Claims
- 1. 13,14 dihydro-.omega.-pentanorprostaglandins of the A.sub.2, F.sub.2 and E.sub.2 series having at the 15-position one hydrogen or lower alkyl substituent and one substituent of the formula:
- Ar--CH.sub.2 --
- wherein Ar is .alpha.- or .beta.-naphthyl; phenyl; 3,4-dimethoxyphenyl; 3,4-methylenedioxyphenyl; 3,4,5-trimethoxyphenyl; or monosubstituted phenyl wherein said substituent is halo, trifluoromethyl, phenyl, lower alkyl or lower alkoxy.
- 2. A compound of the structure: ##STR36## wherein M is = 0, ##STR37## Ar is .alpha.- or .beta.-napththyl; phenyl; 3,4-dimethoxyphenyl; 3,4-methylenedioxyphenyl; 3,4,5-trimethoxyphenyl; or monosubstituted phenyl wherein said substituent is halo, trifluoromethyl, phenyl, lower alkyl or lower alkoxy;
- R is hydrogen or lower alkyl;
- L is a single bond or cis double bond;
- N is hydrogen or .alpha.-hydroxyl;
- and wherein L, M and N are so selected as to complete the structure of a prostaglandin of the A, E or F series.
- 3. A compound of the structure: ##STR38## wherein Ar is .alpha.- or .beta.-naphthyl; phenyl; 3,4-dimethoxyphenyl; 3,4-methylenedioxyphenyl; 3,4,5-trimethoxyphenyl; or monosubstituted phenyl wherein said substituent is halo, trifluoromethyl, phenyl, lower alkyl or lower alkoxy;
- R is hydrogen or lower alkyl.
- 4. A compound of the structure: ##STR39## wherein Ar is .alpha.- or .beta.-naphthyl; phenyl; 3,4-dimethoxyphenyl; 3,4-methylenedioxyphenyl; 3,4,5-trimethoxyphenyl; or monosubstituted phenyl wherein said substituent is halo, trifluormethyl, phenyl, lower alkyl or lower alkoxy;
- and R is hydrogen or lower alkyl.
- 5. A compound of the structure: ##STR40## wherein Ar is .alpha.- or .beta.-naphthyl; phenyl; 3,4-dimethoxyphenyl; 3,4-methylenedioxyphenyl; 3,4,5-trimethoxyphenyl; or monosubstituted phenyl wherein said substituent is halo, trifluoromethyl, phenyl, lower alkyl or lower alkoxy; and R is hydrogen or lower alkyl.
- 6. The compound of claim 1 wherein Ar is phenyl, n is 1 and said prostaglandin is 13,14-dihydro PGE.sub.2.
- 7. The compound of claim 1 wherein Ar is phenyl, n is 1 and said prostaglandin is 13,14-dihydro PGF.sub.2.sub..beta..
- 8. The compound of claim 1 wherein Ar is .beta.-naphthyl, n is 1 and said prostaglandin is 13,14-dihydro PGF.sub.2.sub..beta..
- 9. The compound of claim 1 wherein Ar is .beta.-naphthyl, n is 1 and said prostaglandin is 13,14-dihydro PGE.sub.2.
- 10. The compound of claim 1 wherein Ar is phenyl, n is 1 and said prostaglandin is 13,14-dihydro-15-methyl PGE.sub.2.
- 11. The compound of claim 1 wherein Ar is phenyl, n is 1 and said prostaglandin is 13,14-dihydro PGA.sub.2.
- 12. The compound of claim 1 wherein Ar is m-tolyl, n is 1 and said prostaglandin is 13,14-dihydro PGE.sub.2.
- 13. The compound of claim 1 wherein Ar is m-tolyl, n is 1 and said prostaglandin is 13,14-dihydro PGF .sub.2.sub..beta..
CROSS REFERENCE TO RELATED APPLICATIONS
This application is a continuation-in-part of our copending United States patent applications, Ser. No. 271,220 filed July 13, 1972 and now abandoned Ser. No. 425,519 filed Dec. 17, 1973 and now abandoned.
US Referenced Citations (3)
Foreign Referenced Citations (1)
Number |
Date |
Country |
2,154,309 |
May 1972 |
DT |
Related Publications (1)
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Number |
Date |
Country |
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425519 |
Dec 1973 |
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Continuation in Parts (1)
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Number |
Date |
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Parent |
271220 |
Jul 1972 |
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