phenylethyl)-5-phenyl-2,3-dihydro-4H -1,3-oxazin-4-one (Compound No. 388)

Xylene (2 ml) was added to a mixture of 5-phenyl-2,2-dimethyl-2H,4H-1,3-dioxin-4-one (0.82 g) and N-methylene-1-methyl-1-phenylethylamine (0.59 g), and the resulting mixture was heated at reflux for 20 minutes for reaction. The reaction mixture was purified by silica gel chromatography to obtain the captioned compound (0.9 g).

EXAMPLE 10

Production of 6-ethyl-3-(1-methyl-1-phenylethyl)-5-phenyl-2,3-dihydro-4H-1,3-oxazin-4-one (Compound No. 402)

Xylene (2 ml) was added to a mixture of 6-ethyl-5-phenyl-2,2-dimethyl-2H,4H-1,3-dioxin-4-one (0.70 g) and N-methylene-1-methyl-1-phenylethylamine (0.44 g), and the resulting mixture was heated at reflux for 20 minutes for reaction. The reaction mixture was purified by silica gel chromatography to obtain the captioned compound (0.72 g).

EXAMPLE 11

Production of 5-isobutyl-6-methyl-3-[1-methyl-1-(3-chlorophenyl)ethyl]-2,3-dihydro-4H-1,3-oxazin -4-one (Compound No. 514)

Xylene (1 ml) was added to a mixture of 5-isobutyl-2,2,6-trimethyl-2H,4H-1,3-dioxin-4-one (0.59 g) and N-methylene-1-methyl-1-(3-chlorophenyl)ethylamine (0.55 g), and the resulting mixture was heated at reflux for 60 minutes for reaction. The reaction mixture was purified by silica gel chromatography to obtain the captioned compound (0.52 g).

EXAMPLE 12

Production of 6-methyl-3-[1-methyl-1-(3chlorophenyl)propyl]-2,3-dihydro-4H-1,3-oxazin-4-one (Compound No. 801)

A mixture of 5-phenyl-2,2,6-trimethyl-2H,4H-1,3-dioxin-4-one (0.65 g) and N-methylene-1-methyl-1-(3-chlorophenyl)propylamine (0.76 g) was heated at 150.degree. C. for 30 minutes for reaction. The reaction mixture was purified by silica gel chromatography to obtain the captioned compound (0.79 g).

EXAMPLE 13

Production of 3-[1-(3-chlorophenyl)cyclopentyl]-6-methyl-5-phenyl-2,3-dihydro-4H-1,3-oxazin-4-one (Compound No. 857)

A mixture of 5-phenyl-2,2,6-trimethyl-2H,4H-1,3-dioxin-4-one (0.65 g) and N-methylene-1-(3-chlorophenyl)cyclopentylamine (0.78 g) and xylene (3 ml) was heated at reflux for 30 minutes for reaction. The reaction mixture was purified by silica gel chromatography to obtain the captioned compound (0.97 g).

EXAMPLE 14

Production of 6-methyl-5-phenyl-3-(1,1,2,2-tetramethylpropyl)-2,3-dihydro-4H-1,3-oxazin-4-one (Compound No. 666)

A mixture of 5-phenyl-2,2,6-trimethyl-2h,4h-1,3-dioxin-4-one (0.65 g), N-methylene-1,1,2,2-tetramethylpropylamine (0.54 g) and xylene (2 ml) was heated at reflux for 30 minutes for reaction. The reaction mixture was purified by silica gel chromatography to obtain the captioned compound (0.40 g).

EXAMPLE 15

Production of 3-(1,1-dimethyl-2-phenylethyl)6-methyl-5-phenyl-2,3-dihydro-4H-1,3-oxazin-4-one (Compound No. 700)

5-phenyl-2,2,6-trimethyl-2H,4H-1,3-dioxin-4-one (0.65 g) and N-methylene-1,1-dimethyl-2-phenylethylamine (0.63 g) were reacted at 140.degree. for 30 minutes. The reaction mixture was purified by silica gel chromatography to obtain the captioned compound (0.74 g).

EXAMPLE 16

Production of 6-methyl-3-[1-methyl-1-(2naphthyl)ethyl]-5-phenyl-2,3-dihydro-4H-1,3-oxazin-4-one (Compound No. 606)

A mixture of 5-phenyl-2,2,6-trimethyl-2H,4H-1,3-dioxin-4-one (0.65 g), N-methylene-1-methyl-1-(2-naphthyl)ethylamine (0.60 g) and xylene (3 ml) was heated at reflux for 20 minutes for reaction. The reaction mixture was purified by silica gel chromatography to obtain the captioned compound (0.40 g).

Melting points of the substances produced according to Examples 5 to 16 and of substances produced by similar methods are shown in Tables 1 to 6 above, and .sup.1 H-NMR peak values are shown in Table 10 below.

TABLE 10__________________________________________________________________________CompoundNo. NMR .delta. [ppm.] (300 MHz) Solvent CDCl.sub.3, TMS = 0__________________________________________________________________________ ppm 1 1.82(s, 6H), 1.89(s, 3H), 5.07(s, 2H), 7.21-7.45(m, 10H) 2 1.82(s, 6H), 1.88(s, 3H), 5.10(s, 2H), 7.0-7.2(m, 2H), 7.2-7.5(m, 7H) 3 1.76(s, 6H), 1.90(s, 3H), 5.22(s, 2H), 7.15-7.35(m, 5H), 7.37-7.49(m, 2H), 7.54-7.62(m, 2H) 4 1.80(s, 3H), 1.81(s, 3H), 1.88(s, 3H), 5.07(s, 2H), 6.97-7.05(m, 2H) 7.20-7.43(m, 7H) 5 1.82(s, 3H), 1.83(s, 6H), 5.12 and 5.14(ABq, 2H), 7.18-7.45(m, 9H) 6 1.82(s, 6H), 1.90(s, 3H), 5.08(s, 2H), 7.11-7.44(m, 9H) 7 1.81(s, 6H), 1.89(s, 3H), 5.07(s, 2H), 7.18-7.42(m, 9H) 23 1.78(s, 3H), 1.79(s, 3H), 1.83(s, 3H), 2.14(s, 3H) 5.11 and 5.13(ABq, 2H), 7.08-7.44(m, 9H) 45 1.81(s, 6H), 1.82(s, 3H), 3.75(s, 3H), 5.10(s, 2H) 6.85-6.96(m, 2H), 7.16-7.45(m, 7H) 62 1.73(s, 3H), 1.79(s, 3H), 1.83(s, 3H), 5.09(s, 2H), 7.19-7.27(m, 1H) 7.27-7.43(m, 4H), 7.52(t, 1H), 7.66(d, 1H) 63 183(s, 6H), 1.89(s, 3H), 5.10(s, 2H), 7.20-7.62(m, 9H) 73 1.77(s, 6H), 1.91(s, 3H), 5.18(s, 2H), 7.10-7.42(m, 9H) 74 1.76(s, 6H), 1.89(s, 3H), 5.20(s, 2H), 7.00-7.13(m, 2H). 7.17-7.32(m, 5H), 7.33-7.37(m, 1H) 75 1.77(s, 6H), 1.92(s, 3H), 5.18(s, 2H), 6.91-7.07(m, 3H), 7.17-7.37(m, 5H) 76 1.76(s, 6H), 1.90(s, 3H), 5.18(s, 2H), 6.96-7.10(m, 3H) 7.17-7.35(m, 5H) 77 1.77(s, 6H), 1.86(s, 3H), 5.24 and 5.25(ABq, 2H), 7.17-7.42(m, 8H) 78 1.77(s, 6H), 1.92(s, 3H), 5.18(s, 2H), 7.1-7.4(m, 8H) 79 1.76(s, 6H), 1.90(s, 3H), 5.28(s, 2H), 7.15-7.37(m, 8H)104 1.73(s, 3H), 1.79(s, 3H), 1.81(s, 3H), 2.12(s, 3H), 5.23 and 5.25(ABq, 2H), 7.04-7.38(m, 8H)135 1.75(brs, 6H), 1.85(s, 3H), 3.74(s, 3H), 5.21(s, 2H), 6.86(d, 1H), 6.91(t, 1H), 7.12-7.30(m, 5H), 7.34-7.38(m, 1H)161 1.75(s, 3H), 1.76(s, 3H), 1.77(s, 3H), 5.23 and 5.25(ABq, 2H), 7.18-7.32(m, 4H), 7.33(s, 1H), 7.39(t, 1H), 7.52(t, 1H), 7.66(d, 1H)162 1.78(s, 6H), 1.91(s, 3H), 5.20(s, 2H), 7.14-7.62(m, 8H)176 1.78(s, 6H), 1.91(s, 3H), 5.17(s, 2H), 6.88-6.96(m, 1H), 7.06-7.13(m, 1H), 7.17(d, 1H), 97.21-7.36(m, 6H)177 1.78(s, 6H), 1.89(s, 3H), 5.19(s, 2H), 6.87-6.96(m, 1H), 7.00-7.14(m, 3H), 7.17(d, 1H), 7.21-7.34(m, 3H)180 1.77(s, 3H), 1.79(s, 3H), 1.85(s, 3H), 5.21 and 5.24(ABq, 2H), 6.87-7.43(m, 8H)187 1.75(s, 3H), 1.79(s, 3H), 1.80(s, 3H), 2.12(s, 3H) 5.22 and 5.22(ABq, 2H), 6.86-7.35(m, 8H)208 1.75(s, 3H), 1.76(s, 3H), 1.79(s, 3H), 5.18 and 5.22(ABq, 2H), 6.87-6.95(m, 1H), 7.07(dt, 1H), 7.14(d, 1H), 7.24-7.33(m, 2H), 7.39(t, 1H), 7.52(t, 1H), 7.66(d, 1H)217 1.80(s, 6H), 1.90(s, 3H), 5.12(s, 2H), 6.96-7.42(m, 9H)221 1.86(s, 6H), 1.87(s, 3H), 5.33(s, 2H), 7.08-7.14(m, 1H), 7.17-7.31(m, 7H), 7.46-7.50(m, 1H)225 1.75(s, 6H), 1.89(s, 3H), 5.14(s, 2H), 7.19-7.35(m, 9H)230 1.77(s, 6H), 1.92(s, 3H), 5.18(s, 2H), 7.17-7.41(m, 8H), 7.51(t, 1H)232 1.76(s, 6H), 1.89(s, 3H), 5.20(s, 2H), 6.98-7.14(m, 2H), 7.15-7.38(m, 2H), 7.50(t, 1H)233 1.76(s, 6H), 1.91(s, 3H), 5.17(s, 2H), 7.06(t, 1H), 7.14-7.40(m, 6H), 7.56(brd, 1H), 7.70(t, 1H)235 1.73(s, 6H), 1.93(s, 3H), 3.87(s, 3H), 5.25(s, 2H), 7.20-7.32(m, 5H) , 7.47(s, 2H)236 1.73(s, 6H), 1.92(s, 3H), 3.87(s, 3H), 5.28(s, 2H), 7.01-7.31(m, 4H) , 7.47(s, 2H)243 1.85(s, 6H), 1.88(s, 3H), 5.39(s, 2H), 7.11-7.45(m, 8H)247 1.74(s, 6H), 1.92(s, 3H), 5.24(s, 2H), 7.18-7.45(m, 8H)248 1.73(s, 6H), 1.93(s, 3H), 5.26(s, 2H), 7.19-7.35(m, 8H)249 1.71(s, 3H), 1.73(s, 3H), 1.88(s, 3H), 5.33 and 5.34(ABq, 2H), 7.17-7.42(m, 7H)252 1.66(s, 3H), 1.74(s, 3H), 1.82(s, 3H), 2.10(s, 3H), 5.30 and 5.32(ABq, 2H), 7.01-7.26(m, 7H)253 1.73(s, 6H), 1.92(s, 3H), 5.29(s, 2H), 7.00-7.32(m, 7H)256 1.72(s, 6H), 1.94(s, 3H), 5.30(s, 2H), 7.18-7.35(m, 5H) , 7.35(s, 2H)257 1.72(s, 6H), 1.93(s, 3H), 5.33(s, 2H), 7.00-7.14(m, 2H), 7.22-7.30(m, 2H), 7.35(s, 2H)263 1.81(s, 6H), 1.88(s, 3H), 2.36(s, 3H), 5.04(s, 2H), 6.95-7.40(m, 9H)267 1.81(s, 6H), 1.83(s, 3H), 2.36(s, 3H), 5.11 and 5.13(ABq, 2H), 7.02-7.43(n, 8H)274 1.78(s, 3H), 1.78(s, 3H), 1.82(s, 3H), 2.15(s, 3H), 2.35(s, 3H), 5.11 and 5.12(ABq, 2H), 7.01-7.28(m, 8H)283 1.82(s, 6H), 1.89(s, 3H), 2.37(s, 3H), 5.08(s, 2H), 7.04-7.61(m, 8H)290 1.77(s, 6H), 1.90(s, 3H), 2.34(s, 3H), 5.14(s, 2H), 7.15-7.37(m, 8H)296 1.80(s, 6H), 1.89(s, 3H), 2.32(s, 6H), 5.03(s, 2H), 6.86-7.36(m, 8H)321 1.73(s, 6H), 1.93(s, 3H), 3.88(s, 3H), 5.25(s, 2H), 7.27(s, 2H), 7.20-7.36(m, 5H)322 1.73(s, 6H), 1.92(s, 3H), 3.88(s, 3H), 5.28(s, 2H), 7.27(s, 2H), 7.01-7.14(m, 2H), 7.22-7.31(m, 2H)323 1.81(s, 6H), 1.89(s, 3H), 3.80(s, 3H), 5.01(s, 2H), 6.74-7.36(m, 9H)324 1.80(s, 6H), 1.87(s, 3H), 3.80(s, 3H), 5.10(s, 2H), 6.74-7.37(m, 8H)325 1.80(s, 3H), 1.81(s, 3H), 1.83(s, 3H), 3.80(s, 3H), 5.10 and 5.14(ABq, 2H), 6.74-7.36(m, 8H)358 11.81(s, 6H), 1.89(s, 3H), 5.08(s, 2H), 6.90-7.05(m, 3H), 7.20-7.43(m, 6H)359 1.77(s, 6H), 1.89(s, 3H), 5.26(s, 2H), 6.97-7.11(m, 2H), 7.18-7.28(m, 2H), 7.38-7.40, (m, 2H), 7.54-7.62(m, 2H)360 1.79(s, 6H), 1.86(s, 3H), 5.31 and 5.31(ABq, 2H), 7.16-7.64(m, 8H)363 1.73(s, 3H), 1.81(s, 3H), 1.81(s, 3H), 2.06(s, 3H), 5.29 and 5.32(ABq, 2H), 7.00-7.62(m, 8H)365 1.82(s, 6H), 1.91(s, 3H), 5.55(s, 2H), 7.15-7.76(m, 8H)370 1.78(s, 6H), 1.94(s, 3H), 5.37(s, 2H), 7.12-7.18(m, 2H), 7.20-7.35(m, 3H), 7.72(brs, 1H), 7.77(brs, 2H)374 1.78(s, 6H), 1.91(s, 3H), 5.20(s, 2H), 6.50(t, 1H), 6.94-6.99(m, 1H), 7.11-7.14(m, 1H), 7.19-7.36(m, 7H)375 1.76(s, 6H), 1.89(s, 3H), 5.22(s, 2H), 6.49(t, 1H), 6.93-7.38(m, 8H)376 1.77(s, 3H), 1.78(s, 3H), 1.86(s, 3H), 5.258 and 5.26(ABq, 2H), 6.50(t, 1H), 6.93-6.99(m, 1H), 7.11-7.14(m, 1H), 7.19-7.42(m, 6H)388 1.84(s, 6H), 5.14(s, 2H), 7.21-7.46(m, 11H)392 1.79(s, 6H), 5.24(s, 2H), 7.17-7.45(m, 10H)402 1.06(t, 3H), 1.82(s, 6H), 2.17(q, 2H), 5.08(s, 2H) 7.21-7.44(m, 10H)403 1.08(t, 3H), 1.77(s, 6H), 2.19(q, 2H), 5.18(s, 2H), 7.17-7.36(m, 9H)418 1.10(t, 3H), 1.73(s, 6H), 2.21(q, 2H), 3.87(s, 3H), 5.26(s, 2H), 7.18-7.36(m,5H), 7.46(s, 2H)421 0.85(t, 3H), 1.45-1.61(m, 2H), 1.82(s, 6H), 2.14(t, 2H), 5.07(s, 2H), 7.18-7.45(m, 10H)422 0.86(t, 3H), 1.45-1.63(m, 2H), 1.77(s, 6H), 2.16(t, 2H), 5.18(s, 2H), 7.10-7.40(m, 9H)440 1.05(d, 6H), 1.82(s, 6H), 2.50-2.65(m, 1H), 5.07(s, 2H), 7.15-7.45(m, 10H)505 0.86(d, 6H), 1.61-1.76(m, 1H), 1.77(s, 6H), 1.96(s, 3H), 2.12(d, 2H), 4.96(s, 2H), 7.18-7.39(m, 5H)514 0.85(d, 6H), 1.59-1.70(m, 1H), 1.71(s, 6H), 1.98(s, 3H), 2.10(d, 2H), 5.05(s, 2H), 7.15-7.31(m, 4H)606 1.90(s, 3H), 1.93(s, 6H), 5.07(s, 2H), 7.21-7.36(m, 5H), 7.42-7.52(m, 2H), 7.61(dd, 1H), 7.78-7.88(m, 4H)666 0.98(s, 9H), 1.56(s, 6H), 1.86(s, 3H), 5.20(s, 2H), 7.20-7.42(m, 5H)700 1.51(s, 6H), 1.82(s, 3H), 3.21(s, 2H), 4.66(s, 2H), 7.10-7.45(m, 10H)704 1.53(s, 6H), 1.86(s, 3H), 3.45(s, 2H), 4.86(s, 2H), 7.10-7.45(m, 9H)705 1.50(s, 6H), 1.84(s, 3H), 3.20(s, 2H), 4.73(s, 2H), 6.99-7.44(m, 9H)706 1.49(s, 6H), 1.81(s, 3H), 3.19(s, 2H), 4.68(s, 2H), 6.83-7.42(m, 9H)710 1.51(s, 6H), 1.88(s, 3H), 2.18-2.28(m, 2H), 2.52-2.68(m, 2H), 5.18(s, 2H), 7.12-7.42(m, 10H)801 0.89(t, 3H), 1.65(s, 3H), 1.93(s, 3H), 1.95-2.10(m, 1H), 2.48-2.63(m, 1H), 5.18 and 5.22(ABq, 2H), 7.15-7.38(m, 9H)818 1.49(s, 3H), 1.56(s, 9H, 1.79(s, 3H), 4.35(s, 2H), 7.20-7.50(m, 10H)857 1.60-1.75(m, 2H), 1.75-1.88(m, 2H), 1.89(s, 3H), 2.30-2.53(m, 4H), 5.22(s, 2H), 7.15-7.40(m, 9H)860 1.30-1.90(m, 10H), 1.92(s, 3H), 5.23(s, 2H), 7.13-7.40(m, 9H)330 1.78(s, 6H), 1.90(s, 3H), 3.89(s, 3H), 5.12(s, 2H), 6.86-7.42(m, 8H)567 1.72(s, 6H), 2.25(s, 3H), 3.21(s, 1H), 5.15(s, 2H), 7.17-7.23(m, 3H)__________________________________________________________________________

The compounds of formula (I) provided by this invention have strong herbicidal activities against many kinds of weeds and very weak phytotoxicities to useful crops as will be apparent from test examples described later on.

For example, the compounds of this invention exhibit excellent herbicidal effects at very low doses over a wide time range of from germination to and including growth period of annual weeds such as Echinochloa crus-galli P. Beauv., Cyperus difformis L., Monochoria vaginalis Presl., Rotala indica Koehne, Lindernia procumbens Philcox, and Dopatrium junceum Hamilt., and perennial weeds such as Scirpus hotarui Ohwi, Eleocharis acicularis Roem. et Schult. var. longiseta Svenson, Alisma canaliculatum A. Br. et Bouche and Cyperus serotinus Rottb., while simultaneously showing high safety toward paddy field rice plant. The compounds of this invention are featured that when applied to soil or stems and leaves, they exhibit high herbicidal effects on various weeds which cause problems also in farmlands perennial and annual Cyperaceous weeds such as Cyperus rotundus L., Cyperus polystachyos Rottb.*, Cyperus brevifolius Hassk. var. leiolepis T. Koyama, Cyperus microiria Steud., and Cyperus iria L.*, and Gramineous weeds such as Echinochloa crus-galli P. Beauv., Digitaria adscendens Henr., Setaria viridis P. Beauv., Poa annua L., Sorghum halepense Pers, and Alopecurus aequalis Sobol. var. amurensis Ohwi as well as broad-leaved weeds such as, for example, Polygonum hydropiper L., Amaranthus retroflexus L., and Chenopodium album L., while simultaneously showing high safety toward soybean, cotton, sugar beet, upland rice plant, wheat, etc.

Further, the compounds of this invention can be used not only in paddy fields, and uplands, but also in orchards, mulberry fields, lawn, and non-crop lands.

The compounds of this invention can be used in combination with other agricultural and horticultural active compounds. For example, when the compounds of this invention are used in combination with other compounds having herbicidal or growth controlling activities, they ekhibit complete herbicidal effects on weeds which are difficult to control with each of the compounds applied singly, and effectively control various weeds by synergistic herbicidal effects at doses at which a single compound is not effective, and they are highly safe toward paddy field rice plant, soybean, cotton, sugar beet, upland rice plant, wheat, etc., so that they can provide herbicides which are very useful in agriculture.

Thus, according to this invention, there are provided herbicides containing 1,3-oxazin-4-one derivatives represented by formula (I) above as active ingredients.

When the compounds of this invention are used as herbicides, they are mixed with agriculturally or horticulturally acceptable carriers or diluents and formed into various formulations, for example, dusts, granules, wettable powders, emulsifiable concentrates, soluble powders, flowables, etc. They can be used as mixtures or in combination with other agricultural chemicals, for example, fungicides, insecticides, acaricides, herbicides, plant growth regulators, fertilizers and soil.

In particular, the use of the compounds of this invention as mixtures with other herbicides can lead not only to reduction in dose and reduction in manpower, but also to broadening of herbicidal spectrum attributable to cooperative activities and further improved effects attributable to synergistic activities by the both agents.

The carriers or diluents used upon formulation include generally used solid or liquid carriers or diluents.

Examples of the solid carriers or diluents include clays represented by kaolinites, montmorillonites, illites, polygroskites, etc., more specifically pyrophyllite, attapulgite, sepiolite, kaolinite, bentonite, vermiculite, mica, talc, etc.; and other inorganic substances such as gypsum, calcium carbonate, dolomite, diatomaceus earth, magnesium line, phosphorus lime, zeolite, silicic anhydride, synthetic calcium silicate, etc.; organic substances of vegetable origin such as soybean flour, tobacco flour, walnut flour, wheat flour, wood flour, starch, crystalline cellulose, etc.; synthetic or natural polymers such as coumarone resin, petroleum resin, alkyd resin, polyvinyl chloride, polyalkylene glycol, ketone resin, ester gum, copal gum, dammar gum, etc.; waxes such as carnauba wax, bee wax, etc.; or urea and the like.

Examples of suitable liquid carriers or diluents include paraffin or naphthene hydrocarbons such as kerosene, mineral oil, spindle oil, white oil, etc.; aromatic hydrocarbons such as xylene, ethylbenzene, cumene, methylnaphthalene, etc.; chlorinated hydrocarbons such as trichloroethylene, monochlorobenzene, o-chlorotoluene, etc.; ethers such as dioxane, tetrahydrofuran, etc., ketones such as acetone, methyl ethyl ketone, diisobutyl ketone, cyclohexanone, acetophenone, isophorone; esters such as ethyl acetate, amyl acetate, ethylene glycol acetate, diethylene glycol acetate, dibutyl maleate, diethyl succinate, etc.; alcohols such as methanol, n-hexanol, ethylene glycol, diethylene glycol, cyclohexanol, benzyl alcohol, etc.; ether alcohols such as ethylene glycol ethyl ether, diethylene glycol butyl ether, etc.; polar solvents such as dimethylformamide, dimethyl sulfoxide, etc., or water.

In addition, surfactants and other auxiliary agents may be used for various purposes such as emulsification, dispersion, humidification, spreading, dilation, combination destruction control, stabilization of active ingredients, improvement of flowability, prevention of corrosion, prevention of freezing, etc., of the compounds of this invention.

As the surfactant, there may be used one of any type among nonionic, anionic, cationic and amphoteric surfactants. Usually, nonionic and (or) anionic surfactants are used. Examples of suitable nonionic surfactants include addition polymerization products of ethylene oxide with higher alcohols such as lauryl alcohol, stearyl alcohol, oleyl alcohol, etc.; addition polymerization products of ethylene oxide with alkylnaphthols such as butylnaphthol, octylnaphthol, etc.; addition polymerization products of ethylene oxide with higher fatty acids such as palmitic acid, stearic acid, oleic acid, etc.; higher fatty acid esters of polyhydric alcohols such as sorbitan, and addition polymerization products of ethylene oxide therewith; etc.

As suitable anionic surfactants, there can be cited, for example, alkyl sulfate salts such as sodium laurylsulfate, amine salts of sulfuric acid ester of oleyl alcohol, etc., alkyl sulfonate salts such as sodium dioctyl sulfosuccinate, sodium 2-ethylhexenesulfonate, etc., arylsulfonate salts such as sodium isopropyl naphthalenesulfonate, sodium methylenebisnaphthalenesulfonate, sodium lignin sulfonate, sodium dodecyl benzenesulfonate, etc., and the like.

Further, for the purpose of improvement of properties of formulations, enhancement of effects, etc., the herbicides of this invention may be used in combination with polymers and other auxiliary agents such as casein, gelatin, albumin, glue, sodium alginate, carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, polyvinyl alcohol, etc.

The above-described carriers or diluents and various auxiliary agents are used singly or in combination with others depending on the purpose taking into consideration forms of formulation, conditions of application, etc.

The contents of active ingredients in the various formulations of this invention thus prepared may vary widely depending on forms of formulation, and suitable content is within the range of usually 0.1 to 99% by weight, and preferably 1 to 80% by weight, which is most suitable.

Wettable powders contain active ingredient compounds in amounts of usually 25 to 90%, and the remainder solid carriers or diluents and dispersion wetting agents. If necessary, colloid proltection agents, defoaming agents, etc. may be added thereto.

Granules contain, for example, active ingredient compounds in amounts of usually 1 to 35%, and the remainder may be solid carriers or diluents and surfactants. The active ingredient compounds may be mixed with solid carriers or diluents uniformly, or fixed to or adsorbed on the surfaces of solid carriers or diluents uniformly. It is preferred that the diameter of the granules be within the range of about 0.2 to 1.5 mm.

Emulsifiable concentrates contain, for example, active ingredient compounds of usually 5 to 30%, and in addition about 5 to 20% by weight of emulsifiers, the remainder being liquid carriers or diluents. If necessary, spreading agents and anticorrosive agents may be added thereto.

Flowables contain, for example, active ingredient compounds in amounts of usually 5 to 50%, and in addition 3 to 10% by weight of dispersion wetting agents, and the remainder being water. If necessary, protective colloid agents, preservatives, defoaming agents, etc. may be added thereto.

The compounds of this invention may be used as herbicides as they are or in any of the forms of formulation described above.

The herbicides of this invention may be applied in effective amounts to various places to be protected, for example, farm-lands such as paddy fields and upland, or non-crop lands, prior to germination of weeds or to weeds of various stages from after germination to growth period. The dose is generally, as amount of active ingredients, on the order of 0.1 to 10,000 g/ha, preferably 1 to 5,000 g/ha. The dose may be varied properly depending on the kind of objective weeds, their growth stages, places of application, weather, etc.

Next, several embodiments of formulations using the compounds of this invention. In the following formulations, all "parts" are by weight.

______________________________________Formulation Example 1 (Emulsifiable concentrate)______________________________________Compound No. 73 20 partsXylene 50 partsCyclohexanone 20 partsCalcium dodecylbenzenesulfonate 5 partsPolyoxyethylenestyryl phenyl ether 5 parts______________________________________

The above substances were mixed and dissolved uniformly to obtain 100 parts of an emulsifiable concentrate.

______________________________________Formulation Example 2 (Wettable powder)______________________________________Compound No. 73 20 partsClay 70 partsCalcium ligninsulfonate 7 partsCondensate of alkylnaphthalene- 5 partssulfonic acid with formaldehyde______________________________________

The above substances were mixed and pulverized using a jet mill mixed to obtain 100 parts of a wettable powder.

______________________________________Formulation Example 3 (Flowable)______________________________________Compound No. 74 20 partsSodium di(2-ethylhexyl 2 partssulfosuccinatePolyoxyethylene nonylphenyl ether 2 partsDefoaming agent 0.5 partPropylene glycol 5 partsWater 70.5 parts______________________________________

The above substances were mixed and pulverized using a wet ball mill to obtain 100 parts of a flowable.

The herbicidal effects of the compounds of this invention will be explained below according to test examples.

Test Example 1 (Paddy field soil application)

Suitable amounts of water and a chemical fertilizer were added to paddy field soil. This was filled in 130 cm.sup.2 plastic pots followed by kneading to convert it to a state of paddy field, to which a stock of paddy field rice plant (variety: Koshihikari) composed of a pair of two seedlings that had been grown in advance in a greenhouse to a stage of two leaves were transplanted in the pots in a population of 1 stock/pot. Further, in each pot, there were sown predetermined amounts of seeds of Echinochloa crus-galli P. Beauv., Monochoria vaginalis Presl., Lindernia procumbens Philcox, and Scirpus hotarui Ohwi, respectively, and water was filled to a depth of 3 cm. On the next day, wettable powders were prepared using compounds shown in Table 11 below according to Formulation Example 2, and they were diluted with a suitable amount of water so that they contain active ingredients in amounts of 5 kg or 1 kg per 1 ha. They were applied using a pipette. After 21 days from the application with the chemicals, herbicidal effects on each weed and phytotoxicity on paddy field rice plant were judged according the following criteria. Results obtained are shown in Table 11.

______________________________________Evaluation Criteria (11 Ranks) Herbicidal Effect Phototoxicity to Crops Ratio of Killed Weeds Ratio of Injured CropsScore Compared to Control (%) Compared to Control (%)______________________________________0 01 Above 0 to 10 Above 0 to 102 Above 10 to 20 Above 10 to 203 Above 20 to 30 Above 20 to 304 Above 30 to 40 Above 30 to 405 Above 40 to 50 Above 40 to 506 Above 50 to 60 Above 50 to 607 Above 60 to 70 Above 60 to 708 Above 70 to 80 Above 70 to 809 Above 80 to 90 Above 80 to 9010 Above 90 to 100 Above 90 to 100 (Withered) (Withered)______________________________________

In the tables 11-18, abbriviations of weeds are as follows.

Weed A: Echinochloa grus-galli P. Beauv. Weed B: Monochoria Vaginalis Presl. Weed C: Lindernia procumbens Philcox. Weed D: Scirpus hotarui Ohwi. Weed E: Cyperus serotinus Rott. Weed F: Digitaria adscendens Henr. Weed G: Setaria viridis Beauv. TABLE 11__________________________________________________________________________ Dose of Active PhototoxicityCompound Ingredient Herbicidal Effect Paddy FieldNo. g ai/ha Weed A Weed B Weed C Weed D Rice Plant__________________________________________________________________________ 5 1000 10 10 10 10 0 5000 10 10 10 10 0 6 1000 8 9 10 10 0 5000 10 10 10 10 045 1000 9 10 10 10 0 5000 10 10 10 10 063 1000 9 9 9 9 0 5000 10 10 10 10 073 1000 10 10 10 10 0 5000 10 10 10 10 077 1000 10 9 10 9 0 5000 10 10 10 10 078 1000 10 10 10 10 0 5000 10 10 10 10 079 1000 10 10 10 10 0 5000 10 10 10 10 0104 1000 10 10 10 10 0 5000 10 10 10 10 0135 1000 10 9 10 10 0 5000 10 10 10 10 0162 1000 9 9 10 10 0 5000 10 10 10 10 0187 1000 10 9 10 10 0 5000 10 10 10 10 0217 1000 10 10 10 10 0 5000 10 10 10 10 0248 1000 10 10 10 10 0 5000 10 10 10 10 0274 1000 10 9 10 10 0 5000 10 10 10 10 0283 1000 9 9 9 9 0 5000 10 10 10 10 0323 1000 10 9 10 10 0 5000 10 10 10 10 0360 1000 10 10 10 10 0 5000 10 10 10 10 0363 1000 10 9 10 10 0 5000 10 10 10 10 0374 1000 10 10 10 10 0 5000 10 10 10 10 0376 1000 10 10 10 10 0 5000 10 10 10 10 0388 1000 10 10 10 10 0 5000 10 10 10 10 0392 1000 10 10 10 10 0 5000 10 10 10 10 0403 1000 10 10 10 10 0 5000 10 10 10 10 0606 1000 10 10 10 10 0 5000 10 10 10 10 0801 1000 10 9 10 10 0 5000 10 10 10 10 0857 1000 10 9 10 10 0 5000 10 10 10 10 0__________________________________________________________________________

Test Example 2 (Paddy field foliar application-1)

Suitable amounts of water and a chemical fertilizer were added to paddy field soil. This was filled in 130 cm.sup.2 plastic pots followed by kneading to convert it to a state of paddy field, to which a stock of paddy field rice plant (variety: Koshihikari) composed of a pair of two seedlings that had been grown in advance in a greenhouse to a stage of two leaves were transplanted in the pots in a population of 1 stocks/pot. Further, in each pot, there were sown predetermined amounts of seeds of Echinochloa crus-galli P. Beauv., Monochoria vaginalis Presl., Lindernia procumbens Philcox, and Scirpus hotarui Ohwi, respectively, and water was filled to a depth of 3 cm. After having grown the plants in a greenhouse until Echinochloa crus-galli P. Beauv. reached a stage of 1.5 leaves, wettable powders were prepared using compounds shown in Table 12 below according to Formulation Example 2, and diluted with a suitable amount of water so that they contain active ingredients in amounts of 5 kg or 1 kg per 1 ha, and then drop-wise applied using a pipette. After 21 days from the application with the chemicals, herbicidal effects on each weed and phytotoxicity on paddy field rice plant were judged according to the criteria in Test Example 1. Results obtained are shown in Table 12.

TABLE 11__________________________________________________________________________ Dose of Active PhototoxicityCompound Ingredient Herbicidal Effect Paddy FieldNo. g ai/ha Weed A Weed B Weed C Weed D Rice Plant__________________________________________________________________________ 5 1000 10 9 9 6 0 5000 10 10 10 10 045 1000 9 8 9 6 0 5000 10 10 10 10 073 1000 10 10 10 10 0 5000 10 10 10 10 077 1000 10 8 9 6 0 5000 10 10 10 10 078 1000 10 9 9 6 0 5000 10 10 10 10 079 1000 8 7 9 6 0 5000 10 10 10 10 0104 1000 10 9 10 8 0 5000 10 10 10 10 0135 1000 10 8 9 6 0 5000 10 10 10 10 0187 1000 10 9 9 7 0 5000 10 10 10 10 0217 1000 10 9 9 8 0 5000 10 10 10 10 0248 1000 10 7 10 10 0 5000 10 10 10 10 0274 1000 9 8 10 6 0 5000 10 10 10 10 0323 1000 10 8 9 7 0 5000 10 10 10 10 0360 1000 10 10 10 9 0 5000 10 10 10 10 0363 1000 10 9 9 7 0 5000 10 10 10 10 0374 1000 10 10 10 10 0 5000 10 10 10 10 0376 1000 10 10 10 10 0 5000 10 10 10 10 0388 1000 10 9 9 6 0 5000 10 10 10 10 0392 1000 10 10 10 10 0 5000 10 10 10 10 0403 1000 10 10 10 9 0 5000 10 10 10 10 0606 1000 10 9 10 9 0 5000 10 10 10 10 0801 1000 10 9 10 9 0 5000 10 10 10 10 0857 1000 10 9 10 9 0 5000 10 10 10 10 0__________________________________________________________________________

Test Example 3 (Paddy field foliar application-2)

Suitable amounts of water and a chemical fertilizer were added to paddy field soil. This was filled in 310 cm.sup.2 plastic pots followed by kneading to convert it to a state of.paddy field, to which a stock of paddy field rice plant (variety: Koshihikari) composed of a pair of two seedlings that had been grown in advance in a greenhouse to a stage of two leaves were transplanted in the pots in a population of 2 stocks/pot. Further, in each pot, there were sown or transplanted predetermined amounts of seeds or bulbs of Echinochloa crus-galli P. Beauv., Monochoria vaginalis Presl., Lindernia procumbens Philcox, and Cyperus serotinus Rottb., respectively, and each pot was flushed to a depth of 3 cm. After having grown the plants in a greenhouse until Echinochloa crus-galli P. Beauv. reached a stage of 1.5 to 2 leaves, wettable powders were prepared using compounds shown in Table 13 below according to Formulation Example 2, and diluted with a suitable amount of water so that they contain active ingredients in amounts of 150 g, 300 g, 600 g, and 1,200 g, respectively, per 1 ha, and then drop-wise applied using a pipette. After 21 days from the application with the chemicals, herbicidal effects on paddy field rice plant were judged according to the criteria in Test Example 1. Results obtained are shown in Table 13.

TABLE 13__________________________________________________________________________ Dose of Active PhototoxicityCompound Ingredient Herbicidal Effect Paddy FieldNo. g ai/ha Weed A Weed B Weed C Weed E Rice Plant__________________________________________________________________________ 73 150 10 10 10 10 0 300 10 10 10 10 0 600 10 10 10 10 0 1200 10 10 10 10 0248 150 10 10 10 10 0 300 10 10 10 10 0 600 10 10 10 10 0 1200 10 10 10 10 0321 150 10 10 9 9 0 300 10 10 10 10 0 600 10 10 10 10 0 1200 10 10 10 10 0360 150 10 9 7 7 0 300 10 9 9 9 0 600 10 10 9 10 0 1200 10 10 10 10 0374 150 10 10 9 9 0 300 10 10 10 9 0 600 10 10 10 10 0 1200 10 10 10 10 0376 150 10 10 9 9 0 300 10 10 10 10 0 600 10 10 10 10 0 1200 10 10 10 10 0392 150 10 10 10 10 0 300 10 10 10 10 0 600 10 10 10 10 0 1200 10 10 10 10 0403 150 10 9 9 9 0 300 10 10 10 9 0 600 10 10 10 10 0 1200 10 10 10 10 0406 150 10 10 10 9 0 300 10 10 10 10 0 600 10 10 10 10 0 1200 10 10 10 10 0606 150 10 10 10 9 0 300 10 10 10 10 0 600 10 10 10 10 0 1200 10 10 10 10 0__________________________________________________________________________

Test Example 4 (upland soil application)

Upland soil was filled in 130 cm.sup.2 plastic pots, in which there were sown predetermined amounts of seeds of Echinochloa crus-galli P. Beauv., Digitaria adscendens Henr., and Setaria viridis Beauv., respectively, and soil was placed thereon to a thickness of 1 cm. On the next day after the sowing, wettable powders were prepared using compounds shown in Table 14 below according to Formulation Example 2, and they were diluted with a suitable amount of water so that they contain active ingredients in amounts of 5 kg or 1 kg per 1 ha. They were sprayed uniformly on the surface of the soil. After 21 days from the application with the chemicals, herbicidal effects on each weed and phytotoxicity on paddy field rice plant were judged according to the criteria in Test Example 1. Results obtained are shown in Table 14.

TABLE 14______________________________________ Dose of ActiveCompound Ingredient Herbicidal EffectNo. g ai/ha Weed A Weed F Weed G______________________________________ 73 1000 10 10 10 5000 10 10 10 77 1000 10 10 10 5000 10 10 10104 1000 10 10 10 5000 10 10 10135 1000 10 10 10 5000 9 10 9187 1000 10 10 10 5000 10 10 10217 1000 10 10 10 5000 10 10 10248 1000 10 10 10 5000 10 10 10274 1000 10 10 10 5000 10 10 10323 1000 10 10 10 5000 10 10 10359 1000 10 10 10 5000 10 10 10363 1000 10 10 10 5000 10 10 10374 1000 10 10 10 5000 10 10 10392 1000 10 10 10 5000 10 10 10606 1000 10 10 10 5000 10 10 10______________________________________

Example 5 (Upland foliar application)

Upland soil was filled in 130 cm plastic pots, in which there were sown predetermined amounts of seeds of Echinochloa crus-galli P. Beauv., Digitaria adscendens Henr., and Setaria viridis Beauv., respectively, and soil was placed thereon to a thickness of 1 cm. After the sowing, the pots were placed in a glass greenhouse and the plants were grown until they reached a stage of 2-4 leaves. Thereafter, wettable powders were prepared using compounds shown in Table 15 below according to Formulation Example 2, and they were diluted with a suitable amount of water so that they contain active ingredients in amounts of 5 kg or 1 kg per 1 ha. They were sprayed uniformly on the surface of the soil. After 21 days from the application with the chemicals, herbicidal effects on each weed and phytotoxicity on paddy field rice plant were judged according to the criteria in Test Example 1. Results obtained are shown in Table 15.

TABLE 15______________________________________ Dose of ActiveCompound Ingredient Herbicidal EffectNo. g ai/ha Weed A Weed F Weed G______________________________________ 73 1000 10 10 10 5000 10 10 10104 1000 10 10 9 5000 10 10 10248 1000 10 10 10 5000 10 10 10274 1000 10 10 9 5000 10 10 10360 1000 10 10 10 5000 10 10 10374 1000 10 10 10 5000 10 10 10392 1000 10 10 10 5000 10 10 10606 1000 3 4 3 5000 10 10 10______________________________________

Test Example 6 (Water seeded foliar application)

A chemical fertilizer was put in each of 200 cm.sup.2 Wagner pots, which were then filled with coarse clod paddy field soil. Then, water was added thereto until the clods sank therein completely, and rice plant seeds (variety: Koshihikari) germinated in advance were sown uniformly in a population amounting to 120 kg/ha. Simultaneously, a predetermined amount of seeds of Echinochloa crus-galli P. Beauv. were sown and grown in a greenhouse until it reached stages of 1 leaf, 2 leaves and 3 leaves. In these stages, the leaf ages of the rice plant were 0.5 leaf, 1.5 leaves and 2.5 leaves, respectively. When the weed reached each leaf age, wettable powders were prepared using compounds shown in Table 16 below according to Formulation Example 2, and diluted with a suitable amount of water so that they contain active ingredients in amounts of 50 g, 75 g, 100 g, 150 g and 200 g, per 1 ha, and then drop-wise applied using a pipette. After 30 days from the application with the chemicals, herbicidal effects on the weed and phytotoxicity on the paddy field rice plant were judged according to the criteria in Test Example 1. Results obtained are shown in Table 16.

TABLE 16______________________________________ Phytotoxicity Dose of Herbicidal Effect Leaf Age in Leaf Active Leaf Age in Leaf Number of PaddyCompound Ingredient Number of Weed A Field Rice PlantNo. a ai/ha 1.0 2.0 3.0 0.5 1.5 2.5______________________________________ 73 50 10 10 10 0 0 0 75 10 10 10 0 0 0 100 10 10 10 1 0 0 150 10 10 10 1 0 0 200 10 10 10 3 2 1248 50 10 10 10 0 0 0 75 10 10 10 0 0 0 100 10 10 10 0 0 0 150 10 10 10 1 0 0 200 10 10 10 1 1 1606 50 10 10 9 0 0 0 75 10 10 10 0 0 0 100 10 10 10 0 0 0 150 10 10 10 1 0 0 200 10 10 10 1 1 1______________________________________

Test Example 7 (Dry-seeded foliar application)

A chemical fertilizer was put in each of 200 cm.sup.2 plastic pots, which were then filled with coarse clod farmland soil. Then, rice plant seeds amounting to 120 kg/ha and a predetermined amount of seeds of Echinochloa crus-galli P. Beauv. were sown in a depth of 2 cm, and grown in a greenhouse. During the growth, each pot was flushed for 24 hours immediately after the sowing, at a stage of 1 leaf, and at a stage of 2 leaves. After completion of the flushing at the stage of 2 leaves of the rice plant, water was added to a flushing depth of 5 cm. Incidentally, the leaf age in leaf number of Echinochloa crus-galli P. Beauv. was 3 leaves. Then, wettable powders were prepared using compounds shown in Table 17 below according to Formulation Example 2, and diluted with a suitable amount of water so that they contain active ingredients in amounts of 50 g, 100 g, 150 g and 200 g, per 1 ha, and then drop-wise applied using a pipette. After 30 days from the application with the chemicals, herbicidal effects on the weed and phytotoxicity on the rice plant were judged according to the criteria in Text Example 1. Results obtained are shown in Table 17.

TABLE 17______________________________________ Dose of ActiveCompound Ingredient Herbicidal Phyto-No. g ai/ha Effect toxicity______________________________________ 73 50 10 0 100 10 0 150 10 0 200 10 0248 50 10 0 100 10 0 150 10 0 200 10 0606 50 9 0 100 10 0 150 10 0 200 10 0______________________________________

Test Example 8 (Upland soil application-2)

Farmland soil was filled in 900 cm.sup.2 plastic pots, in which there were sown predetermined amounts of seeds of Echinochloa crus-galli P. Beauv., Digitaria adscendens Henr., and Setaria viridis Beauv., respectively, and soil was placed thereon to a thickness of 2 cm. On the next day after the sowing, wettable powders were prepared using compounds shown in Table 18 below according to Formulation Example 2, and they were diluted with a suitable amount of water so that they contain active ingredients in amounts of 50 g, 100 g, 200 g, 400 g, 800 g, or 1,600 g, per 1 ha. They were sprayed uniformly on the surface of the soil. After 30 days from the application with the chemicals, herbicidal effects on each weed and phytotoxicity on paddy field rice plant were judged according to the criteria in Test Example 1. Results obtained are shown in Table 18.

TABLE 18______________________________________ Dose of ActiveCompound Ingredient Herbicidal EffectNo. g ai/ha Weed A Weed F Weed G______________________________________ 73 50 10 10 10 100 10 10 10 200 10 10 10 400 10 10 10 800 10 10 10 1600 10 10 10248 50 9 10 10 100 10 10 10 200 10 10 10 400 10 10 10 800 10 10 10 1600 10 10 10359 50 10 10 10 100 10 10 10 200 10 10 10 400 10 10 10 800 10 10 10 1600 10 10 10606 50 9 10 10 100 10 10 10 200 10 10 10 400 10 10 10 800 10 10 10 1600 10 10 10______________________________________

Industrial Applicability

As described above, the compounds of this invention have broad herbicidal spectra and potent herbicidal activities and in addition high safety to useful crops, so that they are useful as herbicides.

Claims

1. A 1,3-oxazin-4-one derivative of the formula (I) ##STR91## wherein R.sup.1 is a lower alkyl group, a lower alkenyl group, an aryl group which may be substituted, or an aralkyl group which may be substituted;

R.sup.2 is a hydrogen atom or a lower alkyl group,

R.sup.3 is a lower alkyl group, an aryl group which may be substituted, or an aralkyl group which may be substituted; and

R.sup.4 and R.sup.5, independently, each is a lower alkyl group, or R.sup.4 and R.sup.5 taken together with the carbon atom to which they are bonded, combine to form a 3- to 8-membered carbocyclic group which may possess a lower alkyl group as a ring substituent.

2. A compound according to claim 1, wherein

R.sup.1 is a branched chain lower alkyl group or a phenyl group which may be substituted with one substituent selected from the group consisting of a halogen atom and a lower alkyl group;

R.sup.2 is a methyl group or an ethyl group;

R.sup.3 is an aryl group which may be substituted with 1 to substituents selected from the group consisting of a halogen atom, a lower alkyl group, a lower haloalkyl group and a lower haloalkoxy group; and

R.sup.4 and R.sup.9 each is a methyl group.

3. A compound according to claim 1 of the formula ##STR92## wherein R.sup.21 is a methyl group or an ethyl group; X is a halogen atom or a lower alkyl group;

Y is a halogen atom, a lower haloalkyl group or a lower haloalkoxy group;

m is 0, 1, 2 or 3; and

n is 0 or 1.

4. A compound of claim 3 which is 6-methyl-3-[1-methyl-1(3,5-dichlorophenyl) ethyl]-5-phenyl-2,3-dihydro-4H-1,3-oxazine-4-one.

5. A method of producing a 1,3-oxazin-4-one derivative of formula (I) as described in claim 1, comprising the step of:

reacting a compound of the formula ##STR93## wherein R.sup.1 and R.sup.2 are as defined in claim 1, with a compound of the formula ##STR94## wherein R.sup.3, R.sup.4 and R.sup.5 are as defined in claim 1.

6. A herbicide comprising as an active ingredient a 1,3-oxaxzin-4-one derivative as defined in claim 1.

7. A herbicidal composition comprising an effective amount of a 1,3-oxazin-4-one derivative as defined in claim 1, and an agriculturally or horticulturally acceptable carrier or diluent.

8. A method of controlling weeds, comprising the step of:

applying an effective amount of a 1,3-oxazin-4-one derivative as defined in claim 1 to a place to be protected.