Claims
- 1. A composition for treating hypertension, comprising an effective amount of at least one compound of the formula: ##STR10## wherein, R.sub.1 and R.sub.4 independently represent a C.sub.1-4 alkyl group;
- R.sub.2 and R.sub.3 independently represent a C.sub.1-6 straight or branched alkyl chain which may be interrupted by an oxygen atom;
- R.sub.5 represents a straight or branched chain C.sub.1-13 alkyl group or a C.sub.5-8 cycloalkyl group which cycloalkyl group may be substituted by a C.sub.1-13 alkyl group, and a physiologically acceptable carrier.
- 2. A composition as claimed in claim 1 in a form suitable for oral, sub lingual, transdermal, parenteral or rectal administration.
- 3. A composition as claimed in claim 2 in the form of a tablet or capsule for oral administration.
- 4. A composition as claimed in claim 3 wherein the amount of the oral administration is between about 0.01 to about 50 mg per day.
- 5. A composition as claimed in claim 3 wherein the amount of the oral administration is between about 0.1 to about 20 mg per day.
- 6. A composition as claimed in claim 2 for parenteral administration in the form of a bolus injection or continuous infusion.
- 7. A composition as claimed in claim 6 wherein the amount of the parenteral administration is between 0.005 to about 1 mg per day.
- 8. A composition as claimed in claim 6 wherein the amount of the parenteral administration is between 0.01 to about 0.5 mg per day.
- 9. A composition as claimed in claim 2 for transdermal administration in the form of ointments or creams.
- 10. A composition as claimed in claim 2 for rectal administration in the form of suppositories or retention enemas.
- 11. A composition as claimed in claim 1 wherein the amount of the compound is between about 0.005 to about 50 mg.
- 12. A pharmaceutical composition comprising an effective amount of 4-(2-(3-(1,1-dimethylethoxy)-3-oxo-1-propenyl)phenyl) -1,4-dihydro-2-6-dimethyl-3,5-pyridinedicarboxylic acid diethyl ester and a physiologically acceptable carrier.
- 13. A composition as claimed in claim 12 in a form suitable for oral, sub-lingual, transdermal, parenteral or rectal administration.
- 14. A composition as claimed in claim 13 for oral administration in the form of a tablet or capsule.
- 15. A pharmaceutical composition of claim 12, for treating cardiovascular disorders resulting from transmembranal calcium ion flux.
- 16. A pharmaceutical composition of claim 12, for treating hypertension.
- 17. A composition as claimed in claim 14 wherein the amount of the oral administration is between about 0.01 to about 50 mg per day.
- 18. A composition as claimed in claim 14 wherein the amount of the oral administration is between about 0.1 to about 20 mg per day.
- 19. A composition as claimed in claim 13 for parenteral administration in the form of a bolus injection or continuous infusion.
- 20. A composition as claimed in claim 19 wherein the amount of the parenteral administration is between 0.005 to about 1 mg per day.
- 21. A composition as claimed in claim 19 wherein the amount of the parenteral administration is between 0.01 to about 0.5 mg per day.
- 22. A composition as claimed in claim 13 for transdermal administration in the form of ointments or creams.
- 23. A composition as claimed in claim 13 for rectal administration in the form of suppositories or retention enemas.
- 24. A composition as claimed in claim 13 wherein the amount of compound is between about 0.005 to about 50 mg.
- 25. A method of treating cardiovascular disorders arising from transmembranal calcium ion influx comprising administering to a patient in need of such treatment, an effective amount of the composition of claim 12.
- 26. A method of treating hypertension comprising administering to a patient in need of such treatment, an effective amount of the composition of claim 1.
- 27. A method for treating hypertension comprising administering to a patient in need of such treatment, an effective amount of the composition of claim 12.
Priority Claims (2)
Number |
Date |
Country |
Kind |
22383 A/84 |
Aug 1984 |
ITX |
|
21460 A/85 |
Jul 1985 |
ITX |
|
Parent Case Info
This is a divisional of co-pending application Ser. No. 767,593 filed Aug. 20, 1985 now U.S. Pat. No. 4,801,599 issued Jan. 31, 1989.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4801599 |
Semeraro et al. |
Jan 1989 |
|
Non-Patent Literature Citations (1)
Entry |
Rahwan et al.-Annual Reports in Medicinal Chem.-16, 1981, pp. 257-266. |
Divisions (1)
|
Number |
Date |
Country |
Parent |
767593 |
Aug 1985 |
|