Claims
- 1. A prostaglandin analog of the formula ##STR2## wherein m is one to 5, inclusive; WHEREIN M.sub.1 is ##STR3## wherein R.sub.5 and R.sub.6 are hydrogen or methyl, with the proviso that one of R.sub.5 and R.sub.6 is methyl only when the other is hydrogen;
- Wherein L.sub.1 is ##STR4## or a mixture of ##STR5## wherein R.sub.3 and R.sub.4 are hydrogen, methyl, or fluoro, being the same or different, with the proviso that one of R.sub.3 and R.sub.4 is fluoro only when the other is hydrogen or fluoro;
- Wherein R.sub.1 is hydrogen, alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, phenyl substituted with one, two, or three chloro or alkyl of one to 3 carbon atoms, inclusive, or a pharmacologically acceptable cation; and
- Wherein Z.sub.7 is
- (1) --(CH.sub.2).sub.3 --(CH.sub.2).sub.g --CF.sub.2 --, or
- (2) --(CH.sub.2).sub.3 --(CH.sub.2).sub.6 --CH.sub.2 --,
- wherein g is one, 2, or 3.
- 2. A compound according to claim 1, wherein M.sub.1 is ##STR6##
- 3. A compound according to claim 1, wherein M.sub.1 is ##STR7##
- 4. A compound according to claim 3, wherein m is 3.
- 5. A compound according to claim 4, wherein Z.sub.7 is
- --(CH.sub.2).sub.3 --(CH.sub.2).sub.g --CF.sub.2 --.
- 6. A compound according to claim 5, wherein g is 3.
- 7. A compound according to claim 5, wherein g is one.
- 8. A compound according to claim 7, wherein R.sub.5 and R.sub.6 are both hydrogen.
- 9. A compound according to claim 8, wherein R.sub.3 and R.sub.4 are both hydrogen.
- 10. 2,2-Difluoro-13,14-dihydro-9.beta.-PGD.sub.1, a compound according to claim 9.
- 11. A compound according to claim 8, wherein R.sub.3 and R.sub.4 are both fluoro.
- 12. 2,2,16,16-Tetrafluoro-13,14-dihydro-9.beta.-PGD.sub.1, a compound according to claim 11.
- 13. A compound according to claim 4, wherein Z.sub.7 is
- --(CH.sub.2).sub.3 --(CH.sub.2).sub.g --CH.sub.2 --.
- 14. A compound according to claim 13, wherein g is 3.
- 15. A compound according to claim 14, wherein R.sub.5 and R.sub.6 are both hydrogen.
- 16. A compound according to claim 15, wherein R.sub.3 and R.sub.4 are both hydrogen.
- 17. 2a,2b-Dihomo-13,14-dihydro-9.beta.-PGD.sub.1, a compound according to claim 16.
- 18. A compound according to claim 15, wherein R.sub.3 and R.sub.4 are both fluoro.
- 19. 2a,2b-Dihomo-16,16-difluoro-13,14-dihydro-9.beta.-PGD.sub.1, a compound according to claim 18.
- 20. A compound according to claim 13, wherein g is one.
- 21. A compound according to claim 20, wherein R.sub.5 and R.sub.6 are both hydrogen.
- 22. A compound according to claim 21, wherein R.sub.3 and R.sub.4 are both hydrogen.
- 23. 13,14-Dihydro-9.beta.-PGD.sub.1, a compound according to claim 22.
- 24. A compound according to claim 21, wherein R.sub.3 and R.sub.4 are both fluoro.
- 25. 16,16-Difluoro-13,14-dihydro-9.beta.-PGD.sub.1, a compound according to claim 24.
Parent Case Info
The present application is a divisional application of Ser. No. 614,242, filed Sept. 17, 1975, now issued as U.S. Pat. No. 4,016,184, on Apr. 5, 1977.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3862979 |
Gondolfi et al. |
Jan 1975 |
|
3933904 |
Strike |
Jan 1976 |
|
3954844 |
Colton et al. |
May 1976 |
|
Divisions (1)
|
Number |
Date |
Country |
Parent |
614242 |
Sep 1975 |
|