Claims
- 1. A compound of general formula (I) ##STR12## wherein, R.sub.1 and R.sub.4 independently represent a C.sub.1-4 alkyl group;
- R.sub.2 and R.sub.3 independently represent a C.sub.1-6 straight or branched chain alkyl or a C.sub.1-4 alkyl group substituted by a C.sub.1-3 alkoxy group;
- R.sub.5 represents a group CH.dbd.CR.sub.6 R.sub.7 where R.sub.6 is a hydrogen atom or C.sub.1-3 alkyl group and R.sub.7 represents a phenyl group optionally substituted by one or more halogen atoms or C.sub.1-4 alkyl or C.sub.1-4 alkoxy groups, pyridyl or cyano group; or
- R.sub.5 represents the group C.vertline.CR.sub.8 where R.sub.8 is a phenyl group optionally substituted by one or more halogen atoms or C.sub.1-4 alkyl or C.sub.1-4 alkoxy groups.
- 2. A compound as claimed in claim 1 wherein R.sub.1 and R.sub.4 represent a methyl group.
- 3. A compound as claimed in claim 1 wherein R.sub.3 and R.sub.2 independently represent a methyl or ethyl group.
- 4. A compound as claimed in claim 1 wherein R.sub.6 represents hydrogen.
- 5. A compound as claimed in claim 1 wherein R.sub.7 represents a cyano, pyridyl or a phenyl group, optionally substituted by one or two chlorine or bromine atoms, a methyl or methoxy group or R.sub.8 represents a phenyl group optionally substituted by one or two chlorine or bromine atoms or a methyl or methoxy group.
- 6. A compound as claimed in claim 1 wherein R.sub.7 represents a phenyl group optionally substituted by a chlorine atom or a methoxy or methyl group or R.sub.8 represents a phenyl group.
- 7. A compound as claimed in claim 1 in which R.sub.3 and R.sub.2 independently represent a methyl or ethyl group, R.sub.6 represents hydrogen, R.sub.5 represents the group C.vertline.CR.sub.8 where R.sub.8 is a phenyl group optionally substituted by one or more halogen atoms or a C.sub.1-4 alkyl or a C.sub.1-4 alkoxy group and R.sub.7 represents a cyano, pyridyl or a phenyl group optionally substituted by one or two chlorine or bromine atoms, a methyl or methoxy group.
- 8. A compound as claimed in claim 7 in which R.sub.2 and R.sub.3 each represent an ethyl group.
- 9. A compound as claimed in claim 7 in which R.sub.3 and R.sub.2 each represent a methyl group.
- 10. A compound as claimed in claim 7 in which R.sub.5 represents the group C.vertline.CR.sub.8 where R.sub.8 is an unsubstituted phenyl group.
- 11. A compound as claimed in claim 1 in which R.sub.5 represents the group C.vertline.CR.sub.8 where R.sub.8 is an unsubstituted phenyl group.
- 12. A compound as claimed in claim 7 in which R.sub.7 represents a phenyl group optionally substituted by one or two chlorine or bromine atoms.
- 13. A compound as claimed in claim 7 in which R.sub.5 represents the group C.vertline.CR.sub.8 where R.sub.8 is a phenyl group substituted by one halogen atom.
- 14. A compound as claimed in claim 7 in which R.sub.5 represents the group C.vertline.CR.sub.8 where R.sub.8 is a phenyl group substituted by C.sub.1-4 alkoxy groups.
- 15. A compound as claimed in claim 7 in which R.sub.7 represents pyridyl.
- 16. A compound as claimed in claim 7 in which R.sub.5 represents the group C.vertline.CR.sub.8 where R.sub.8 is a phenyl group substituted by a C.sub.1-4 alkyl group.
- 17. A compound as claimed in claim 1 in which R.sub.2 and R.sub.3 each independently represent a C.sub.1-6 straight or branched chain alkoxyalkyl group.
- 18. A composition for treating cardiovascular disorders resulting from transmembranal calcium ion flux comprising an effective amount of at least one compound as defined in claim 1 and a physiologically acceptable carrier.
Priority Claims (1)
Number |
Date |
Country |
Kind |
19481 A/86 |
Feb 1986 |
ITX |
|
Parent Case Info
This application is a continuation of Ser. No. 016,256, filed Feb. 19, 1987 now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4492703 |
Goldmann et al. |
Jan 1985 |
|
Foreign Referenced Citations (2)
Number |
Date |
Country |
1409865 |
Oct 1975 |
GBX |
2105989A |
Apr 1983 |
GBX |
Continuations (1)
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Number |
Date |
Country |
Parent |
16256 |
Feb 1987 |
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