Claims
- 1. Compounds of the formula ##STR16## wherein A is --CO-- or --CHOH--; B is --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--; Q is 1,4-phenylene or 1,4-naphthylene; R.sup.1 is H or OH; R.sup.2 is H or CH.sub.3 ; R.sup.3 is alkyl of 1-8 carbon atoms or alkyl of 1-8 carbon atoms substituted by (a) phenyl, (b) phenyl substituted by at least one of CH.sub.3, F, Cl, Br, OH, OCH.sub.3 or CF.sub.3, (c) phenoxy or (d) phenoxy substituted by at least one of CH.sub.3, F, Cl, Br, OH, OCH.sub.3 or CF.sub.3 ; and R.sup.4 is NH.sub.2, CH.sub.3, phenyl, p-acetylaminophenyl, p-benzoylaminophenyl or phenylamino.
- 2. The compounds of claim 1, wherein R.sup.1 is OH.
- 3. The compounds of claim 1, wherein R.sup.3 is a straight chain alkyl group of 4-7 carbon atoms.
- 4. The compounds of claim 1, wherein R.sup.3 is alkyl of 1 or 2 carbon atoms substituted by phenyl or phenoxy, either of which is monosubstituted in the m- or p-position.
- 5. The compounds of claim 1, wherein Q is 1,4-phenylene.
- 6. The compounds of claim 1, wherein R.sup.4 is CH.sub.3, NH.sub.2, 4-acetylaminophenyl or phenyl.
- 7. 11.alpha.,15-Dihydroxy-15-methyl-9-oxo-13-thiaprostanoic acid (4-benzoylaminophenyl ester), a compound of claim 1.
- 8. 11.alpha.,15.alpha.-Dihydroxy-9-oxo-13-thiaprostanoic acid (4-benzoylaminophenyl ester), a compound of claim 1.
- 9. A pharmaceutical composition which comprises an amount of a compound of claim 1 effective for lowering blood pressure and a pharmaceutically acceptable carrier, adjuvant or mixture thereof.
- 10. A method of lowering blood pressure in mammals which comprises administering an amount of a compound of claim 1 effective for lowering blood pressure.
- 11. The compounds of claim 1 wherein R.sup.1 is OH; R.sup.3 is a straight chain alkyl group of 4-7 carbon atoms; and Q is 1,4-phenylene.
Priority Claims (1)
Number |
Date |
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Kind |
2644972 |
Oct 1976 |
DEX |
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CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a continuation-in-part application of copending United States application Ser. No. 837,975, filed on Sept. 29, 1977.
US Referenced Citations (7)
Continuation in Parts (1)
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Number |
Date |
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Parent |
837975 |
Sep 1977 |
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