Claims
- 1. A compound of the formula:
- 2. The compound of claim 1 wherein R1 and R2 are independently selected from the group consisting of hydrogen, lower alkyl.
- 3. The compound of claim 2 wherein R1 and R2 are both hydrogen.
- 4. The compound of claim 2 wherein R3 is selected from the group consisting of substituted or unsubstituted phenyl, pyridinyl, pyrrolyl, pyrazolyl, imidazolyl, triazinyl, furfuryl, and thiophenyl, and lower alkyl, wherein said substitutents are one to three independently selected from the group consisting of lower alkyl, lower alkoxy, amino, lower alkylamino, di-lower alkylamino, carboxyl, aminosulfonyl, and lower alkylsulfonyl.
- 5. The compound of claim 3 wherein R3 is selected from the group consisting of substituted or unsubstituted phenyl, pyridinyl, pyrazinyl, pyrimidinyl, and triazinyl wherein said substitutents are one to three independently selected from the group consisting of lower alkyl, lower alkoxy, di-lower alkylamino, aminosulfonyl, and lower alkylsulfonyl
- 6. The compound of claim 4 wherein R4 is selected from the group consisting of substituted or unsubstituted phenyl, pyridinyl, pyrrolyl, imidazolidinyl, morpholinyl, triazinyl, thiophenyl, and lower alkyl; wherein said substitutents are one to three independently selected from the group consisting of lower alkoxy, amino, di-lower alkylamino, hydroxy, nitrile, carboxyl, aminosulfonyl, and lower alkylsulfonyl.
- 7. The compound of claim 5 wherein R4 is selected from the group consisting of substituted or unsubstituted phenyl, pyridinyl, morpholinyl, triazinyl, thiophenyl, and lower alkyl; wherein said substitutents are one to three independently selected from the group consisting of lower alkoxy, di-lower alkylamino, aminosulfonyl, and lower alkylsulfonyl.
- 8. The compound of claim 6 wherein R5 is selected from the group consisting of hydrogen, lower alkyl, hydroxy, and dilower alkylamino.
- 9. The compound of claim 7 wherein R5 is selected from the group consisting of hydrogen and lower alkyl.
- 10. The compound of claim 8 wherein Y is selected from the group consisting of C═O and CH—OH and m is an integer from 0-2.
- 11. The compound of claim 9 wherein Y is C═O, and m is 0 or 1
- 12. The compound of claim 10 wherein X is selected from the group consisting of CH2, C═O, and SO2; and n is 0 or 1.
- 13. A method of treating a patient having neoplasia comprising administering a pharmacologically effective amount of a compound of Formula I to the patient with a neoplasia sensitive to such a compound:
- 14. The method of claim 13 wherein R1 and R2 are independently selected from the group consisting of hydrogen, lower alkyl.
- 15. The method of claim 14 wherein R1 and R2 are both hydrogen.
- 16. The method of claim 14 wherein R3 is selected from the group consisting of substituted or unsubstituted phenyl, pyridinyl, pyrrolyl, pyrazolyl, imidazolyl, triazinyl, furfuryl, and thiophenyl, and lower alkyl, wherein said substitutents are one to three independently selected from the group consisting of lower alkyl, lower alkoxy, amino, lower alkylamino, di-lower alkylamino, carboxyl, aminosulfonyl, and lower alkylsulfonyl.
- 17. The method of claim 15 wherein R3 is selected from the group consisting of substituted or unsubstituted phenyl, pyridinyl, pyrazinyl, pyrimidinyl, and triazinyl wherein said substitutents are one to three independently selected from the group consisting of lower alkyl, lower alkoxy, di-lower alkylamino, aminosulfonyl, and lower alkylsulfonyl.
- 18. The method of claim 16 wherein R4 is selected from the group consisting of substituted or unsubstituted phenyl, pyridinyl, pyrrolyl, imidazolidinyl, morpholinyl, triazinyl, thiophenyl, and lower alkyl; wherein said substitutents are one to three independently selected from the group consisting of lower alkoxy, amino, di-lower alkylamino, hydroxy, nitrile, carboxyl, aminosulfonyl, and lower alkylsulfonyl.
- 19. The method of claim 17 wherein R4 is selected from the group consisting of substituted or unsubstituted phenyl, morpholinyl, triazinyl, thiophenyl, and lower alkyl; wherein said substitutents are one to three independently selected from the group consisting of lower alkoxy, di-lower alkylamino, aminosulfonyl, and lower alkylsulfonyl.
- 20. The method of claim 18 wherein R5 is selected from the group consisting of hydrogen, lower alkyl, hydroxy, and dilower alkylamino.
- 21. The method of claim 19 wherein R5 is selected from the group consisting of hydrogen and lower alkyl.
- 22. The method of claim 20 wherein Y is selected from the group consisting of C═O and CH—OH and m is an integer from 0-2.
- 23. The method of claim 21 wherein Y is C═O, and m is 0 or 1
- 24. The method of claim 22 wherein X is selected from the group consisting of CH2, C═O, and SO2; and n is 0 or 1.
Parent Case Info
[0001] This application is a continuation of U.S. application Ser. No. 09/258,989 filed Feb. 26, 1999, which is a divisional of U.S. application Ser. No. 09/174,815 filed Oct. 19, 1998, both of which are incorporated herein by reference.
Divisions (1)
|
Number |
Date |
Country |
Parent |
09174815 |
Oct 1998 |
US |
Child |
09258989 |
Feb 1999 |
US |
Continuations (1)
|
Number |
Date |
Country |
Parent |
09258989 |
Feb 1999 |
US |
Child |
09731570 |
Dec 2000 |
US |